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From parameter to phenotype

The statistical assessment determines whether mouse mutants exhibit a significant phenotypic difference from control (or wildtype) mice for each parameter measured. When the difference is significant, an onotology term is assigned to describe the phenotype. As the phenotype calls are made on parameter basis, the results should be considered in the context of the procedure the parameter is part of.

The particular Mammalian Phenotype (MP) Onotology term associated with a parameter are maintained in IMPReSS. Often, an increase or a decrease of the parameter can be determined. However, in some cases, the direction cannot be determined and so the called phenotype only indicates a general abnormality.

Screenshot of IMPReSS, showing the ontology terms associated to a particular parameter, in this case Total Cholesterol.