MCP Orthology server
What is it?
The Orthology server helps you find the equivalent genes between mouse and human. Since IMPC studies mouse genes, researchers often need to know which human gene corresponds to a particular mouse gene (and vice versa). These equivalent genes are called “orthologs”.
The server supports both one-to-one orthologs (where one mouse gene corresponds to exactly one human gene) and one-to-many relationships (where a mouse gene may correspond to multiple human genes).
This server is supported by the GenTaR Orthology API, you can visit the documentation page
How can you search?
- By mouse gene symbol: e.g., Bmp4, Lepr, Notch1
- By human gene symbol: e.g., BRCA1, TP53, EGFR
- By MGI accession ID: e.g., MGI:104874 (the unique identifier for a mouse gene)
- By HGNC accession ID: e.g., HGNC:24086 (the unique identifier for a human gene)
- Browse all orthologs: Page through the complete list of mouse-human ortholog pairs
Example questions you can ask
- “What is the human ortholog of the mouse gene Lepr?”
- “Find the mouse equivalent of human gene BRCA1.”
- “What are the orthologs for BRCA1 and BRCA2?”
- “Find the human ortholog for MGI:104809.”
- “Is there a one-to-one ortholog relationship between mouse Tp53 and human TP53?”
- “Show me all ortholog relationships for the gene Notch1.”
- “What human gene corresponds to mouse Arid1b?”
What to expect in responses
You will receive the matched gene pair with both mouse and human gene symbols, their database accession IDs (MGI and HGNC), the orthology category, and a confidence indicator (support count) showing how many databases agree on the ortholog relationship.