Gene Summary

Name:
p21 (RAC1) activated kinase 5
Synonyms:
Pak7,  2900083L08Rik,  Pak5

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased vertical activity Pak5em1(IMPC)Mbp HOM Early adult 7.88×10-08
limb grasping Pak5em1(IMPC)Mbp HOM   Early adult 3.06×10-06
enlarged lymph nodes Pak5em1(IMPC)Mbp HOM Early adult 0.00
abnormal lymph node morphology Pak5em1(IMPC)Mbp HOM Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Pak5 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Pak5 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Specific Language Impairment 2
Deficit in phonologic short-term memory OMIM:606712
Specific Language Impairment 1
Deficit in phonologic short-term memory OMIM:606711
Presenile Dementia, Kraepelin Type
Dementia OMIM:176600
Schizophrenia 19
Cognitive impairment OMIM:617629
Monoamine Oxidase A Deficiency
Cognitive impairment ORPHA:3057
Immunodeficiency 32A
Lymphadenopathy OMIM:614893
Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Irf8 Deficiency
Lymphadenopathy ORPHA:319600
Immunodeficiency 38 With Basal Ganglia Calcification
Lymphadenopathy OMIM:616126
Hepatic Venoocclusive Disease With Immunodeficiency
Absence of lymph node germinal center OMIM:235550
Squamous Cell Carcinoma Of The Esophagus
Lymphadenopathy ORPHA:99977
Reticuloendotheliosis, X-Linked
Lymphadenopathy, Hepatosplenomegaly OMIM:312500
Pulmonary Nodular Lymphoid Hyperplasia
Mediastinal lymphadenopathy, Follicular hyperplasia ORPHA:60026
Mantle Cell Lymphoma
Lymphadenopathy, Splenomegaly ORPHA:52416
Kerion Celsi
Lymphadenopathy ORPHA:499
Immunodeficiency 75
Lymphadenopathy, Hepatosplenomegaly, Follicular hyperplasia OMIM:619126
Kimura Disease
Lymphadenopathy, Follicular hyperplasia ORPHA:482
Fragile Site, Distamycin A Type, Rare, Fra(16)(Q22.1)
Abnormality of the lymph nodes OMIM:136580
Immunodeficiency 7
Lymphadenopathy OMIM:615387
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Positive
Lymphadenopathy, Splenomegaly OMIM:608971
Adenocarcinoma Of The Esophagus
Lymphadenopathy ORPHA:99976
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity
Lymphadenopathy, Splenomegaly OMIM:618495
Mast Cell Sarcoma
Lymphadenopathy, Mediastinal lymphadenopathy, Splenomegaly ORPHA:66661
Deafness, Autosomal Dominant 34, With Or Without Inflammation
Lymphadenopathy OMIM:617772
Carcinoma Of Esophagus
Lymphadenopathy ORPHA:70482
Autoinflammation With Episodic Fever And Lymphadenopathy
Lymphadenopathy, Recurrent tonsillitis, Splenomegaly OMIM:618852
Hodgkin Lymphoma
Lymphadenopathy, Ataxia, Splenomegaly ORPHA:98293
Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome
Lymphadenopathy, Splenomegaly ORPHA:444463
Immunodeficiency 27B
Generalized lymphadenopathy OMIM:615978
Follicular Lymphoma
Lymphadenopathy, Mediastinal lymphadenopathy, Splenomegaly ORPHA:545
Nodular Lymphocyte Predominant Hodgkin Lymphoma
Lymphadenopathy, Splenomegaly ORPHA:86893
Lymphoproliferative Syndrome 3
Lymphadenopathy, Hepatosplenomegaly OMIM:618261
Immunodeficiency With Hyper-Igm, Type 2
Lymphadenopathy OMIM:605258
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation
Absent tonsils, Aplasia of the thymus, Lymph node hypoplasia OMIM:602450
Granulomatous Slack Skin
Abnormality of the lymph nodes ORPHA:33111
Polyglucosan Body Myopathy 1 With Or Without Immunodeficiency
Lymphadenopathy OMIM:615895
Familial Papillary Thyroid Carcinoma With Renal Papillary Neoplasia
Chronic noninfectious lymphadenopathy, Abnormality of the lymph nodes ORPHA:97290
Immunodeficiency With Hyper-Igm, Type 5
Lymphadenopathy OMIM:608106
Familial Papillary Or Follicular Thyroid Carcinoma
Chronic noninfectious lymphadenopathy, Abnormality of the lymph nodes ORPHA:319487
Candidiasis, Familial, 2
Lymphadenopathy OMIM:212050
Immunodeficiency 73C With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia
Cervical lymphadenopathy OMIM:618987
Immunodeficiency 76
Lymphadenopathy, Splenomegaly OMIM:619164
Rosaï-Dorfman Disease
Lymphadenopathy ORPHA:158014
Mu-Heavy Chain Disease
Lymphadenopathy, Splenomegaly ORPHA:100024
Immunodeficiency 14A, Autosomal Dominant
Lymphadenopathy, Splenomegaly OMIM:615513
Immunodeficiency 72 With Autoinflammation
Lymphadenopathy, Hepatosplenomegaly OMIM:618982
Immunodeficiency 55
Lymphadenopathy OMIM:617827
Immunodeficiency 78 With Autoimmunity And Developmental Delay
Fluctuating splenomegaly, Lymphadenopathy OMIM:619220
Immunodeficiency With Hyper-Igm, Type 3
Absence of lymph node germinal center OMIM:606843
Burkitt Lymphoma
Abnormality of the spleen, Abnormality of the lymph nodes ORPHA:543
Laryngeal Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy ORPHA:100083
Alpha-Heavy Chain Disease
Lymphadenopathy, Splenomegaly ORPHA:100025
Fish-Eye Disease
Lymphadenopathy, Splenomegaly ORPHA:79292
Pfapa Syndrome
Lymphadenopathy, Splenomegaly ORPHA:42642
Immunodeficiency 64
Mediastinal lymphadenopathy, Lymphadenopathy, Splenomegaly, Hepatosplenomegaly, Cervical lymphade... OMIM:618534
Hemophagocytic Lymphohistiocytosis, Familial, 5, With Or Without Microvillus Inclusion Disease
Lymphadenopathy, Hepatosplenomegaly, Splenomegaly OMIM:613101
Classic Hodgkin Lymphoma
Lymphadenopathy, Ataxia, Bone marrow hypocellularity, Splenomegaly ORPHA:391
Hemophagocytic Lymphohistiocytosis, Familial, 4
Lymphadenopathy, Splenomegaly OMIM:603552
Immunodeficiency With Hyper-Igm, Type 4
Absence of lymph node germinal center OMIM:608184
Immunodeficiency 52
Lymphadenopathy, Splenomegaly OMIM:617514
Immunodeficiency, Common Variable, 2
Lymphadenopathy, Follicular hyperplasia, Splenomegaly OMIM:240500
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia
Lymphadenopathy, Mediastinal lymphadenopathy, Splenomegaly OMIM:300853
Proteasome-Associated Autoinflammatory Syndrome 2
Lymphadenopathy OMIM:618048
Mycosis Fungoides
Lymphadenopathy OMIM:254400
Autoimmune Lymphoproliferative Syndrome, Type Iii
Mediastinal lymphadenopathy, Lymphadenopathy, Splenomegaly, Hepatosplenomegaly, Generalized lymph... OMIM:615559
Leukocyte Adhesion Deficiency, Type Iii
Hepatosplenomegaly, Abnormality of the lymph nodes, Splenomegaly OMIM:612840
Immunodeficiency 27A
Lymphadenopathy, Hepatosplenomegaly, Enlarged mesenteric lymph node, Splenomegaly OMIM:209950
Scrub Typhus
Lymphadenopathy, Tremor, Splenomegaly, Lethargy ORPHA:83317
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Absent tonsils, Absence of lymph node germinal center ORPHA:277
Classic Mycosis Fungoides
Lymphadenopathy, Splenomegaly ORPHA:2584
Pseudomyxoma Peritonei
Lymphadenopathy ORPHA:26790
Schnitzler Syndrome
Lymphadenopathy, Splenomegaly ORPHA:37748
Familial Cold Autoinflammatory Syndrome 2
Lymphadenopathy, Splenomegaly OMIM:611762
Caspase 8 Deficiency
Lymphadenopathy, Splenomegaly OMIM:607271
Pleural Mesothelioma
Lymphadenopathy ORPHA:50251
Purine Nucleoside Phosphorylase Deficiency
Tremor, Ataxia, Lymph node hypoplasia, Splenomegaly OMIM:613179
Immunodeficiency, Common Variable, 1
Lymphadenopathy, Splenomegaly OMIM:607594
