Gene: Asic4 MGI:2652846

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Gene Summary

Name:
acid-sensing (proton-gated) ion channel family member 4
Synonyms:
Accn4

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased body length Asic4tm1b(KOMP)Mbp HOM Early adult 9.74×10-06
prolonged RR interval Asic4tm1b(KOMP)Mbp HOM Early adult 1.41×10-05
decreased heart rate Asic4tm1b(KOMP)Mbp HOM Early adult 2.39×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
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Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland  Section images heterozygote 100% (2 of 2)
Epididymis  Section images heterozygote 50% (1 of 2)
Esophagus  Section images heterozygote 50% (1 of 2)
Eye  Section images heterozygote 50% (1 of 2)
Ileum  Section images heterozygote 50% (1 of 2)
Midbrain  Section images heterozygote 50% (1 of 2)
Pituitary gland  Section images heterozygote 100% (2 of 2)
Testis  Section images heterozygote 50% (1 of 2)
Vas deferens  Section images heterozygote 50% (1 of 2)
Vesicular gland  Section images heterozygote 50% (1 of 2)
Aorta N/A heterozygote 0.0% (0 of 2)
Blood N/A heterozygote 0.0% (0 of 2)
Bone marrow N/A heterozygote 0.0% (0 of 2)
Brain N/A heterozygote Not available
Brainstem N/A heterozygote Not available
Brown adipose tissue N/A heterozygote 0.0% (0 of 2)
Cartilage tissue N/A heterozygote Not available
Cecum N/A heterozygote 0.0% (0 of 2)
Cerebellum N/A heterozygote 0.0% (0 of 2)
Cerebral cortex N/A heterozygote Not available
Chest bone N/A heterozygote Not available
Colon N/A heterozygote 0.0% (0 of 2)
Diaphragm N/A heterozygote 0.0% (0 of 2)
Duodenum N/A heterozygote 0.0% (0 of 2)
Gall bladder N/A heterozygote Not available
Gonadal fat pad N/A heterozygote 0.0% (0 of 2)
Harderian gland N/A heterozygote 0.0% (0 of 2)
Heart N/A heterozygote Not available
Hindlimb N/A heterozygote Not available
Hippocampus N/A heterozygote Not available
Hypothalamus N/A heterozygote Not available
Jejunum N/A heterozygote 0.0% (0 of 2)
Kidney N/A heterozygote 0.0% (0 of 2)
Large intestine N/A heterozygote Not available
Liver N/A heterozygote 0.0% (0 of 2)
Lower urinary tract N/A heterozygote Not available
Lung N/A heterozygote 0.0% (0 of 2)
Lymph node N/A heterozygote Not available
Mammary gland N/A heterozygote 0.0% (0 of 2)
Mesenteric adipose tissue N/A heterozygote 0.0% (0 of 2)
Mesenteric lymph node N/A heterozygote 0.0% (0 of 2)
Olfactory lobe N/A heterozygote 0.0% (0 of 2)
Ovary N/A heterozygote 0.0% (0 of 2)
Oviduct N/A heterozygote 0.0% (0 of 2)
Pancreas N/A heterozygote 0.0% (0 of 2)
Parathyroid gland N/A heterozygote 0.0% (0 of 2)
Parotid gland N/A heterozygote 0.0% (0 of 2)
Penis N/A heterozygote 0.0% (0 of 2)
Peripheral nervous system N/A heterozygote Not available
Peyer's patch N/A heterozygote Not available
