Gene Summary

Name:
glutathione S-transferase, mu 1
Synonyms:
Gstb1,  Gstb-1

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

X-ray

XRay Images Whole Body Lateral Orientation

7 Images

Human diseases caused by Gstm1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Gstm1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Chromosome 15Q11-Q13 Duplication Syndrome
Restrictive behavior, Truncal ataxia, Inflexible adherence to routines, Unsteady gait, Reduced so... OMIM:608636
Autism, Susceptibility To, 20
Attention deficit hyperactivity disorder, Compulsive behaviors, Reduced social reciprocity OMIM:618830
Autism
Restrictive behavior, Inflexible adherence to routines, Motor stereotypy, Impaired ability to for... OMIM:209850
Autism, Susceptibility To, 8
Restrictive behavior, Inflexible adherence to routines, Motor stereotypy, Impaired ability to for... OMIM:607373
Intellectual Developmental Disorder With Autism And Speech Delay
Inability to walk, Reduced social reciprocity, Pachygyria, Motor stereotypy OMIM:606053
Intellectual Developmental Disorder, Autosomal Recessive 66
Gait ataxia, Attention deficit hyperactivity disorder, Aggressive behavior, Excessive shyness OMIM:618221
Asperger Syndrome, Susceptibility To, 1
Inflexible adherence to routines, Impaired ability to form peer relationships, Restrictive behavi... OMIM:608638
Asperger Syndrome, Susceptibility To, 2
Inflexible adherence to routines, Impaired ability to form peer relationships, Restrictive behavi... OMIM:608631
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Hyperactivity, Abnormal social behavior ORPHA:436151
Intellectual Developmental Disorder, Autosomal Recessive 64
Reduced social reciprocity, Aggressive behavior OMIM:618103
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Hyperinsulinemia, Polyphagia, Reduced social reciprocity, Aggressive behavior ORPHA:329249
Pheochromocytoma/Paraganglioma Syndrome 6
Elevated circulating catecholamine level, Paraganglioma OMIM:618464
Hereditary Geniospasm
Abnormal social behavior ORPHA:53372
Autism, Susceptibility To, 3
Restrictive behavior, Inflexible adherence to routines, Motor stereotypy, Impaired ability to for... OMIM:608049
Neurodevelopmental Disorder With Or Without Hyperkinetic Movements And Seizures, Autosomal Recessive
Self-injurious behavior, Inability to walk, Reduced social reciprocity, Motor stereotypy OMIM:617820
Female Restricted Epilepsy With Intellectual Disability
Abnormal social behavior, Hyperactivity, Compulsive behaviors, Impulsivity, Abnormal eating behav... ORPHA:101039
Severe Intellectual Disability-Progressive Postnatal Microcephaly-Midline Stereotypic Hand Movements Syndrome
Self-injurious behavior, Reduced social reciprocity, Stereotypical hand wringing ORPHA:397933
Hsd10 Disease
Abnormal social behavior, Gait disturbance, Ataxia, Dysphagia, Choreoathetosis ORPHA:391417
Foxg1 Syndrome
Difficulty walking, Inability to walk, Stereotypical hand wringing, Choreoathetosis, Reduced soci... ORPHA:561854
X-Linked Intellectual Disability, Van Esch Type
Absence of secondary sex characteristics, Hypergonadotropic hypogonadism, Reduced social reciproc... ORPHA:163976
X-Linked Intellectual Disability-Cerebellar Hypoplasia Syndrome
Attention deficit hyperactivity disorder, Ataxia, Reduced social reciprocity ORPHA:137831
11Q22.2Q22.3 Microdeletion Syndrome
Attention deficit hyperactivity disorder, Compulsive behaviors, Abnormal social behavior ORPHA:444002
Intellectual Developmental Disorder, Autosomal Recessive 6
Reduced social reciprocity OMIM:611092
Atypical Rett Syndrome
Agitation, Restrictive behavior, Inability to walk, Tongue thrusting, Stereotypical hand wringing... ORPHA:3095
Syngap1-Related Developmental And Epileptic Encephalopathy
Obsessive-compulsive trait, Recurrent hand flapping, Gait disturbance, Ataxia, Reduced social rec... ORPHA:544254
Lamb-Shaffer Syndrome
Abnormal temper tantrums, Abnormal social behavior, Hyperactivity, Ataxia, Motor stereotypy ORPHA:530983
Mitochondrial Complex Iii Deficiency, Nuclear Type 2
Limb ataxia, Bradykinesia, Dysdiadochokinesis, Compulsive behaviors, Gait apraxia, Gait ataxia, A... OMIM:615157
Symptomatic Form Of Fragile X Syndrome In Female Carriers
Abnormal temper tantrums, Hyperactivity, Recurrent hand flapping, Excessive shyness, Hypothyroidi... ORPHA:449291
