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Gene: Taar8c MGI:3527452

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Gene Summary

Name:
trace amine-associated receptor 8C
Synonyms:
N/A

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
anophthalmia Taar8cem1(IMPC)Mbp HOM Early adult 0.00
small liver Taar8cem1(IMPC)Mbp HOM Early adult 0.00
thick skin Taar8cem1(IMPC)Mbp HOM Early adult 0.00
abnormal liver morphology Taar8cem1(IMPC)Mbp HOM Early adult 0.00
cataract Taar8cem1(IMPC)Mbp HOM   Early adult 3.75×10-05
abnormal skin morphology Taar8cem1(IMPC)Mbp HOM Early adult 0.00
abnormal eye morphology Taar8cem1(IMPC)Mbp HOM Early adult 0.00
abnormal vitreous body morphology Taar8cem1(IMPC)Mbp HOM   Early adult 2.13×10-05

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

45 Images

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X-ray

XRay Images Whole Body Lateral Orientation

15 Images

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Human diseases caused by Taar8c mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Taar8c by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Microphthalmia/Coloboma 10
Iris coloboma, Microcoria, Anophthalmia, Microphthalmia OMIM:616428
Alpha-N-Acetylgalactosaminidase Deficiency Type 3
Hepatomegaly, Cataract ORPHA:79281
Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome
Anophthalmia, Microphthalmia ORPHA:85275
Microphthalmia/Coloboma 5
Iris coloboma, Anophthalmia, Bilateral microphthalmos, Microphthalmia OMIM:611638
Microphthalmia, Isolated 1
Anophthalmia, Microphthalmia OMIM:251600
Galactosemia Iv
Hepatomegaly, Cataract, Prolonged neonatal jaundice OMIM:618881
Microphthalmia, Isolated, With Cataract 1
Cataract, Microphthalmia OMIM:156850
Microphthalmia, Syndromic 16
Sclerocornea, Anophthalmia, Microphthalmia OMIM:611038
Microphthalmia, Isolated 8
Retinal coloboma, True anophthalmia, Anophthalmia, Retinal detachment, Microphthalmia, Optic nerv... OMIM:615113
Cataract 9, Multiple Types
Cataract, Microcornea, Progressive cataract, Developmental cataract, Microphthalmia, Iris coloboma OMIM:604219
Corneal Dystrophy, Groenouw Type I
Cataract, Punctate corneal dystrophy, Nodular corneal dystrophy, Granular corneal dystrophy OMIM:121900
Cataract 11, Multiple Types
Cataract, Developmental cataract, Microphthalmia OMIM:610623
Microphthalmia/Coloboma 3
Cataract, Iris coloboma, Microphthalmia OMIM:610092
Cataract 42
Cataract, Developmental cataract OMIM:115900
Galactosemia Ii
Prolonged neonatal jaundice, Cataract OMIM:230200
Microcornea-Posterior Megalolenticonus-Persistent Fetal Vasculature-Coloboma Syndrome
Microcornea, Remnants of the hyaloid vascular system, Microphthalmia, Posterior lenticonus, Iris ... ORPHA:231736
Anterior Segment Dysgenesis 8
Cataract, Ectopia lentis, Ectopia pupillae, Hypoplasia of the iris, Uveal ectropion, Optic nerve ... OMIM:617319
Microphthalmia, Syndromic 12
Anophthalmia, Microphthalmia OMIM:615524
Peroxisome Biogenesis Disorder 8A (Zellweger)
Hepatomegaly, Cataract, Jaundice, Elevated circulating aspartate aminotransferase concentration OMIM:614876
Microphthalmia With Brain And Digit Anomalies
Cataract, Microcornea, Anophthalmia, Microphthalmia, Sclerocornea, Iris coloboma ORPHA:139471
Cataract-Microcornea Syndrome
