Gene Summary

Name:
cyclin-dependent kinase 8
Synonyms:
N/A

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal embryo size Cdk8tm1b(EUCOMM)Hmgu HOM E9.5 0.00
abnormal embryo turning Cdk8tm1b(EUCOMM)Hmgu HOM E9.5 0.00
abnormal neural tube closure Cdk8tm1b(EUCOMM)Hmgu HOM E9.5 0.00
preweaning lethality, complete penetrance Cdk8tm1b(EUCOMM)Hmgu HOM   Early adult 0.00
abnormal freezing behavior Cdk8tm1b(EUCOMM)Hmgu HET   Early adult 6.56×10-05
decreased exploration in new environment Cdk8tm1b(EUCOMM)Hmgu HET Early adult 6.48×10-06
abnormal heart morphology Cdk8tm1b(EUCOMM)Hmgu HOM E9.5 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

Gross Morphology Embryo E9.5

Images

2 Images

Immunophenotyping

Panel A FCS file(s)

7 Images

Immunophenotyping

Panel B FCS file(s)

7 Images

Human diseases caused by Cdk8 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Cdk8 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Intellectual Developmental Disorder With Hypotonia And Behavioral Abnormalities
Ventricular septal defect, Patent foramen ovale, Tetralogy of Fallot, Hypoplastic left heart OMIM:618748

