Gene Summary

Name:
trace amine-associated receptor 8C
Synonyms:
N/A

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal vitreous body morphology Taar8cem1(IMPC)Mbp HOM   Early adult 2.13×10-05
abnormal skin morphology Taar8cem1(IMPC)Mbp HOM Early adult 0.00
abnormal eye morphology Taar8cem1(IMPC)Mbp HOM Early adult 0.00
abnormal liver morphology Taar8cem1(IMPC)Mbp HOM Early adult 0.00
small liver Taar8cem1(IMPC)Mbp HOM Early adult 0.00
thick skin Taar8cem1(IMPC)Mbp HOM Early adult 0.00
cataract Taar8cem1(IMPC)Mbp HOM   Early adult 3.75×10-05
anophthalmia Taar8cem1(IMPC)Mbp HOM Early adult 0.00

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

45 Images

X-ray

XRay Images Whole Body Lateral Orientation

15 Images

Human diseases caused by Taar8c mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Taar8c by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Microphthalmia/Coloboma 10
Anophthalmia, Microphthalmia, Microcoria, Iris coloboma OMIM:616428
Alpha-N-Acetylgalactosaminidase Deficiency Type 3
Cataract, Hepatomegaly ORPHA:79281
Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome
Microphthalmia, Anophthalmia ORPHA:85275
Microphthalmia/Coloboma 5
Bilateral microphthalmos, Microphthalmia, Anophthalmia, Iris coloboma OMIM:611638
Microphthalmia, Isolated 1
Microphthalmia, Anophthalmia OMIM:251600
Galactosemia Iv
Cataract, Prolonged neonatal jaundice, Hepatomegaly OMIM:618881
Microphthalmia, Isolated, With Cataract 1
Cataract, Microphthalmia OMIM:156850
Microphthalmia, Syndromic 16
Microphthalmia, Sclerocornea, Anophthalmia OMIM:611038
Microphthalmia, Isolated 8
Microphthalmia, True anophthalmia, Anophthalmia, Retinal detachment, Optic nerve hypoplasia, Reti... OMIM:615113
Cataract 9, Multiple Types
Microphthalmia, Microcornea, Progressive cataract, Developmental cataract, Cataract, Iris coloboma OMIM:604219
Corneal Dystrophy, Groenouw Type I
Cataract, Nodular corneal dystrophy, Granular corneal dystrophy, Punctate corneal dystrophy OMIM:121900
Cataract 11, Multiple Types
Cataract, Microphthalmia, Developmental cataract OMIM:610623
Microphthalmia/Coloboma 3
Cataract, Microphthalmia, Iris coloboma OMIM:610092
Cataract 42
Cataract, Developmental cataract OMIM:115900
Galactosemia Ii
Cataract, Prolonged neonatal jaundice OMIM:230200
Microcornea-Posterior Megalolenticonus-Persistent Fetal Vasculature-Coloboma Syndrome
Posterior lenticonus, Microphthalmia, Microcornea, Remnants of the hyaloid vascular system, Iris ... ORPHA:231736
Anterior Segment Dysgenesis 8
Optic nerve dysplasia, Iris transillumination defect, Microphakia, Iridodonesis, Corneal stromal ... OMIM:617319
Microphthalmia, Syndromic 12
Microphthalmia, Anophthalmia OMIM:615524
Peroxisome Biogenesis Disorder 8A (Zellweger)
Cataract, Elevated circulating aspartate aminotransferase concentration, Jaundice, Hepatomegaly OMIM:614876
Microphthalmia With Brain And Digit Anomalies
Microphthalmia, Anophthalmia, Microcornea, Sclerocornea, Cataract, Iris coloboma ORPHA:139471
Cataract-Microcornea Syndrome
Microcornea, Corneal dystrophy, Corneal opacity, Cataract, Iris coloboma ORPHA:1377
Microphthalmia, Isolated 5
Microphthalmia, Bone spicule pigmentation of the retina, Optic disc drusen, Retinal pigment epith... OMIM:611040
