Hipk4 | homeodomain interacting protein kinase 4

GeneMGI:2685008Synonyms: LOC233020

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Behavior/neurological

14 No significant impact

7 Not tested

Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues

Phenotypes

limb grasping1 supporting datasetHipk4tm1b(KOMP)MbphomozygoteLate adult2.23x10-5 
increased circulating serum albumin level1 supporting datasetHipk4tm1b(KOMP)MbphomozygoteLate adult1.7x10-7 
impaired righting response1 supporting datasetHipk4tm1b(KOMP)MbphomozygoteLate adult8.02x10-5 
male infertility1 supporting datasetHipk4tm1b(KOMP)MbphomozygoteEarly adultN/A * 
decreased blood urea nitrogen level1 supporting datasetHipk4tm1b(KOMP)MbphomozygoteLate adult1.21x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/2)0.7% (4/570)
aortaheterozygoten/a0% (0/2)0.19% (1/533)
brainheterozygoteSection images
100% (2/2)0.86% (5/579)
brainstemheterozygoteSection images
100% (2/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a0% (0/2)0.22% (1/454)
cerebellumheterozygoten/a0% (0/2)0.56% (3/532)
cerebral cortexheterozygoten/a0% (0/2)0.41% (2/491)
epididymisheterozygoten/a0% (0/1)87.5% (21/24)
esophagusheterozygoten/a0% (0/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Hipk4tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Hipk4tm1a(KOMP)MbpKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Hipk4tm1b(KOMP)MbpReporter-tagged deletion allele (with selection cassette)mouse
Hipk4tm1e(KOMP)MbpTargeted, non-conditional alleleES Cell

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