Cold Agglutinin Disease
Lymphadenopathy, Splenomegaly ORPHA:56425
Indolent Systemic Mastocytosis
Lymphadenopathy, Splenomegaly ORPHA:98848
Autoinflammatory Syndrome, Familial, With Or Without Immunodeficiency
Lymphadenopathy, Splenomegaly OMIM:619375
Sézary Syndrome
Lymphadenopathy, Tremor, Splenomegaly ORPHA:3162
Tularemia
Lymphadenopathy, Abnormal nasopharyngeal adenoid morphology, Mediastinal lymphadenopathy, Cervica... ORPHA:3392
Congenital Toxoplasmosis
Lymphadenopathy ORPHA:858
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome
Lymphadenopathy, Splenomegaly OMIM:150550
Middle Ear Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy ORPHA:100084
Immunodeficiency 54
Lymphadenopathy, Splenomegaly OMIM:609981
Corticosteroid-Sensitive Aseptic Abscess Syndrome
Abnormality of the lymphatic system, Abnormality of the lymph nodes ORPHA:54251
Systemic-Onset Juvenile Idiopathic Arthritis
Lymphadenopathy, Splenomegaly ORPHA:85414
Ras-Associated Autoimmune Leukoproliferative Disorder
Follicular hyperplasia, Splenomegaly OMIM:614470
Heme Oxygenase 1 Deficiency
Lymphadenopathy, Cervical lymphadenopathy, Asplenia OMIM:614034
Lymphoproliferative Syndrome 2
Lymphadenopathy, Hepatosplenomegaly, Splenomegaly OMIM:615122
Meige Disease
Absence of lymph node germinal center, Lymph node hypoplasia ORPHA:90186
Immunodeficiency 10
Lymphadenopathy OMIM:612783
Cinca Syndrome
Lymphadenopathy, Hepatosplenomegaly OMIM:607115
Griscelli Syndrome
Lymphadenopathy, Ataxia, Bone marrow hypocellularity, Splenomegaly ORPHA:381
Nephroblastoma
Lymphadenopathy ORPHA:654
Omenn Syndrome
Lymphadenopathy, Hypoplasia of the thymus, Splenomegaly OMIM:603554
Rhabdoid Tumor
Lymphadenopathy ORPHA:69077
Acquired Hypertrichosis Lanuginosa
Lymphadenopathy ORPHA:2221
Griscelli Syndrome Type 2
Lymphadenopathy, Splenomegaly ORPHA:79477
Combined Immunodeficiency Due To Zap70 Deficiency
Lymphadenopathy, Lymphadenitis, Hepatosplenomegaly, Abnormality of the lymph nodes ORPHA:911
Roifman Syndrome
Lymphadenopathy, Splenomegaly OMIM:616651
Roifman Syndrome
Lymphadenopathy, Hepatosplenomegaly ORPHA:353298
Pyogenic Arthritis-Pyoderma Gangrenosum-Acne Syndrome
Lymphadenopathy ORPHA:69126
Thyroid Lymphoma
Lymphadenopathy ORPHA:97285
Autoimmune Lymphoproliferative Syndrome
Chronic noninfectious lymphadenopathy, Follicular hyperplasia, Splenomegaly OMIM:601859
Squamous Cell Carcinoma Of The Anal Canal
Lymphadenopathy ORPHA:424019
Niemann-Pick Disease, Type A
Athetosis, Inability to walk, Lymphadenopathy, Splenomegaly OMIM:257200
Lymphoproliferative Syndrome, X-Linked, 1
Lymphadenopathy, Splenomegaly OMIM:308240
Granulomatous Disease, Chronic, Autosomal Recessive, 5
Lymphadenopathy, Lymphadenitis, Splenomegaly, Hepatosplenomegaly, Recurrent tonsillitis OMIM:618935
Deafness-Lymphedema-Leukemia Syndrome
Lymphadenopathy, Bone marrow hypocellularity, Splenomegaly ORPHA:3226
Leishmaniasis
Lymphadenopathy, Splenomegaly ORPHA:507
Desmoplastic Small Round Cell Tumor
Lymphadenopathy, Mediastinal lymphadenopathy ORPHA:83469
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
Absent tonsils, Lymph node hypoplasia ORPHA:276
Proteasome-Associated Autoinflammatory Syndrome 4
Lymphadenopathy, Splenomegaly OMIM:619183
Boutonneuse Fever
Lymphadenopathy, Cervical lymphadenopathy ORPHA:83313
Klatskin Tumor
Lymphadenopathy ORPHA:99978
Autoimmune Lymphoproliferative Syndrome, Type Iia
Lymphadenopathy, Chronic noninfectious lymphadenopathy, Follicular hyperplasia, Splenomegaly OMIM:603909
