banner
Genes Phenotypes Help, News, Blog

Gene: Plk1 MGI:97621

Log in to follow

Gene Summary

Name:
polo like kinase 1
Synonyms:
Plk,  STPK13

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
embryonic lethality prior to tooth bud stage Plk1tm1b(EUCOMM)Hmgu HOM   E12.5 0.00
embryonic lethality prior to organogenesis Plk1tm1b(EUCOMM)Hmgu HOM   E9.5 0.00
preweaning lethality, complete penetrance Plk1tm1b(EUCOMM)Hmgu HOM   Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

No Adult expression data was found for this gene.

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Axial skeleton N/A heterozygote 0.0% (0 of 2)
Brain N/A heterozygote 0.0% (0 of 5)
Central nervous system ganglion N/A heterozygote 0.0% (0 of 2)
Ear N/A heterozygote 0.0% (0 of 5)
Embryo N/A heterozygote 0.0% (0 of 5)
Eye N/A heterozygote 0.0% (0 of 5)
Footplate N/A heterozygote 0.0% (0 of 5)
Forebrain N/A heterozygote 0.0% (0 of 5)
Forelimb N/A heterozygote 0.0% (0 of 5)
Gut N/A heterozygote 0.0% (0 of 2)
Handplate N/A heterozygote 0.0% (0 of 5)
Head N/A heterozygote 0.0% (0 of 5)
Heart N/A heterozygote 0.0% (0 of 5)
Hindbrain N/A heterozygote 0.0% (0 of 5)
Hindlimb N/A heterozygote 0.0% (0 of 5)
Liver N/A heterozygote 0.0% (0 of 5)
Lung N/A heterozygote 0.0% (0 of 5)
Mandibular process N/A heterozygote 0.0% (0 of 5)
Maxillary process N/A heterozygote 0.0% (0 of 5)
Midbrain N/A heterozygote 0.0% (0 of 5)
Nose N/A heterozygote 0.0% (0 of 2)
Oral cavity N/A heterozygote 0.0% (0 of 5)
Skeleton N/A heterozygote 0.0% (0 of 2)
Skin N/A heterozygote 0.0% (0 of 5)
Spinal cord N/A heterozygote 0.0% (0 of 2)
Tail somite N/A heterozygote 0.0% (0 of 5)
Tail N/A heterozygote 0.0% (0 of 5)
Trachea N/A heterozygote 0.0% (0 of 2)
Urinary system N/A heterozygote 0.0% (0 of 2)

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)

Background staining occurs in wild type mice and embryos at an incidental rate.

Background staining occurs in wild type embryos at a measurable rate.

Anatomy Background staining in controls(WT)
axial skeleton 1.56% (1 of 64)
brain 1.18% (6 of 508)
central nervous system ganglion 1.37% (1 of 73)
ear 0.2% (1 of 508)
embryo 0.2% (1 of 509)
eye 0.2% (1 of 508)
footplate 0.2% (1 of 508)
forebrain 0.2% (1 of 508)
forelimb 0.2% (1 of 508)
gut 1.69% (1 of 59)
handplate 0.2% (1 of 508)
head 0.98% (5 of 508)
heart 0.2% (1 of 508)
hindbrain 1.18% (6 of 508)
hindlimb 0.2% (1 of 508)
liver 0.2% (1 of 503)
lung 0.2% (1 of 503)
mandibular process 0.2% (1 of 508)
maxillary process 0.2% (1 of 508)
midbrain 0.2% (1 of 508)
nose 1.28% (1 of 78)
oral cavity 0.2% (1 of 503)
skeleton 1.28% (1 of 78)
skin 0.2% (1 of 508)
spinal cord 1.39% (1 of 72)
tail 0.2% (1 of 508)
tail somite group 0.2% (1 of 508)
trachea 1.69% (1 of 59)
urinary system 1.69% (1 of 59)

