Gene: Dyrk1b

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Name
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
MGI ID
MGI:1330302
Synonyms
Mirk
Viability
Embryo viewer
N/A
Other links
Expression & images (0) Disease models (0) Order (3)
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased total retina thickness Dyrk1btm1b(EUCOMM)Wtsi HET Early adult 1.14×10-12
abnormal auditory brainstem response Dyrk1btm1b(EUCOMM)Wtsi HET   Early adult 8.84×10-08
decreased large unstained cell number Dyrk1btm1b(EUCOMM)Wtsi HET Early adult 6.58×10-05
preweaning lethality, complete penetrance Dyrk1btm1b(EUCOMM)Wtsi HOM   Early adult 0.00
decreased startle reflex Dyrk1btm1b(EUCOMM)Wtsi HET Early adult 7.31×10-05
decreased body weight Dyrk1btm1b(EUCOMM)Wtsi HET   Late adult 2.88×10-05
abnormal retinal inner nuclear layer morphology Dyrk1btm1b(EUCOMM)Wtsi HET Late adult 2.49×10-16
decreased circulating triglyceride level Dyrk1btm1b(EUCOMM)Wtsi HET Early adult 6.41×10-05
decreased total retina thickness Dyrk1btm1b(EUCOMM)Wtsi HET Late adult 3.49×10-17
decreased startle reflex Dyrk1btm1b(EUCOMM)Wtsi HET Late adult 1.89×10-06
abnormal retinal inner nuclear layer morphology Dyrk1btm1b(EUCOMM)Wtsi HET Early adult 2.31×10-11
decreased blood urea nitrogen level Dyrk1btm1b(EUCOMM)Wtsi HET   Early adult 6.06×10-05

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Select physiological systems to view:
Viewing: all phenotypes

 Expression

Expression data not available

 Associated Images

X-ray: XRay Images Whole Body Dorso Ventral
19 Images
X-ray: XRay Images Whole Body Lateral Orientation
19 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
Immunophenotyping: Panel B FCS file(s)
6 Images
Immunophenotyping: Panel A FCS file(s)
6 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Dyrk1btm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Dyrk1btm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Dyrk1btm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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