Hyperimmunoglobulinemia D With Periodic Fever
Lymphadenopathy, Ataxia ORPHA:343
Medullary Thyroid Carcinoma
Lymphadenopathy ORPHA:1332
Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia
Lymphadenopathy OMIM:617718
Pulmonary Non-Tuberculous Mycobacterial Infection
Lymphadenopathy ORPHA:411703
Melkersson-Rosenthal Syndrome
Lymphadenopathy ORPHA:2483
Immunodeficiency 91 And Hyperinflammation
Lymphadenopathy, Hepatosplenomegaly OMIM:619644
American Trypanosomiasis
Lymphadenopathy, Splenomegaly ORPHA:3386
Immune Dysregulation With Autoimmunity, Immunodeficiency, And Lymphoproliferation
Lymphadenopathy, Splenomegaly OMIM:616100
Cyclic Neutropenia
Lymphadenopathy, Cervical lymphadenopathy, Recurrent tonsillitis ORPHA:2686
Primary Myelofibrosis
Lymphadenopathy, Hepatosplenomegaly, Splenomegaly ORPHA:824
Hypocomplementemic Urticarial Vasculitis
Lymphadenopathy, Ataxia, Splenomegaly ORPHA:36412
Chediak-Higashi Syndrome
Gait disturbance, Lymphadenopathy, Splenomegaly, Tremor, Ataxia OMIM:214500
Legionnaires Disease
Lymphadenopathy, Ataxia, Bone marrow hypocellularity, Splenomegaly ORPHA:549
Anaplastic Thyroid Carcinoma
Lymphadenopathy ORPHA:142
Pancreatoblastoma
Abnormality of the lymph nodes ORPHA:677
Thymic Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy, Mediastinal lymphadenopathy, Neoplasm of the thymus ORPHA:97289
Diffuse Cutaneous Mastocytosis
Lymphadenopathy, Abnormality of the spleen ORPHA:79456
Aggressive Systemic Mastocytosis
Lymphadenopathy, Hepatosplenomegaly, Hypersplenism ORPHA:98850
Omenn Syndrome
Lymphadenopathy, Splenomegaly ORPHA:39041
Felty Syndrome
Lymphadenopathy, Bone marrow hypocellularity, Splenomegaly ORPHA:47612
Cherubism
Marcus Gunn pupil, Submandibular lymph node enlargement OMIM:118400
Mevalonic Aciduria
Fluctuating splenomegaly, Lymphadenopathy, Progressive cerebellar ataxia, Hepatosplenomegaly, Ataxia OMIM:610377
Cinca Syndrome
Lymphadenopathy, Splenomegaly ORPHA:1451
Combined Immunodeficiency Due To Crac Channel Dysfunction
Lymphadenopathy, Splenomegaly ORPHA:169090
Agammaglobulinemia, X-Linked
Lymph node hypoplasia OMIM:300755
Castleman Disease
Lymphadenopathy, Generalized lymphadenopathy, Mediastinal lymphadenopathy, Follicular hyperplasia ORPHA:160
Hereditary Amyloidosis With Primary Renal Involvement
Lymphadenopathy, Hepatosplenomegaly, Abnormality of the lymph nodes ORPHA:85450
Lymphoproliferative Syndrome 1
Lymphadenopathy, Splenomegaly OMIM:613011
Immunodeficiency With Hyper-Igm, Type 1
Enlarged tonsils, Absence of lymph node germinal center, Splenomegaly OMIM:308230
Gamma-Heavy Chain Disease
Lymphadenopathy, Splenomegaly ORPHA:100026
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Lymphadenopathy, Hepatosplenomegaly ORPHA:169154
Macrophage Activation Syndrome
Lymphadenopathy, Splenomegaly ORPHA:158061
Cutaneous Neuroendocrine Carcinoma
Chronic noninfectious lymphadenopathy ORPHA:79140
Hemophagocytic Lymphohistiocytosis, Familial, 1
Lymphadenopathy, Ataxia, Splenomegaly OMIM:267700
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Lymphadenopathy, Hepatosplenomegaly, Enlarged tonsils OMIM:606367
Hemophagocytic Lymphohistiocytosis, Familial, 2
Lymphadenopathy, Ataxia, Hepatosplenomegaly, Splenomegaly OMIM:603553
Mixed Connective Tissue Disease
Lymphadenopathy, Mediastinal lymphadenopathy, Splenomegaly ORPHA:809
Immunodeficiency, Common Variable, 8, With Autoimmunity
Lymphadenopathy, Generalized lymphadenopathy, Splenomegaly OMIM:614700