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

View images
Embryo LacZ

LacZ images wholemount

21 Images

View images
X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

View images
X-ray

XRay Images Whole Body Dorso Ventral

10 Images

View images
X-ray

XRay Images Skull Lateral Orientation

10 Images

View images
Gross Pathology and Tissue Collection

Images

8 Images

View images
Download thumbnail Download
Immunophenotyping

Panel B FCS file(s)

3 Images

View images
Eye Morphology

Images Ophthalmoscopy

6 Images

View images
X-ray

XRay Images Hind Leg and Hip

1 Images

View images
Download thumbnail Download
Immunophenotyping

Panel A FCS file(s)

3 Images

View images
Histopathology

Images

3 Images

View images

Human diseases caused by Plk1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Plk1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Reticulum Cell Sarcoma
Sarcoma, Neoplasm OMIM:267730
Melanoma-Pancreatic Cancer Syndrome
Pancreatic squamous cell carcinoma, Pancreatic adenocarcinoma, Oropharyngeal squamous cell carcin... OMIM:606719
Li-Fraumeni Syndrome 2
Meningioma, Stomach cancer, Breast carcinoma, Sarcoma, Glioma OMIM:609265
Lichen Sclerosus Et Atrophicus
Squamous cell carcinoma, Carcinoma OMIM:151590
Myofibromatosis, Infantile, 1
Fibroma, Myofibromatosis OMIM:228550
Ewing Sarcoma
Ewing sarcoma OMIM:612219
Cerebral Sarcoma
Fibrosarcoma, Neoplasm OMIM:117600
Epidermodysplasia Verruciformis, Susceptibility To, 3
Basal cell carcinoma, Squamous cell carcinoma OMIM:618267
Nut Midline Carcinoma
Neuroblastoma, Pancreatic squamous cell carcinoma, Leukemia, Oropharyngeal squamous cell carcinom... ORPHA:443167
Squamous Cell Carcinoma, Head And Neck
Squamous cell carcinoma OMIM:275355
Multiple Fibroadenomas Of The Breast
Fibroadenoma of the breast OMIM:615554
Alveolar Soft Part Sarcoma
Alveolar soft part sarcoma OMIM:606243
Sarcoma, Synovial
Synovial sarcoma OMIM:300813
Disseminated Superficial Actinic Porokeratosis
Squamous cell carcinoma ORPHA:79152
Cheilitis Glandularis
Squamous cell carcinoma, Neoplasm ORPHA:1221
Rhabdoid Tumor Predisposition Syndrome 2
Neoplasm of the central nervous system, Carcinoma OMIM:613325
Tumor Predisposition Syndrome
Cutaneous melanoma, Meningioma, Lung adenocarcinoma, Renal cell carcinoma, Uveal melanoma OMIM:614327
Chondrosarcoma, Extraskeletal Myxoid
Chondrosarcoma OMIM:612237
Chondrosarcoma
Chondrosarcoma OMIM:215300
Enchondromatosis, Multiple, Ollier Type
Hemangioma, Chondrosarcoma, Multiple enchondromatosis OMIM:166000
Desmoid Disease, Hereditary
Desmoid tumors, Colon cancer OMIM:135290
Colorectal Cancer, Susceptibility To, 12
Colorectal polyposis, Carcinoma OMIM:615083
Lung Cancer
Non-small cell lung carcinoma, Alveolar cell carcinoma, Lung adenocarcinoma OMIM:211980
Hyperkeratosis Lenticularis Perstans
Basal cell carcinoma, Squamous cell carcinoma ORPHA:409
Acne Inversa, Familial, 2, With Or Without Dowling-Degos Disease
Squamous cell carcinoma OMIM:613736
Li-Fraumeni Syndrome
Adrenocortical carcinoma, Prostate neoplasm, Choriocarcinoma, Acute leukemia, Lung adenocarcinoma... OMIM:151623
Schopf-Schulz-Passarge Syndrome
Squamous cell carcinoma, Apocrine hidrocystoma, Basal cell carcinoma, Poroma OMIM:224750
Cancer, Alopecia, Pigment Dyscrasia, Onychodystrophy, And Keratoderma
Squamous cell carcinoma OMIM:618373
Multiple Enchondromatosis, Maffucci Type
Hemangioma, Chondrosarcoma, Multiple enchondromatosis OMIM:614569
Nthl1-Related Attenuated Familial Adenomatous Polyposis
Neoplasm of the skin, Neoplasm of the rectum, Meningioma, Adenomatous colonic polyposis, Endometr... ORPHA:454840
Cheilitis Glandularis
Squamous cell carcinoma, Carcinoma OMIM:118330
Undifferentiated Pleomorphic Sarcoma
Soft tissue sarcoma ORPHA:2023
Schöpf-Schulz-Passarge Syndrome
Ovarian neoplasm, Basal cell carcinoma, Squamous cell carcinoma ORPHA:50944
Xeroderma Pigmentosum Variant
Basal cell carcinoma, Squamous cell carcinoma, Melanoma ORPHA:90342
Epidermodysplasia Verruciformis, Susceptibility To, 2
Verruca plana, Squamous cell carcinoma of the skin OMIM:618231
Dermatofibrosarcoma Protuberans
Fibrosarcoma, Neoplasm of the skin ORPHA:31112
Dyskeratosis Congenita, Autosomal Recessive 3
Squamous cell carcinoma OMIM:613988
Epidermodysplasia Verruciformis, X-Linked
Verrucae, Squamous cell carcinoma of the skin OMIM:305350
Paraneoplastic Pemphigus
Sarcoma, B-cell lymphoma, Thymoma ORPHA:63455
Acquired Ichthyosis
Sarcoma, Multiple myeloma, Lymphoma, Neoplasm ORPHA:454
Acquired Hemophagocytic Lymphohistiocytosis Associated With Malignant Disease
Acute lymphoblastic leukemia, Neoplasm of the lung, Myelodysplasia, Multiple myeloma, Hepatocellu... ORPHA:158057
Maffucci Syndrome
Neoplasm of the parathyroid gland, Ovarian neoplasm, Astrocytoma, Neoplasm of the adrenal cortex,... ORPHA:163634
Ollier Disease
Hemangioma, Visceral angiomatosis, Lymphangioma, Chondrosarcoma, Neoplasm, Sarcoma, Multiple ench... ORPHA:296
Combined Immunodeficiency Due To Dock8 Deficiency
Anal canal squamous carcinoma, Verrucae, Squamous cell carcinoma of the vulva, Squamous cell carc... ORPHA:217390
Punctate Palmoplantar Keratoderma Type 1
Neoplasm of the lung, Esophageal neoplasm, Stomach cancer, Adenocarcinoma of the small intestine,... ORPHA:79501
Oral Submucous Fibrosis
Oropharyngeal squamous cell carcinoma ORPHA:357154
Cutaneous Neuroendocrine Carcinoma
Multiple myeloma, Lymphoid leukemia, Brain neoplasm, Basal cell carcinoma, Squamous cell carcinom... ORPHA:79140
Epidermodysplasia Verruciformis
Verrucae, Squamous cell carcinoma ORPHA:302
Neuroendocrine Carcinoma Of Salivary Glands, Sensorineural Hearing Loss, And Enamel Hypoplasia
Unilateral vestibular Schwannoma, Carcinoma OMIM:603641
Ichthyosis, Hystrix-Like, With Deafness
Squamous cell carcinoma OMIM:602540
Progressive Osseous Heteroplasia
Sarcoma ORPHA:2762
Xeroderma Pigmentosum, Variant Type
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma OMIM:278750
Large Congenital Melanocytic Nevus
Cutaneous melanoma, Neoplasm of the skin, Rhabdomyosarcoma, Neoplasm, Sarcoma ORPHA:626
Muir-Torre Syndrome
Sebaceous gland carcinoma, Malignant genitourinary tract tumor, Benign gastrointestinal tract tum... OMIM:158320
Palmoplantar Carcinoma, Multiple Self-Healing
Squamous cell carcinoma, Carcinoma OMIM:615225
Mast Cell Sarcoma
Sarcoma ORPHA:66661
Necrobiosis Lipoidica
Squamous cell carcinoma ORPHA:542592
Colorectal Cancer, Susceptibility To, 10
Endometrial carcinoma, Colorectal polyposis, Carcinoma OMIM:612591
Liposarcoma
Sarcoma ORPHA:69078
Epidermodysplasia Verruciformis, Susceptibility To, 5
Verrucae, Squamous cell carcinoma of the skin OMIM:618309
Palmoplantar Keratoderma-Xx Sex Reversal-Predisposition To Squamous Cell Carcinoma Syndrome
Squamous cell carcinoma of the skin ORPHA:85112
Infantile Myofibromatosis
Neoplasm of the skin, Neoplasm of the lung, Neoplasm of the pancreas, Fibroma, Sarcoma, Benign ne... ORPHA:2591
Apc-Related Attenuated Familial Adenomatous Polyposis
Astrocytoma, Adenomatous colonic polyposis, Multiple gastric polyps, Papillary thyroid carcinoma,... ORPHA:247806
Rhabdoid Tumor
Renal neoplasm, Sarcoma, Neoplasm of the central nervous system, Neoplasm of the liver ORPHA:69077
Attenuated Familial Adenomatous Polyposis
Colorectal polyposis, Rectal polyposis, Astrocytoma, Neoplasm of the stomach, Adenomatous colonic... ORPHA:220460
Werner Syndrome
Cutaneous melanoma, Ovarian neoplasm, Thyroid carcinoma, Meningioma, Neoplasm of the lung, Acral ... ORPHA:902
Exostoses, Multiple, Type Ii
Rib exostoses, Chondrosarcoma, Scapular exostoses, Pelvic bone exostoses OMIM:133701
Exostoses, Multiple, Type I
Rib exostoses, Chondrosarcoma, Scapular exostoses, Pelvic bone exostoses OMIM:133700
Desmoplastic Small Round Cell Tumor
Ovarian neoplasm, Neoplasm of the lung, Neoplasm of the central nervous system, Neoplasm of the p... ORPHA:83469
Recurrent Respiratory Papillomatosis
Squamous cell carcinoma ORPHA:60032
Li-Fraumeni Syndrome
Ovarian neoplasm, Acute lymphoblastic leukemia, Astrocytoma, Thyroid carcinoma, Choriocarcinoma, ... ORPHA:524
Gardner Syndrome
Astrocytoma, Adenomatous colonic polyposis, Small intestine carcinoid, Brain neoplasm, Papillary ... ORPHA:79665
Porokeratosis
Squamous cell carcinoma of the skin ORPHA:79358
Familial Adenomatous Polyposis 1
Adrenocortical carcinoma, Osteoma, Astrocytoma, Adrenocortical adenoma, Adenomatous colonic polyp... OMIM:175100
Huriez Syndrome
Squamous cell carcinoma of the skin OMIM:181600
Bazex Syndrome
Liposarcoma, Neoplasm, Lung adenocarcinoma ORPHA:166113
Bloom Syndrome
Leukemia, Squamous cell carcinoma, Lymphoma, Azoospermia OMIM:210900
Gastrointestinal Stromal Tumor
Neoplasm of the rectum, Esophageal neoplasm, Gastrointestinal stroma tumor, Neoplasm of the stoma... ORPHA:44890
Fanconi Anemia, Complementation Group P
Squamous cell carcinoma OMIM:613951
Yellow Nail Syndrome
Neoplasm of the lung, Biliary tract neoplasm, Neoplasm, Sarcoma, Renal neoplasm ORPHA:662
Chromomycosis
Multiple cutaneous malignancies, Squamous cell carcinoma ORPHA:182
Papillon-Lefèvre Syndrome
Neoplasm of the skin, Squamous cell carcinoma, Melanoma ORPHA:678
Hereditary Leiomyomatosis And Renal Cell Cancer
Uterine leiomyoma, Renal cell carcinoma, Uterine leiomyosarcoma, Cutaneous leiomyosarcoma, Cutane... OMIM:150800
Desmoid Tumor
Fibroma, Neoplasm of the skin, Desmoid tumors, Intestinal polyposis ORPHA:873
Acromesomelic Dysplasia, Grebe Type
Sarcoma ORPHA:2098
Retinoblastoma
Leukemia, Lymphoma, Osteosarcoma, Pinealoma, Retinoblastoma, Ewing sarcoma OMIM:180200
Epidermolysis Bullosa Dystrophica, Autosomal Recessive
Squamous cell carcinoma OMIM:226600
Pleuropulmonary Blastoma
Medulloblastoma, Rhabdomyosarcoma, Pleuropulmonary blastoma OMIM:601200
Xeroderma Pigmentosum, Complementation Group E
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma OMIM:278740
Trichothiodystrophy 1, Photosensitive
Basal cell carcinoma, Squamous cell carcinoma OMIM:601675
Opsoclonus-Myoclonus Syndrome
Neuroblastoma, Neoplasm of the lung, Neoplasm, Breast carcinoma, Ovarian teratoma, Small cell lun... ORPHA:1183
Ovarian Fibrothecoma
Fibrosarcoma, Diffuse leiomyomatosis, Ovarian fibroma ORPHA:314478
Familial Adenomatous Polyposis
Neoplasm of the gallbladder, Astrocytoma, Neoplasm of the adrenal gland, Cholangiocarcinoma, Aden... ORPHA:733
Fanconi Renotubular Syndrome 5
Lung adenocarcinoma OMIM:618913
Xeroderma Pigmentosum, Complementation Group C
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin OMIM:278720
Keratitis-Ichthyosis-Deafness Syndrome, Autosomal Dominant
Squamous cell carcinoma OMIM:148210
Rothmund-Thomson Syndrome Type 1
Neoplasm of the skin, Myelodysplasia, Leukemia, Basal cell carcinoma, Osteosarcoma, Squamous cell... ORPHA:221008
Rothmund-Thomson Syndrome Type 2
Neoplasm of the skin, Myelodysplasia, Leukemia, Basal cell carcinoma, Lymphoma, Osteosarcoma, Squ... ORPHA:221016
Rothmund-Thomson Syndrome
Neoplasm of the skin, Myelodysplasia, Leukemia, Basal cell carcinoma, Squamous cell carcinoma, Me... ORPHA:2909
Tuberous Sclerosis 2
Subungual fibromas, Cardiac rhabdomyoma, Astrocytoma, Ependymoma, Optic nerve glioma, Renal cell ... OMIM:613254
Milroy Disease
Neoplasm of the skin, Angiosarcoma ORPHA:79452
Cancer-Associated Retinopathy
Cutaneous melanoma, Malignant genitourinary tract tumor, Neoplasm of the breast, Hodgkin lymphoma... ORPHA:71505
Multiple Endocrine Neoplasia, Type Iv
Pancreatic endocrine tumor, Carcinoma, Pituitary adenoma, Carcinoid tumor, Renal angiomyolipoma, ... OMIM:610755
Legius Syndrome
Non-small cell lung carcinoma, Ovarian neoplasm, Vestibular Schwannoma, Desmoid tumors, Acute mon... ORPHA:137605
Oculocutaneous Albinism Type 1B
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma ORPHA:79434
Terminal Osseous Dysplasia
Fibroma OMIM:300244
Mastocytosis
Sarcoma, Chronic leukemia, Acute leukemia ORPHA:98292
Pseudohypoparathyroidism With Albright Hereditary Osteodystrophy
Sarcoma, Neoplasm of the breast, Neoplasm of the thyroid gland, Testicular neoplasm ORPHA:457059
Rhabdomyosarcoma, Embryonal, 1
Embryonal rhabdomyosarcoma OMIM:268210
Rhabdomyosarcoma 2
Alveolar rhabdomyosarcoma OMIM:268220
Neurofibromatosis, Type Iv, Of Riccardi
Lisch nodules, Atypical neurofibromatosis OMIM:162270
Retinoblastoma
Rhabdomyosarcoma, Leukemia, Leiomyosarcoma, Lymphoma, Ewing sarcoma, Osteosarcoma, Retinoblastoma... ORPHA:790
Xeroderma Pigmentosum, Complementation Group B
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin, Neoplasm OMIM:610651
Rothmund-Thomson Syndrome, Type 2
Osteosarcoma, Basal cell carcinoma, Squamous cell carcinoma OMIM:268400
Kid Syndrome
Trichilemmoma, Neoplasm of the skin, Squamous cell carcinoma, Neoplasm of the tongue ORPHA:477
