The IMPC has several major collaborators, listed below. If you are interested in collaborating with us please get in touch at email@example.com.
The IMPC follows the FAIR Data Principles in order to make data findable, accessible, interoperable and reusable.
Illuminating the Druggable Genome (IDG)
IDG is an NIH Common Fund project focused on collecting, integrating and making available biological data on 395 human genes from three key druggable protein families that have been identified as potential therapeutic targets:
- non-olfactory G-protein coupled receptors (GPCRs)
- ion channels
- protein kinases
The IMPC consortium is creating knockout mouse strains for the IDG project to advance understanding of the function of these proteins.
Link to sub-page: http://www.mousephenotype.org/data/secondaryproject/idg
Find out more: https://commonfund.nih.gov/idg
The Monarch Initiative
The Monarch initiative is a tool that has been developed using computational reasoning to enable phenotype comparisons both within and across species to identify new animal models of human disease.
Find out more: https://monarchinitiative.org/
The RIKEN BioResource partners provide IMPC data in a Resource Description Framework (RDF) via the RIKEN MetaDatabase.
Find out more: http://metadb.riken.jp/
The Infection and Immunity Immunophenotyping (3i) consortium conducts a high-throughput immunological phenotyping of approximately 550 knockout mouse lines generated by the Wellcome Trust Sanger Institute (WTSI).
The project is entirely open access and all data is made available online via this website and the website of the International Mouse Phenotyping Consortium (IMPC). All generated knockout mouse lines can be requested from the IMPC.
Find out more: http://www.immunophenotype.org/
Deciphering the mechanisms of developmental disorders (DMDD) is a programme to find out more about gene knockouts that in the mouse cause embryonic or perinatal death. DMDD is carrying out detailed imaging and morphological phenotyping to find out why these genes are critical for embryo survival.
Find out more: https://dmdd.org.uk/programme
This resource is performing in-depth bone phenotyping of IMPC mice produced by the Jackson Laboratory and draws from the expertise of a multi-disciplinary team based at the University of Connecticut, the UCONN Health Center, the University of Rochester Medical Center, and the Jackson Laboratory.
IMPC mouse lines are subjected to detailed microCT analysis and those lines determined as having abnormal trabecular or cortical bone are further characterised in dynamic and cellular histomorphometry assays.
Find out more: http://bonebase.org/bonebase/
Origins of Bone Cartilage Disease Project
An international collaboration identifying genetic causes of bone and cartilage disease.
Find out more: http://www.boneandcartilage.com/gallery.html
100,000 genomes project
This project will sequence 100,000 genomes from around 70,000 people. Participants are NHS patients with a rare disease, plus their families, and patients with cancer.
A National Institutes of Health-sponsored resource that provides experimental testing services to scientists studying diabetes, obesity, diabetic complications, and other metabolic diseases in mice.
Find out more: https://www.mmpc.org/
The NIH Gabriella Miller Kids First Pediatric Research Program (Kids First) and the Knockout Mouse Phenotyping Program (KOMP2) are collaborating on a pilot project to develop mouse strains to study, phenotype, and validate coding and noncoding genetic variants (e.g. missense, structural variants, copy number variants, INDELS, frame shifts) identified from Kids First datasets.
Find out more: https://commonfund.nih.gov/kidsfirst/collaboration