Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
abnormal neural tube closure | Cdk8tm1b(EUCOMM)Hmgu | HOM | E9.5 | 0.00 | ||
abnormal embryo size | Cdk8tm1b(EUCOMM)Hmgu | HOM | E9.5 | 0.00 | ||
abnormal freezing behavior | Cdk8tm1b(EUCOMM)Hmgu | HET | Early adult | 6.56×10-05 | ||
preweaning lethality, complete penetrance | Cdk8tm1b(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
decreased exploration in new environment | Cdk8tm1b(EUCOMM)Hmgu | HET | Early adult | 6.48×10-06 | ||
abnormal heart morphology | Cdk8tm1b(EUCOMM)Hmgu | HOM | E9.5 | 0.00 | ||
abnormal embryo turning | Cdk8tm1b(EUCOMM)Hmgu | HOM | E9.5 | 0.00 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Cdk8 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Intellectual Developmental Disorder With Hypotonia And Behavioral Abnormalities | Ventricular septal defect, Hypoplastic left heart, Tetralogy of Fallot, Patent foramen ovale | OMIM:618748 |
The table below shows human diseases predicted to be associated to Cdk8 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cdk8.
There are 7 publications which use IMPC produced mice or data.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Cdk8tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
Cdk8tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Cdk8tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | Mice |
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