Cataract, Microcornea, Corneal opacity, Iris coloboma, Corneal dystrophy ORPHA:1377
Microphthalmia, Isolated 5
Cataract, Optic disc drusen, Optic disc pallor, Bone spicule pigmentation of the retina, Micropht... OMIM:611040
Iris Pigment Layer, Cleavage Of
Cataract, Peripheral retinal detachment OMIM:147610
Microphthalmia, Syndromic 5
Cataract, Microcornea, Anophthalmia, Microphthalmia, Optic nerve hypoplasia OMIM:610125
Megalocornea
Cataract, Deep anterior chamber, Megalocornea, Lens subluxation, Astigmatism, Iridodonesis, Retin... OMIM:309300
Uveal Coloboma-Cleft Lip And Palate-Intellectual Disability
Cataract, Optic atrophy, Posterior embryotoxon, Retinal detachment, Corneal opacity, Microphthalm... ORPHA:1473
Fryns Microphthalmia Syndrome
Anophthalmia, Microphthalmia OMIM:600776
Coats Disease
Cataract, Retinal detachment, Abnormal anterior chamber morphology, Aplasia/Hypoplasia of the iris ORPHA:190
Walker-Warburg Syndrome
Cataract, Microcornea, Optic atrophy, Anophthalmia, Retinal detachment, Corneal opacity, Micropht... ORPHA:899
Cataract 50 With Or Without Glaucoma
Cataract, Persistent pupillary membrane, Retinal detachment OMIM:620253
Trisomy 13
Cataract, Optic atrophy, Aplasia/Hypoplasia of the iris, Anophthalmia, Microphthalmia, Iris coloboma ORPHA:3378
Oculocerebrocutaneous Syndrome
Anophthalmia, Microphthalmia OMIM:164180
Galactose Epimerase Deficiency
Hepatomegaly, Cataract, Jaundice, Splenomegaly ORPHA:79238
Galactose Mutarotase Deficiency
Cholestasis, Cataract, Decreased liver function, Hepatomegaly ORPHA:570422
Persistent Hyperplastic Primary Vitreous
Cataract, Microcornea, Hyaloid vascular remnant and retrolental mass, Persistent pupillary membra... ORPHA:91495
Autosomal Dominant Keratitis
Cataract, Microcornea, Keratitis, Bilateral microphthalmos, Abnormal corneal limbus morphology, A... ORPHA:2334
Anencephaly 2
Anophthalmia OMIM:619452
Cockayne Syndrome Type 2
Hepatomegaly, Conjunctivitis, Anophthalmia, Developmental cataract ORPHA:90322
Meckel Syndrome, Type 8
Anophthalmia, Microphthalmia OMIM:613885
Early-Onset Epileptic Encephalopathy-Cortical Blindness-Intellectual Disability-Facial Dysmorphism Syndrome
Anophthalmia ORPHA:411986
Anterior Segment Dysgenesis 7
Cataract, Microcornea, Sclerocornea, Corneal opacity, Ocular anterior segment dysgenesis, Anterio... OMIM:269400
Aniridia 2
Cataract, Optic atrophy, Aniridia, Lens subluxation, Iris coloboma OMIM:617141
Hemorrhagic Destruction Of The Brain, Subependymal Calcification, And Cataracts
Hepatomegaly, Cataract, Optic disc pallor, Microphthalmia OMIM:613730
Coloboma, Ocular, With Or Without Hearing Impairment, Cleft Lip/Palate, And/Or Impaired Intellectual Development
Cataract, Iris coloboma, Microphthalmia OMIM:120433
Leber Congenital Amaurosis 1
Keratoconus, Pigmentary retinopathy, Cataract, Optic disc drusen, Hepatomegaly OMIM:204000
Aniridia-Intellectual Disability Syndrome
Cataract, Aniridia, Ectopia lentis, Optic nerve hypoplasia ORPHA:1068
Anophthalmia Plus Syndrome
Iris coloboma, Anophthalmia ORPHA:1104
Persistent Hyperplastic Primary Vitreous, Autosomal Recessive
Cataract, Microcornea, Retinal nonattachment, Posterior synechiae of the anterior chamber, Persis... OMIM:221900
Triokinase And Fmn Cyclase Deficiency Syndrome
Cataract, Hepatic steatosis, Elevated circulating alanine aminotransferase concentration, Pancrea... OMIM:618805
