Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

G protein-coupled receptor 37-like 1
D0Kist8,  CAG-18

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Gpr37l1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Gpr37l1 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Hyperaldosteronism, Familial, Type Iv
Hypertension OMIM:617027
Platelet Prostacyclin Receptor Defect
Intermittent claudication OMIM:262875
Raynaud Disease
Raynaud phenomenon OMIM:179600
Coronary Artery Disease, Autosomal Dominant, 1
Myocardial infarction, Hypertension OMIM:608320
Intracranial Hypertension, Idiopathic
Hypertension OMIM:243200
Cardiogenic Shock
Abnormal left ventricular function, Low pulse pressure, Increased pulmonary capillary wedge press... ORPHA:97292
Congenital Pulmonary Veins Atresia Or Stenosis
Hypertension ORPHA:3188
Antithrombin Iii Deficiency
Pulmonary embolism, Arterial occlusion OMIM:613118
Abdominal Obesity-Metabolic Syndrome 1
Hypertension OMIM:605552
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2
Hypertension OMIM:605572
Spinocerebellar Ataxia Type 27
Akinesia, Limb ataxia, Truncal ataxia, Memory impairment, Gait disturbance, Difficulty walking, G... ORPHA:98764
Congenital Aortic Valve Stenosis
Angina pectoris, Abnormal left ventricular function, Abnormal T-wave, Aortic valve stenosis, Abno... ORPHA:3093
Spinocerebellar Ataxia Type 21
Akinesia, Cerebellar vermis atrophy, Progressive cerebellar ataxia, Cognitive impairment, Gait at... ORPHA:98773
Chudley-Mccullough Syndrome
Hydrocephalus, Gray matter heterotopia, Cerebellar hypoplasia, Polymicrogyria, Cerebellar dysplasia OMIM:604213
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Type II lissencephaly, Cerebellar dysplasia OMIM:615041
Spinocerebellar Ataxia 21
Akinesia, Ataxia, Progressive cerebellar ataxia, Limb ataxia, Cognitive impairment, Mental deteri... OMIM:607454
Paragangliomas 6
Hypertension OMIM:618464
Lissencephaly Type Iii And Bone Dysplasia
Akinesia, Microlissencephaly, Agenesis of cerebellar vermis OMIM:601160
Hyperaldosteronism, Familial, Type Ii
Hypertension OMIM:605635
Progressive Supranuclear Palsy-Pure Akinesia With Gait Freezing Syndrome
Gait imbalance, Akinesia, Freezing of gait, Blepharospasm, Loss of ambulation, Falls, Unsteady ga... ORPHA:240094
Congenital Analbuminemia
Low pulse pressure ORPHA:86816
Proliferative Vasculopathy And Hydranencephaly-Hydrocephaly Syndrome
Akinesia, Hydrocephalus, Cerebellar hypoplasia, Hydranencephaly, Dandy-Walker malformation OMIM:225790
Fibromuscular Dysplasia, Arterial
Intermittent claudication, Myocardial infarction, Renovascular hypertension OMIM:135580
Sporadic Adult-Onset Ataxia Of Unknown Etiology
Akinesia, Ataxia, Dysdiadochokinesis, Memory impairment, Shuffling gait, Gait ataxia, Cerebellar ... ORPHA:247234
Exercise-Induced Malignant Hyperthermia
Abnormal T-wave, Abnormal pulse pressure, ST segment depression, Hypotension, Sinus tachycardia, ... ORPHA:466650
Ataxia-Intellectual Disability-Oculomotor Apraxia-Cerebellar Cysts Syndrome
Elongated superior cerebellar peduncle, Ataxia, Cognitive impairment, Dilated fourth ventricle, I... ORPHA:370022
Atrial Fibrillation, Familial, 14
Prolonged PR interval, Hypertension, Paroxysmal atrial fibrillation, ST segment elevation OMIM:615378
Arterial Calcification, Generalized, Of Infancy, 2
Myocardial infarction, Hypertension, Congestive heart failure OMIM:614473
Liddle Syndrome 3
Hypertension OMIM:618126
Akinesia, Ataxia, Blepharospasm, Limb ataxia, Cognitive impairment, Memory impairment, Abnormal d... ORPHA:48818
Corticosteroid-Binding Globulin Deficiency
Hypertension, Hypotension OMIM:611489
Hypertension, Early-Onset, Autosomal Dominant, With Severe Exacerbation In Pregnancy
Hypertension OMIM:605115
Corticobasal Syndrome