Lig4 Syndrome
Lymphadenopathy ORPHA:99812
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked
Lymphadenopathy OMIM:304790
Aregenerative Anemia
Lymphadenopathy, Bone marrow hypocellularity ORPHA:101096
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia
Lymphadenitis, Generalized lymphadenopathy, Hepatosplenomegaly OMIM:618986
Pulmonary Capillary Hemangiomatosis
Lymphadenopathy, Mediastinal lymphadenopathy ORPHA:199241
Hyper-Igd Syndrome
Lymphadenopathy, Lymphadenitis, Hepatosplenomegaly, Splenomegaly OMIM:260920
Acute Interstitial Pneumonia
Lymphadenopathy ORPHA:79126
Familial Hemophagocytic Lymphohistiocytosis
Lymphadenopathy, Splenomegaly ORPHA:540
Granulomatous Disease, Chronic, Autosomal Recessive, 1
Lymphadenopathy, Lymphadenitis, Splenomegaly OMIM:233700
Granulomatous Disease, Chronic, Autosomal Recessive, 2
Lymphadenopathy, Lymphadenitis, Splenomegaly OMIM:233710
Kikuchi-Fujimoto Disease
Lymphadenopathy, Abnormality of the lymph nodes, Splenomegaly, Ataxia, Generalized lymphadenopath... ORPHA:50918
Waldenström Macroglobulinemia
Lymphadenopathy, Ataxia, Splenomegaly ORPHA:33226
Malt Lymphoma
Lymphadenopathy, Mediastinal lymphadenopathy ORPHA:52417
Chédiak-Higashi Syndrome
Gait disturbance, Lymphadenopathy, Splenomegaly, Tremor, Ataxia, Inability to walk, Hepatosplenom... ORPHA:167
Granulomatous Disease, Chronic, Autosomal Recessive, 4
Lymphadenopathy, Lymphadenitis, Splenomegaly OMIM:233690
Granulomatous Disease, Chronic, X-Linked
Lymphadenopathy, Lymphadenitis, Splenomegaly OMIM:306400
Autoinflammation, Panniculitis, And Dermatosis Syndrome
Lymphadenopathy OMIM:617099
Proteasome-Associated Autoinflammatory Syndrome 3
Lymphadenopathy, Splenomegaly OMIM:617591
Carney Triad
Lymphadenopathy, Mediastinal lymphadenopathy ORPHA:139411
Pediatric Systemic Lupus Erythematosus
Lymphadenopathy ORPHA:93552
Lymphatic Filariasis
Lymphadenopathy, Lymphadenitis, Lymphangiectasis, Abnormality of the lymphatic system ORPHA:2035
Acute Promyelocytic Leukemia
Lymphadenopathy ORPHA:520
Drug Reaction With Eosinophilia And Systemic Symptoms
Lymphadenopathy ORPHA:139402
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Hepatosplenomegaly, Absence of lymph node germinal center ORPHA:79124
Familial Pancreatic Carcinoma
Lymphadenopathy, Hepatosplenomegaly ORPHA:1333
Graft Versus Host Disease
Lymphadenopathy, Hepatosplenomegaly ORPHA:39812
Farber Disease
Lymphadenopathy, Hepatosplenomegaly ORPHA:333
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Lymphadenopathy, Bone marrow hypocellularity, Splenomegaly, Ataxia, Hepatosplenomegaly OMIM:615688
Systemic Mastocytosis With Associated Hematologic Neoplasm
Lymphadenopathy, Splenomegaly ORPHA:98849
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
Absent peripheral lymph nodes in presence of infection OMIM:600802
Histiocytosis-Lymphadenopathy Plus Syndrome
Lymphadenopathy, Hepatosplenomegaly, Cervical lymphadenopathy, Splenomegaly OMIM:602782
Poems Syndrome
Lymphadenopathy ORPHA:2905
H Syndrome
Lymphadenopathy, Hepatosplenomegaly ORPHA:168569
Common Variable Immunodeficiency
Lymphadenopathy, Splenomegaly ORPHA:1572
Q Fever
Lymphadenopathy, Hepatosplenomegaly, Splenomegaly ORPHA:781
Thymic Aplasia
Lymphadenopathy, Aplasia of the thymus ORPHA:83471
Neurologic, Endocrine, And Pancreatic Disease, Multisystem, Infantile-Onset 2
Lymphadenopathy, Accessory spleen, Polysplenia, Splenomegaly OMIM:619418
Spondyloenchondrodysplasia With Immune Dysregulation
