Krt1 | keratin 1

GeneMGI:96698Synonyms: Krt-2.1, Krt2-1

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Respiratory system Hematopoietic system Behavior/neurological Cardiovascular system

13 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:20Significant phenotypes
14Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal heart morphology2 supporting datasetsKrt1em1(IMPC)CcpczhomozygoteEarly adultN/A * 
increased effector memory CD8-positive, alpha-beta T cell number1 supporting datasetKrt1em1(IMPC)CcpczhomozygoteEarly adult3.37x10-8 
abnormal thymus morphology1 supporting datasetKrt1em1(IMPC)CcpczhomozygoteEarly adultN/A * 
small epididymis1 supporting datasetKrt1em1(IMPC)CcpczhomozygoteEarly adultN/A * 
decreased grip strength4 supporting datasetsKrt1em1(IMPC)CcpczhomozygoteEarly adult9x10-10 
abnormal epididymis morphology1 supporting datasetKrt1em1(IMPC)CcpczhomozygoteEarly adultN/A * 
enlarged thymus1 supporting datasetKrt1em1(IMPC)CcpczhomozygoteEarly adultN/A * 
abnormal seminal vesicle morphology1 supporting datasetKrt1em1(IMPC)CcpczhomozygoteEarly adultN/A * 
small testis1 supporting datasetKrt1em1(IMPC)CcpczhomozygoteEarly adultN/A * 
enlarged heart2 supporting datasetsKrt1em1(IMPC)CcpczhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* Does not have a P-value assigned because it was manually marked as significant.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Krt1em1(IMPC)CcpczExon Deletionmouse
Krt1tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)es cell
Krt1tm96263(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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