How We Generate Our Data

  • Targeting genes that haven’t been studied yet
  • Standardised production methods to knock out genes
  • Mutants and wildtype mice tested under the same phenotyping protocols

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Understanding Our Data

  • We generate our own data, it is not aggregated from publications
  • A constantly growing dataset; mice continually tested
  • Data from 19 IMPC phenotyping centres, in 11 countries

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About the IMPC Project

The International Mouse Phenotyping Consortium (IMPC) is a global effort to identify the function of every protein-coding gene in the mouse genome. Our growing catalogue of mammalian gene function is freely available for researchers.

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Latest Data Release

Data release 10 has now been published. The number of phenotyped mutant lines has reached 6,255, bringing the total number of phenotyped genes to 5,861.

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Animal Welfare

The IMPC collects data from member institutes who collect phenotyping data guided by their own ethical review panels, licenses, and accrediting bodies that reflect the national and/or geo-political constructs in which they operate.

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We’re systematically phenotyping new knockout mice every day

IMPC Strategy 2021-2030

The IMPC’s 10-year strategy presents a bold ambition for the future functional annotation of the genome and deciphering genetic variation in the context of gene function and disease.

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PIK3CA inhibition with BYL719 - a novel treatment for CLOVES syndrome

By initially undertaking research on a mouse model, and subsequently with human patients, it has been shown that BYL719 can prevent and improve organ dysfunction and can improve disease symptoms in patients suffering from CLOVES syndrome.

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Maintaining and expanding a world-wide consortium of institutions

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