Congenital Varicella Syndrome
Cataract, Microphthalmia ORPHA:291
Matthew-Wood Syndrome
Annular pancreas, Anophthalmia, Abnormal spleen morphology, Microphthalmia, Aplasia/Hypoplasia of... ORPHA:2470
Microphthalmia/Coloboma And Skeletal Dysplasia Syndrome
Cataract, Microcornea, Ectopia pupillae, Anophthalmia, Microphthalmia, Sclerocornea OMIM:615877
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Sclerocornea, Iris coloboma, Anophthalmia, Microphthalmia ORPHA:77298
Myopia, High, With Cataract And Vitreoretinal Degeneration
Lens subluxation, Cataract, Retinal detachment, Lattice retinal degeneration OMIM:614292
Thanatophoric Dysplasia, Glasgow Variant
Cataract, Hepatosplenomegaly OMIM:273680
Microphthalmia/Coloboma 12
Peters anomaly, Optic disc coloboma, Optic nerve aplasia, Remnants of the hyaloid vascular system... OMIM:120200
Cockayne Syndrome Type 1
Cataract, Optic atrophy, Elevated circulating hepatic transaminase concentration, Pigmentary reti... ORPHA:90321
Meckel Syndrome
Accessory spleen, Cataract, Microcornea, Optic atrophy, Aplasia/Hypoplasia of the iris, Anophthal... ORPHA:564
Exfoliation Syndrome
Cataract, Mydriasis, Pseudoexfoliation, Abnormal lens morphology, Phakodonesis, Pigment depositio... OMIM:177650
Stickler Syndrome Type 2
Cataract, Retinal detachment, Corneal opacity ORPHA:90654
Congenital Rubella Syndrome
Cataract, Microphthalmia, Aplasia/Hypoplasia of the iris, Splenomegaly, Abnormality of retinal pi... ORPHA:290
Anterior Segment Dysgenesis 2
Cataract, Microcornea, Peters anomaly, Posterior synechiae of the anterior chamber, Aniridia, Con... OMIM:610256
Norrie Disease
Cataract, Optic atrophy, Hypoplasia of the iris, Opacification of the corneal stroma, Leukocoria,... OMIM:310600
Optic Disc Anomalies With Retinal And/Or Macular Dystrophy
Cataract, Corneal scarring, Macular atrophy, Retinal detachment, Microphthalmia, Buphthalmos, Iri... OMIM:212550
Ectopia Lentis Et Pupillae
Cataract, Ectopia lentis, Ectopia pupillae, Retinal detachment, Iris transillumination defect, Pe... OMIM:225200
Aniridia-Ptosis-Intellectual Disability-Familial Obesity Syndrome
Cataract, Persistent pupillary membrane, Aplasia/Hypoplasia of the iris, Corneal opacity ORPHA:1067
Retinitis Pigmentosa 84
Cataract, Bone spicule pigmentation of the retina, Macular coloboma, Macular atrophy OMIM:618220
Oculopalatocerebral Syndrome
Leukocoria, Remnants of the hyaloid vascular system, Microphthalmia OMIM:257910
Myopia 28, Autosomal Recessive
Cataract, Retinal detachment OMIM:619781
Blindness-Scoliosis-Arachnodactyly Syndrome
Cataract, Abnormality of retinal pigmentation, Retinal detachment, Lens subluxation, Microphakia ORPHA:171844
Aniridia, Microcornea, And Spontaneously Reabsorbed Cataract
Cataract, Aniridia, Microcornea OMIM:106230
Isolated Aniridia
Cataract, Aniridia, Peters anomaly, Aplasia/Hypoplasia of the macula ORPHA:250923
Coloboma-Obesity-Hypogenitalism-Impaired Intellectual Development Syndrome
Cataract, Retinal coloboma, Microphthalmia OMIM:601794
Hydrolethalus
Anophthalmia, Microphthalmia ORPHA:2189
Cerebrooculonasal Syndrome
Anophthalmia ORPHA:66625
Colobomatous Microphthalmia-Obesity-Hypogenitalism-Intellectual Disability Syndrome
Cataract, Retinal coloboma, Microphthalmia ORPHA:363741
Vitreoretinal Degeneration, Snowflake Type
