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Gene: Prl7d1 MGI:97619

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Gene Summary

Name:
prolactin family 7, subfamily d, member 1
Synonyms:
Plfr,  PLF-RP,  PRP

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
enlarged lymph nodes Prl7d1em1(IMPC)Tcp HOM Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Histopathology

Images

3 Images

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X-ray

XRay Images Skull Lateral Orientation

10 Images

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Gross Pathology and Tissue Collection

Images

8 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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Eye Morphology

Images Slit Lamp

3 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

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Eye Morphology

Images Ophthalmoscopy

1 Images

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Human diseases caused by Prl7d1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Prl7d1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Irf8 Deficiency
Lymphadenopathy ORPHA:319600
Fragile Site, Distamycin A Type, Rare, Fra(16)(Q22.1)
Abnormal lymph node morphology OMIM:136580
Immunodeficiency 38 With Basal Ganglia Calcification
Axillary lymphadenopathy, Inguinal lymphadenopathy, Lymphadenopathy OMIM:616126
Reticuloendotheliosis, X-Linked
Hepatosplenomegaly, Lymphadenopathy OMIM:312500
Placental Insufficiency
Small placenta, Abnormal placenta morphology, Abnormal umbilical cord blood vessel morphology ORPHA:439167
Immunodeficiency 75 With Lymphoproliferation
Hepatosplenomegaly, Follicular hyperplasia, Lymphadenopathy OMIM:619126
Silver-Russell Syndrome Due To A Point Mutation
Microphallus, Bifid scrotum, Small placenta, Oligohydramnios, Abnormal scrotum morphology, Crypto... ORPHA:397590
Kimura Disease
Follicular hyperplasia, Lymphadenopathy ORPHA:482
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Small placenta, Hypogonadism ORPHA:73272
Immunodeficiency 32A
Lymphadenitis, Lymphadenopathy OMIM:614893
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Polyhydramnios, Large placenta, Umbilical hernia ORPHA:254534
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation
Lymph node hypoplasia, Splenomegaly, Aplasia of the thymus, Generalized lymphadenopathy, Absent t... OMIM:602450
Fetal Akinesia Deformation Sequence 1
Small placenta, Increased nuchal translucency, Short umbilical cord, Cryptorchidism, Nonimmune hy... OMIM:208150
Neu-Laxova Syndrome 1
Hydranencephaly, Small placenta, Polyhydramnios, Cryptorchidism, Short umbilical cord, Decreased ... OMIM:256520
Restrictive Dermopathy
Small placenta, Large placenta, Short umbilical cord, Decreased fetal movement, Premature deliver... ORPHA:1662
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Microdeletion
Polyhydramnios, Large placenta, Umbilical hernia ORPHA:254528
Meige Disease
Lymph node hypoplasia, Absence of lymph node germinal center ORPHA:90186
Mayer-Rokitansky-Kuster-Hauser Syndrome
Hematocolpos, Abnormal female external genitalia morphology, Aplasia of the vagina, Polycystic ov... OMIM:277000
Congenital Syphilis
Extramedullary hematopoiesis, Hepatosplenomegaly, Large placenta, Thrombocytopenia, Anemia, Hydro... ORPHA:499009
Kagami-Ogata Syndrome
Polyhydramnios, Large placenta, Premature birth ORPHA:254519
Trichohepatoenteric Syndrome 1
Large placenta, Abnormalities of placenta or umbilical cord, Splenomegaly, Thrombocytosis, Polyhy... OMIM:222470
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
Absent tonsils, Lymph node hypoplasia ORPHA:276
Mosaic Trisomy 16
Large placenta, Hypospadias, Single umbilical artery, Premature birth ORPHA:1708
Meckel Syndrome, Type 1
Accessory spleen, Occipital encephalocele, Abnormality of the uterus, Ambiguous genitalia, female... OMIM:249000
Greenberg Dysplasia
Hepatosplenomegaly, Large placenta, Increased nuchal translucency, Nonimmune hydrops fetalis, Pol... OMIM:215140
Purine Nucleoside Phosphorylase Deficiency
Lymph node hypoplasia, Splenomegaly OMIM:613179
Beckwith-Wiedemann Syndrome
Subchorionic septal cyst, Polycythemia, Abnormal pancreas morphology, Umbilical hernia, Large pla... ORPHA:116
Restrictive Dermopathy 1
Premature rupture of membranes, Spontaneous chorioamniotic separation, Hydropic placenta, Oligohy... OMIM:275210
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Spinal dysraphism, Hepatosplenomegaly, Large placenta, External genital hypoplasia, Cryptorchidis... ORPHA:96334
Agammaglobulinemia, X-Linked
Lymph node hypoplasia OMIM:300755

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Prl7d1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Prl7d1.

No publications found that use IMPC mice or data for Prl7d1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Prl7d1tm459504(L1L2_GT0_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Prl7d1em1(IMPC)Tcp Exon Deletion Mice

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