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Gene: Lrrk1

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Name
leucine-rich repeat kinase 1
MGI ID
MGI:2142227
Synonyms
D130026O16Rik C230002E15Rik
Viability
Data available
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (39) Measurements chart (200) All data table (347)
Expression & images (46) Disease models (0) Order (5)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal fibula morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.63×10-14
abnormal locomotor behavior Lrrk1tm1b(KOMP)Wtsi HOM Early adult 6.80×10-07
increased circulating creatine kinase level Lrrk1tm1b(KOMP)Wtsi HOM   Early adult 3.59×10-05
abnormal clavicle morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.62×10-14
decreased lean body mass Lrrk1tm1b(KOMP)Wtsi HOM Early adult 1.56×10-05
abnormal snout morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 1.08×10-06
abnormal tibia morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.62×10-14
abnormal humerus morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.86×10-14
increased spleen weight Lrrk1tm1b(KOMP)Wtsi HOM Early adult 1.40×10-12
abnormal rib morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 1.58×10-13
decreased circulating alkaline phosphatase level Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.23×10-05
abnormal joint morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 1.12×10-05
increased total body fat amount Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.68×10-05
thrombocytopenia Lrrk1tm1b(KOMP)Wtsi HOM Early adult 3.60×10-18
increased circulating calcium level Lrrk1tm1b(KOMP)Wtsi HOM   Early adult 2.62×10-05
abnormal radius morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.57×10-08
abnormal gait Lrrk1tm1b(KOMP)Wtsi HOM Early adult 4.55×10-08
increased circulating aspartate transaminase level Lrrk1tm1b(KOMP)Wtsi HOM Early adult 4.88×10-06
absent teeth Lrrk1tm1b(KOMP)Wtsi HOM Early adult 7.35×10-10
abnormal maxilla morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 7.27×10-12
increased bone mineral density Lrrk1tm1b(KOMP)Wtsi HOM Early adult 0.00
abnormal vertebrae morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 3.38×10-05
increased red blood cell distribution width Lrrk1tm1b(KOMP)Wtsi HOM Early adult 6.69×10-22
abnormal zygomatic bone morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 1.47×10-12
abnormal tooth morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 5.32×10-15
increased circulating HDL cholesterol level Lrrk1tm1b(KOMP)Wtsi HOM Early adult 5.91×10-09
decreased blood urea nitrogen level Lrrk1tm1b(KOMP)Wtsi HOM Early adult 6.44×10-06
abnormal ulna morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.57×10-07
increased circulating cholesterol level Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.09×10-12
increased neutrophil cell number Lrrk1tm1b(KOMP)Wtsi HOM   Early adult 2.11×10-17
decreased basophil cell number Lrrk1tm1b(KOMP)Wtsi HOM Early adult 8.05×10-05
increased bone mineral content Lrrk1tm1b(KOMP)Wtsi HOM Early adult 0.00
abnormal femur morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.59×10-14
abnormal mandible morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.93×10-14
abnormal pelvic girdle bone morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 4.14×10-06
decreased lymphocyte cell number Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.98×10-13
decreased eosinophil cell number Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.22×10-06
abnormal eyelid morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 1.38×10-30
short tibia Lrrk1tm1b(KOMP)Wtsi HOM Early adult 3.08×10-15

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Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/584)  (2/2)  Wholemount images
Aorta 2 No  (1/584)  (2/2) N/A
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (4/584)  (2/2)  Wholemount images
Brainstem 2 No  (2/584) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/584)  (2/2)  Wholemount images
Cerebellum 2 No  (3/584) N/A
Cerebral cortex 2 No  (2/584) N/A
Esophagus 2 No  (7/408)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (2/584)  (2/2) N/A
Hippocampus 2 No  (3/584) N/A
Hypothalamus 2 No  (2/584) N/A
Kidney 2 No  (21/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (1/584)  (2/2)  Wholemount images
Lung 2 No  (2/584)  (2/2)  Wholemount images
Lymph node 2 No  (1/584)  (2/2)  Wholemount images
Mammary gland 2 No  (1/2)  Wholemount images
Olfactory lobe 2 No  (2/584) N/A
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584)  (2/2)  Wholemount images
Parathyroid gland 2 No  (1/562)  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/584) N/A
Peyer's patch 2 No  (2/2)  Wholemount images
Pituitary gland 2 No  (1/584) N/A
Prostate gland 2 No  (12/584)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No  (1/584)  (2/2)  Wholemount images
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (3/584) N/A
Spleen 2 No  (3/584)  (2/2)  Wholemount images
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (3/584) N/A
Testis 2 No  (6/584)  (1/2)  Wholemount images
Thymus 2 No  (1/584)  (2/2)  Wholemount images
Thyroid gland 2 No  (16/584)  (2/2)  Wholemount images
Trachea 2 No  (3/584)  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
LacZ Wholemount Images
cardiovascular system (1)
Cartilage tissue expression
Vascular System expression
Bone expression
MA:0002718
MA:0000104
MA:0001459
digestive system (5)
Gall Bladder expression
MA:0000356
endocrine system (2)
Adrenal gland expression
MA:0000116
exocrine system (2)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
immune system (4)
Lymph Node expression
MA:0000139
integumental system (2)
Mammary gland expression
MA:0000145
musculoskeletal system (1)
Cartilage tissue expression
Vascular System expression
Bone expression
MA:0002718
MA:0000104
MA:0001459
nervous system (3)
Brain expression
MA:0000168
postnatal mouse (23)
Adrenal gland expression
MA:0000116
reproductive system (3)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
respiratory system (3)
Lung expression
MA:0000415
sensory organ (1)
Eye expression
MA:0000261
set of connective tissues (1)
Cartilage tissue expression
Vascular System expression
Bone expression
MA:0002718
MA:0000104
MA:0001459
trunk (14)
Adrenal gland expression
MA:0000116
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
No Embryo expression data was found for this gene.

 Associated Images

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Echo: M-Mode Images
28 Images
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X-ray: XRay Images Whole Body Dorso Ventral
10 Images
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X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
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Adult LacZ: LacZ Images Wholemount
23 Images
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X-ray: XRay Images Whole Body Lateral Orientation
10 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Lrrk1tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Lrrk1tm1c(KOMP)Wtsi Wild type floxed exon (post-Flp) Mice
Lrrk1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Lrrk1tm43355(L1L2_gt0) Targeting vectors
Lrrk1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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