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Gene: Nrk MGI:1351326

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
Nik related kinase
Synonyms:
Nesk

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Nrk mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Nrk by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Granulomas, Congenital Cerebral
Neonatal death OMIM:306300
Genitourinary Tract Anomalies
Neonatal death OMIM:305690
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Large placenta, Umbilical hernia, Polyhydramnios ORPHA:254534
Placental Insufficiency
Abnormal placenta morphology, Abnormal umbilical cord blood vessel morphology, Miscarriage, Small... ORPHA:439167
Mitochondrial Complex I Deficiency, Nuclear Type 30
Neonatal death, Premature birth OMIM:301021
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Microdeletion
Umbilical hernia, Large placenta, Polyhydramnios ORPHA:254528
Pulmonary Hypoplasia, Primary
Neonatal death OMIM:265430
Epidermolysis Bullosa With Diaphragmatic Hernia
Neonatal death OMIM:226735
Greenberg Dysplasia
Nonimmune hydrops fetalis, Polyhydramnios, Echogenic fetal bowel, Large placenta, Increased nucha... OMIM:215140
Hernia, Anterior Diaphragmatic
Neonatal death OMIM:306950
Fetal Akinesia, Respiratory Insufficiency, Microcephaly, Polymicrogyria, And Dysmorphic Facies
Neonatal death, Polyhydramnios, Fetal akinesia sequence OMIM:619602
Kagami-Ogata Syndrome
Large placenta, Premature birth, Polyhydramnios ORPHA:254519
Trichohepatoenteric Syndrome 1
Large placenta, Abnormalities of placenta or umbilical cord, Polyhydramnios OMIM:222470
Mosaic Trisomy 16
Large placenta, Single umbilical artery, Premature birth ORPHA:1708
Restrictive Dermopathy 1
Spontaneous chorioamniotic separation, Decreased fetal movement, Premature birth, Polyhydramnios,... OMIM:275210
Ichthyosis, Congenital, Autosomal Recessive 4B
Neonatal death, Death in infancy, Premature birth OMIM:242500
Meckel Syndrome, Type 1
Occipital encephalocele, Breech presentation, Large placenta, Cryptorchidism, Anencephaly, Single... OMIM:249000
Silver-Russell Syndrome Due To A Point Mutation
Cryptorchidism, Dysmenorrhea, Small placenta, Oligohydramnios ORPHA:397590
Neutropenia, Lethal Congenital, With Eosinophilia
Neonatal death OMIM:257100
Restrictive Dermopathy
Decreased fetal movement, Premature birth, Premature delivery because of cervical insufficiency o... ORPHA:1662
Lymphatic Malformation 12
Nonimmune hydrops fetalis, Fetal ascites, Polyhydramnios, Fetal pericardial effusion, Death in ad... OMIM:620014
Arthrogryposis Multiplex Congenita 6
Decreased fetal movement, Death in infancy, Polyhydramnios, Death in childhood, Neonatal death OMIM:619334
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Premature birth, Miscarriage, Polyhydramnios, Cryptorchidism, Large placenta, Spinal dysraphism ORPHA:96334
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Hypogonadism, Small placenta ORPHA:73272
Beckwith-Wiedemann Syndrome
Premature birth, Polyhydramnios, Large placenta, Cryptorchidism, Subchorionic septal cyst, Umbili... ORPHA:116
Ulnar Agenesis And Endocardial Fibroelastosis
Neonatal death, Hydrops fetalis OMIM:276822
Fetal Akinesia Deformation Sequence 1
Decreased fetal movement, Premature birth, Nonimmune hydrops fetalis, Polyhydramnios, Fetal akine... OMIM:208150
Neu-Laxova Syndrome 1
Decreased fetal movement, Spina bifida, Polyhydramnios, Fetal akinesia sequence, Cryptorchidism, ... OMIM:256520

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Nrk

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Nrk.

No publications found that use IMPC mice or data for Nrk.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Nrktm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Nrktm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Nrktm1e(KOMP)Mbp Targeted, non-conditional allele ES Cells

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