Cdk8 | cyclin dependent kinase 8

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Embryo Growth/size/body region Nervous system Behavior/neurological Mortality/aging Cardiovascular system

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal embryo size1 supporting datasetCdk8tm1b(EUCOMM)HmguhomozygoteE9.5N/A * 
abnormal embryo turning1 supporting datasetCdk8tm1b(EUCOMM)HmguhomozygoteE9.5N/A * 
abnormal freezing behavior1 supporting datasetCdk8tm1b(EUCOMM)HmguheterozygoteEarly adult6.56x10-5 
abnormal neural tube closure1 supporting datasetCdk8tm1b(EUCOMM)HmguhomozygoteE9.5N/A * 
preweaning lethality, complete penetrance1 supporting datasetCdk8tm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
decreased exploration in new environment1 supporting datasetCdk8tm1b(EUCOMM)HmguheterozygoteEarly adult6.48x10-6 
abnormal heart morphology1 supporting datasetCdk8tm1b(EUCOMM)HmguhomozygoteE9.5N/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Cdk8tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Cdk8tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Cdk8tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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