Mapt | microtubule-associated protein tau

GeneMGI:97180Synonyms: Mtapt, Tau

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Growth/size/body region Vision/eye Behavior/neurological Cardiovascular system Renal/urinary system

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

13Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased exploration in new environment	1 supporting dataset	Mapt^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.68x10^-10
decreased grip strength	2 supporting datasets	Mapt^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.47x10^-5
polycystic kidney	1 supporting dataset	Mapt^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal retina vasculature morphology	1 supporting dataset	Mapt^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.7x10^-14
persistence of hyaloid vascular system	1 supporting dataset	Mapt^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.22x10^-10
decreased total retina thickness	2 supporting datasets	Mapt^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.14x10^-7
increased fluid intake	1 supporting dataset	Mapt^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.45x10^-5
abnormal retina blood vessel morphology	1 supporting dataset	Mapt^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.7x10^-14

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mapt.

Associated images

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Histopathology

There is no histopathology data found for Mapt.

IMPC related publications

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External links

No external links available for Mapt.

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*Mapt^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Mapt^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Mapt^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Mapt^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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