Trichothiodystrophy
Squamous cell carcinoma ORPHA:33364
Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma
Fibrosarcoma, Osteosarcoma, Histiocytoma OMIM:112250
Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Intermediate Form
Squamous cell carcinoma ORPHA:89842
Oculocutaneous Albinism Type 1A
Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:79431
Hereditary Acrokeratotic Poikiloderma
Transitional cell carcinoma of the bladder, Squamous cell carcinoma ORPHA:2907
Dyskeratosis Congenita, X-Linked
Myelodysplasia, Hodgkin lymphoma, Carcinoma, Acute myeloid leukemia, Squamous cell carcinoma OMIM:305000
Asbestos Intoxication
Malignant mesothelioma, Lung adenocarcinoma ORPHA:2302
Lambert-Eaton Myasthenic Syndrome
Small cell lung carcinoma ORPHA:43393
Neurofibromatosis Type 1
Neoplasm of the skin, Astrocytoma, Meningioma, Plexiform neurofibroma, Spinal neurofibromas, Neop... ORPHA:636
Hereditary Mixed Polyposis Syndrome
Colorectal polyposis, Rectal polyposis, Thyroid carcinoma, Neoplasm of the rectum, Adenomatous co... ORPHA:157794
Osteogenic Sarcoma
Osteosarcoma, Retinoblastoma OMIM:259500
Kindler Epidermolysis Bullosa
Squamous cell carcinoma, Neoplasm of the urethra ORPHA:2908
Oncogenic Osteomalacia
Carcinoma, Giant cell tumor of bone, Osteosarcoma, Neoplasm of head and neck, Neoplasm of the ske... ORPHA:352540
Monosomy 22
Sarcoma, Schwannoma, Meningioma, Gonadal neoplasm ORPHA:96123
Cowden Syndrome
Cavernous hemangioma, Neoplasm of the skin, Colorectal polyposis, Neoplasm of the central nervous... ORPHA:201
Multiple Endocrine Neoplasia Type 4
Neuroendocrine neoplasm, Adrenocortical adenoma, Parathyroid carcinoma, Pituitary null cell adeno... ORPHA:276152
Oculocutaneous Albinism
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:55
Xeroderma Pigmentosum-Cockayne Syndrome Complex
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma ORPHA:220295
Congenital Erythropoietic Porphyria
Neoplasm of the skin, Squamous cell carcinoma ORPHA:79277
Oculocutaneous Albinism Type 2
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:79432
Adrenocortical Carcinoma
Adrenocortical carcinoma, Lung adenocarcinoma ORPHA:1501
Meige Disease
Angiosarcoma ORPHA:90186
Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome
Oropharyngeal squamous cell carcinoma, Esophageal carcinoma ORPHA:391487
Severe Generalized Junctional Epidermolysis Bullosa
Squamous cell carcinoma ORPHA:79404
Lymphedema-Distichiasis Syndrome
Fibrosarcoma ORPHA:33001
Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Severe Form
Cutaneous melanoma, Squamous cell carcinoma ORPHA:79408
Dyskeratosis Congenita, Autosomal Dominant 1
Myelodysplasia, Squamous cell carcinoma of the skin OMIM:127550
Cowden Syndrome 1
Meningioma, Transitional cell carcinoma of the bladder, Carcinoma, Thyroid adenoma, Breast carcin... OMIM:158350
Lmna-Related Cardiocutaneous Progeria Syndrome
Papillary renal cell carcinoma, Basal cell carcinoma, Pulmonary carcinoid tumor, Squamous cell ca... ORPHA:363618
X-Linked Alport Syndrome-Diffuse Leiomyomatosis
Esophageal neoplasm, Diffuse leiomyomatosis, Fibroma, Vaginal neoplasm, Tracheobronchial leiomyom... ORPHA:1018
