Gene: Prl7d1 MGI:97619

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Gene Summary

prolactin family 7, subfamily d, member 1
PRP,  PLF-RP,  Plfr

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased prepulse inhibition Prl7d1em1(IMPC)Tcp HOM Early adult 5.49×10-05
enlarged lymph nodes Prl7d1em1(IMPC)Tcp HOM Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.


XRay Images Whole Body Lateral Orientation

10 Images

Gross Pathology and Tissue Collection


8 Images


XRay Images Skull Lateral Orientation

10 Images

Eye Morphology

Images Ophthalmoscopy

1 Images

Eye Morphology

Images Slit Lamp

3 Images


XRay Images Skull Dorso Ventral Orientation

10 Images


XRay Images Whole Body Dorso Ventral

10 Images



3 Images

Human diseases caused by Prl7d1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Prl7d1 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Immunodeficiency 32A
Lymphadenopathy OMIM:614893
Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Irf8 Deficiency
Lymphadenopathy ORPHA:319600
Placental Insufficiency
Maternal hypertension, Preeclampsia, Eclampsia, Abnormal placenta morphology, Small placenta, Spo... ORPHA:439167
Reticuloendotheliosis, X-Linked
Hepatosplenomegaly, Lymphadenopathy OMIM:312500
Silver-Russell Syndrome Due To A Point Mutation
Cryptorchidism, Microphallus, Abnormality of the scrotum, Oligohydramnios, Bifid scrotum, Dysmeno... ORPHA:397590
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Hypogonadism, Small placenta ORPHA:73272
Kimura Disease
Follicular hyperplasia, Lymphadenopathy ORPHA:482
Fragile Site, Distamycin A Type, Rare, Fra(16)(Q22.1)
Abnormality of the lymph nodes OMIM:136580
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation
Absent tonsils, Lymph node hypoplasia, Aplasia of the thymus OMIM:602450
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Polyhydramnios, Large placenta, Umbilical hernia ORPHA:254534
Leydig Cell Hypoplasia
Cryptorchidism, Hyoplasia of the Leydig cells, Male hypogonadism, Increased circulating gonadotro... ORPHA:755
Fetal Akinesia Deformation Sequence 1
Polyhydramnios, Cryptorchidism, Short umbilical cord, Fetal akinesia sequence, Premature birth, S... OMIM:208150
Neu-Laxova Syndrome 1
Polyhydramnios, Cryptorchidism, Spina bifida, Bifid uterus, Short umbilical cord, Decreased fetal... OMIM:256520
Restrictive Dermopathy
Polyhydramnios, Short umbilical cord, Large placenta, Decreased fetal movement, Premature birth, ... ORPHA:1662
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Microdeletion
Polyhydramnios, Large placenta, Umbilical hernia ORPHA:254528
Meige Disease
Lymph node hypoplasia, Absence of lymph node germinal center ORPHA:90186
Mosaic Trisomy 16
Maternal diabetes, Preeclampsia, Large placenta, Single umbilical artery, Premature birth, Hyposp... ORPHA:1708
Meckel Syndrome, Type 1
Cryptorchidism, Abnormality of the uterus, Accessory spleen, Ambiguous genitalia, male, Oligohydr... OMIM:249000
Trichohepatoenteric Syndrome 1
Polyhydramnios, Thrombocytosis, Large placenta, Abnormalities of placenta or umbilical cord, Incr... OMIM:222470
Kagami-Ogata Syndrome
Polyhydramnios, Large placenta, Premature birth ORPHA:254519
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
Absent tonsils, Lymph node hypoplasia ORPHA:276
Purine Nucleoside Phosphorylase Deficiency
Lymph node hypoplasia, Splenomegaly OMIM:613179
Agammaglobulinemia, X-Linked
Lymph node hypoplasia OMIM:300755
Restrictive Dermopathy, Lethal
Polyhydramnios, Short umbilical cord, Premature rupture of membranes, Decreased fetal movement, H... OMIM:275210
Beckwith-Wiedemann Syndrome
Polyhydramnios, Cryptorchidism, Pseudohypoparathyroidism, Gonadoblastoma, Polycythemia, Large pla... ORPHA:116
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Polyhydramnios, Cryptorchidism, Spinal dysraphism, Large placenta, External genital hypoplasia, H... ORPHA:96334


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Prl7d1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Prl7d1.

No publications found that use IMPC mice or data for Prl7d1.

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MGI Allele Allele Type Produced
Prl7d1tm459504(L1L2_GT0_LF2A_LacZ_BetactP_neo) Targeting vectors
Prl7d1em1(IMPC)Tcp Exon Deletion Mice

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