How We Generate Our Data
- Targeting genes that haven’t been studied yet
- Standardised production methods to knock out genes
- Mutants and wildtype mice tested under the same phenotyping protocols
Understanding Our Data
- We generate our own data, it is not aggregated from publications
- A constantly growing dataset; mice continually tested
- Data from 19 IMPC phenotyping centres, in 11 countries
About the IMPC Project
The International Mouse Phenotyping Consortium (IMPC) is a global effort to identify the function of every protein-coding gene in the mouse genome. Our growing catalogue of mammalian gene function is freely available for researchers.
Latest Data Release
Data release 10 has now been published. The number of phenotyped mutant lines has reached 6,255, bringing the total number of phenotyped genes to 5,861.
Animal Welfare
The IMPC collects data from member institutes who collect phenotyping data guided by their own ethical review panels, licenses, and accrediting bodies that reflect the national and/or geo-political constructs in which they operate.
IMPC Strategy 2021-2030
The IMPC’s 10-year strategy presents a bold ambition for the future functional annotation of the genome and deciphering genetic variation in the context of gene function and disease.
PIK3CA inhibition with BYL719 - a novel treatment for CLOVES syndrome
By initially undertaking research on a mouse model, and subsequently with human patients, it has been shown that BYL719 can prevent and improve organ dysfunction and can improve disease symptoms in patients suffering from CLOVES syndrome.
Maintaining and expanding a world-wide consortium of institutions
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