About mouse production
Each center has their own internal processes for mouse production, but these can be combined into a few categories. Centers have historically used ES cells as the starting point of the production process, but are transitioning towards CRISPR methods to produce mice. The production numbers and status are available on GenTaR (iMits has been discontinued; see more in the next section, Production tracking – iMits and GenTaR).
More about the IMPC production efforts is available here: A resource of targeted mutant mouse lines for 5,061 genes, Nature Genetics 2021.