The table below shows human diseases predicted to be associated to Cdk8 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Panic Disorder 1
Anxiety OMIM:167870
Intellectual Developmental Disorder, Autosomal Recessive 25
Anxiety OMIM:614346
Severe Primary Trimethylaminuria
Depression, Anxiety, Low self esteem, Aggressive behavior, Emotional lability, Negative affectivity ORPHA:468726
Obsessive-Compulsive Disorder
Depression, Anxiety, Skin-picking OMIM:164230
Familial Alzheimer-Like Prion Disease
Cognitive impairment, Depression, Deficit in phonologic short-term memory, Anxiety, Emotional lab... ORPHA:280397
Intellectual Developmental Disorder, Autosomal Recessive 59
Aggressive behavior OMIM:617323
Intellectual Developmental Disorder, X-Linked 63
Anxiety OMIM:300387
Persistent Idiopathic Facial Pain
Depression, Anxiety ORPHA:398147
Geniospasm 1
Anxiety OMIM:190100
Epilepsy, Nocturnal Frontal Lobe, 5
Depression, Personality disorder, Aggressive behavior, Cognitive impairment OMIM:615005
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Chorea, Benign Hereditary
Anxiety OMIM:118700
Creutzfeldt-Jakob Disease
Apathy, Depression, Anxiety, Memory impairment, Irritability, Dementia OMIM:123400
Basal Ganglia Calcification, Idiopathic, 5
Apathy, Cognitive impairment, Depression, Anxiety, Dementia OMIM:615483
Myelopathy, Htlv-1-Associated
Myelopathy OMIM:159580
Myoclonus-Dystonia Syndrome
Depression, Personality disorder, Anxiety, Panic attack ORPHA:36899
Prkar1B-Related Neurodegenerative Dementia With Intermediate Filaments
Apathy, Anxiety, Inappropriate behavior, Memory impairment, Motor deterioration, Inertia, Frontot... ORPHA:412066
Spina Bifida-Hypospadias Syndrome
Spinal dysraphism, Spina bifida ORPHA:3176
Dystonia 11, Myoclonic
Depression, Agoraphobia, Anxiety OMIM:159900
Pandas
Agoraphobia, Abnormal fear/anxiety-related behavior, Impulsivity, Depression, Separation insecuri... ORPHA:66624
Childhood-Onset Benign Chorea With Striatal Involvement
Anxiety ORPHA:494541
Huntington Disease-Like Syndrome Due To C9Orf72 Expansions
Cognitive impairment, Depression, Anxiety, Inappropriate behavior, Memory impairment ORPHA:401901
Intellectual Developmental Disorder With Epilepsy, Behavioral Abnormalities, And Coarse Facies
Anxiety, Self-injurious behavior, Aggressive behavior OMIM:619031
Huntington Disease-Like 2
Apathy, Depression, Anxiety, Irritability, Dementia OMIM:606438
Childhood Disintegrative Disorder
Social and occupational deterioration, Progressive language deterioration, Abnormal emotion/affec... ORPHA:168782
Huntington Disease-Like 1
Depression, Anxiety, Aggressive behavior, Dementia OMIM:603218
Epilepsy, Progressive Myoclonic, 12
Depression, Anxiety, Mental deterioration OMIM:619191
Parkinson Disease 6, Autosomal Recessive Early-Onset
Depression, Anxiety, Dementia OMIM:605909
Neural Tube Defects, X-Linked
Spina bifida, Anencephaly OMIM:301410
Anencephaly 1
Spina bifida, Anencephaly OMIM:206500
Convulsions, Familial Infantile, With Paroxysmal Choreoathetosis
Anxiety OMIM:602066
Bilateral Parasagittal Parieto-Occipital Polymicrogyria
Abnormal fear/anxiety-related behavior, Aggressive behavior, Suicidal ideation ORPHA:208441
Leukoencephalopathy, Motor Delay, Spasticity, And Dysarthria Syndrome
Anxiety OMIM:618878
Early-Onset Schizophrenia
Impairment in personality functioning, Cognitive impairment, Abnormal emotion/affect behavior, De... ORPHA:96369
Dystonia 26, Myoclonic
Depression, Anxiety OMIM:616398
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Abnormal fear/anxiety-related behavior, Aggressive behavior, Abnormal aggressive, impulsive or vi... ORPHA:3077
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Craniorachischisis
Myelomeningocele, Cervical spina bifida, Anencephaly, Sirenomelia, Spinal dysraphism ORPHA:63260
Gm2 Gangliosidosis, Ab Variant
Abnormal fear/anxiety-related behavior, Anxiety, Inappropriate behavior, Cognitive impairment ORPHA:309246
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Alg3-Cdg
Cardiomyopathy, Neural tube defect ORPHA:79321
Posterior Meningocele
Occipital meningocele, Hydrocephalus, Neural tube defect, Meningocele, Lipomyelomeningocele ORPHA:268810
Alobar Holoprosencephaly
Hydrocephalus, Neural tube defect, Abnormal heart morphology ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Hydrocephalus, Neural tube defect, Abnormal heart morphology ORPHA:93926
Lobar Holoprosencephaly
Hydrocephalus, Neural tube defect, Abnormal heart morphology ORPHA:93924
Semilobar Holoprosencephaly
Hydrocephalus, Neural tube defect, Abnormal heart morphology ORPHA:220386
Schinzel-Giedion Syndrome
Abnormal heart morphology, Neural tube defect, Umbilical hernia ORPHA:798
Intellectual Developmental Disorder With Hypotonia And Behavioral Abnormalities
Ventricular septal defect, Patent foramen ovale, Tetralogy of Fallot, Hypoplastic left heart OMIM:618748

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cdk8

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cdk8.

There are 6 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
The Role of CDKs and CDKIs in Murine Development. International journal of molecular sciences (July 2020) Cdk8tm1a(EUCOMM)Hmgu PMC7432401
Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development. Development (Cambridge, England) (June 2020) Cdk8tm1a(EUCOMM)Hmgu PMC7295591
A kinase-independent role for CDK8 in BCR-ABL1+ leukemia. Nature communications (October 2019) Cdk8tm1c(EUCOMM)Hmgu PMC6802219
Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions. Molecular cell (September 2019) Cdk8tm1c(EUCOMM)Hmgu 31495563
CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells. Cell reports (September 2019) Cdk8tm1a(EUCOMM)Hmgu 31509750
NK Cell-Specific CDK8 Deletion Enhances Antitumor Responses. Cancer immunology research (January 2018) Cdk8tm1c(EUCOMM)Hmgu 29386186

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MGI Allele Allele Type Produced
Cdk8tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Cdk8tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Cdk8tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice

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