Il6st | interleukin 6 signal transducer

GeneMGI:96560Synonyms: CD130, gp130, +2 more

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Mortality/aging

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

7Associated diseases

Expression examined in:50Adult tissues

50Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	1 supporting dataset	Il6st^{tm1b(KOMP)Mbp}	homozygote	Early adult	N/A ^*
embryonic lethality prior to tooth bud stage	1 supporting dataset	Il6st^{tm1b(KOMP)Mbp}	homozygote	E12.5	N/A ^*
increased circulating bilirubin level	1 supporting dataset	Il6st^{tm1b(KOMP)Mbp}	heterozygote	Early adult	6.57x10^-5
increased mean corpuscular hemoglobin concentration	1 supporting dataset	Il6st^{tm1b(KOMP)Mbp}	heterozygote	Early adult	4.89x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Il6st.

Associated images

Loading...

Histopathology

There is no histopathology data found for Il6st.

IMPC related publications

Loading...

External links

No external links available for Il6st.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Il6st^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Il6st^{tm1b(KOMP)Mbp}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Il6st^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell
*Il6st^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Il6st^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

My Genes