Lymphadenopathy OMIM:607944
Tangier Disease
Hepatosplenomegaly, Chronic noninfectious lymphadenopathy, Orange discolored tonsils ORPHA:31150
Selective Igm Deficiency
Lymphadenopathy, Lymphadenitis ORPHA:331235
Gallbladder Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy ORPHA:100086
Multiple Myeloma
Lymphadenopathy, Splenomegaly ORPHA:29073
Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis
Lymphadenopathy, Hepatosplenomegaly ORPHA:85408
Lymphangioleiomyomatosis
Lymphadenopathy, Pulmonary lymphangiomyomatosis, Abnormality of the lymphatic system ORPHA:538
Autoimmune Lymphoproliferative Syndrome
Lymphadenopathy, Bone marrow hypocellularity, Splenomegaly, Hypersplenism, Chronic noninfectious ... ORPHA:3261
Hennekam Syndrome
Lymphadenopathy, Lymphangioma, Pulmonary lymphangiectasia, Splenomegaly ORPHA:2136
X-Linked Lymphoproliferative Disease
Lymphadenopathy, Bone marrow hypocellularity, Splenomegaly, Hepatosplenomegaly, Cervical lymphade... ORPHA:2442
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Lymphadenopathy, Splenomegaly ORPHA:37042
Autosomal Recessive Malignant Osteopetrosis
Lymphadenopathy, Tremor, Splenomegaly ORPHA:667
Adenocarcinoma Of The Anal Canal
Lymphadenopathy ORPHA:424016
Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome
Lymphadenopathy, Splenomegaly ORPHA:32960
Behçet Disease
Lymphadenopathy, Gait disturbance, Ataxia, Splenomegaly ORPHA:117
Ileal Neuroendocrine Tumor
Lymphadenopathy ORPHA:100078
Jejunal Neuroendocrine Tumor
Lymphadenopathy ORPHA:100077
Coccidioidomycosis
Lymphadenopathy, Abnormality of the spleen, Mediastinal lymphadenopathy ORPHA:228123
Familial Mediterranean Fever
Lymphadenopathy, Splenomegaly ORPHA:342
African Trypanosomiasis
Gait disturbance, Lymphadenopathy, Splenomegaly, Tremor, Hepatosplenomegaly, Akinesia, Difficulty... ORPHA:3385
Chikungunya
Lymphadenopathy, Cervical lymphadenopathy ORPHA:324625
Duodenal Neuroendocrine Tumor
Lymphadenopathy ORPHA:100076
Igg4-Related Submandibular Gland Disease
Lymphadenopathy ORPHA:449432
Brucellosis
Lymphadenopathy, Hypersplenism, Splenomegaly ORPHA:1304
Igg4-Related Kidney Disease
Lymphadenopathy, Lymphadenitis ORPHA:449395
Marburg Hemorrhagic Fever
Lymphadenopathy, Lethargy ORPHA:99826
Proteasome-Associated Autoinflammatory Syndrome 1
Lymphadenopathy, Splenomegaly OMIM:256040
Sarcoidosis
Lymphadenopathy, Abnormality of the lymph nodes ORPHA:797
Primary Sjögren Syndrome
Lymphadenopathy ORPHA:289390
Crimean-Congo Hemorrhagic Fever
Lymphadenopathy, Splenomegaly ORPHA:99827
Igg4-Related Ophthalmic Disease
Lymphadenopathy ORPHA:449563
Igg4-Related Dacryoadenitis And Sialadenitis
Lymphadenopathy ORPHA:79078
Immunodeficiency 82 With Systemic Inflammation
Lymphadenopathy, Follicular hyperplasia, Splenomegaly OMIM:619381
Blau Syndrome
Lymphadenopathy, Splenomegaly ORPHA:90340
Cushing Syndrome Due To Ectopic Acth Secretion
Abnormality of the lymph nodes, Neoplasm of the thymus ORPHA:99889
Leptospirosis
Lymphadenopathy ORPHA:509

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Pak5

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Pak5.

No publications found that use IMPC mice or data for Pak5.

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MGI Allele Allele Type Produced
Pak5tm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Pak5tm278118(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Pak5em1(IMPC)Mbp Intra-exon deletion Mice, Tissue

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