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Gene: Gstm1 MGI:95860

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Gene Summary

Name:
glutathione S-transferase, mu 1
Synonyms:
Gstb1,  Gstb-1

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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X-ray

XRay Images Whole Body Lateral Orientation

7 Images

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Human diseases caused by Gstm1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Gstm1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Chromosome 15Q11-Q13 Duplication Syndrome
Increased serum serotonin, Restrictive behavior, Impaired ability to form peer relationships, Inf... OMIM:608636
Autism, Susceptibility To, 20
Compulsive behaviors, Attention deficit hyperactivity disorder, Reduced social reciprocity OMIM:618830
Autism
Increased serum serotonin, Impaired ability to form peer relationships, Restrictive behavior, Inf... OMIM:209850
Autism, Susceptibility To, 8
Increased serum serotonin, Impaired ability to form peer relationships, Restrictive behavior, Inf... OMIM:607373
Intellectual Developmental Disorder With Autism And Speech Delay
Pachygyria, Motor stereotypy, Reduced social reciprocity, Inability to walk OMIM:606053
Intellectual Developmental Disorder, Autosomal Recessive 66
Aggressive behavior, Attention deficit hyperactivity disorder, Gait ataxia, Excessive shyness OMIM:618221
Asperger Syndrome, Susceptibility To, 1
Restrictive behavior, Impaired ability to form peer relationships, Motor stereotypy, Inflexible a... OMIM:608638
Asperger Syndrome, Susceptibility To, 2
Restrictive behavior, Impaired ability to form peer relationships, Motor stereotypy, Inflexible a... OMIM:608631
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Hyperactivity, Abnormal social behavior ORPHA:436151
Intellectual Developmental Disorder, Autosomal Recessive 64
Aggressive behavior, Reduced social reciprocity OMIM:618103
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Aggressive behavior, Hyperinsulinemia, Polyphagia, Reduced social reciprocity ORPHA:329249
Pheochromocytoma/Paraganglioma Syndrome 6
Elevated circulating catecholamine level, Paraganglioma OMIM:618464
Hereditary Geniospasm
Abnormal social behavior ORPHA:53372
Autism, Susceptibility To, 3
Increased serum serotonin, Impaired ability to form peer relationships, Restrictive behavior, Inf... OMIM:608049
Neurodevelopmental Disorder With Or Without Hyperkinetic Movements And Seizures, Autosomal Recessive
Inability to walk, Self-injurious behavior, Motor stereotypy, Reduced social reciprocity OMIM:617820
Female Restricted Epilepsy With Intellectual Disability
Abnormal eating behavior, Aggressive behavior, Hyperactivity, Compulsive behaviors, Abnormal soci... ORPHA:101039
Severe Intellectual Disability-Progressive Postnatal Microcephaly-Midline Stereotypic Hand Movements Syndrome
Self-injurious behavior, Reduced social reciprocity, Stereotypical hand wringing ORPHA:397933
Hsd10 Disease
Gait disturbance, Ataxia, Dysphagia, Choreoathetosis, Abnormal social behavior ORPHA:391417
Foxg1 Syndrome
Difficulty walking, Inability to walk, Bruxism, Reduced social reciprocity, Stereotypical hand wr... ORPHA:561854
X-Linked Intellectual Disability, Van Esch Type
Male hypogonadism, Absence of secondary sex characteristics, Decreased serum testosterone concent... ORPHA:163976
X-Linked Intellectual Disability-Cerebellar Hypoplasia Syndrome
Attention deficit hyperactivity disorder, Reduced social reciprocity, Ataxia ORPHA:137831
11Q22.2Q22.3 Microdeletion Syndrome
Compulsive behaviors, Attention deficit hyperactivity disorder, Abnormal social behavior ORPHA:444002
Intellectual Developmental Disorder, Autosomal Recessive 6
Reduced social reciprocity OMIM:611092
Atypical Rett Syndrome
Restrictive behavior, Inability to walk, Bruxism, Inappropriate laughter, Gait ataxia, Reduced so... ORPHA:3095
Syngap1-Related Developmental And Epileptic Encephalopathy
Abnormal eating behavior, Recurrent hand flapping, Obsessive-compulsive trait, Reduced social rec... ORPHA:544254
Lamb-Shaffer Syndrome
Abnormal temper tantrums, Hyperactivity, Ataxia, Motor stereotypy, Abnormal social behavior ORPHA:530983
Mitochondrial Complex Iii Deficiency, Nuclear Type 2
Limb ataxia, Gait ataxia, Dysmetria, Reduced social reciprocity, Aggressive behavior, Gait apraxi... OMIM:615157
