Gene Summary

Name:
G protein-coupled receptor 101
Synonyms:
LOC245424

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal eye anterior chamber depth Gpr101tm1b(KOMP)Mbp HOM   Early adult 7.55×10-09
decreased thigmotaxis Gpr101tm1b(KOMP)Mbp HEM   Early adult 5.87×10-05
decreased locomotor activity Gpr101tm1b(KOMP)Mbp HEM   Early adult 4.39×10-05
decreased locomotor activity Gpr101tm1b(KOMP)Mbp HOM   Early adult 7.15×10-13
abnormal behavior Gpr101tm1b(KOMP)Mbp HEM   Early adult 5.87×10-05
decreased anxiety-related response Gpr101tm1b(KOMP)Mbp HEM   Early adult 8.24×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

Immunophenotyping

Panel B FCS file(s)

6 Images

Immunophenotyping

Panel A FCS file(s)

6 Images

Human diseases caused by Gpr101 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Gpr101 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Acromegaly
Depression, Anxiety ORPHA:963
Pituitary Adenoma 2, Growth Hormone-Secreting
OMIM:300943

The table below shows human diseases predicted to be associated to Gpr101 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Severe Primary Trimethylaminuria
Depression, Anxiety, Low self esteem, Aggressive behavior, Emotional lability, Negative affectivity ORPHA:468726
Panic Disorder 1
Anxiety OMIM:167870
Intellectual Developmental Disorder, Autosomal Recessive 25
Anxiety OMIM:614346
Obsessive-Compulsive Disorder
Depression, Anxiety, Skin-picking OMIM:164230
Chorea, Benign Hereditary
Gait disturbance, Anxiety OMIM:118700
Geniospasm 1
Anxiety OMIM:190100
Prkar1B-Related Neurodegenerative Dementia With Intermediate Filaments
Apathy, Bradykinesia, Anxiety, Inappropriate behavior, Falls, Shuffling gait, Inertia, Short step... ORPHA:412066
Epilepsy, Progressive Myoclonic, 12
Ataxia, Dysmetria, Depression, Anxiety, Difficulty walking OMIM:619191
Dystonia 12
Bradykinesia, Depression, Anxiety, Unsteady gait, Emotional lability OMIM:128235
Leukoencephalopathy, Motor Delay, Spasticity, And Dysarthria Syndrome
Anxiety, Bradykinesia OMIM:618878
Huntington Disease-Like 2
Apathy, Bradykinesia, Depression, Anxiety, Irritability OMIM:606438
Pandas
Agoraphobia, Abnormal fear/anxiety-related behavior, Impulsivity, Depression, Separation insecuri... ORPHA:66624
Acromegaly
Depression, Anxiety ORPHA:963
Pituitary Adenoma 2, Growth Hormone-Secreting
OMIM:300943

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gpr101

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gpr101.

No publications found that use IMPC mice or data for Gpr101.

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MGI Allele Allele Type Produced
Gpr101tm1b(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Mice
Gpr101tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Gpr101tm1e(KOMP)Mbp Targeted, non-conditional allele ES Cells
Gpr101tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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