Prostate gland N/A heterozygote 0.0% (0 of 2)
Quadriceps N/A heterozygote 0.0% (0 of 2)
Sciatic nerve N/A heterozygote 0.0% (0 of 2)
Skeletal muscle N/A heterozygote Not available
Skin N/A heterozygote 0.0% (0 of 2)
Small intestine N/A heterozygote Not available
Spinal cord N/A heterozygote 0.0% (0 of 2)
Spleen N/A heterozygote 0.0% (0 of 2)
Stomach pyloric region N/A heterozygote Not available
Stomach N/A heterozygote 0.0% (0 of 2)
Striatum N/A heterozygote Not available
Sublingual gland N/A heterozygote 0.0% (0 of 2)
Submandibular gland N/A heterozygote 0.0% (0 of 2)
Thymus N/A heterozygote 0.0% (0 of 2)
Thyroid gland N/A heterozygote 0.0% (0 of 2)
Tongue N/A heterozygote 0.0% (0 of 2)
Trachea N/A heterozygote 0.0% (0 of 2)
Trigeminal V nerve N/A heterozygote 0.0% (0 of 2)
Urinary bladder N/A heterozygote 0.0% (0 of 2)
Uterus N/A heterozygote 0.0% (0 of 2)
Vagina N/A heterozygote 0.0% (0 of 2)
Vascular system N/A heterozygote Not available
White adipose tissue N/A heterozygote Not available
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.68% (4 of 584)
aorta 0.17% (1 of 584)
blood 0.0%
bone marrow 0.0%
brain 0.68% (4 of 584)
brainstem 0.34% (2 of 584)
brown adipose tissue 0.0%
cartilage tissue 0.17% (1 of 584)
cecum 2.97% (11 of 370)
cerebellum 0.51% (3 of 584)
cerebral cortex 0.34% (2 of 584)
chest bone Unavailable
colon 8.73% (11 of 126)
diaphragm 0.0%
duodenum 0.79% (1 of 126)
epididymis 12.78% (17 of 133)
esophagus 1.72% (7 of 408)
eye 0.0%
gall bladder 0.0%
gonadal fat pad 0.0%
harderian gland 0.0%
heart 0.34% (2 of 584)
hindlimb 0.0%
hippocampus 0.51% (3 of 584)
hypothalamus 0.34% (2 of 584)
ileum 10.32% (13 of 126)
jejunum 3.97% (5 of 126)
kidney 3.6% (21 of 584)
large intestine 1.71% (10 of 584)
liver 0.0%
lower urinary tract 0.17% (1 of 584)
lung 0.34% (2 of 584)
lymph node 0.17% (1 of 584)
mammary gland 0.0%
mesenteric adipose tissue 0.0%
mesenteric lymph node 0.0%
midbrain 0.0%
olfactory lobe 0.34% (2 of 584)
ovary 0.17% (1 of 584)
oviduct 0.0%
pancreas 0.86% (5 of 584)
parathyroid gland 0.18% (1 of 562)
parotid gland 0.0%
penis 0.0%
peripheral nervous system 0.34% (2 of 584)
peyers patch 0.0%
pituitary gland 0.17% (1 of 584)
prostate gland 2.05% (12 of 584)
quadriceps 0.0%
sciatic nerve 0.0%
skeletal muscle 0.0%
skin 0.17% (1 of 584)
small intestine 1.54% (9 of 584)
spinal cord 0.51% (3 of 584)
spleen 0.51% (3 of 584)
stomach 2.05% (12 of 584)
stomach pyloric region 0.0%
striatum 0.51% (3 of 584)
sublingual gland 0.0%
submandibular gland 1.53% (2 of 131)
testis 1.03% (6 of 584)
thymus 0.17% (1 of 584)
thyroid gland 2.74% (16 of 584)
tongue 3.97% (5 of 126)
trachea 0.51% (3 of 584)
trigeminal v nerve 0.0%
urinary bladder 0.0%
uterus 0.0%
vagina 0.0%
vas deferens 3.67% (14 of 381)
vascular system 0.0%
vesicular gland 0.0%
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

20 Images

Adult LacZ

LacZ Images Section

19 Images

X-ray

XRay Images Forepaw

10 Images

X-ray

XRay Images Whole Body Lateral Orientation

20 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

X-ray

XRay Images Hind Leg and Hip

10 Images

X-ray

XRay Images Skull Lateral Orientation

10 Images

Human diseases caused by Asic4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Asic4 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Atrial Fibrillation, Familial, 18
OMIM:617280
Sinoatrial Node Dysfunction And Deafness
OMIM:614896
Cardiac Conduction Defect
OMIM:115080
Ventricular Tachycardia, Catecholaminergic Polymorphic, 2
OMIM:611938
Long Qt Syndrome 15
OMIM:616249
Supravalvular Aortic Stenosis
ORPHA:3193
Language Delay And Attention Deficit-Hyperactivity Disorder/Cognitive Impairment With Or Without Cardiac Arrhythmia
OMIM:617182
Atrial Septal Defect 6
OMIM:613087
Cardiomyopathy, Familial Hypertrophic, 11
OMIM:612098
Cataract 46, Juvenile-Onset, With Or Without Arrhythmic Cardiomyopathy
OMIM:212500
Familial Short Qt Syndrome
ORPHA:51083
Short Qt Syndrome 2
OMIM:609621
Progressive Familial Heart Block, Type Ib
OMIM:604559
His Bundle Tachycardia
ORPHA:3283
Long Qt Syndrome 16
OMIM:618782
Cardiac Arrhythmia, Ankyrin-B-Related
OMIM:600919
Intellectual Developmental Disorder With Cardiac Arrhythmia
OMIM:617173
Long Qt Syndrome 9
OMIM:611818
Progressive Familial Heart Block, Type Ii
OMIM:140400
Sick Sinus Syndrome 1
OMIM:608567
Long Qt Syndrome 14
OMIM:616247
Cardiac Conduction Disease With Or Without Dilated Cardiomyopathy
OMIM:616117
Chronic Atrial And Intestinal Dysrhythmia
OMIM:616201
Arrhythmogenic Right Ventricular Dysplasia, Familial, 12
OMIM:611528
Emery-Dreifuss Muscular Dystrophy 7, Autosomal Dominant
OMIM:614302
Brugada Syndrome
ORPHA:130
Catecholaminergic Polymorphic Ventricular Tachycardia
ORPHA:3286
Ventricular Fibrillation, Paroxysmal Familial, 1
OMIM:603829
Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/Or Dilated Cardiomyopathy
OMIM:604772
Atrial Standstill
ORPHA:1344
Ventricular Tachycardia, Catecholaminergic Polymorphic, 3
OMIM:614021
Paroxysmal Extreme Pain Disorder
OMIM:167400
Ventricular Tachycardia, Catecholaminergic Polymorphic, 4
OMIM:614916
Ventricular Tachycardia, Familial
OMIM:192605
Incessant Infant Ventricular Tachycardia
ORPHA:45453
Long Qt Syndrome 13
OMIM:613485
Arrhythmogenic Right Ventricular Dysplasia, Familial, 5
OMIM:604400
Cardiomyopathy, Familial Hypertrophic, 12
OMIM:612124
Arrhythmogenic Right Ventricular Dysplasia, Familial, 1
OMIM:107970
Cardiomyopathy, Familial Hypertrophic, 6
OMIM:600858
Atrial Fibrillation, Familial, 1
OMIM:608583
Atrial Fibrillation, Familial, 3
OMIM:607554
Arrhythmogenic Right Ventricular Dysplasia, Familial, 10
OMIM:610193
Brugada Syndrome 9
OMIM:616399
Brugada Syndrome 1
OMIM:601144
Romano-Ward Syndrome
ORPHA:101016
Heart-Hand Syndrome, Slovenian Type
ORPHA:168796
Cardiomyopathy, Dilated, 1O
OMIM:608569
Short Qt Syndrome 3
OMIM:609622
Long Qt Syndrome 10
OMIM:611819
Cardiomyopathy, Dilated, 1G
OMIM:604145
Sudden Cardiac Failure, Infantile
OMIM:617222
Atrial Fibrillation, Familial, 4
OMIM:611493
Cardiac Arrhythmia Syndrome, With Or Without Skeletal Muscle Weakness
OMIM:615441
Myopathy, Myofibrillar, 1
OMIM:601419
Cardiomyopathy, Dilated, 1E
OMIM:601154
Arrhythmogenic Right Ventricular Dysplasia, Familial, 8
OMIM:607450
Cardiomyopathy, Dilated, 1P
OMIM:609909
Arrhythmogenic Right Ventricular Dysplasia, Familial, 3
OMIM:602086
Brugada Syndrome 8
OMIM:613123
Jervell And Lange-Nielsen Syndrome 1
OMIM:220400
Long Qt Syndrome 2
OMIM:613688
Long Qt Syndrome 6
OMIM:613693
Long Qt Syndrome 5
OMIM:613695
Long Qt Syndrome 3
OMIM:603830
Tako-Tsubo Cardiomyopathy
ORPHA:66529
Brugada Syndrome 3
OMIM:611875
Arrhythmogenic Right Ventricular Dysplasia, Familial, 4
OMIM:602087
Short Qt Syndrome 1
OMIM:609620
Long Qt Syndrome 11
OMIM:611820
Arrhythmogenic Right Ventricular Dysplasia, Familial, 13
OMIM:615616
Long Qt Syndrome 1
OMIM:192500
X-Linked Intellectual Disability-Plagiocephaly Syndrome
ORPHA:2898
Atrial Septal Defect-Atrioventricular Conduction Defects Syndrome
ORPHA:1479
Wolff-Parkinson-White Syndrome
OMIM:194200
Atrial Standstill 1
OMIM:108770
Atrial Standstill 2
OMIM:615745
Arrhythmogenic Right Ventricular Dysplasia, Familial, 14
OMIM:618920
Sick Sinus Syndrome 2
OMIM:163800
Coenzyme Q10 Deficiency, Primary, 7
OMIM:616276
Brugada Syndrome 6
OMIM:613119
Arrhythmogenic Right Ventricular Dysplasia, Familial, 11
OMIM:610476
Congenital Heart Defects, Multiple Types, 3
OMIM:614954
Long Qt Syndrome 12
OMIM:612955
Idiopathic Neonatal Atrial Flutter
ORPHA:45452
Ventricular Arrythmias Due To Cardiac Ryanodine Receptor Calcium Release Deficiency Syndrome
OMIM:115000
Cardiomyopathy, Dilated, 1Y
OMIM:611878
Cardiomyopathy, Familial Hypertrophic, 16
OMIM:613838
Atrial Fibrillation, Familial, 7
OMIM:612240
Jervell And Lange-Nielsen Syndrome 2
OMIM:612347
Familial Progressive Cardiac Conduction Defect
ORPHA:871
Cardiomyopathy, Familial Hypertrophic, 10
OMIM:608758
Cardiomyopathy, Dilated, 1B
OMIM:600884
Brugada Syndrome 7
OMIM:613120
Glycogen Storage Disease Xv
OMIM:613507
Cardiomyopathy, Familial Hypertrophic, 1
OMIM:192600
Muscular Dystrophy, Becker Type
OMIM:300376
Lipoyltransferase 1 Deficiency
OMIM:616299
Chromosome 1P36.33 Duplication Syndrome, Atad3 Gene Cluster, Autosomal Dominant
OMIM:618815
Gnb5-Related Intellectual Disability-Cardiac Arrhythmia Syndrome
ORPHA:542306
Atrial Tachyarrhythmia With Short Pr Interval
OMIM:108950
Arrhythmogenic Right Ventricular Dysplasia, Familial, 6
OMIM:604401
Coenzyme Q10 Deficiency, Primary, 5
OMIM:614654
Brugada Syndrome 2
OMIM:611777
Cardiomyopathy, Dilated, 1Nn
OMIM:615916
Ventricular Fibrillation, Paroxysmal Familial, 2
OMIM:612956
Brugada Syndrome 5
OMIM:612838
Trimethylaminuria
OMIM:602079
Cardiomyopathy, Familial Hypertrophic, 17
OMIM:613873
Nathalie Syndrome
OMIM:255990
Mitochondrial Complex Iv Deficiency, Nuclear Type 4
OMIM:619048
Left Ventricular Noncompaction 8
OMIM:615373
Cardiomyopathy, Dilated, 1A
OMIM:115200
Infant Acute Respiratory Distress Syndrome
ORPHA:70587
Atrial Septal Defect, Sinus Venosus Type
ORPHA:99105
Variegate Porphyria
OMIM:176200
Congenital Left Ventricular Aneurysm
ORPHA:1055
Atrial Fibrillation, Familial, 14
OMIM:615378
Atrial Fibrillation, Familial, 15
OMIM:615770
3-Methylglutaconic Aciduria, Type Viii
OMIM:617248
Illum Syndrome
OMIM:208155
Brugada Syndrome 4
OMIM:611876
Cardiomyopathy, Familial Hypertrophic, 8
OMIM:608751
Cardiomyopathy, Familial Hypertrophic, 13
OMIM:613243
Wild Type Attr Amyloidosis
ORPHA:330001
Cardiomyopathy, Dilated, 1Aa, With Or Without Left Ventricular Noncompaction
OMIM:612158
Carnitine-Acylcarnitine Translocase Deficiency
OMIM:212138
Muscular Dystrophy, Cardiac Type
OMIM:309930
Atrial Fibrillation, Familial, 10
OMIM:614022
Rigidity And Multifocal Seizure Syndrome, Lethal Neonatal
OMIM:614498
Familial Dilated Cardiomyopathy With Conduction Defect Due To Lmna Mutation
ORPHA:300751
Idiopathic Congenital Hypothyroidism
ORPHA:95717
Sinus Node Disease And Myopia
OMIM:182190
Hydroxykynureninuria
OMIM:236800
Familial Dilated Cardiomyopathy
ORPHA:217607
Ventricular Extrasystoles With Syncope, Perodactyly, And Robin Sequence
OMIM:192445
Timothy Syndrome
OMIM:601005
Glycogen Storage Disease Of Heart, Lethal Congenital
OMIM:261740
Hyperthyroidism, Familial Gestational
OMIM:603373
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 25
OMIM:616812
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 3
OMIM:609286
Microcephaly, Cerebellar Hypoplasia, And Cardiac Conduction Defect Syndrome
OMIM:614407
Sudden Infant Death With Dysgenesis Of The Testes Syndrome
OMIM:608800
Arrhythmogenic Right Ventricular Dysplasia, Familial, 2
OMIM:600996
Pulmonic Stenosis, Atrial Septal Defect, And Unique Electrocardiographic Abnormalities
OMIM:178650
Malignant Hyperthermia, Susceptibility To, 5
OMIM:601887
Tetanus
ORPHA:3299
Jervell And Lange-Nielsen Syndrome
ORPHA:90647
Arrhythmogenic Right Ventricular Dysplasia, Familial, 9
OMIM:609040
Aapoaiv Amyloidosis
ORPHA:439232
Pseudo-Torch Syndrome 2
OMIM:617397
Glycogen Storage Disease With Severe Cardiomyopathy Due To Glycogenin Deficiency
ORPHA:263297
Distichiasis With Congenital Anomalies Of The Heart And Peripheral Vasculature
OMIM:126320
Glutamine Deficiency, Congenital
OMIM:610015
Congenitally Corrected Transposition Of The Great Arteries
ORPHA:216694
Pulmonary Hypertension, Primary, 4
OMIM:615344
Deafness, Nerve Type, With Mesenteric Diverticula Of Small Bowel And Progressive Sensory Neuropathy
OMIM:221400
Congenital Hypothyroidism Due To Maternal Intake Of Antithyroid Drugs
ORPHA:226313
Thyrotoxic Periodic Paralysis, Susceptibility To, 2
OMIM:613239
Neuropathy, Hereditary Sensory And Autonomic, Type Vi
OMIM:614653
Naxos Disease
ORPHA:34217
Familial Thyroid Dyshormonogenesis
ORPHA:95716
Ectodermal Dysplasia, Hidrotic, Christianson-Fourie Type
OMIM:601375
Coproporphyria, Hereditary
OMIM:121300
Acitretin/Etretinate Embryopathy
ORPHA:40366
Peripartum Cardiomyopathy
ORPHA:563
Cardiomyopathy, Dilated, With Woolly Hair And Keratoderma
OMIM:605676
Thyrotoxic Periodic Paralysis, Susceptibility To, 1
OMIM:188580
Mitochondrial Complex I Deficiency, Nuclear Type 37
OMIM:619272
Lipodystrophy, Congenital Generalized, Type 4
OMIM:613327
Ebstein Anomaly
OMIM:224700
Glossopharyngeal Neuralgia
ORPHA:221098
Necrotizing Enterocolitis
ORPHA:391673
Naxos Disease
OMIM:601214
Hyperinsulinism Due To Ucp2 Deficiency
ORPHA:276556
Pheochromocytoma--Islet Cell Tumor Syndrome
OMIM:171420
Mitochondrial Complex Iii Deficiency, Nuclear Type 10
OMIM:618775
Atrial Septal Defect, Ostium Secundum Type
ORPHA:99103
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
ORPHA:276575
Paragangliomas 3
OMIM:605373
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
ORPHA:276580
Combined Oxidative Phosphorylation Defect Type 39
ORPHA:565624
Cardiogenic Shock
ORPHA:97292
Acquired Methemoglobinemia
ORPHA:464453
Drug-Induced Autoimmune Hemolytic Anemia
ORPHA:90037
Complete Atrioventricular Septal Defect
ORPHA:1329
Linear Skin Defects With Multiple Congenital Anomalies 3
OMIM:300952
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
ORPHA:276608
Hyperinsulinism Due To Hnf1A Deficiency
ORPHA:324575
Sepsis In Premature Infants
ORPHA:90051
Neuroleptic Malignant Syndrome
ORPHA:94093
Cardiomyopathy, Dilated, With Woolly Hair, Keratoderma, And Tooth Agenesis
OMIM:615821
Encephalitis Lethargica
ORPHA:83600
Hypothyroidism Due To Tsh Receptor Mutations
ORPHA:90673
Paragangliomas 1
OMIM:168000
Tropical Endomyocardial Fibrosis
ORPHA:75565
Snakebite Envenomation
ORPHA:449285
Malignant Hyperthermia, Susceptibility To, 1
OMIM:145600
Sheehan Syndrome
ORPHA:91355
Proximal Spinal Muscular Atrophy
ORPHA:70
Myotonic Dystrophy 2
OMIM:602668
Hirschsprung Disease, Cardiac Defects, And Autonomic Dysfunction
OMIM:613870
Hyperthyroidism, Nonautoimmune
OMIM:609152
Hydroxykynureninuria
ORPHA:79155
Abnormal Hair, Joint Laxity, And Developmental Delay
OMIM:261990
Car T Cell Therapy-Associated Cytokine Release Syndrome
ORPHA:542323
Isolated Thyroid-Stimulating Hormone Deficiency
ORPHA:90674
Congenital Disorder Of Glycosylation, Type It
OMIM:614921
Histiocytoid Cardiomyopathy
ORPHA:137675
Carnitine Palmitoyltransferase Ii Deficiency, Infantile
OMIM:600649
Mixed-Type Autoimmune Hemolytic Anemia
ORPHA:90036
Autoimmune Hemolytic Anemia, Warm Type
ORPHA:90033
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
ORPHA:26793
Hereditary Pulmonary Alveolar Proteinosis
ORPHA:264675
Pheochromocytoma
OMIM:171300
Bohring-Opitz Syndrome
ORPHA:97297
Juvenile Neuronal Ceroid Lipofuscinosis
ORPHA:79264
Glycogen Storage Disease Due To Muscle Glycogen Phosphorylase Deficiency
ORPHA:368
Hypothyroidism, Congenital, Nongoitrous, 2
OMIM:218700
Mercury Poisoning
ORPHA:330021
Cutis Laxa, Autosomal Recessive, Type Ib
OMIM:614437
Tularemia
ORPHA:3392
Hereditary Coproporphyria
ORPHA:79273
Scorpion Envenomation
ORPHA:466677
Cocaine Intoxication
ORPHA:90068
Fructose-1,6-Bisphosphatase Deficiency
OMIM:229700
Stiff-Person Syndrome
OMIM:184850
Congenital Fibrinogen Deficiency
ORPHA:335
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
ORPHA:226307
Paragangliomas 4
OMIM:115310
Carney Triad
ORPHA:139411
Relapsing Fever
ORPHA:91547
Double Outlet Right Ventricle
ORPHA:3426
Porphyria, Acute Intermittent
OMIM:176000
Ethylene Glycol Poisoning
ORPHA:31826
Severe Generalized Junctional Epidermolysis Bullosa
ORPHA:79404
Malignant Hyperthermia Of Anesthesia
ORPHA:423
Hyperinsulinism Due To Hnf4A Deficiency
ORPHA:263455
Serotonin Syndrome
ORPHA:43116
16P12.1P12.3 Triplication Syndrome
ORPHA:485405
Renal Nutcracker Syndrome
ORPHA:71273
Neuropathy, Hereditary Sensory And Autonomic, Type Iii
OMIM:223900
Porphyria Variegata
ORPHA:79473
Bacterial Toxic-Shock Syndrome
ORPHA:36234
Eisenmenger Syndrome
ORPHA:97214
Fructose-1,6-Bisphosphatase Deficiency
ORPHA:348
Cholera
ORPHA:173
Familial Dysautonomia
ORPHA:1764
Mucopolysaccharidosis-Like Syndrome With Congenital Heart Defects And Hematopoietic Disorders
ORPHA:505248
Systemic Mastocytosis With Associated Hematologic Neoplasm
ORPHA:98849
Graft Versus Host Disease
ORPHA:39812
Acute Intermittent Porphyria
ORPHA:79276
Mirizzi Syndrome
ORPHA:521219
45,X/46,Xy Mixed Gonadal Dysgenesis
ORPHA:1772
Truncus Arteriosus
ORPHA:3384
Plague
ORPHA:707
Congenital Total Pulmonary Venous Return Anomaly
ORPHA:99125

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Asic4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Asic4.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Distribution of ASIC4 transcripts in the adult wild-type mouse brain. Neuroscience letters (April 2017) Asic4tm1a(KOMP)Mbp 28461138

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MGI Allele Allele Type Produced
Asic4tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Asic4tm1b(KOMP)Mbp Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Asic4tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Asic4em2(IMPC)Mbp Null reporter Mice, Tissue

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