Symptomatic Form Of Fragile X Syndrome In Female Carriers
Self-injurious behavior, Abnormal temper tantrums, Recurrent hand flapping, Reduced social recipr... ORPHA:449291
Pheochromocytoma/Paraganglioma Syndrome 1
Elevated circulating catecholamine level, Vagal paraganglioma, Chemodectoma, Carotid paragangliom... OMIM:168000
Intellectual Developmental Disorder, Autosomal Dominant 56
Broad-based gait, Inability to walk, Reduced social reciprocity, Attention deficit hyperactivity ... OMIM:617854
Pitt-Hopkins-Like Syndrome 1
Reduced social reciprocity, Aggressive behavior, Attention deficit hyperactivity disorder, Hypera... OMIM:610042
Pheochromocytoma/Paraganglioma Syndrome 3
Elevated circulating catecholamine level, Extraadrenal pheochromocytoma, Chemodectoma, Adrenal ph... OMIM:605373
47,Xyy Syndrome
Reduced social reciprocity, Attention deficit hyperactivity disorder, Increased serum testosteron... ORPHA:8
Parkinsonism-Dystonia 3, Childhood-Onset
Aggressive behavior, Dysphagia, Reduced social reciprocity, Ataxia OMIM:619738
Early-Onset Autosomal Dominant Alzheimer Disease
Disinhibition, Abnormal social behavior, Agitation, Ataxia ORPHA:1020
Pure Autonomic Failure
Abnormality of circulating catecholamine level ORPHA:441
Myoclonic-Astatic Epilepsy
Reduced social reciprocity, Attention deficit hyperactivity disorder, Hyperactivity, Ataxia, Unst... ORPHA:1942
Neurodevelopmental Disorder With Microcephaly And Gray Sclerae
Reduced social reciprocity OMIM:617051
Temple Syndrome Due To Paternal 14Q32.2 Hypomethylation
Precocious puberty, Maturity-onset diabetes of the young, Reduced social reciprocity ORPHA:254531
Childhood Disintegrative Disorder
Motor stereotypy, Reduced social reciprocity ORPHA:168782
Intellectual Developmental Disorder, Autosomal Dominant 30, With Speech Delay And Behavioral Abnormalities
Aggressive behavior, Reduced social reciprocity OMIM:616083
Young-Onset Parkinson Disease
Gait imbalance, Restless legs, Agitation, Reduced social reciprocity, Bradykinesia, Impulsivity ORPHA:2828
Intellectual Developmental Disorder, X-Linked 98
Central hypothyroidism, Bulimia, Bruxism, Stereotypical body rocking, Recurrent hand flapping, Re... OMIM:300912
Childhood Absence Epilepsy
Punding, Attention deficit hyperactivity disorder, Abnormal social behavior ORPHA:64280
Neuroblastoma
Elevated circulating catecholamine level, Antalgic gait, Ataxia ORPHA:635
Rett Syndrome, Congenital Variant
Bruxism, Reduced social reciprocity, Tongue thrusting, Pachygyria, Athetosis, Motor stereotypy, S... OMIM:613454
Neurodegeneration With Brain Iron Accumulation 2A
Unsteady gait, Reduced social reciprocity, Ataxia OMIM:256600
Metachromatic Leukodystrophy, Late Infantile Form
Progressive gait ataxia, Gait ataxia, Tip-toe gait, Abnormal social behavior ORPHA:309256
Cerebral Creatine Deficiency Syndrome 1
Broad-based gait, Reduced social reciprocity, Aggressive behavior, Attention deficit hyperactivit... OMIM:300352
Cortical Dysgenesis With Pontocerebellar Hypoplasia Due To Tubb3 Mutation
Polymicrogyria, Type II lissencephaly, Inability to walk, Reduced social reciprocity, Spastic ata... ORPHA:300570
Alg11-Cdg
Gray matter heterotopia, Reduced social reciprocity, Ataxia ORPHA:280071
48,Xxxy Syndrome
Hypogonadism, Attention deficit hyperactivity disorder, Type II diabetes mellitus, Abnormal socia... ORPHA:96263
Fg Syndrome Type 1
Small pituitary gland, Broad-based gait, Attention deficit hyperactivity disorder, Compulsive beh... ORPHA:93932
Pontocerebellar Hypoplasia, Type 8
Gait ataxia, Dysphagia, Reduced social reciprocity OMIM:614961
Prader-Willi Syndrome Due To Translocation
Abnormal temper tantrums, Head-banging, Decreased response to growth hormone stimulation test, Re... ORPHA:177907
Non-Progressive Cerebellar Ataxia With Intellectual Disability
Ataxia, Abnormal cortical gyration, Dysmetria, Aggressive behavior, Unsteady gait, Nonprogressive... ORPHA:314647
Chromosome 15Q11.2 Deletion Syndrome
Reduced social reciprocity, Attention deficit hyperactivity disorder, Ataxia, Compulsive behavior... OMIM:615656
Intellectual Developmental Disorder, Autosomal Dominant 1
Self-injurious behavior, Bruxism, Inappropriate laughter, Recurrent hand flapping, Reduced social... OMIM:156200
Phelan-Mcdermid Syndrome
Broad-based gait, Bruxism, Reduced social reciprocity, Aggressive behavior, Tongue thrusting, Uns... OMIM:606232
Lead Poisoning
