Mapk15 | mitogen-activated protein kinase 15

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Pigmentation Integument Hematopoietic system Behavior/neurological

12 No significant impact

7 Not tested

Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues

Phenotypes

decreased fasting circulating glucose level1 supporting datasetMapk15tm1b(EUCOMM)HmguhomozygoteEarly adult6.91x10-5 
abnormal coat/hair pigmentation1 supporting datasetMapk15tm1b(EUCOMM)HmguhomozygoteLate adult1.58x10-6 
increased mean corpuscular hemoglobin concentration1 supporting datasetMapk15tm1b(EUCOMM)HmguhomozygoteEarly adult8.33x10-6 
hyperactivity2 supporting datasetsMapk15tm1b(EUCOMM)HmguhomozygoteLate adult3.75x10-7 
decreased locomotor activity1 supporting datasetMapk15tm1b(EUCOMM)HmguhomozygoteEarly adult4.34x10-6 
abnormal startle reflex1 supporting datasetMapk15tm1b(EUCOMM)HmguhomozygoteLate adult3.31x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/2)0.7% (4/570)
aortaheterozygoten/a0% (0/2)0.19% (1/533)
brainheterozygoteSection images
100% (2/2)0.86% (5/579)
brainstemheterozygoten/a0% (0/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a0% (0/2)0.22% (1/454)
cerebellumheterozygoten/a0% (0/2)0.56% (3/532)
cerebral cortexheterozygoten/a0% (0/2)0.41% (2/491)
epididymisheterozygoteSection images
100% (1/1)87.5% (21/24)
esophagusheterozygoten/a0% (0/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Mapk15tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Mapk15tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Mapk15tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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