Pheochromocytoma/Paraganglioma Syndrome 1
Vagal paraganglioma, Extraadrenal pheochromocytoma, Adrenal pheochromocytoma, Glomus jugular tumo... OMIM:168000
Intellectual Developmental Disorder, Autosomal Dominant 56
Bradykinesia, Inability to walk, Broad-based gait, Impulsivity, Ataxia, Reduced social reciprocit... OMIM:617854
Pitt-Hopkins-Like Syndrome 1
Hyperactivity, Ataxia, Reduced social reciprocity, Motor stereotypy, Attention deficit hyperactiv... OMIM:610042
Pheochromocytoma/Paraganglioma Syndrome 3
Chemodectoma, Adrenal pheochromocytoma, Glomus jugular tumor, Paraganglioma, Elevated circulating... OMIM:605373
47,Xyy Syndrome
Increased serum testosterone level, Hyperactivity, Impulsivity, Reduced social reciprocity, Atten... ORPHA:8
Parkinsonism-Dystonia 3, Childhood-Onset
Ataxia, Reduced social reciprocity, Dysphagia, Aggressive behavior OMIM:619738
Early-Onset Autosomal Dominant Alzheimer Disease
Agitation, Ataxia, Abnormal social behavior, Disinhibition ORPHA:1020
Pure Autonomic Failure
Abnormality of circulating catecholamine level ORPHA:441
Myoclonic-Astatic Epilepsy
Hyperactivity, Ataxia, Reduced social reciprocity, Unsteady gait, Attention deficit hyperactivity... ORPHA:1942
Neurodevelopmental Disorder With Microcephaly And Gray Sclerae
Reduced social reciprocity OMIM:617051
Temple Syndrome Due To Paternal 14Q32.2 Hypomethylation
Precocious puberty, Maturity-onset diabetes of the young, Reduced social reciprocity ORPHA:254531
Intellectual Developmental Disorder, Autosomal Dominant 30, With Speech Delay And Behavioral Abnormalities
Reduced social reciprocity, Aggressive behavior OMIM:616083
Childhood Disintegrative Disorder
Reduced social reciprocity, Motor stereotypy ORPHA:168782
Young-Onset Parkinson Disease
Bradykinesia, Agitation, Gait imbalance, Impulsivity, Restless legs, Reduced social reciprocity ORPHA:2828
Intellectual Developmental Disorder, X-Linked 98
Hyperactivity, Recurrent hand flapping, Stereotypical hand wringing, Central hypothyroidism, Ster... OMIM:300912
Childhood Absence Epilepsy
Attention deficit hyperactivity disorder, Punding, Abnormal social behavior ORPHA:64280
Neuroblastoma
Elevated circulating catecholamine level, Ataxia, Antalgic gait ORPHA:635
Rett Syndrome, Congenital Variant
Tongue thrusting, Athetosis, Simplified gyral pattern, Reduced social reciprocity, Pachygyria, Mo... OMIM:613454
Neurodegeneration With Brain Iron Accumulation 2A
Unsteady gait, Ataxia, Reduced social reciprocity OMIM:256600
Metachromatic Leukodystrophy, Late Infantile Form
Tip-toe gait, Progressive gait ataxia, Abnormal social behavior, Gait ataxia ORPHA:309256
Cerebral Creatine Deficiency Syndrome 1
Broad-based gait, Gait disturbance, Reduced social reciprocity, Motor stereotypy, Attention defic... OMIM:300352
Cortical Dysgenesis With Pontocerebellar Hypoplasia Due To Tubb3 Mutation
Inability to walk, Delayed early-childhood social milestone development, Polymicrogyria, Type II ... ORPHA:300570
Alg11-Cdg
Ataxia, Reduced social reciprocity, Gray matter heterotopia ORPHA:280071
48,Xxxy Syndrome
Attention deficit hyperactivity disorder, Hypogonadism, Type II diabetes mellitus, Abnormal socia... ORPHA:96263
Fg Syndrome Type 1
Small pituitary gland, Abnormal social behavior, Broad-based gait, Compulsive behaviors, Attentio... ORPHA:93932
Pontocerebellar Hypoplasia, Type 8
Reduced social reciprocity, Dysphagia, Gait ataxia OMIM:614961
Prader-Willi Syndrome Due To Translocation
Abnormal temper tantrums, Decreased response to growth hormone stimulation test, Abnormal social ... ORPHA:177907
Non-Progressive Cerebellar Ataxia With Intellectual Disability
Abnormal cortical gyration, Abnormal social behavior, Nonprogressive cerebellar ataxia, Ataxia, U... ORPHA:314647
Chromosome 15Q11.2 Deletion Syndrome
Compulsive behaviors, Ataxia, Reduced social reciprocity, Motor stereotypy, Attention deficit hyp... OMIM:615656
Intellectual Developmental Disorder, Autosomal Dominant 1
Recurrent hand flapping, Polyphagia, Inappropriate laughter, Ataxia, Reduced social reciprocity, ... OMIM:156200
Lead Poisoning
Delayed puberty, Anorexia, Reduced social reciprocity, Attention deficit hyperactivity disorder, ... ORPHA:330015
Phelan-Mcdermid Syndrome
Tongue thrusting, Broad-based gait, Unsteady gait, Reduced social reciprocity, Motor stereotypy, ... OMIM:606232