Iris Pigment Layer, Cleavage Of
Cataract, Peripheral retinal detachment OMIM:147610
Microphthalmia, Syndromic 5
Microphthalmia, Anophthalmia, Optic nerve hypoplasia, Microcornea, Cataract OMIM:610125
Megalocornea
Corneal arcus, Iris transillumination defect, Iridodonesis, Astigmatism, Mosaic corneal dystrophy... OMIM:309300
Uveal Coloboma-Cleft Lip And Palate-Intellectual Disability
Optic atrophy, Microphthalmia, Retinal detachment, Corneal opacity, Posterior embryotoxon, Catara... ORPHA:1473
Fryns Microphthalmia Syndrome
Microphthalmia, Anophthalmia OMIM:600776
Coats Disease
Retinal detachment, Abnormal anterior chamber morphology, Aplasia/Hypoplasia of the iris, Cataract ORPHA:190
Walker-Warburg Syndrome
Optic atrophy, Microphthalmia, Retinal dysplasia, Anophthalmia, Retinal detachment, Microcornea, ... ORPHA:899
Cataract 50 With Or Without Glaucoma
Retinal detachment, Persistent pupillary membrane, Cataract OMIM:620253
Trisomy 13
Optic atrophy, Microphthalmia, Anophthalmia, Cataract, Aplasia/Hypoplasia of the iris, Iris coloboma ORPHA:3378
Oculocerebrocutaneous Syndrome
Microphthalmia, Anophthalmia OMIM:164180
Galactose Epimerase Deficiency
Cataract, Jaundice, Splenomegaly, Hepatomegaly ORPHA:79238
Galactose Mutarotase Deficiency
Cataract, Hepatomegaly, Cholestasis, Decreased liver function ORPHA:570422
Persistent Hyperplastic Primary Vitreous
Microphthalmia, Microcornea, Corneal opacity, Persistent pupillary membrane, Remnants of the hyal... ORPHA:91495
Autosomal Dominant Keratitis
Corneal neovascularization, Bilateral microphthalmos, Aniridia, Limbal stem cell deficiency, Micr... ORPHA:2334
Anencephaly 2
Anophthalmia OMIM:619452
Cockayne Syndrome Type 2
Hepatomegaly, Developmental cataract, Anophthalmia, Conjunctivitis ORPHA:90322
Meckel Syndrome, Type 8
Microphthalmia, Anophthalmia OMIM:613885
Early-Onset Epileptic Encephalopathy-Cortical Blindness-Intellectual Disability-Facial Dysmorphism Syndrome
Anophthalmia ORPHA:411986
Anterior Segment Dysgenesis 7
Ocular anterior segment dysgenesis, Microphthalmia, Microcornea, Corneal opacity, Sclerocornea, C... OMIM:269400
Aniridia 2
Optic atrophy, Aniridia, Cataract, Lens subluxation, Iris coloboma OMIM:617141
Hemorrhagic Destruction Of The Brain, Subependymal Calcification, And Cataracts
Cataract, Microphthalmia, Hepatomegaly, Optic disc pallor OMIM:613730
Coloboma, Ocular, With Or Without Hearing Impairment, Cleft Lip/Palate, And/Or Impaired Intellectual Development
Cataract, Microphthalmia, Iris coloboma OMIM:120433
Leber Congenital Amaurosis 1
Hepatomegaly, Optic disc drusen, Keratoconus, Cataract, Pigmentary retinopathy OMIM:204000
Aniridia-Intellectual Disability Syndrome
Cataract, Optic nerve hypoplasia, Ectopia lentis, Aniridia ORPHA:1068
Anophthalmia Plus Syndrome
Anophthalmia, Iris coloboma ORPHA:1104
Persistent Hyperplastic Primary Vitreous, Autosomal Recessive
Microphthalmia, Microcornea, Corneal opacity, Retinal nonattachment, Persistent pupillary membran... OMIM:221900
Triokinase And Fmn Cyclase Deficiency Syndrome
Microphthalmia, Hepatomegaly, Pancreatitis, Elevated circulating alanine aminotransferase concent... OMIM:618805
Congenital Varicella Syndrome
Cataract, Microphthalmia ORPHA:291
Matthew-Wood Syndrome
