The International Mouse Phenotyping Consortium (IMPC) is an international research infrastructure aiming to identify the function of every gene in the mouse genome by creating and phenotyping mouse knockout lines for each of the 20,000 or so protein-coding genes. Our database is continuously growing as data is being generated. A brief description of the project can be found here, and consortium publications are listed here.
Briefly, the data the IMPC is collecting allows to identify the physiological systems that are disrupted when a gene is disabled and thus generate gene-phenotype associations. For this purpose, the IMPC has developed specific in-house protocols for high-throughput mice production and tracking, phenotyping and data analysis. Protocols are described in the corresponding sections.
This website freely displays the IMPC research by capturing, storing and disseminating the IMPC processes, data and annotations to the scientific community and the public. Users are able to search this data by specifying a gene or phenotype of interest by using the gene/ phenotype search bar available on all pages. Bulk downloads are also supported. For more information about this, please look under Non Programmatic Data Access. Finally, the IMPC blog provides information on recent relevant publications, interviews and news.
We invite you to learn more about the IMPC trhough these pages, our webinar and our online training course. The webinar focuses on IMPC findings as described in papers, including the description of the phenotyping pipelines, statistical analyses, and engagement with clinical and external consortia. Our online training course exemplifies IMPC website navigation and data accessing, with numerous website screenshots, videos, interactive content and a “try it yourself” activity.