Corneal guttata, Cataract, Retinal detachment, Snowflake vitreoretinal degeneration OMIM:193230
Solitary Median Maxillary Central Incisor
Anophthalmia, Microphthalmia OMIM:147250
Microphthalmia With Limb Anomalies
Anophthalmia, Microphthalmia OMIM:206920
Microphthalmia, Syndromic 3
Cataract, Optic nerve aplasia, Anophthalmia, Microphthalmia, Sclerocornea, Optic nerve hypoplasia OMIM:206900
Manitoba Oculotrichoanal Syndrome
Corneopalpebral synechiae, Anophthalmia, Microphthalmia OMIM:248450
Reese Retinal Dysplasia
Retinal dysplasia, Remnants of the hyaloid vascular system OMIM:266400
Morning Glory Disc Anomaly
Cataract, Retinal detachment, Abnormality of retinal pigmentation, Optic disc coloboma ORPHA:35737
Trisomy 1Q
Anophthalmia ORPHA:261344
Hyposmia-Nasal And Ocular Hypoplasia-Hypogonadotropic Hypogonadism Syndrome
Cataract, Iris coloboma, Anophthalmia, Microphthalmia ORPHA:2250
Oculotrichoanal Syndrome
Anophthalmia, Microphthalmia ORPHA:2717
Anophthalmia-Megalocornea-Cardiopathy-Skeletal Anomalies Syndrome
Aniridia, Corneal dystrophy, Anophthalmia, Megalocornea ORPHA:1101
Cataract 47
Cataract, Microcornea OMIM:612018
Coloboma, Ocular, Autosomal Recessive
Cataract, Optic disc coloboma, Retinal coloboma, Lens subluxation, Iris coloboma OMIM:216820
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Cataract, Optic atrophy, Anophthalmia, Abnormality of retinal pigmentation, Retinal detachment, M... ORPHA:2526
Pierson Syndrome
Cataract, Hypoplasia of the iris, Rieger anomaly, Uveal ectropion, Macular hypoplasia, Hypoplasia... OMIM:609049
Cataract 10, Multiple Types
Posterior Y-sutural cataract, Developmental cataract, Nuclear cataract, Zonular cataract OMIM:600881
Microphthalmia, Syndromic 9
Multilobulated spleen, Hypoplastic spleen, Anophthalmia, Bilateral microphthalmos OMIM:601186
Oculo-Palato-Cerebral Syndrome
Cataract, Leukocoria, Retinal detachment, Remnants of the hyaloid vascular system, Microphthalmia ORPHA:2714
Aniridia 1
Cataract, Ectopia lentis, Hypoplasia of the iris, Ectopia pupillae, Aniridia, Corneal neovascular... OMIM:106210
Amoebic Keratitis
Cataract, Corneal perforation, Abnormal cornea morphology, Punctate opacification of the cornea, ... ORPHA:67043
Vacterl With Hydrocephalus
Microcornea, Anophthalmia, Microphthalmia ORPHA:3412
Holoprosencephaly
Optic atrophy, Abnormality of the spleen, Anophthalmia, Microphthalmia, Iris coloboma ORPHA:2162
Optic Nerve Hypoplasia, Bilateral
Optic nerve aplasia, Remnants of the hyaloid vascular system, Optic nerve hypoplasia OMIM:165550
Oculoauricular Syndrome
Cataract, Microcornea, Posterior synechiae of the anterior chamber, Retinal coloboma, Iris cyst, ... OMIM:612109
Aniridia 3
Cataract, Aniridia OMIM:617142
Fibular Hemimelia
Abnormal anterior chamber morphology, Anophthalmia ORPHA:93323
Proboscis Lateralis
Cataract, Microcornea, Optic disc coloboma, Anophthalmia, Corneal opacity, Microphthalmia, Iris c... ORPHA:141099
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 7
Cataract, Peters anomaly, Retinal detachment, Remnants of the hyaloid vascular system, Microphtha... OMIM:614643
Microgastria-Limb Reduction Defect Syndrome
Hepatomegaly, Abnormality of the spleen, Anophthalmia, Microphthalmia ORPHA:2538
Cerebrooculonasal Syndrome
Iris coloboma, Anophthalmia, Optic nerve hypoplasia OMIM:605627
Aniridia And Absent Patella
Cataract, Aniridia OMIM:106220
Joubert Syndrome 21
Splenomegaly, Optic atrophy, Anophthalmia, Megalopapilla OMIM:615636
Microphthalmia With Linear Skin Defects Syndrome
Microphthalmia, Anophthalmia, Abnormality of retinal pigmentation, Posterior embryotoxon, Corneal... ORPHA:2556
Microphthalmia, Syndromic 2
Microcornea, Anophthalmia, Retinal detachment, Developmental cataract, Microphthalmia, Remnants o... OMIM:300166
Exudative Vitreoretinopathy 6
Cataract, Nuclear cataract, Tractional retinal detachment, Retinal detachment, Cortical cataract,... OMIM:616468
Cataract 5, Multiple Types
Nuclear cataract, Pulverulent cataract, Lamellar cataract, Anterior polar cataract, Zonular cataract OMIM:116800
14Q22Q23 Microdeletion Syndrome
Optic nerve aplasia, Anophthalmia ORPHA:264200
Charge Syndrome
Optic atrophy, Webbed neck, Anophthalmia, Microphthalmia, Iris coloboma ORPHA:138
Hyperferritinemia With Or Without Cataract
Cataract, Nuclear cataract, Anterior subcapsular cataract, Pulverulent cataract OMIM:600886
Autoimmune Polyendocrine Syndrome, Type Ii
Cataract, Band keratopathy, Hepatitis, Exocrine pancreatic insufficiency, Keratoconjunctivitis, C... OMIM:269200
Focal Dermal Hypoplasia
Optic atrophy, Ectopia lentis, Aniridia, Anophthalmia, Microphthalmia, Iris coloboma OMIM:305600
Charge Syndrome
Webbed neck, Cataract, Retinal coloboma, Unilateral microphthalmos, Anophthalmia, Microphthalmia,... OMIM:214800
Fraser Syndrome 1
Anophthalmia, Bilateral microphthalmos, Corneal opacity OMIM:219000
Atelis Syndrome 2
Remnants of the hyaloid vascular system, Developmental cataract, Microphthalmia OMIM:620185
Holoprosencephaly 9
Optic nerve hypoplasia, Anophthalmia, Microphthalmia OMIM:610829
Microphthalmia With Limb Anomalies
Optic atrophy, True anophthalmia, Microphthalmia ORPHA:1106
Branchiooculofacial Syndrome
Cataract, Retinal coloboma, Anophthalmia, Microphthalmia, Iris coloboma OMIM:113620
Norrie Disease
Cataract, Optic atrophy, Ectopia lentis, Hypoplasia of the iris, Abnormal pupil morphology, Retin... ORPHA:649
Microphthalmia, Syndromic 6
Sclerocornea, Microcornea, Anophthalmia, Microphthalmia OMIM:607932
Neuroocular Syndrome 1
Cataract, Microcornea, Stellate iris, Peters anomaly, Hypoplasia of the fovea, Blue irides, Remna... OMIM:619539
Microphthalmia, Syndromic 1
Webbed neck, Microcornea, Optic disc coloboma, Ciliary body coloboma, Anophthalmia, Microphthalmi... OMIM:309800
Fraser Syndrome
Anophthalmia, Microphthalmia ORPHA:2052
Full Nf2-Related Schwannomatosis
Posterior subcapsular cataract, Cortical cataract, Remnants of the hyaloid vascular system ORPHA:637
Craniofacial Microsomia 1
Limbal dermoid, Anophthalmia, Microphthalmia OMIM:164210
Acromelic Frontonasal Dysostosis
Remnants of the hyaloid vascular system, Optic nerve hypoplasia OMIM:603671
Holoprosencephaly 2
Iris coloboma, Remnants of the hyaloid vascular system, Microphthalmia OMIM:157170

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Taar8c

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Taar8c.

No publications found that use IMPC mice or data for Taar8c.

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MGI Allele Allele Type Produced
Taar8cem1(IMPC)Mbp Whole-gene deletion Mice, Tissue

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