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Genes Phenotypes

Gene: Lrrk1

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Name
leucine-rich repeat kinase 1
MGI ID
MGI:2142227
Synonyms
D130026O16Rik C230002E15Rik
Viability
Homozygous - Viable
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (39) Measurements chart (202) All data table (347)
Expression & images (46) Disease models (0) Order (5)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
increased bone mineral density Lrrk1tm1b(KOMP)Wtsi HOM Early adult 0.00
increased bone mineral content Lrrk1tm1b(KOMP)Wtsi HOM Early adult 0.00
small thymus Lrrk1tm1b(KOMP)Wtsi HOM Early adult 0.00
abnormal pelvic girdle bone morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 5.42×10-06
absent teeth Lrrk1tm1b(KOMP)Wtsi HOM Early adult 7.58×10-10
abnormal mandible morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.84×10-14
abnormal femur morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.91×10-14
abnormal vertebrae morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 3.34×10-05
abnormal ulna morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.52×10-07
abnormal snout morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 1.11×10-06
decreased blood urea nitrogen level Lrrk1tm1b(KOMP)Wtsi HOM Early adult 3.46×10-06
increased red blood cell distribution width Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.70×10-20
increased circulating cholesterol level Lrrk1tm1b(KOMP)Wtsi HOM Early adult 5.86×10-12
increased circulating creatine kinase level Lrrk1tm1b(KOMP)Wtsi HOM   Early adult 5.66×10-05
abnormal tibia morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.94×10-14
abnormal eyelid morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 1.61×10-30
abnormal tooth morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 5.61×10-15
decreased eosinophil cell number Lrrk1tm1b(KOMP)Wtsi HOM Early adult 5.84×10-06
abnormal fibula morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.95×10-14
decreased lymphocyte cell number Lrrk1tm1b(KOMP)Wtsi HOM Early adult 1.95×10-11
short tibia Lrrk1tm1b(KOMP)Wtsi HOM Early adult 4.22×10-17
increased neutrophil cell number Lrrk1tm1b(KOMP)Wtsi HOM   Early adult 8.26×10-15
abnormal humerus morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.78×10-14
decreased lean body mass Lrrk1tm1b(KOMP)Wtsi HOM Early adult 1.59×10-05
abnormal rib morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 1.77×10-13
abnormal joint morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 1.11×10-05
increased total body fat amount Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.64×10-05
abnormal clavicle morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.94×10-14
abnormal locomotor behavior Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.10×10-06
increased spleen weight Lrrk1tm1b(KOMP)Wtsi HOM Early adult 8.25×10-12
abnormal radius morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 2.53×10-08
abnormal zygomatic bone morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 1.67×10-12
increased circulating aspartate transaminase level Lrrk1tm1b(KOMP)Wtsi HOM Early adult 9.59×10-06
thrombocytopenia Lrrk1tm1b(KOMP)Wtsi HOM Early adult 1.98×10-16
increased circulating HDL cholesterol level Lrrk1tm1b(KOMP)Wtsi HOM Early adult 1.17×10-08
abnormal maxilla morphology Lrrk1tm1b(KOMP)Wtsi HOM Early adult 7.19×10-12
increased circulating calcium level Lrrk1tm1b(KOMP)Wtsi HOM   Early adult 5.05×10-05
decreased circulating alkaline phosphatase level Lrrk1tm1b(KOMP)Wtsi HOM Early adult 1.30×10-05
abnormal gait Lrrk1tm1b(KOMP)Wtsi HOM Early adult 5.58×10-08

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Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/590)  (2/2)  Wholemount images
Aorta 2 No  (1/590)  (2/2) N/A
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (3/590)  (2/2)  Wholemount images
Brainstem 2 No  (2/590) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2)  Wholemount images
Cerebellum 2 No  (3/590) N/A
Cerebral cortex 2 No  (2/590) N/A
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (1/590)  (2/2) N/A
Hippocampus 2 No  (3/590) N/A
Hypothalamus 2 No  (2/590) N/A
Kidney 2 No  (20/590)  (2/2)  Wholemount images
Large intestine 2 No  (10/590)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (1/590)  (2/2)  Wholemount images
Lung 2 No  (1/590)  (2/2)  Wholemount images
Lymph node 2 No  (2/2)  Wholemount images
Mammary gland 2 No  (1/2)  Wholemount images
Olfactory lobe 2 No  (2/590) N/A
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/590)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/590)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (1/590) N/A
Peyer's patch 2 No  (2/2)  Wholemount images
Pituitary gland 2 No  (1/590) N/A
Prostate gland 2 No  (12/590)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/590)  (2/2)  Wholemount images
Spinal cord 2 No  (2/590) N/A
Spleen 2 No  (2/590)  (2/2)  Wholemount images
Stomach 2 No  (13/590)  (2/2)  Wholemount images
Striatum 2 No  (3/590) N/A
Testis 2 No  (5/590)  (1/2)  Wholemount images
Thymus 2 No  (2/2)  Wholemount images
Thyroid gland 2 No  (16/590)  (2/2)  Wholemount images
Trachea 2 No  (2/590)  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
LacZ Wholemount Images
cardiovascular system (1)
Cartilage tissue expression
Vascular System expression
Bone expression
MA:0002718
MA:0000104
MA:0001459
digestive system (5)
Gall Bladder expression
MA:0000356
endocrine system (2)
Adrenal gland expression
MA:0000116
exocrine system (2)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
immune system (4)
Lymph Node expression
MA:0000139
integumental system (2)
Mammary gland expression
MA:0000145
musculoskeletal system (1)
Cartilage tissue expression
Vascular System expression
Bone expression
MA:0002718
MA:0000104
MA:0001459
nervous system (3)
Brain expression
MA:0000168
postnatal mouse (23)
Adrenal gland expression
MA:0000116
reproductive system (3)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
respiratory system (3)
Lung expression
MA:0000415
sensory organ (1)
Eye expression
MA:0000261
set of connective tissues (1)
Cartilage tissue expression
Vascular System expression
Bone expression
MA:0002718
MA:0000104
MA:0001459
trunk (14)
Adrenal gland expression
MA:0000116
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
No Embryo expression data was found for this gene.

 Associated Images

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X-ray: XRay Images Whole Body Lateral Orientation
10 Images
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Echo: M-Mode Images
28 Images
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Adult LacZ: LacZ Images Wholemount
23 Images
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X-ray: XRay Images Whole Body Dorso Ventral
10 Images
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X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Lrrk1tm1c(KOMP)Wtsi Wild type floxed exon (post-Flp) Mice
Lrrk1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Lrrk1tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Lrrk1tm43355(L1L2_gt0) Targeting vectors
Lrrk1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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