Proximal 16P11.2 Microdeletion Syndrome
Attention deficit hyperactivity disorder, Choreoathetosis, Reduced social reciprocity, Motor ster... ORPHA:261197
Congenital Disorder Of Deglycosylation 2
Polymicrogyria, Reduced social reciprocity, Dysphagia, Gray matter heterotopia OMIM:619775
Wagro Syndrome
Agitation, Compulsive behaviors, Polyphagia, Reduced social reciprocity, Aggressive behavior OMIM:612469
Beck-Fahrner Syndrome
Attention deficit hyperactivity disorder, Reduced social reciprocity OMIM:618798
Intellectual Developmental Disorder, X-Linked, Syndromic, Lujan-Fryns Type
Hyperactivity, Compulsive behaviors, Reduced social reciprocity, Aggressive behavior OMIM:309520
Tuberous Sclerosis Complex
Abnormal social behavior, Pancreatic endocrine tumor, Hyperactivity, Pheochromocytoma, Impulsivit... ORPHA:805
Metachromatic Leukodystrophy, Juvenile Form
Abnormal social behavior, Progressive gait ataxia ORPHA:309263
7Q11.23 Microduplication Syndrome
Hyperactivity, Polyphagia, Collectionism, Simplified gyral pattern, Reduced social reciprocity, P... ORPHA:96121
Metachromatic Leukodystrophy, Adult Form
Difficulty walking, Abnormal social behavior, Progressive gait ataxia ORPHA:309271
Developmental Delay, Impaired Speech, And Behavioral Abnormalities
Delayed puberty, Tip-toe gait, Agitation, Restrictive behavior, Broad-based gait, Hyperactivity, ... OMIM:619475
Von Hippel-Lindau Disease
Pancreatic endocrine tumor, Adrenal pheochromocytoma, Pancreatic islet cell adenoma, Elevated cir... ORPHA:892
Koolen-De Vries Syndrome Due To A Point Mutation
Decreased response to growth hormone stimulation test, Abnormal social behavior, Hypothyroidism, ... ORPHA:363965
17Q21.31 Microdeletion Syndrome
Decreased response to growth hormone stimulation test, Abnormal social behavior, Hypothyroidism, ... ORPHA:363958
Niemann-Pick Disease Type C
Abnormal social behavior, Compulsive behaviors, Gait disturbance, Ataxia, Dysphagia, Disinhibitio... ORPHA:646
Dihydropyrimidine Dehydrogenase Deficiency
Inability to walk, Abnormal social behavior ORPHA:1675
Adnp Syndrome
Abnormal temper tantrums, Oral-pharyngeal dysphagia, Compulsive behaviors, Polyphagia, Reduced so... ORPHA:404448
Mend Syndrome
Hyperactivity, Abnormal social behavior, Aggressive behavior ORPHA:401973
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Delayed puberty, Central diabetes insipidus, Decreased response to growth hormone stimulation tes... ORPHA:293987
Helsmoortel-Van Der Aa Syndrome
Decreased response to growth hormone stimulation test, Hyperactivity, Polyphagia, Compulsive beha... OMIM:615873
Trichothiodystrophy
Reduced social reciprocity, Gait ataxia ORPHA:33364
Williams Syndrome
Gait imbalance, Abnormal social behavior, Compulsive behaviors, Gait disturbance, Hypothyroidism,... ORPHA:904
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Abnormal fear-induced behavior, Hyperactivity, Compulsive behaviors, Impulsivity, Reduced social ... ORPHA:353281
Megalencephaly-Severe Kyphoscoliosis-Overgrowth Syndrome
Difficulty walking, Reduced social reciprocity, Gait ataxia ORPHA:457359
Chromosome 1P36 Deletion Syndrome, Distal
Polymicrogyria, Polyphagia, Congenital hypothyroidism, Hypothyroidism, Oppositional defiant disor... OMIM:607872
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Abnormal fear-induced behavior, Hyperactivity, Compulsive behaviors, Impulsivity, Reduced social ... ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Abnormal fear-induced behavior, Hyperactivity, Compulsive behaviors, Impulsivity, Reduced social ... ORPHA:353277
17Q11 Microdeletion Syndrome
Delayed puberty, Elevated circulating parathyroid hormone level, Pheochromocytoma, Precocious pub... ORPHA:97685
Mowat-Wilson Syndrome
Inability to walk, Broad-based gait, Polymicrogyria, Ataxia, Reduced social reciprocity, Dysphagi... ORPHA:2152

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gstm1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gstm1.

No publications found that use IMPC mice or data for Gstm1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Gstm1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Gstm1em1(IMPC)Hmgu Exon Deletion Mice
Gstm1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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