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Gene: Il6st

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Name
interleukin 6 signal transducer
MGI ID
MGI:96560
Synonyms
gp130 CD130 D13Ertd699e 5133400A03Rik
Viability
Data available
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (6) Measurements chart (210) All data table (620)
Expression & images (75) Disease models (0) Order (2)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
embryonic lethality prior to tooth bud stage Il6sttm1b(KOMP)Mbp HOM   E12.5 0.00
preweaning lethality, complete penetrance Il6sttm1b(KOMP)Mbp HOM   Early adult 0.00
increased startle reflex Il6sttm1b(KOMP)Mbp HOM   Early adult 1.28×10-06
increased bone mineral content Il6sttm1b(KOMP)Mbp HOM Early adult 3.01×10-05
increased bone mineral density Il6sttm1b(KOMP)Mbp HOM Early adult 1.77×10-06
decreased total body fat amount Il6sttm1b(KOMP)Mbp HOM Early adult 1.28×10-06

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No  (4/530)  (4/4)  Section images
Aorta 4 No  (1/517)  (4/4)  Section images
Bone 2 No  (2/2)  Section images
Bone marrow 2 No  (2/2)  Section images
Brain 4 No  (4/526)  (4/4)  Section images
Brainstem 4 No  (2/532)  (4/4)  Section images
Brown adipose tissue 4 No  (4/4)  Section images
Cartilage tissue 4 No  (1/538)  (4/4)  Section images
Cerebellum 4 No  (3/537)  (4/4)  Section images
Cerebral cortex 4 No  (2/535)  (4/4)  Section images
Epididymis 4 No  (17/124)  (2/4)  Section images
Esophagus 4 No  (6/377)  (4/4)  Section images
Eye 4 No  (4/4)  Section images
Heart 4 No  (2/539)  (4/4)  Section images
Hippocampus 4 No  (3/533)  (4/4)  Section images
Hypothalamus 4 No  (2/525)  (4/4)  Section images
Kidney 4 No  (18/525)  (4/4)  Section images
Large intestine 4 No  (9/523)  (4/4)  Section images
Liver 4 No  (4/4)  Section images
Lower urinary tract 4 No  (1/528) N/A
Lung 4 No  (1/530)  (4/4)  Section images
Lymph node 4 No  (1/531)  (4/4)  Section images
Mammary gland 4 No  (2/4)  Section images
Midbrain 4 No  (4/4)  Section images
Olfactory lobe 4 No  (2/508)  (4/4)  Section images
Ovary 4 No  (1/530)  (2/4)  Section images
Oviduct 4 No  (2/4)  Section images
Pancreas 4 No  (5/528)  (4/4)  Section images
Peripheral nervous system 4 No  (2/532)  (4/4)  Section images
Peyer's patch 4 No  (2/4)  Section images
Pituitary gland 4 No  (4/4)  Section images
Prostate gland 4 No  (9/526) N/A
Skeletal muscle 4 No  (2/4)  Section images
Skin 4 No  (1/539)  (4/4)  Section images
Small intestine 4 No  (8/524)  (4/4)  Section images
Spinal cord 4 No  (2/527)  (4/4)  Section images
Spleen 4 No  (3/536)  (4/4)  Section images
Stomach 4 No  (12/526)  (4/4)  Section images
Striatum 4 No  (2/521)  (2/4)  Section images
Submandibular gland 3 No  (1/107)  (3/3)  Section images
Testis 4 No  (6/532)  (2/4)  Section images
Thalamus 4 No  (4/4)  Section images
Thymus 4 No  (1/521)  (4/4)  Section images
Thyroid gland 4 No  (15/530)  (4/4)  Section images
Trachea 4 No  (3/523)  (4/4)  Section images
Urinary bladder 4 No  (4/4)  Section images
Uterus 4 No  (2/4)  Section images
Vascular system 4 No  (4/4)  Section images
Vesicular gland 4 No N/A
White adipose tissue 4 No  (4/4)  Section images
LacZ Wholemount Images
LacZ Section Images
adipose tissue (4)
Brown adipose tissue expression
MA:0000057
cardiovascular system (5)
Aorta expression
MA:0000062
digestive system (13)
Esophagus expression
MA:0000352
endocrine system (4)
Adrenal gland expression
MA:0000116
exocrine system (4)
Mammary gland expression
MA:0000145
immune system (8)
Bone Marrow expression
MA:0000134
integumental system (4)
Mammary gland expression
MA:0000145
musculoskeletal system (3)
Bone expression
MA:0001459
nervous system (25)
Brain expression
MA:0000168
postnatal mouse (88)
Adrenal gland expression
MA:0000116
reproductive system (10)
Epididymis expression
MA:0000397
respiratory system (6)
Lung expression
MA:0000415
sensory organ (2)
Eye expression
MA:0000261
set of connective tissues (6)
Brown adipose tissue expression
MA:0000057
trunk (43)
Adrenal gland expression
MA:0000116
urinary system (4)
Kidney expression
MA:0000368
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/507)  (2/3) N/A
Dorsal root ganglion 2  (1/59) Image Only N/A
Ear 2  (1/507) Image Only N/A
Embryo 2  (1/508)  (2/3)  Wholemount images
Eye 2  (1/507)  (2/3) N/A
Footplate 2  (1/507)  (2/3) N/A
Forebrain 2  (1/507)  (2/3) N/A
Forelimb 2  (1/507)  (2/3) N/A
Fronto-nasal process 2  (1/60) Image Only N/A
Handplate 2  (1/507)  (2/3) N/A
Head 2  (5/507)  (2/3) N/A
Heart 2  (1/507)  (2/3) N/A
Hindbrain 2  (6/507)  (2/3) N/A
Hindlimb 2  (1/507)  (2/3) N/A
Liver 2  (1/502) N/A
Lung 2  (1/502) Image Only N/A
Mandibular process 2  (1/507)  (2/3) N/A
Maxillary process 2  (1/507)  (2/3) N/A
Midbrain 2  (1/507)  (2/3) N/A
Nose 2  (1/77)  (2/3) N/A
Oral cavity 2  (1/502) Image Only N/A
Skin 2  (1/507)  (2/3) N/A
Spinal cord 2  (1/71)  (2/3) N/A
Tail 2  (1/507)  (2/3) N/A
Tail somite group 2  (1/507)  (2/3) N/A
embryo or Unassigned (12)
Embryo imageOnly

 Associated Images

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Original Image
Adult LacZ: LacZ Images Section
88 Images
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X-ray: XRay Images Skull Dorso Ventral Orientation
9 Images
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Embryo LacZ: LacZ images wholemount
12 Images
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X-ray: XRay Images Whole Body Lateral Orientation
9 Images
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X-ray: XRay Images Whole Body Dorso Ventral
9 Images
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X-ray: XRay Images Skull Lateral Orientation
9 Images
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X-ray: XRay Images Forepaw
9 Images
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Gross Morphology Embryo E9.5
1 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
7 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Il6sttm1b(KOMP)Mbp Reporter-tagged deletion allele (post-Cre) Mice
Il6sttm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells