Gene: Kcnh3

Name potassium voltage-gated channel, subfamily H (eag-related), member 3

Synonyms
  • Melk2
  • Elk2
  • C030044P22Rik
  • ether a go-go like

Status ES CellsMice
tm1
Mice
tm1.1
phenotype data available

Links MGI:1341723   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Viable

Phenotype associations for Kcnh3

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Kcnh3 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
increased hemoglobin content Kcnh3tm1.1(KOMP)Vlcg HOM Female Male postnatal 2.62E-5
cardiovascular system phenotype Kcnh3tm1.1(KOMP)Vlcg HOM Female Male postnatal 3.05E-5
decreased circulating HDL cholesterol level Kcnh3tm1.1(KOMP)Vlcg HOM Female postnatal 3.97E-5
increased circulating HDL cholesterol level Kcnh3tm1.1(KOMP)Vlcg HOM Male postnatal 3.97E-5
decreased heart rate variability Kcnh3tm1.1(KOMP)Vlcg HOM Female Male postnatal 5.71E-5
thrombocytopenia Kcnh3tm1.1(KOMP)Vlcg HOM Female Male postnatal 8.35E-5
decreased mean corpuscular volume Kcnh3tm1.1(KOMP)Vlcg HOM Female Male postnatal 9.15E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393) (1/2)
Aorta 2 No (1/562)
Bone 2 No (1/539)
Bone marrow 2 No
Brain 2 No (5/562) (1/2)
Brainstem 2 No (4/562) (1/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562)
Cerebellum 2 No (4/562) (1/2)
Cerebral cortex 2 No (5/562) (1/2)
Epididymis 2 No (4/106)
Esophagus 2 No (2/393)
Eye 2 No (1/562)
Heart 2 No (3/562)
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562)
Kidney 2 No (19/562) (1/2)
Large intestine 2 No (12/562)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562)
Lymph node 2 No (1/562)
Main olfactory bulb 2 No (1/2)
Mammary gland 2 No
Midbrain 2 No (1/2)
Olfactory lobe 2 No (4/393) (1/2)
Ovary 2 No (1/562) (1/2)
Oviduct 2 No (2/562)
Pancreas 2 No (6/562)
Peripheral nervous system 2 No (3/562)
Peyer's patch 2 No (1/393)
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562)
Quadriceps 2 No
Skeletal muscle 2 No
Skin 2 No (1/562)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562) (1/2)
Spleen 2 No (4/562)
Stomach 2 No (9/562)
Striatum 2 No (4/562)
Submandibular gland 2 No (1/104) (1/2)
Testis 2 No (3/562)
Thalamus 2 No (1/2)
Thymus 2 No
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562)
Urinary bladder 2 No
Uterus 2 No (2/562)
Vascular system 2 No (1/393)
Vesicular gland 1 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    postnatal mouse
    respiratory system
    digestive system
    nervous system
    reproductive system
    exocrine system
    trunk
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (5/439)
Dorsal root ganglion 1 Image Only
Ear 2
Embryo 2
Eye 2
Foot 2
Forebrain 2
Forelimb 2
Fronto-nasal process 1
Hand 2
Head 2 (4/439)
Heart 2
Hindbrain 2 (5/439)
Hindlimb 2
Liver 2
Lung 2
Mandibular process 2
Maxillary process 2
Midbrain 2
Nose 1 Image Only
Oral cavity 2
Skin 2
Spinal cord 1 Image Only
Tail 2
Tail somite 2


Associated Images

Associated Images
  • Combined SHIRPA and Dysmorphology
    7 Images
  • Electroretinography: Rod waveform (pdf format)
    7 Images
  • Electroretinography: Cone waveform (pdf format)
    7 Images
  • Electroretinography 2: Rod and cone PDF
    2 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Kcnh3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Kcnh3tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene
Kcnh3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene