The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Adck1 by phenotypic similarity.
|Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Irf8 Deficiency||
|Immunodeficiency 38 With Basal Ganglia Calcification||
||Lymphadenopathy, Hepatosplenomegaly, Follicular hyperplasia||OMIM:619126|
|Fragile Site, Distamycin A Type, Rare, Fra(16)(Q22.1)||
||Abnormality of the lymph nodes||OMIM:136580|
||Lymphadenopathy, Follicular hyperplasia||ORPHA:482|
|Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation||
||Absent tonsils, Aplasia of the thymus, Lymph node hypoplasia||OMIM:602450|
||Absence of lymph node germinal center, Lymph node hypoplasia||ORPHA:90186|
|T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency||
||Absent tonsils, Lymph node hypoplasia||ORPHA:276|
|Purine Nucleoside Phosphorylase Deficiency||
||Lymph node hypoplasia, Splenomegaly||OMIM:613179|
||Lymph node hypoplasia||OMIM:300755|
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
There is no histopathology data for Adck1
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|MGI Allele||Allele Type||Produced|
|Adck1em2(IMPC)Tcp||Intra-exon deletion||Mice, Tissue|