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Phenotype: increased heart rate

Definition
greater than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute
Synonyms
tachycardia
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased heart rate

Total number of significant genotype-phenotype associations: 45

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Klhl29
Klhl29tm1b(EUCOMM)Hmgu 		HOM   Early adult increased heart rate HR
Echo		 ICS
IMPC		 3.91×10-08
Gnb2
Gnb2em1(IMPC)J 		HOM Early adult increased heart rate HR
Electrocardiogram (ECG)		 JAX
IMPC		 4.91×10-08
Fhod1
Fhod1em1(IMPC)J 		HOM Early adult increased heart rate HR
Electrocardiogram (ECG)		 JAX
IMPC		 6.69×10-08
Fsd2
Fsd2em1(IMPC)Mbp 		HOM Early adult increased heart rate HR
Electrocardiogram (ECG)		 UC Davis
IMPC		 2.89×10-07
Prkab1
Prkab1tm1b(KOMP)Wtsi 		HOM   Early adult increased heart rate HR
Electrocardiogram (ECG)		 CCP-IMG
IMPC		 3.72×10-07
Dipk1c
Dipk1cem1(IMPC)J 		HOM Early adult increased heart rate HR
Electrocardiogram (ECG)		 JAX
IMPC		 1.29×10-06
Fsd2
Fsd2em1(IMPC)Mbp 		HOM Early adult shortened RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 1.70×10-06
Gnb2
Gnb2em1(IMPC)J 		HOM Early adult shortened RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 2.19×10-06
Kmt2a
Kmt2aem1(IMPC)Marc 		HET Early adult increased heart rate HR
Echo		 MARC
IMPC		 2.95×10-06
Prkab1
Prkab1tm1b(KOMP)Wtsi 		HOM   Early adult shortened RR interval RR
Electrocardiogram (ECG)		 CCP-IMG
IMPC		 3.18×10-06
Slc22a15
Slc22a15em1(IMPC)J 		HOM   Early adult increased heart rate HR
Electrocardiogram (ECG)		 JAX
IMPC		 3.80×10-06
Fhod1
Fhod1em1(IMPC)J 		HOM Early adult shortened RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 3.86×10-06
Fam161a
Fam161atm1b(KOMP)Wtsi 		HOM   Early adult increased heart rate HR
Electrocardiogram (ECG)		 JAX
IMPC		 3.86×10-06
Rrad
Rradtm1.1(KOMP)Vlcg 		HOM Early adult increased heart rate HR
Electrocardiogram (ECG)		 JAX
IMPC		 6.69×10-06
Arsj
Arsjem1(IMPC)J 		HOM Early adult increased heart rate HR
Electrocardiogram (ECG)		 JAX
IMPC		 7.63×10-06
Arsj
Arsjem1(IMPC)J 		HOM Early adult shortened RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 9.60×10-06
Leprotl1
Leprotl1tm1b(EUCOMM)Hmgu 		HOM   Early adult increased heart rate HR
Echo		 MRC Harwell
IMPC		 1.03×10-05
Slc22a15
Slc22a15em1(IMPC)J 		HOM   Early adult shortened RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 1.14×10-05
Secisbp2l
Secisbp2lem1(IMPC)J 		HOM   Late adult increased heart rate HR
Electrocardiogram (ECG)		 JAX
IMPC		 1.32×10-05
Wdfy1
Wdfy1em1(IMPC)J 		HOM Early adult increased heart rate HR
Electrocardiogram (ECG)		 JAX
IMPC		 1.66×10-05
Sorbs2
Sorbs2tm1.1(KOMP)Mbp 		HOM   Early adult increased heart rate HR
Electrocardiogram (ECG)		 JAX
IMPC		 2.18×10-05
Dipk1c
Dipk1cem1(IMPC)J 		HOM Early adult shortened RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 2.24×10-05
Sun1
Sun1tm1b(EUCOMM)Wtsi 		HOM   Early adult increased heart rate HR
Echo		 ICS
IMPC		 2.26×10-05
Lilr4b
Lilr4bem1(IMPC)J 		HOM   Early adult shortened RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 2.37×10-05
Mthfd2
Mthfd2tm1b(EUCOMM)Wtsi 		HET   Early adult increased heart rate HR
Echo		 BCM
IMPC		 2.63×10-05
Fbxo38
Fbxo38em2(IMPC)Marc 		HOM Early adult increased heart rate HR
Echo		 MARC
IMPC		 3.08×10-05
Kin
Kinem1(IMPC)J 		HET   Early adult increased heart rate HR
Electrocardiogram (ECG)		 JAX
IMPC		 3.14×10-05
Prdm8
Prdm8em1(IMPC)Wtsi 		HOM   Early adult increased heart rate HR
Echo		 CCP-IMG
IMPC		 3.43×10-05
Izumo2
Izumo2em1(IMPC)Bay 		HOM Early adult increased heart rate HR
Echo		 BCM
IMPC		 3.47×10-05
Ercc4
Ercc4em1(IMPC)J 		HET Early adult shortened RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 3.98×10-05
Kin
Kinem1(IMPC)J 		HET   Early adult shortened RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 4.11×10-05
Hnrnpm
Hnrnpmem1(IMPC)Marc 		HET   Early adult increased heart rate HR
Echo		 MARC
IMPC		 4.54×10-05
Gtpbp10
Gtpbp10tm1b(KOMP)Mbp 		HOM Late adult increased heart rate HR
Electrocardiogram (ECG)		 JAX
IMPC		 5.14×10-05
Mtg1
Mtg1em1(IMPC)Bay 		HET Early adult increased heart rate HR
Electrocardiogram (ECG)		 BCM
IMPC		 5.44×10-05
Cav1
Cav1em2(IMPC)Ics 		HOM Early adult increased heart rate HR
Echo		 ICS
IMPC		 5.53×10-05
Bzw2
Bzw2tm1b(KOMP)Mbp 		HOM   Early adult increased heart rate HR
Electrocardiogram (ECG)		 JAX
IMPC		 5.60×10-05
Rrad
Rradtm1.1(KOMP)Vlcg 		HOM Early adult shortened RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 6.27×10-05
Synrg
Synrgtm1b(EUCOMM)Wtsi 		HET Early adult increased heart rate HR
Echo		 BCM
IMPC		 6.47×10-05
Fam161a
Fam161atm1b(KOMP)Wtsi 		HOM   Early adult shortened RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 6.59×10-05
Mtg1
Mtg1em1(IMPC)Bay 		HET Early adult shortened RR interval RR
Electrocardiogram (ECG)		 BCM
IMPC		 6.74×10-05
Pitx3
Pitx3tm1.1(KOMP)Vlcg 		HOM Early adult increased heart rate HR
Electrocardiogram (ECG)		 JAX
IMPC		 7.44×10-05
Hunk
Hunktm1b(EUCOMM)Wtsi 		HOM   Early adult increased heart rate HR
Electrocardiogram (ECG)		 HMGU
IMPC		 9.09×10-05
Sorl1
Sorl1tm1a(EUCOMM)Wtsi 		HOM   Late adult increased heart rate HR
Echo		 ICS
IMPC		 9.85×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Electrocardiogram (ECG)
Echo
Non-Invasive blood pressure

 Phenotype associations stats

0.52% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased heart rate (32/6106)

0.17% females (10/5914) 0.14% males (8/5736)

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