Phenotype: decreased cardiac muscle contractility

Definition
inability or reduced ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max, fractional shortening (FS), velocity of circumferential fiber shortening (Vcfc), peak of aortic outflow velocity (PAV), and ventricular ejection fraction volume
Synonyms
impaired cardiac contractility,  reduced cardiac muscle contractility,  impaired cardiac muscle contractility,  decreased cardiac muscle contraction,  reduced cardiac contractility
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased cardiac muscle contractility

Total number of significant genotype-phenotype associations: 20

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Zfp280d
Zfp280dem1(IMPC)Hmgu
HOM Early adult decreased cardiac muscle contractility Ejection Fraction
Echo
HMGU
IMPC
2.73×10-32
Fbxo10
Fbxo10tm1b(KOMP)Wtsi
HOM Early adult decreased cardiac muscle contractility Fractional Shortening
Echo
MARC
IMPC
5.49×10-09
Alpk3
Alpk3tm1b(EUCOMM)Hmgu
HOM   Early adult decreased cardiac muscle contractility Ejection Fraction
Echo
MRC Harwell
IMPC
3.99×10-08
Ints6l
Ints6lem1(IMPC)Marc
HEM   Early adult decreased cardiac muscle contractility Fractional Shortening
Echo
MARC
IMPC
3.97×10-07
Wars
Warstm1b(EUCOMM)Hmgu
HET Early adult decreased cardiac muscle contractility Ejection Fraction
Echo
HMGU
IMPC
8.24×10-07
Pex1
Pex1tm1e.1(EUCOMM)Hmgu
HET Early adult decreased cardiac muscle contractility Ejection Fraction
Echo
HMGU
IMPC
1.03×10-06
Dsg2
Dsg2tm1b(EUCOMM)Wtsi
HOM   Early adult decreased cardiac muscle contractility Ejection Fraction
Echo
BCM
IMPC
1.86×10-06
Ufm1
Ufm1em1(IMPC)Marc
HET Early adult decreased cardiac muscle contractility Ejection Fraction
Echo
MARC
IMPC
2.83×10-06
Clec9a
Clec9atm1b(KOMP)Wtsi
HOM Early adult decreased cardiac muscle contractility Fractional Shortening
Echo
ICS
IMPC
5.90×10-06
Tspan15
Tspan15em1(IMPC)Hmgu
HET Early adult decreased cardiac muscle contractility Ejection Fraction
Echo
HMGU
IMPC
6.36×10-06
Hilpda
Hilpdaem1(IMPC)Mhzh
HOM Early adult decreased cardiac muscle contractility Ejection Fraction
Echo
MARC
IMPC
1.26×10-05
Sh3tc1
Sh3tc1tm1b(EUCOMM)Hmgu
HOM Early adult decreased cardiac muscle contractility Fractional Shortening
Echo
ICS
IMPC
2.09×10-05
Abhd3
Abhd3em1(IMPC)Marc
HOM   Early adult decreased cardiac muscle contractility Ejection Fraction
Echo
MARC
IMPC
2.40×10-05
Cav1
Cav1em2(IMPC)Ics
HOM   Early adult decreased cardiac muscle contractility Fractional Shortening
Echo
ICS
IMPC
3.40×10-05
Ncam2
Ncam2tm1b(EUCOMM)Hmgu
HOM   Early adult decreased cardiac muscle contractility Fractional Shortening
Echo
ICS
IMPC
4.17×10-05
Wsb2
Wsb2tm1b(EUCOMM)Hmgu
HOM Early adult decreased cardiac muscle contractility Fractional Shortening
Echo
HMGU
IMPC
4.52×10-05
Ndrg4
Ndrg4tm1b(KOMP)Wtsi
HOM   Early adult decreased cardiac muscle contractility Ejection Fraction
Echo
MRC Harwell
IMPC
4.55×10-05
Nxn
Nxntm1a(EUCOMM)Wtsi
HET Early adult decreased cardiac muscle contractility Ejection Fraction
Echo
BCM
IMPC
4.86×10-05
Tmprss2
Tmprss2tm2b(EUCOMM)Hmgu
HOM Early adult decreased cardiac muscle contractility Fractional Shortening
Echo
ICS
IMPC
6.08×10-05
Kcng2
Kcng2em1(IMPC)Bay
HOM Early adult decreased cardiac muscle contractility Ejection Fraction
Echo
BCM
IMPC
7.13×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Echo

 Phenotype associations stats

1.11% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased cardiac muscle contractility (20/1808)

0.51% females (9/1781) 0.27% males (4/1505)

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