Essential function of a liver gene in fatty liver and obesity



Published 4th September 2018

Seung-Hoi Koo discusses his recent article in Nature Communications: Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis


More information can be found on the website of Professor Seung-Hoi Koo:

Nishanth Ulhas Nair discusses his recent article in Scientific Reports: Putative functional genes in idiopathic dilated cardiomyopathy

Link to article:



Amalio Telenti discusses his recent article in Nature: Human gene essentiality

Link to article: 

More information on this research can be found on Amalio’s website:

You can also follow Amalio on Twitter:

Brendan Doe talks about his work in using Cytoplasmic Microinjection to generate CRISPR mediated mutations.


Melanie Samuel discusses her research in neural development and disease, and explains how she has used IMPC data.


Jesse Mager discusses his work in mammalian developmental genetics, and how he uses IMPC data for this research.


Martin Fray from the MRC Harwell Institute discusses the shipment and storage of mouse sperm using dry ice. This technique saves shipping costs and reduces the need to ship live mice around the world.


Lauryl Nutter talks about CRISPR-Cas9 and its uses for studying mouse genetics. Lauryl talks about what CRISPR/Cas9 gene editing is and what it can be used for, as well as how this technique helps generate IMPC data.



The goal of the International Mouse Phenotyping Consortium (IMPC) is to discover functional insight for every gene by generating and systematically phenotyping 20,000 knockout mouse strains.

The IMPC is supported by grants from a number of national governments, including the NIH Common Fund KOMP Program.

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