Akinesia, Memory impairment, Gait disturbance, Somatic sensory dysfunction, Dementia ORPHA:454887
Autosomal Dominant Cerebellar Ataxia
Impaired proprioception, Akinesia, Progressive cerebellar ataxia, Cognitive impairment, Impaired ... ORPHA:99
Classic Progressive Supranuclear Palsy Syndrome
Gait imbalance, Akinesia, Social and occupational deterioration, Blepharospasm, Mental deteriorat... ORPHA:240071
Atypical Juvenile Parkinsonism
Akinesia, Inability to walk, Shuffling gait, Gait ataxia, Short stepped shuffling gait ORPHA:391411
Fetal Akinesia Deformation Sequence
Pterygium, Akinesia, Dandy-Walker malformation ORPHA:994
Kufor-Rakeb Syndrome
Akinesia, Ataxia, Distal sensory impairment, Gait disturbance, Dementia OMIM:606693
Manganese Poisoning
Gait disturbance, Akinesia, Memory impairment ORPHA:306682
Multiple Pterygium Syndrome, Lethal Type
Epicanthus, Akinesia, Multiple pterygia OMIM:253290
Parkinson Disease 23, Autosomal Recessive Early-Onset
Mental deterioration, Akinesia, Dementia OMIM:616840
Perry Syndrome
Akinesia, Frontotemporal dementia, Short stepped shuffling gait OMIM:168605
Parkinson Disease 17
Akinesia OMIM:614203
Postencephalitic Parkinsonism
Bilateral ptosis, Akinesia, Paresthesia ORPHA:97349
Atrioventricular Septal Defect 3
Midsystolic murmur, First degree atrioventricular block, Hypertension, Pulmonary arterial hyperte... OMIM:600309
Intellectual Developmental Disorder With Language Impairment And Early-Onset Dopa-Responsive Dystonia-Parkinsonism
Akinesia, Freezing of gait OMIM:619911
Myopathy, Congenital, With Respiratory Insufficiency And Bone Fractures
Akinesia OMIM:618822
Arthrogryposis Multiplex Congenita 6
Akinesia OMIM:619334
Lethal Congenital Contracture Syndrome 2
Akinesia OMIM:607598
Supranuclear Palsy, Progressive, 2
Frontolimbic dementia, Gait imbalance, Akinesia, Falls, Memory impairment, Eyelid apraxia OMIM:609454
Neurodegeneration With Brain Iron Accumulation 1
Akinesia, Ataxia, Blepharospasm, Mental deterioration, Eyelid apraxia, Gait disturbance, Choreoat... OMIM:234200
Myopathy, Congenital, Compton-North
Akinesia OMIM:612540
Hereditary Late-Onset Parkinson Disease
Mental deterioration, Shuffling gait, Akinesia, Dementia ORPHA:411602
Supranuclear Palsy, Progressive, 1
Frontolimbic dementia, Gait imbalance, Akinesia, Falls, Memory impairment, Eyelid apraxia OMIM:601104
Akinesia, Abnormal cerebellum morphology, Inability to walk, Ataxia, Cerebellar hypoplasia ORPHA:86309
Gaucher Disease, Perinatal Lethal
Akinesia, Progressive neurologic deterioration OMIM:608013
Leukoencephalopathy, Progressive, Infantile-Onset, With Or Without Deafness
Akinesia OMIM:619147
Arthrogryposis Multiplex Congenita 5
Akinesia, Upslanted palpebral fissure, Ptosis OMIM:618947
African Trypanosomiasis
Akinesia, Myelopathy, Gait disturbance, Somatic sensory dysfunction, Difficulty walking, Choreoat... ORPHA:3385


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gpr37l1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gpr37l1.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Metabolic Profiling of Mice with Deletion of the Orphan G Protein-Coupled Receptor, GPR37L1. Cells (June 2022) Gpr37l1tm1d(EUCOMM)Wtsi PMC9180194
Mouse Mutants of Gpr37 and Gpr37l1 Receptor Genes: Disease Modeling Applications. International journal of molecular sciences (April 2022) Gpr37l1tm1a(EUCOMM)Wtsi Gpr37l1tm1b(EUCOMM)Wtsi Gpr37l1tm1d(EUCOMM)Wtsi PMC9025225
Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control. Biology of sex differences (April 2018) Gpr37l1tm1c(EUCOMM)Wtsi Gpr37l1tm1a(EUCOMM)Wtsi PMC5889568

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MGI Allele Allele Type Produced
Gpr37l1tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Gpr37l1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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