Hyperparathyroidism-Jaw Tumor Syndrome
Thyroid carcinoma, Uterine leiomyoma, Pancreatic adenocarcinoma, Renal hamartoma, Fibroma, Lipoma... ORPHA:99880
Parathyroid Carcinoma
Thyroid carcinoma, Parathyroid carcinoma, Uterine leiomyoma, Pancreatic adenocarcinoma, Renal ham... ORPHA:143
Palmoplantar Hyperkeratosis With Squamous Cell Carcinoma Of Skin And 46,Xx Sex Reversal
Laryngeal carcinoma, Carcinoma OMIM:610644
Dermatomyositis
Gastrointestinal stroma tumor, Lung adenocarcinoma, Neoplasm, Lymphoma, Breast carcinoma ORPHA:221
Hermansky-Pudlak Syndrome
Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:79430
Cushing Syndrome Due To Ectopic Acth Secretion
Pancreatic endocrine tumor, Neuroendocrine neoplasm, Neoplasm of the stomach, Atypical pulmonary ... ORPHA:99889
Tuberous Sclerosis Complex
Cardiac rhabdomyoma, Pancreatic endocrine tumor, Pheochromocytoma, Renal cell carcinoma, Subepend... ORPHA:805
Aicardi Syndrome
Carcinoma, Hemangioma, Hepatoblastoma, Lipoma, Metastatic angiosarcoma, Teratoma OMIM:304050
Multiple Endocrine Neoplasia Type 1
Thyroid carcinoma, Meningioma, Gingival fibromatosis, Insulinoma, Intestinal carcinoid, Pituitary... ORPHA:652
Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form
Squamous cell carcinoma of the skin ORPHA:79396
Fanconi Anemia, Complementation Group E
Prolonged G2 phase of cell cycle OMIM:600901
Fanconi Anemia, Complementation Group A
Prolonged G2 phase of cell cycle OMIM:227650
Fanconi Anemia, Complementation Group C
Prolonged G2 phase of cell cycle OMIM:227645
Fanconi Anemia, Complementation Group D2
Prolonged G2 phase of cell cycle OMIM:227646
Sotos Syndrome
Neuroblastoma, Astrocytoma, Acute lymphoblastic leukemia, Cholesteatoma, Hemangioma, Neoplasm, Sa... ORPHA:821
Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion
Spinal neurofibromas, Optic nerve glioma, Subcutaneous neurofibromas, Hemangioma, Lisch nodules, ... ORPHA:363700

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Plk1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Plk1.

There are 5 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma. NPJ systems biology and applications (May 2021) Plk1tm1b(EUCOMM)Hmgu PMC8163790
PLK1 is required for chromosome compaction and microtubule organization in mouse oocytes. Molecular biology of the cell (April 2020) Plk1tm1c(EUCOMM)Hmgu Plk1tm1a(EUCOMM)Hmgu 32267211
Plk1 Mediates Paxillin Phosphorylation (Ser-272), Centrosome Maturation, and Airway Smooth Muscle Layer Thickening in Allergic Asthma. Scientific reports (May 2019) Plk1tm1c(EUCOMM)Hmgu PMC6525254
Polo-like Kinase 1 Regulates Vimentin Phosphorylation at Ser-56 and Contraction in Smooth Muscle. The Journal of biological chemistry (September 2016) Plk1tm1b(EUCOMM)Hmgu PMC5095422
The perfect host: a mouse host embryo facilitating more efficient germ line transmission of genetically modified embryonic stem cells. PloS one (July 2013) Plk1tm1a(EUCOMM)Hmgu PMC3699516

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Plk1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice, Tissue
Plk1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Plk1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter