Gene Summary

Name:
cyclin dependent kinase 8
Synonyms:
N/A

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased exploration in new environment Cdk8tm1b(EUCOMM)Hmgu HET Early adult 6.48×10-06
abnormal freezing behavior Cdk8tm1b(EUCOMM)Hmgu HET   Early adult 6.56×10-05
abnormal embryo size Cdk8tm1b(EUCOMM)Hmgu HOM E9.5 0.00
abnormal embryo turning Cdk8tm1b(EUCOMM)Hmgu HOM E9.5 0.00
abnormal heart morphology Cdk8tm1b(EUCOMM)Hmgu HOM E9.5 0.00
abnormal neural tube closure Cdk8tm1b(EUCOMM)Hmgu HOM E9.5 0.00
preweaning lethality, complete penetrance Cdk8tm1b(EUCOMM)Hmgu HOM   Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

Gross Morphology Embryo E9.5

Images

2 Images

Immunophenotyping

Panel A FCS file(s)

10 Images

Immunophenotyping

Panel B FCS file(s)

10 Images

Human diseases caused by Cdk8 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Cdk8 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Intellectual Developmental Disorder With Hypotonia And Behavioral Abnormalities
Ventricular septal defect, Hypoplastic left heart, Tetralogy of Fallot, Patent foramen ovale OMIM:618748

The table below shows human diseases predicted to be associated to Cdk8 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Major Affective Disorder 1
Mania, Depression OMIM:125480
Major Depressive Disorder
Depression OMIM:608516
Attention Deficit-Hyperactivity Disorder, Susceptibility To, 7
Attention deficit hyperactivity disorder, Depression OMIM:613003
Obsessive-Compulsive Disorder
Collectionism, Compulsive behaviors, Skin-picking, Depression OMIM:164230
Pandas
Anorexia, Impulsivity, Abnormal fear-induced behavior, Depression, Irritability, Tics, Attention ... ORPHA:66624
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect OMIM:615041
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
Bilateral Parasagittal Parieto-Occipital Polymicrogyria
Abnormal fear-induced behavior, Pseudobulbar paralysis, Delirium, Aggressive behavior ORPHA:208441
Myelopathy, Htlv-1-Associated
Myelopathy OMIM:159580
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Hyperactivity, Anorexia, Aggressive behavior, Abnormal fear-induced behavior, Irritability, Abnor... ORPHA:3077
Porphyria Due To Ala Dehydratase Deficiency
Restlessness, Confusion, Abnormal fear-induced behavior, Depression, Agitation, Delirium ORPHA:100924
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Craniorachischisis
Cervical spina bifida, Myelomeningocele, Anencephaly, Sirenomelia, Spinal dysraphism ORPHA:63260
Gm2 Gangliosidosis, Ab Variant
Abnormal fear-induced behavior, Inappropriate behavior, Cognitive impairment ORPHA:309246
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Alg3-Cdg
Cardiomyopathy, Neural tube defect ORPHA:79321
Isolated Posterior Meningocele
Hydrocephalus, Lipomyelomeningocele, Meningocele, Neural tube defect, Occipital meningocele ORPHA:268810
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Hyperactivity, Impulsivity, Aggressive behavior, Abnormal fear-induced behavior, Social and occup... ORPHA:353281
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Hyperactivity, Impulsivity, Aggressive behavior, Abnormal fear-induced behavior, Social and occup... ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Hyperactivity, Impulsivity, Aggressive behavior, Abnormal fear-induced behavior, Social and occup... ORPHA:353277
Alobar Holoprosencephaly
Neural tube defect, Hydrocephalus, Abnormal heart morphology ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Neural tube defect, Hydrocephalus, Abnormal heart morphology ORPHA:93926
Lobar Holoprosencephaly
Neural tube defect, Hydrocephalus, Abnormal heart morphology ORPHA:93924
Semilobar Holoprosencephaly
Neural tube defect, Hydrocephalus, Abnormal heart morphology ORPHA:220386
Schinzel-Giedion Syndrome
Umbilical hernia, Neural tube defect, Abnormal heart morphology ORPHA:798
Intellectual Developmental Disorder With Hypotonia And Behavioral Abnormalities
Ventricular septal defect, Hypoplastic left heart, Tetralogy of Fallot, Patent foramen ovale OMIM:618748

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cdk8

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cdk8.

There are 7 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
The role of CDK8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasis. Stem cell reports (June 2022) Cdk8tm1a(EUCOMM)Hmgu PMC9287674
The Role of CDKs and CDKIs in Murine Development. International journal of molecular sciences (July 2020) Cdk8tm1a(EUCOMM)Hmgu PMC7432401
Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development. Development (Cambridge, England) (June 2020) Cdk8tm1a(EUCOMM)Hmgu PMC7295591
A kinase-independent role for CDK8 in BCR-ABL1+ leukemia. Nature communications (October 2019) Cdk8tm1c(EUCOMM)Hmgu PMC6802219
Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions. Molecular cell (September 2019) Cdk8tm1c(EUCOMM)Hmgu 31495563
CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells. Cell reports (September 2019) Cdk8tm1a(EUCOMM)Hmgu 31509750
NK Cell-Specific CDK8 Deletion Enhances Antitumor Responses. Cancer immunology research (January 2018) Cdk8tm1c(EUCOMM)Hmgu 29386186

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Cdk8tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Cdk8tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Cdk8tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice

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