Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
decreased locomotor activity | Gpr101tm1b(KOMP)Mbp | HOM | Early adult | 7.15×10-13 | ||
decreased anxiety-related response | Gpr101tm1b(KOMP)Mbp | HEM | Early adult | 8.24×10-05 | ||
abnormal behavior | Gpr101tm1b(KOMP)Mbp | HEM | Early adult | 5.87×10-05 | ||
abnormal eye anterior chamber depth | Gpr101tm1b(KOMP)Mbp | HOM | Early adult | 7.55×10-09 | ||
decreased locomotor activity | Gpr101tm1b(KOMP)Mbp | HEM | Early adult | 4.39×10-05 | ||
decreased thigmotaxis | Gpr101tm1b(KOMP)Mbp | HEM | Early adult | 5.87×10-05 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Gpr101 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Acromegaly | Depression, Anxiety | ORPHA:963 | |
Pituitary Adenoma 2, Growth Hormone-Secreting | OMIM:300943 |
The table below shows human diseases predicted to be associated to Gpr101 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gpr101.
There are 1 publication which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation. | Biochemical pharmacology (November 2022) | Gpr101tm1a(KOMP)Mbp | 36400250 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Gpr101tm1b(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | Mice |
Gpr101tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | ES Cells |
Gpr101tm1e(KOMP)Mbp | Targeted, non-conditional allele | ES Cells |
Gpr101tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
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