Gene: Pkn1

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Name
protein kinase N1
MGI ID
MGI:108022
Synonyms
Pkn PAK1 PRK1 Stk3 Prkcl1 F730027O18Rik
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased large unstained cell number Pkn1tm1b(KOMP)Wtsi HOM Early adult 1.97×10-07
decreased monocyte cell number Pkn1tm1b(KOMP)Wtsi HOM   Early adult 3.68×10-08
abnormal behavior Pkn1tm1b(KOMP)Wtsi HOM Early adult 4.55×10-05
decreased lymphocyte cell number Pkn1tm1b(KOMP)Wtsi HOM Early adult 1.22×10-11
decreased eosinophil cell number Pkn1tm1b(KOMP)Wtsi HOM   Early adult 1.47×10-06
decreased leukocyte cell number Pkn1tm1b(KOMP)Wtsi HOM Early adult 2.91×10-12
increased hemoglobin content Pkn1tm1b(KOMP)Wtsi HOM Early adult 6.25×10-05
decreased neutrophil cell number Pkn1tm1b(KOMP)Wtsi HOM   Early adult 1.62×10-12
increased total body fat amount Pkn1tm1b(KOMP)Wtsi HOM Early adult 1.43×10-08
increased anxiety-related response Pkn1tm1b(KOMP)Wtsi HOM Early adult 1.74×10-05
decreased red blood cell distribution width Pkn1tm1b(KOMP)Wtsi HOM Early adult 8.93×10-05
increased thigmotaxis Pkn1tm1b(KOMP)Wtsi HOM Early adult 3.64×10-05
hypoactivity Pkn1tm1b(KOMP)Wtsi HOM   Early adult 2.96×10-05

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/590)  (2/2)  Wholemount images
Aorta 2 No  (1/590)  (2/2)  Wholemount images
Bone 2 No N/A
Brain 2 No  (3/590)  (2/2)  Wholemount images
Brainstem 2 No  (2/590)  (2/2)  Wholemount images
Brown adipose tissue 2 No  (2/2)  Wholemount images
Cartilage tissue 2 No N/A
Cerebellum 2 No  (3/590)  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/590)  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (1/590) N/A
Hippocampus 2 No  (3/590)  (2/2)  Wholemount images
Hypothalamus 2 No  (2/590)  (2/2)  Wholemount images
Kidney 2 No  (20/590)  (2/2)  Wholemount images
Large intestine 2 No  (10/590)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (1/590)  (2/2)  Wholemount images
Lung 2 No  (1/590)  (2/2)  Wholemount images
Lymph node 2 No  (2/2)  Wholemount images
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/590)  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/590) N/A
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/590)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (1/590)  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/590)  (2/2)  Wholemount images
Prostate gland 2 No  (12/590) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/590)  (2/2)  Wholemount images
Spinal cord 2 No  (2/590)  (2/2)  Wholemount images
Spleen 2 No  (2/590) N/A
Stomach 2 No  (13/590)  (2/2)  Wholemount images
Striatum 2 No  (3/590)  (2/2)  Wholemount images
Testis 2 No  (5/590)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (16/590)  (1/2)  Wholemount images
Trachea 2 No  (2/590) N/A
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/506)  (4/5) N/A
Ear 2  (1/506)  (2/5) N/A
Embryo 2  (1/507)  (5/5) N/A
Eye 2  (1/506)  (4/5) N/A
Foot 2  (1/506)  (4/5) N/A
Forebrain 2  (1/506)  (4/5) N/A
Forelimb 2  (1/506)  (4/5) N/A
Hand 2  (1/506)  (4/5) N/A
Head 2  (5/506)  (5/5) N/A
Heart 2  (1/506)  (2/5) N/A
Hindbrain 2  (6/506)  (4/5) N/A
Hindlimb 2  (1/506)  (4/5) N/A
Liver 2  (1/504)  (2/5) N/A
Lung 2  (1/504)  (2/5) N/A
Mandibular process 2  (1/506)  (2/5) N/A
Maxillary process 2  (1/506)  (2/5) N/A
Midbrain 2  (1/506)  (4/5) N/A
Oral cavity 2  (1/504) N/A
Skin 2  (1/506) N/A
Tail 2  (1/506)  (4/5) N/A
Tail somite 2  (1/506)  (2/5) N/A

 Associated Images

X-ray: XRay Images Whole Body Dorso Ventral
10 Images
Adult LacZ: LacZ Images Wholemount
22 Images
Embryo LacZ: LacZ images wholemount
8 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Pkn1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Pkn1tm44436(L1L2_gt1) Targeting vectors
Pkn1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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