Npr3 | natriuretic peptide receptor 3

GeneMGI:97373Synonyms: lgj, B430320C24Rik, +3 more

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Endocrine/exocrine gland

15 No significant impact

6 Not tested

Gene metrics:6Significant phenotypes
1Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues

Phenotypes

increased circulating phosphate level1 supporting datasetNpr3tm1.1(KOMP)VlcgheterozygoteEarly adult1.73x10-7 
small testis1 supporting datasetNpr3tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
abnormal testis morphology1 supporting datasetNpr3tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/2)0.7% (4/570)
aortaheterozygoten/a0% (0/2)0.19% (1/533)
bloodheterozygoten/a0% (0/2)0% (0/17)
bone marrowheterozygoten/a0% (0/2)0% (0/22)
brainheterozygoten/a100% (2/2)0.86% (5/579)
brainstemheterozygoten/an/a0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/an/a0.22% (1/454)
cecumheterozygoteSection images
50% (1/2)7.75% (22/284)
cerebellumheterozygoten/a0% (0/2)0.56% (3/532)
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Histopathology

IMPC related publications

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Npr3tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Npr3tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Npr3tm199046(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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