Illuminating the Druggable Genome (IDG)

IDG is an NIH Common Fund project focused on collecting, integrating and making available biological data on 281 human genes from three key druggable protein families that have been identified as potential therapeutic targets: non-olfactory G-protein coupled receptors (GPCRs), ion channels, and protein kinases. The IMPC consortium is creating knockout mouse strains for the IDG project to better understand the function of these proteins.

IMPC data representation for IDG genes

IDG human genes are mapped to mouse orthologs using HCOP. The IMPC consortium is using different complementary targeting strategies to produce Knockout strains. Mice are produced and submitted to standardised phenotyping pipelines. Currently 51.2 % of mouse IDG gene have data representation in IMPC, the bar charts and heatmap below capture the IMPC data representation at different levels. The percentage might increase as we get more data and this page will reflect the change.

IMPC IDG data Heat Map

The heat map indicates the detailed IDG gene data representation in IMPC, from product availability to phenotypes. Phenotypes are grouped by biological systems.

Phenotype Associations

The following chord diagrams represent the various biological systems phenotype associations for IDG genes categorized both in all and in each family group. The line thickness is correlated with the strength of the association. Clicking on chosen phenotype(s) on the diagram allow to select common genes. Corresponding gene lists can be downloaded using the download icon.

All families

Ion channels

IMPC/IDG genes57
ES Cells produced45
Mice produced29
Phenotypes28

GPCRs

IMPC/IDG genes98
ES Cells produced58
Mice produced48
Phenotypes45

Kinases

IMPC/IDG genes124
ES Cells produced101
Mice produced66
Phenotypes61

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to genes listed on the IDG project.

There are 63 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
ADCK2 Haploinsufficiency Reduces Mitochondrial Lipid Oxidation and Causes Myopathy Associated with CoQ Deficiency. Journal of clinical medicine (September 2019) Adck2tm1(KOMP)Vlcg PMC6780728
Whole exome sequencing reveals a functional mutation in the GAIN domain of the Bai2 receptor underlying a forward mutagenesis hyperactivity QTL. Mammalian genome : official journal of the International Mammalian Genome Society (September 2017) Adgrb2tm1b(KOMP)Mbp 28894906
Control of oviductal fluid flow by the G-protein coupled receptor Adgrd1 is essential for murine embryo transit. Nature communications (February 2021) Adgrd1tm1b(EUCOMM)Wtsi Adgrd1tm1a(EUCOMM)Hmgu PMC7902839
Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function. Nature communications (October 2016) Adgrf1tm1a(KOMP)Wtsi PMC5075789
GPR110 (ADGRF1) mediates anti-inflammatory effects of N-docosahexaenoylethanolamine. Journal of neuroinflammation (November 2019) Adgrf1tm1a(KOMP)Wtsi PMC6858791
Ligand-Induced GPR110 Activation Facilitates Axon Growth after Injury. International journal of molecular sciences (March 2021) Adgrf1tm1a(KOMP)Wtsi PMC8037074
GPR110 ligands reduce chronic optic tract gliosis and visual deficit following repetitive mild traumatic brain injury in mice. Journal of neuroinflammation (July 2021) Adgrf1tm1a(KOMP)Wtsi PMC8286622
G protein-coupled receptor Gpr115 (Adgrf4) is required for enamel mineralization mediated by ameloblasts. The Journal of biological chemistry (August 2020) Adgrf4tm1a(KOMP)Wtsi Adgrf4tm1b(KOMP)Wtsi 32868297
Distribution of ASIC4 transcripts in the adult wild-type mouse brain. Neuroscience letters (April 2017) Asic4tm1a(KOMP)Mbp 28461138
Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition. Scientific reports (January 2017) Bckdktm1c(EUCOMM)Wtsi Bckdktm1a(EUCOMM)Wtsi Bckdktm1b(EUCOMM)Wtsi PMC5209746
Endurance performance and energy metabolism during exercise in mice with a muscle-specific defect in the control of branched-chain amino acid catabolism. PloS one (July 2017) Bckdktm1c(EUCOMM)Wtsi PMC5515431
BDK Deficiency in Cerebral Cortex Neurons Causes Neurological Abnormalities and Affects Endurance Capacity. Nutrients (July 2020) Bckdktm1c(EUCOMM)Wtsi PMC7469005
INAM plays a critical role in IFN-γ production by NK cells interacting with polyinosinic-polycytidylic acid-stimulated accessory cells. Journal of immunology (Baltimore, Md. : 1950) (October 2014) Calhm6tm2a(EUCOMM)Wtsi Calhm6tm2b(EUCOMM)Wtsi 25320282
Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice. PLoS genetics (August 2017) Cdk20tm1a(KOMP)Wtsi PMC5574612
CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells. Cell reports (September 2019) Cdk8tm1a(EUCOMM)Hmgu 31509750
Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development. Development (Cambridge, England) (June 2020) Cdk8tm1a(EUCOMM)Hmgu PMC7295591
NK Cell-Specific CDK8 Deletion Enhances Antitumor Responses. Cancer immunology research (January 2018) Cdk8tm1c(EUCOMM)Hmgu 29386186
Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions. Molecular cell (September 2019) Cdk8tm1c(EUCOMM)Hmgu 31495563
A kinase-independent role for CDK8 in BCR-ABL1+ leukemia. Nature communications (October 2019) Cdk8tm1c(EUCOMM)Hmgu PMC6802219
A Murine Model for Human ECO Syndrome Reveals a Critical Role of Intestinal Cell Kinase in Skeletal Development. Calcified tissue international (November 2017) Cilk1tm1a(KOMP)Mbp PMC5820141
Dysregulation of sonic hedgehog signaling causes hearing loss in ciliopathy mouse models. eLife (December 2020) Cilk1tm1a(KOMP)Mbp PMC7806262
Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa. PLoS genetics (August 2018) Clcc1tm1b(KOMP)Mbp PMC6133373
ADCK4 Deficiency Destabilizes the Coenzyme Q Complex, Which Is Rescued by 2,4-Dihydroxybenzoic Acid Treatment. Journal of the American Society of Nephrology : JASN (May 2020) Coq8btm1a(EUCOMM)Hmgu 32381600
Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS. Cancer cell (September 2014) Csnk1a1tm1c(KOMP)Wtsi Csnk1a1tm1a(KOMP)Wtsi PMC4199102
Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome. Leukemia (January 2019) Csnk1a1tm1c(KOMP)Wtsi 30651631
The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis. eLife (August 2020) Dyrk2tm97300(L1L2_Bact_P) PMC7410489
The orphan receptor GPR139 signals via Gq/11 to oppose opioid effects. The Journal of biological chemistry (June 2020) Gpr139tm1.1(KOMP)Vlcg 32576659
EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia. Nature communications (May 2021) Gpr156tm1.1(KOMP)Vlcg Ccdc88ctm1.1(KOMP)Mbp PMC8129141
The GPR171 pathway suppresses T cell activation and limits antitumor immunity. Nature communications (October 2021) Gpr171tm1(KOMP)Vlcg PMC8494883
GPR18 Controls Reconstitution of Mouse Small Intestine Intraepithelial Lymphocytes following Bone Marrow Transplantation. PloS one (July 2015) Gpr18tm1(KOMP)Vlcg Gpr18tm1.1(KOMP)Vlcg PMC4510063
Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control. Biology of sex differences (April 2018) Gpr37l1tm1c(EUCOMM)Wtsi Gpr37l1tm1a(EUCOMM)Wtsi PMC5889568
Loss of GPRC5B impairs synapse formation of Purkinje cells with cerebellar nuclear neurons and disrupts cerebellar synaptic plasticity and motor learning. Neuroscience research (February 2018) Gprc5btm1a(EUCOMM)Wtsi 29481883
Orphan G Protein-Coupled Receptor GPRC5B Controls Smooth Muscle Contractility and Differentiation by Inhibiting Prostacyclin Receptor Signaling. Circulation (January 2020) Gprc5btm1a(EUCOMM)Wtsi 31941358
GPRC5b Modulates Inflammatory Response in Glomerular Diseases via NF-κB Pathway. Journal of the American Society of Nephrology : JASN (July 2019) Gprc5btm1c(EUCOMM)Wtsi Gprc5btm1a(EUCOMM)Wtsi 31285284
HIPK4 is essential for murine spermiogenesis. eLife (March 2020) Hipk4tm1b(KOMP)Mbp PMC7067585
Studying independent Kcna6 knock-out mice reveals toxicity of exogenous LacZ to central nociceptor terminals and differential effects of Kv1.6 on acute and neuropathic pain sensation. The Journal of neuroscience : the official journal of the Society for Neuroscience (September 2021) Kcna6em1(IMPC)J 34544832
Targeted deletion of the Kv6.4 subunit causes male sterility due to disturbed spermiogenesis. Reproduction, fertility, and development (August 2017) Kcng4tm1(KOMP)Vlcg 27677211
Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1. Neuron (December 2017) Kcnk13em1(IMPC)H PMC5783715
Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice. Neuron (October 2017) Lrrk1tm1a(KOMP)Wtsi Lrrk1tm1b(KOMP)Wtsi 29056298
ASK1/p38 signaling in renal tubular epithelial cells promotes renal fibrosis in the mouse obstructed kidney. American journal of physiology. Renal physiology (October 2014) Map3k5tm1a(EUCOMM)Hmgu 25298527
ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype. Molecular metabolism (May 2017) Map3k5tm1a(EUCOMM)Hmgu PMC5485239
ASK1 inhibits browning of white adipose tissue in obesity. Nature communications (April 2020) Map3k5tm1a(EUCOMM)Hmgu PMC7118089
Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module. Cell systems (November 2016) Mark3tm1a(KOMP)Mbp PMC5269473
NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization. Nature communications (June 2018) Nek7tm1a(EUCOMM)Hmgu PMC5997995
Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. The Journal of biological chemistry (March 2013) Oxgr1tm1(KOMP)Vlcg PMC3630866
α-Ketoglutarate regulates acid-base balance through an intrarenal paracrine mechanism. The Journal of clinical investigation (June 2013) Oxgr1tm1(KOMP)Vlcg PMC3696567
Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor. Journal of immunology (Baltimore, Md. : 1950) (November 2013) Oxgr1tm1(KOMP)Vlcg PMC3869987
The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice. Biochemical and biophysical research communications (September 2016) Oxgr1tm1(KOMP)Vlcg PMC5082686
Type 2 Cysteinyl Leukotriene Receptors Drive IL-33-Dependent Type 2 Immunopathology and Aspirin Sensitivity. Journal of immunology (Baltimore, Md. : 1950) (December 2017) Oxgr1tm1(KOMP)Vlcg PMC5780246
The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation. Science immunology (October 2018) Oxgr1tm1(KOMP)Vlcg 30291131
The leukotriene receptors as therapeutic targets of inflammatory diseases. International Immunology (August 2019) Oxgr1tm1(KOMP)Vlcg 31135881
The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis. Human molecular genetics (July 2020) Pak3tm1b(EUCOMM)Hmgu 31943058
Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system. Proceedings of the National Academy of Sciences of the United States of America (June 2016) Pip4k2ctm1b(KOMP)Wtsi PMC4941458
Therapeutic Delivery of Pip4k2c-Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (March 2021) Pip4k2ctm1b(KOMP)Wtsi PMC8132051
Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias. Nature immunology (March 2021) Riok2tm1a(KOMP)Wtsi 33753942
Stk31 is dispensable for embryonic development and spermatogenesis in mice. Molecular reproduction and development (September 2013) Stk31tm2a(KOMP)Wtsi PMC5441557
Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease. eLife (October 2019) Tmc4em1(IMPC)J PMC6850774
Spinocerebellar ataxia type 11-associated alleles of Ttbk2 dominantly interfere with ciliogenesis and cilium stability. PLoS genetics (December 2018) Ttbk2tm1a(EUCOMM)Hmgu PMC6307817
Recurrent deletions of ULK4 in schizophrenia: a gene crucial for neuritogenesis and neuronal motility. Journal of cell science (November 2013) Ulk4tm1a(KOMP)Wtsi 24284070
Ulk4 Is Essential for Ciliogenesis and CSF Flow. The Journal of neuroscience : the official journal of the Society for Neuroscience (July 2016) Ulk4tm1a(KOMP)Wtsi 27445138
Ulk4 deficiency leads to hypomyelination in mice. Glia (October 2017) Ulk4tm1a(KOMP)Wtsi 29034508
Ulk4 regulates GABAergic signaling and anxiety-related behavior. Translational psychiatry (February 2018) Ulk4tm1a(KOMP)Wtsi PMC5804027
Vaccinia-related kinase 2 plays a critical role in microglia-mediated synapse elimination during neurodevelopment. Glia (May 2019) Vrk2tm1d(KOMP)Wtsi 31050055

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