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Gene: Gpr101 MGI:2685211

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Gene Summary

Name:
G protein-coupled receptor 101
Synonyms:
LOC245424

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased locomotor activity Gpr101tm1b(KOMP)Mbp HOM   Early adult 7.15×10-13
decreased anxiety-related response Gpr101tm1b(KOMP)Mbp HEM   Early adult 8.24×10-05
abnormal behavior Gpr101tm1b(KOMP)Mbp HEM   Early adult 5.87×10-05
abnormal eye anterior chamber depth Gpr101tm1b(KOMP)Mbp HOM   Early adult 7.55×10-09
decreased locomotor activity Gpr101tm1b(KOMP)Mbp HEM   Early adult 4.39×10-05
decreased thigmotaxis Gpr101tm1b(KOMP)Mbp HEM   Early adult 5.87×10-05

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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FCS thumbnail FCS
Immunophenotyping

Panel A FCS file(s)

6 Images

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FCS thumbnail FCS
Immunophenotyping

Panel B FCS file(s)

6 Images

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Human diseases caused by Gpr101 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Gpr101 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Acromegaly
Depression, Anxiety ORPHA:963
Pituitary Adenoma 2, Growth Hormone-Secreting
OMIM:300943

The table below shows human diseases predicted to be associated to Gpr101 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Severe Primary Trimethylaminuria
Aggressive behavior, Anxiety, Emotional lability, Low self esteem, Depression, Negative affectivity ORPHA:468726
Panic Disorder 1
Anxiety OMIM:167870
Intellectual Developmental Disorder, Autosomal Recessive 25
Anxiety OMIM:614346
Obsessive-Compulsive Disorder
Skin-picking, Depression, Anxiety OMIM:164230
Chorea, Benign Hereditary
Gait disturbance, Anxiety OMIM:118700
Geniospasm 1
Anxiety OMIM:190100
Epilepsy, Progressive Myoclonic, 12
Ataxia, Dysmetria, Difficulty walking, Depression, Anxiety OMIM:619191
Dystonia 12
Emotional lability, Depression, Anxiety, Unsteady gait, Bradykinesia OMIM:128235
Leukoencephalopathy, Motor Delay, Spasticity, And Dysarthria Syndrome
Bradykinesia, Anxiety OMIM:618878
Parkinson Disease 6, Autosomal Recessive Early-Onset
Depression, Bradykinesia, Anxiety OMIM:605909
Pandas
Abnormal fear/anxiety-related behavior, Separation insecurity, Emotional lability, Depression, Ag... ORPHA:66624
Acromegaly
Depression, Anxiety ORPHA:963
Pituitary Adenoma 2, Growth Hormone-Secreting
OMIM:300943

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gpr101

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gpr101.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation. Biochemical pharmacology (November 2022) Gpr101tm1a(KOMP)Mbp 36400250

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MGI Allele Allele Type Produced
Gpr101tm1b(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Mice
Gpr101tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Gpr101tm1e(KOMP)Mbp Targeted, non-conditional allele ES Cells
Gpr101tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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