Cdk8 | cyclin dependent kinase 8
GeneMGI:1196224
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Embryo Growth/size/body region Nervous system Behavior/neurological Mortality/aging Cardiovascular system
14 No significant impact
4 Not tested
Data collections
Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
abnormal embryo size | 1 supporting dataset | Cdk8tm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * | ||
abnormal embryo turning | 1 supporting dataset | Cdk8tm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * | ||
abnormal freezing behavior | 1 supporting dataset | Cdk8tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 6.56x10-5 | ||
abnormal neural tube closure | 1 supporting dataset | Cdk8tm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * | ||
preweaning lethality, complete penetrance | 1 supporting dataset | Cdk8tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
decreased exploration in new environment | 1 supporting dataset | Cdk8tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 6.48x10-6 | ||
abnormal heart morphology | 1 supporting dataset | Cdk8tm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * |
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External links
No external links available for Cdk8.
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Cdk8tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Cdk8tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
Cdk8tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |