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Gene: Gpr37l1 MGI:1928503

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
G protein-coupled receptor 37-like 1
Synonyms:
D0Kist8,  CAG-18

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Gpr37l1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Gpr37l1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Platelet Prostacyclin Receptor Defect
Intermittent claudication OMIM:262875
Raynaud Disease
Raynaud phenomenon OMIM:179600
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Type II lissencephaly, Cerebellar dysplasia, Neural tube defect OMIM:615041
Intracranial Hypertension, Idiopathic
Hypertension OMIM:243200
Abdominal Obesity-Metabolic Syndrome 1
Hypertension OMIM:605552
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2
Hypertension OMIM:605572
Spinocerebellar Ataxia Type 27
Memory impairment, Cerebellar atrophy, Difficulty walking, Akinesia, Limb ataxia, Gait ataxia, Ga... ORPHA:98764
Congenital Aortic Valve Stenosis
Aortic valve stenosis, Abnormal pulse pressure, Increased QRS voltage, Abnormal T-wave, Reduced l... ORPHA:3093
Cardiogenic Shock
Hypotension, Right ventricular failure, Abnormal left ventricular function, Congestive heart fail... ORPHA:97292
Antithrombin Iii Deficiency
Pulmonary embolism, Arterial occlusion OMIM:613118
Spinocerebellar Ataxia Type 21
Cerebellar vermis atrophy, Akinesia, Gait ataxia, Cognitive impairment, Progressive cerebellar at... ORPHA:98773
Spinocerebellar Ataxia 21
Mental deterioration, Cerebellar atrophy, Akinesia, Limb ataxia, Gait ataxia, Cognitive impairmen... OMIM:607454
Pheochromocytoma/Paraganglioma Syndrome 6
Hypertension OMIM:618464
Neurodegeneration With Brain Iron Accumulation 5
Dementia, Mental deterioration, Akinesia, Cerebellar atrophy OMIM:300894
Progressive Supranuclear Palsy-Pure Akinesia With Gait Freezing Syndrome
Blepharospasm, Short stepped shuffling gait, Falls, Akinesia, Gait imbalance, Freezing of gait, L... ORPHA:240094
Supravalvular Aortic Stenosis
Supravalvular aortic stenosis, Angina pectoris, Arrhythmia, Syncope, Hypertension, Systolic heart... ORPHA:3193
Hyperaldosteronism, Familial, Type Iv
Hypertension OMIM:617027
Congenital Analbuminemia
Low pulse pressure ORPHA:86816
Proliferative Vasculopathy And Hydranencephaly-Hydrocephaly Syndrome
Hydranencephaly, Polymicrogyria, Pterygium, Akinesia, Cerebellar hypoplasia, Hydrocephalus, Dandy... OMIM:225790
Sporadic Adult-Onset Ataxia Of Unknown Etiology
Shuffling gait, Memory impairment, Akinesia, Gait ataxia, Ataxia, Dementia, Cerebellar cortical a... ORPHA:247234
Fibromuscular Dysplasia, Arterial
Renovascular hypertension, Myocardial infarction, Intermittent claudication OMIM:135580
Exercise-Induced Malignant Hyperthermia
Hypotension, Abnormal pulse pressure, Sinus tachycardia, Abnormal T-wave, ST segment depression, ... ORPHA:466650
Atrial Fibrillation, Familial, 14
Paroxysmal atrial fibrillation, Prolonged PR interval, ST segment elevation, Hypertension OMIM:615378
Mitochondrial Complex I Deficiency, Nuclear Type 28
Truncal ataxia, Akinesia, Cerebellar atrophy, Choreoathetosis OMIM:618249
Aceruloplasminemia
Blepharospasm, Memory impairment, Chorea, Limb ataxia, Gait ataxia, Akinesia, Abnormal dentate nu... ORPHA:48818
Hyperaldosteronism, Familial, Type Ii
Hypertension OMIM:605635
Corticobasal Syndrome
Memory impairment, Somatic sensory dysfunction, Akinesia, Gait disturbance, Dementia ORPHA:454887
Hypertension, Early-Onset, Autosomal Dominant, With Severe Exacerbation In Pregnancy
Hypertension OMIM:605115
Classic Progressive Supranuclear Palsy Syndrome
Blepharospasm, Mental deterioration, Falls, Akinesia, Gait imbalance, Conjunctival hyperemia, Soc... ORPHA:240071
Atypical Juvenile Parkinsonism
Short stepped shuffling gait, Shuffling gait, Inability to walk, Akinesia, Gait ataxia ORPHA:391411
Fetal Akinesia Deformation Sequence
Pterygium, Akinesia, Dandy-Walker malformation ORPHA:994
Kufor-Rakeb Syndrome
Akinesia, Distal sensory impairment, Gait disturbance, Ataxia, Dementia OMIM:606693
Manganese Poisoning
Confusion, Akinesia, Memory impairment, Gait disturbance ORPHA:306682
Perry Syndrome
Short stepped shuffling gait, Akinesia, Frontotemporal dementia OMIM:168605
Postencephalitic Parkinsonism
Akinesia, Paresthesia, Bilateral ptosis ORPHA:97349
Parkinson Disease 23, Autosomal Recessive Early-Onset
Dementia, Mental deterioration, Akinesia OMIM:616840
Multiple Pterygium Syndrome, Lethal Type
Epicanthus, Akinesia, Multiple pterygia OMIM:253290
Parkinson Disease 17
Akinesia OMIM:614203
Intellectual Developmental Disorder With Language Impairment And Early-Onset Dopa-Responsive Dystonia-Parkinsonism
Akinesia, Freezing of gait OMIM:619911
Congenital Myopathy 9A
Akinesia OMIM:618822
Arthrogryposis Multiplex Congenita 6
Akinesia OMIM:619334
Lethal Congenital Contracture Syndrome 2
Akinesia OMIM:607598
Supranuclear Palsy, Progressive, 2
Memory impairment, Falls, Frontolimbic dementia, Akinesia, Gait imbalance, Eyelid apraxia OMIM:609454
Neurodegeneration With Brain Iron Accumulation 1
Blepharospasm, Mental deterioration, Akinesia, Gait disturbance, Ataxia, Dementia, Eyelid apraxia... OMIM:234200
Dpagt1-Cdg
Inability to walk, Akinesia, Abnormal cerebellum morphology, Cerebellar hypoplasia, Ataxia ORPHA:86309
Hereditary Late-Onset Parkinson Disease
Dementia, Mental deterioration, Shuffling gait, Akinesia ORPHA:411602
Congenital Myopathy 12
Akinesia OMIM:612540
Supranuclear Palsy, Progressive, 1
Memory impairment, Falls, Frontolimbic dementia, Akinesia, Gait imbalance, Eyelid apraxia OMIM:601104
Gaucher Disease, Perinatal Lethal
Progressive neurologic deterioration, Akinesia OMIM:608013
Leukoencephalopathy, Progressive, Infantile-Onset, With Or Without Deafness
Akinesia OMIM:619147
Arthrogryposis Multiplex Congenita 5
Akinesia, Ptosis, Upslanted palpebral fissure OMIM:618947
African Trypanosomiasis
Myelopathy, Somatic sensory dysfunction, Difficulty walking, Akinesia, Paresthesia, Gait disturba... ORPHA:3385

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gpr37l1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gpr37l1.

There are 4 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Metabolic Profiling of Mice with Deletion of the Orphan G Protein-Coupled Receptor, GPR37L1. Cells (June 2022) Gpr37l1tm1d(EUCOMM)Wtsi PMC9180194
Mouse Mutants of Gpr37 and Gpr37l1 Receptor Genes: Disease Modeling Applications. International journal of molecular sciences (April 2022) Gpr37l1tm1a(EUCOMM)Wtsi Gpr37l1tm1b(EUCOMM)Wtsi Gpr37l1tm1d(EUCOMM)Wtsi PMC9025225
Deletion of Orphan G Protein-Coupled Receptor GPR37L1 in Mice Alters Cardiovascular Homeostasis in a Sex-Specific Manner. Frontiers in pharmacology (January 2020) Gpr37l1tm1a(EUCOMM)Wtsi PMC7901490
Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control. Biology of sex differences (April 2018) Gpr37l1tm1c(EUCOMM)Wtsi Gpr37l1tm1a(EUCOMM)Wtsi PMC5889568

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MGI Allele Allele Type Produced
Gpr37l1tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Gpr37l1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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