Annular pancreas, Microphthalmia, Aplasia/Hypoplasia of the pancreas, Anophthalmia, Abnormal sple... ORPHA:2470
Microphthalmia/Coloboma And Skeletal Dysplasia Syndrome
Microphthalmia, Anophthalmia, Microcornea, Sclerocornea, Ectopia pupillae, Cataract OMIM:615877
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Microphthalmia, Sclerocornea, Anophthalmia, Iris coloboma ORPHA:77298
Myopia, High, With Cataract And Vitreoretinal Degeneration
Retinal detachment, Lens subluxation, Lattice retinal degeneration, Cataract OMIM:614292
Thanatophoric Dysplasia, Glasgow Variant
Cataract, Hepatosplenomegaly OMIM:273680
Microphthalmia/Coloboma 12
Microphthalmia, Corneal opacity, Remnants of the hyaloid vascular system, Optic nerve aplasia, Op... OMIM:120200
Cockayne Syndrome Type 1
Optic atrophy, Hepatomegaly, Elevated circulating hepatic transaminase concentration, Anophthalmi... ORPHA:90321
Meckel Syndrome
Optic atrophy, Microphthalmia, Accessory spleen, Anophthalmia, Microcornea, Asplenia, Sclerocorne... ORPHA:564
Exfoliation Syndrome
Mydriasis, Phakodonesis, Iris hypoperfusion, Anisocoria, Pigment deposition in the trabecular mes... OMIM:177650
Stickler Syndrome Type 2
Retinal detachment, Corneal opacity, Cataract ORPHA:90654
Congenital Rubella Syndrome
Microphthalmia, Jaundice, Hepatomegaly, Corneal opacity, Abnormality of retinal pigmentation, Spl... ORPHA:290
Anterior Segment Dysgenesis 2
Microphthalmia, Aniridia, Microcornea, Corneal opacity, Congenital aphakia, Anterior segment of e... OMIM:610256
Norrie Disease
Optic atrophy, Microphthalmia, Buphthalmos, Retinal dysplasia, Retinal detachment, Corneal opacit... OMIM:310600
Optic Disc Anomalies With Retinal And/Or Macular Dystrophy
Microphthalmia, Retinal detachment, Corneal scarring, Cataract, Buphthalmos, Macular atrophy, Iri... OMIM:212550
Ectopia Lentis Et Pupillae
Iris transillumination defect, Retinal detachment, Persistent pupillary membrane, Ectopia lentis,... OMIM:225200
Aniridia-Ptosis-Intellectual Disability-Familial Obesity Syndrome
Cataract, Aplasia/Hypoplasia of the iris, Corneal opacity, Persistent pupillary membrane ORPHA:1067
Retinitis Pigmentosa 84
Cataract, Macular coloboma, Bone spicule pigmentation of the retina, Macular atrophy OMIM:618220
Oculopalatocerebral Syndrome
Microphthalmia, Remnants of the hyaloid vascular system, Leukocoria OMIM:257910
Myopia 28, Autosomal Recessive
Retinal detachment, Cataract OMIM:619781
Blindness-Scoliosis-Arachnodactyly Syndrome
Microphakia, Retinal detachment, Abnormality of retinal pigmentation, Cataract, Lens subluxation ORPHA:171844
Aniridia, Microcornea, And Spontaneously Reabsorbed Cataract
Cataract, Microcornea, Aniridia OMIM:106230
Isolated Aniridia
Cataract, Aplasia/Hypoplasia of the macula, Peters anomaly, Aniridia ORPHA:250923
Coloboma-Obesity-Hypogenitalism-Mental Retardation Syndrome
Cataract, Microphthalmia, Retinal coloboma OMIM:601794
Hydrolethalus
Microphthalmia, Anophthalmia ORPHA:2189
Cerebrooculonasal Syndrome
Anophthalmia ORPHA:66625
Colobomatous Microphthalmia-Obesity-Hypogenitalism-Intellectual Disability Syndrome
Cataract, Microphthalmia, Retinal coloboma ORPHA:363741
Vitreoretinal Degeneration, Snowflake Type
Retinal detachment, Cataract, Corneal guttata, Snowflake vitreoretinal degeneration OMIM:193230