Decreased circulating osteocalcin level, Reduced social reciprocity, Attention deficit hyperactiv... ORPHA:330015
Proximal 16P11.2 Microdeletion Syndrome
Attention deficit hyperactivity disorder, Motor stereotypy, Choreoathetosis, Reduced social recip... ORPHA:261197
Congenital Disorder Of Deglycosylation 2
Gray matter heterotopia, Dysphagia, Reduced social reciprocity, Polymicrogyria OMIM:619775
Wagro Syndrome
Reduced social reciprocity, Polyphagia, Aggressive behavior, Compulsive behaviors, Agitation OMIM:612469
Beck-Fahrner Syndrome
Attention deficit hyperactivity disorder, Reduced social reciprocity OMIM:618798
Tuberous Sclerosis Complex
Self-injurious behavior, Pituitary adenoma, Pheochromocytoma, Parathyroid hyperplasia, Aggressive... ORPHA:805
Intellectual Developmental Disorder, X-Linked, Syndromic, Lujan-Fryns Type
Compulsive behaviors, Aggressive behavior, Hyperactivity, Reduced social reciprocity OMIM:309520
Metachromatic Leukodystrophy, Juvenile Form
Progressive gait ataxia, Abnormal social behavior ORPHA:309263
7Q11.23 Microduplication Syndrome
Self-injurious behavior, Dysmetria, Reduced social reciprocity, Aggressive behavior, Polyphagia, ... ORPHA:96121
Metachromatic Leukodystrophy, Adult Form
Difficulty walking, Progressive gait ataxia, Abnormal social behavior ORPHA:309271
Developmental Delay, Impaired Speech, And Behavioral Abnormalities
Restrictive behavior, Broad-based gait, Falls, Tip-toe gait, Violent behavior, Bruxism, Reduced s... OMIM:619475
Von Hippel-Lindau Disease
Elevated circulating catecholamine level, Adrenal pheochromocytoma, Pancreatic islet cell adenoma... ORPHA:892
Koolen-De Vries Syndrome Due To A Point Mutation
Precocious puberty, Decreased response to growth hormone stimulation test, Inappropriate laughter... ORPHA:363965
17Q21.31 Microdeletion Syndrome
Precocious puberty, Decreased response to growth hormone stimulation test, Inappropriate laughter... ORPHA:363958
Niemann-Pick Disease Type C
Disinhibition, Progressive gait ataxia, Aggressive behavior, Gait disturbance, Ataxia, Compulsive... ORPHA:646
Dihydropyrimidine Dehydrogenase Deficiency
Inability to walk, Abnormal social behavior ORPHA:1675
Adnp Syndrome
Abnormal temper tantrums, Oral-pharyngeal dysphagia, Reduced social reciprocity, Polyphagia, Atte... ORPHA:404448
Mend Syndrome
Aggressive behavior, Hyperactivity, Abnormal social behavior ORPHA:401973
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Premature adrenarche, Self-injurious behavior, Central hypothyroidism, Polydipsia, Increased circ... ORPHA:293987
Helsmoortel-Van Der Aa Syndrome
Decreased response to growth hormone stimulation test, Bruxism, Reduced social reciprocity, Polyp... OMIM:615873
Trichothiodystrophy
Gait ataxia, Reduced social reciprocity ORPHA:33364
Williams Syndrome
Precocious puberty, Gait imbalance, Type II diabetes mellitus, Dysmetria, Overfriendliness, Hypog... ORPHA:904
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Self-injurious behavior, Abnormal fear-induced behavior, Reduced social reciprocity, Aggressive b... ORPHA:353281
Megalencephaly-Severe Kyphoscoliosis-Overgrowth Syndrome
Difficulty walking, Gait ataxia, Reduced social reciprocity ORPHA:457359
Chromosome 1P36 Deletion Syndrome, Distal
Polymicrogyria, Congenital hypothyroidism, Oppositional defiant disorder, Self-mutilation, Reduce... OMIM:607872
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Self-injurious behavior, Abnormal fear-induced behavior, Reduced social reciprocity, Aggressive b... ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Self-injurious behavior, Abnormal fear-induced behavior, Reduced social reciprocity, Aggressive b... ORPHA:353277
17Q11 Microdeletion Syndrome
Precocious puberty, Elevated circulating parathyroid hormone level, Pheochromocytoma, Reduced soc... ORPHA:97685
Mowat-Wilson Syndrome
Broad-based gait, Polymicrogyria, Inability to walk, Bruxism, Periventricular heterotopia, Reduce... ORPHA:2152

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gstm1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gstm1.

No publications found that use IMPC mice or data for Gstm1.

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MGI Allele Allele Type Produced
Gstm1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Gstm1em1(IMPC)Hmgu Exon Deletion Mice
Gstm1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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