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Genes Phenotypes

Gene: Hipk4

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Name
homeodomain interacting protein kinase 4
MGI ID
MGI:2685008
Synonyms
LOC233020
Viability
Homozygous - Viable
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (10) Measurements chart (138) All data table (405)
Expression & images (73) Disease models (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal retinal blood vessel morphology Hipk4tm1b(KOMP)Mbp HOM   Late adult 2.00×10-06
fused cornea and lens Hipk4tm1b(KOMP)Mbp HOM   Late adult 2.00×10-06
abnormal vitreous body morphology Hipk4tm1b(KOMP)Mbp HOM   Late adult 2.00×10-06
cataract Hipk4tm1b(KOMP)Mbp HOM   Late adult 1.73×10-05
persistence of hyaloid vascular system Hipk4tm1b(KOMP)Mbp HOM   Late adult 7.31×10-06
decreased startle reflex Hipk4tm1b(KOMP)Mbp HOM   Early adult 6.00×10-05
male infertility Hipk4tm1b(KOMP)Mbp HOM Early adult 0.00
iris synechia Hipk4tm1b(KOMP)Mbp HOM   Late adult 1.56×10-06
abnormal retinal vasculature morphology Hipk4tm1b(KOMP)Mbp HOM   Late adult 2.00×10-06
abnormal optic disk morphology Hipk4tm1b(KOMP)Mbp HOM Late adult 4.90×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/590) N/A
Aorta 2 No  (1/590) N/A
Brain 2 No  (3/590)  (2/2)  Section images
Brainstem 2 No  (2/590)  (2/2)  Section images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (3/590) N/A
Cerebral cortex 2 No  (2/590) N/A
Epididymis 2 No  (18/134) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Heart 2 No  (1/590) N/A
Hippocampus 2 No  (3/590) N/A
Hypothalamus 2 No  (2/590) N/A
Kidney 2 No  (20/590)  (2/2)  Section images
Large intestine 2 No  (10/590)  (2/2)  Section images
Liver 2 No N/A
Lower urinary tract 2 No  (1/590) N/A
Lung 2 No  (1/590) N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Midbrain 2 No N/A
Olfactory lobe 2 No  (2/590) N/A
Ovary 2 No  (1/590)  (1/2)  Section images
Oviduct 2 No  (1/2)  Section images
Pancreas 2 No  (5/590) N/A
Peripheral nervous system 2 No  (1/590) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/590) N/A
Prostate gland 2 No  (12/590) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/590)  (2/2)  Section images
Spinal cord 2 No  (2/590) N/A
Spleen 2 No  (2/590) N/A
Stomach 2 No  (13/590) N/A
Striatum 2 No  (3/590) N/A
Submandibular gland 2 No  (2/132)  (2/2)  Section images
Testis 2 No  (5/590)  (1/2)  Section images
Thalamus 2 No N/A
Thymus 2 No N/A
Thyroid gland 2 No  (16/590)  Section images
Trachea 2 No  (2/590) N/A
Urinary bladder 2 No N/A
Uterus 2 No N/A
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
LacZ Section Images
digestive system (3)
Large Intestine expression
MA:0000333
endocrine system (1)
Thyroid gland imageOnly
MA:0000129
exocrine system (1)
Submandibular Gland expression
MA:0001589
nervous system (2)
Brain expression
MA:0000168
postnatal mouse (10)
Brain expression
MA:0000168
reproductive system (3)
Ovary expression
MA:0000384
respiratory system (1)
Submandibular Gland expression
MA:0001589
trunk (6)
Kidney expression
MA:0000368
urinary system (1)
Kidney expression
MA:0000368
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/506) N/A
Dorsal root ganglion 1  (1/61) N/A
Ear 2  (1/506) N/A
Embryo 2  (1/507) N/A
Eye 2  (1/506) N/A
Foot 2  (1/506) N/A
Forebrain 2  (1/506) N/A
Forelimb 2  (1/506) N/A
Fronto-nasal process 1  (1/62) N/A
Hand 2  (1/506) N/A
Head 2  (5/506) N/A
Heart 2  (1/506) N/A
Hindbrain 2  (6/506) N/A
Hindlimb 2  (1/506) N/A
Liver 2  (1/504) N/A
Lung 2  (1/504) N/A
Mandibular process 2  (1/506) N/A
Maxillary process 2  (1/506) N/A
Midbrain 2  (1/506) N/A
Nose 1  (1/76) N/A
Oral cavity 2  (1/504) N/A
Skin 2  (1/506) N/A
Spinal cord 1  (1/73) N/A
Tail 2  (1/506) N/A
Tail somite 2  (1/506) N/A

 Associated Images

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Original Image
Adult LacZ: LacZ Images Section
10 Images
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X-ray: XRay Images Forepaw
9 Images
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X-ray: XRay Images Whole Body Lateral Orientation
9 Images
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X-ray: XRay Images Skull Lateral Orientation
9 Images
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Eye Morphology: Images Ophthalmoscopy
3 Images
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X-ray: XRay Images Whole Body Dorso Ventral
9 Images
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Electrocardiogram (ECG): Waveform Image
3 Images
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X-ray: XRay Images Skull Dorso Ventral Orientation
9 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
1 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Hipk4tm1b(KOMP)Mbp Reporter-tagged deletion allele (post-Cre) Mice
Hipk4tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Hipk4tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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