Solitary Median Maxillary Central Incisor
Microphthalmia, Anophthalmia OMIM:147250
Microphthalmia With Limb Anomalies
Microphthalmia, Anophthalmia OMIM:206920
Microphthalmia, Syndromic 3
Microphthalmia, Anophthalmia, Optic nerve hypoplasia, Optic nerve aplasia, Sclerocornea, Cataract OMIM:206900
Manitoba Oculotrichoanal Syndrome
Microphthalmia, Corneopalpebral synechiae, Anophthalmia OMIM:248450
Reese Retinal Dysplasia
Remnants of the hyaloid vascular system, Retinal dysplasia OMIM:266400
Morning Glory Disc Anomaly
Retinal detachment, Cataract, Abnormality of retinal pigmentation, Optic disc coloboma ORPHA:35737
Trisomy 1Q
Anophthalmia ORPHA:261344
Hyposmia-Nasal And Ocular Hypoplasia-Hypogonadotropic Hypogonadism Syndrome
Cataract, Microphthalmia, Anophthalmia, Iris coloboma ORPHA:2250
Oculotrichoanal Syndrome
Microphthalmia, Anophthalmia ORPHA:2717
Anophthalmia-Megalocornea-Cardiopathy-Skeletal Anomalies Syndrome
Megalocornea, Corneal dystrophy, Aniridia, Anophthalmia ORPHA:1101
Cataract 47
Cataract, Microcornea OMIM:612018
Coloboma, Ocular, Autosomal Recessive
Retinal coloboma, Optic disc coloboma, Cataract, Lens subluxation, Iris coloboma OMIM:216820
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Optic atrophy, Microphthalmia, Retinal dysplasia, Anophthalmia, Retinal detachment, Abnormality o... ORPHA:2526
Pierson Syndrome
Posterior lenticonus, Microphthalmia, Hypoplasia of the ciliary body, Retinal detachment, Remnant... OMIM:609049
Cataract 10, Multiple Types
Developmental cataract, Posterior Y-sutural cataract, Zonular cataract, Nuclear cataract OMIM:600881
Microphthalmia, Syndromic 9
Multilobulated spleen, Bilateral microphthalmos, Hypoplastic spleen, Anophthalmia OMIM:601186
Oculo-Palato-Cerebral Syndrome
Microphthalmia, Retinal detachment, Remnants of the hyaloid vascular system, Leukocoria, Cataract ORPHA:2714
Aniridia 1
Corneal neovascularization, Macular agenesis, Aniridia, Corneal erosion, Optic nerve hypoplasia, ... OMIM:106210
Amoebic Keratitis
Abnormal anterior chamber morphology, Abnormal corneal epithelium morphology, Corneal ulceration,... ORPHA:67043
Vacterl With Hydrocephalus
Microcornea, Microphthalmia, Anophthalmia ORPHA:3412
Optic Nerve Hypoplasia, Bilateral
Optic nerve hypoplasia, Optic nerve aplasia, Remnants of the hyaloid vascular system OMIM:165550
Holoprosencephaly
Optic atrophy, Microphthalmia, Anophthalmia, Abnormality of the spleen, Iris coloboma ORPHA:2162
Oculoauricular Syndrome
Microphakia, Ocular anterior segment dysgenesis, Microphthalmia, Iris cyst, Retinal detachment, M... OMIM:612109
Aniridia 3
Cataract, Aniridia OMIM:617142
Fibular Hemimelia
Abnormal anterior chamber morphology, Anophthalmia ORPHA:93323
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 7
Microphthalmia, Retinal dysplasia, Retinal detachment, Optic nerve hypoplasia, Remnants of the hy... OMIM:614643
Proboscis Lateralis
Microphthalmia, Anophthalmia, Optic nerve hypoplasia, Microcornea, Corneal opacity, Optic disc co... ORPHA:141099
Microgastria-Limb Reduction Defect Syndrome
Microphthalmia, Hepatomegaly, Abnormality of the spleen, Anophthalmia ORPHA:2538
Cerebrooculonasal Syndrome
Optic nerve hypoplasia, Anophthalmia, Iris coloboma OMIM:605627
Aniridia And Absent Patella
Cataract, Aniridia OMIM:106220
Joubert Syndrome 21
Optic atrophy, Megalopapilla, Splenomegaly, Anophthalmia OMIM:615636
Microphthalmia With Linear Skin Defects Syndrome
Microphthalmia, Retinal dysplasia, Anophthalmia, Corneal opacity, Posterior embryotoxon, Abnormal... ORPHA:2556
Microphthalmia, Syndromic 2
Microphthalmia, Anophthalmia, Retinal detachment, Microcornea, Remnants of the hyaloid vascular s... OMIM:300166
Exudative Vitreoretinopathy 6
Patchy atrophy of the retinal pigment epithelium, Retinal detachment, Tractional retinal detachme... OMIM:616468
Cataract 5, Multiple Types
Anterior polar cataract, Zonular cataract, Lamellar cataract, Nuclear cataract, Pulverulent cataract OMIM:116800
14Q22Q23 Microdeletion Syndrome
Optic nerve aplasia, Anophthalmia ORPHA:264200
Charge Syndrome
Optic atrophy, Microphthalmia, Webbed neck, Anophthalmia, Iris coloboma ORPHA:138
Hyperferritinemia With Or Without Cataract
Anterior subcapsular cataract, Nuclear cataract, Pulverulent cataract, Cataract OMIM:600886
Autoimmune Polyendocrine Syndrome, Type Ii
Cirrhosis, Band keratopathy, Keratoconjunctivitis, Asplenia, Chronic hepatitis, Exocrine pancreat... OMIM:269200
Focal Dermal Hypoplasia
Optic atrophy, Microphthalmia, Aniridia, Anophthalmia, Ectopia lentis, Iris coloboma OMIM:305600
Charge Syndrome
Microphthalmia, Webbed neck, Anophthalmia, Unilateral microphthalmos, Retinal coloboma, Cataract,... OMIM:214800
Fraser Syndrome 1
Bilateral microphthalmos, Corneal opacity, Anophthalmia OMIM:219000
Atelis Syndrome 2
Microphthalmia, Developmental cataract, Remnants of the hyaloid vascular system OMIM:620185
Holoprosencephaly 9
Optic nerve hypoplasia, Microphthalmia, Anophthalmia OMIM:610829
Microphthalmia With Limb Anomalies
Optic atrophy, Microphthalmia, True anophthalmia ORPHA:1106
Branchiooculofacial Syndrome
Microphthalmia, Anophthalmia, Retinal coloboma, Cataract, Iris coloboma OMIM:113620
Norrie Disease
Optic atrophy, Microphthalmia, Aplasia/Hypoplasia of the lens, Retinal detachment, Corneal opacit... ORPHA:649
Microphthalmia, Syndromic 6
Microcornea, Microphthalmia, Sclerocornea, Anophthalmia OMIM:607932
Neuroocular Syndrome
Microphthalmia, Microcornea, Stellate iris, Remnants of the hyaloid vascular system, Hypoplasia o... OMIM:619539
Microphthalmia, Syndromic 1
Microphthalmia, Ciliary body coloboma, Webbed neck, Anophthalmia, Microcornea, Optic disc colobom... OMIM:309800
Fraser Syndrome
Microphthalmia, Anophthalmia ORPHA:2052
Full Nf2-Related Schwannomatosis
Cortical cataract, Posterior subcapsular cataract, Remnants of the hyaloid vascular system ORPHA:637
Craniofacial Microsomia 1
Limbal dermoid, Microphthalmia, Anophthalmia OMIM:164210
Acromelic Frontonasal Dysostosis
Optic nerve hypoplasia, Remnants of the hyaloid vascular system OMIM:603671
Holoprosencephaly 2
Microphthalmia, Remnants of the hyaloid vascular system, Iris coloboma OMIM:157170

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Taar8c

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Taar8c.

No publications found that use IMPC mice or data for Taar8c.

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MGI Allele Allele Type Produced
Taar8cem1(IMPC)Mbp Whole-gene deletion Mice, Tissue

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