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Gene: Gnal MGI:95774

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
guanine nucleotide binding protein, alpha stimulating, olfactory type
Synonyms:
Gna10,  Galphaolf,  Golf,  9630020G10Rik,  G alpha 10,  2610011C15Rik

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Gnal mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Gnal by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Autosomal Dominant Focal Dystonia, Dyt25 Type
ORPHA:329466
Dystonia 25
OMIM:615073

The table below shows human diseases predicted to be associated to Gnal by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Autism, Susceptibility To, 20
Attention deficit hyperactivity disorder, Compulsive behaviors, Reduced social reciprocity OMIM:618830
Asperger Syndrome, Susceptibility To, 1
Inflexible adherence to routines, Impaired ability to form peer relationships, Restrictive behavi... OMIM:608638
Asperger Syndrome, Susceptibility To, 2
Inflexible adherence to routines, Impaired ability to form peer relationships, Restrictive behavi... OMIM:608631
Huntington Disease
Irritability, Agitation, Difficulty walking, Gait imbalance, Oral-pharyngeal dysphagia, Inability... ORPHA:399
Kleine-Levin Syndrome
Polydipsia, Irritability, Agitation, Abnormal eating behavior, Transient global amnesia, Depressi... ORPHA:33543
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Hyperactivity, Abnormal social behavior ORPHA:436151
Chromosome 15Q11-Q13 Duplication Syndrome
Restrictive behavior, Truncal ataxia, Inflexible adherence to routines, Unsteady gait, Reduced so... OMIM:608636
Young-Onset Parkinson Disease
Agitation, Gait imbalance, Hyposmia, Depression, Short attention span, Impulsivity, Cognitive imp... ORPHA:2828
Childhood Disintegrative Disorder
Abnormal emotion, Mental deterioration, Progressive language deterioration, Reduced social recipr... ORPHA:168782
Leber Congenital Amaurosis 10
Hyposmia OMIM:611755
Hypogonadotropic Hypogonadism 17 With Or Without Anosmia
Hyposmia OMIM:615266
Body Mass Index Quantitative Trait Locus 19
Hyposmia, Polyphagia, Anosmia OMIM:617885
Hypogonadotropic Hypogonadism 21 With Or Without Anosmia
Hyposmia OMIM:615271
Kufor-Rakeb Syndrome
Akinesia, Hyposmia, Anosmia, Gait disturbance, Ataxia, Dysphagia, Dementia, Aggressive behavior OMIM:606693
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Polyphagia, Reduced social reciprocity, Aggressive behavior ORPHA:329249
Arrhinia-Choanal Atresia-Microphthalmia Syndrome
Choanal atresia, Aplasia/Hypoplasia involving the nose, Abnormality of the sense of smell ORPHA:1135
Hypogonadotropic Hypogonadism 7 With Or Without Anosmia
Abnormality of the sense of smell OMIM:146110
Hereditary Late-Onset Parkinson Disease
Agitation, Akinesia, Hyposmia, Depression, Low frustration tolerance, Shuffling gait, Impulsivity... ORPHA:411602
Female Restricted Epilepsy With Intellectual Disability
Abnormal social behavior, Hyperactivity, Compulsive behaviors, Impulsivity, Abnormal eating behav... ORPHA:101039
Leukoencephalopathy With Dystonia And Motor Neuropathy
Hyposmia OMIM:613724
Peroxisome Biogenesis Disorder 9B
Ataxia, Anosmia, Total anosmia OMIM:614879
Hypogonadotropic Hypogonadism 9 With Or Without Anosmia
Hyposmia, Bifid nose, Anosmia OMIM:614838
Bardet-Biedl Syndrome 17
Hyposmia, Polydipsia, Anosmia, Cognitive impairment OMIM:615994
Thumb Agenesis, Short Stature, And Immunodeficiency
Anosmia OMIM:274190
Chondrodysplasia Punctata 1, X-Linked Recessive
Short nose, Depressed nasal bridge, Anosmia, Short nasal septum OMIM:302950
Anosmia For Butyl Mercaptan
Anosmia OMIM:270350
Isovaleric Acid, Inability To Smell
Anosmia OMIM:243450
Anosmia, Isolated Congenital, X-Linked
Anosmia OMIM:301700
Anosmia, Isolated Congenital
Anosmia OMIM:107200
Anosmia For Isobutyric Acid
Partial anosmia OMIM:207000
Musk, Inability To Smell
Anosmia OMIM:254150
Aural Atresia, Congenital
Hyposmia OMIM:607842
Apnea, Obstructive Sleep
Anosmia OMIM:107650
Hypogonadotropic Hypogonadism 6 With Or Without Anosmia
Hyposmia, Anosmia OMIM:612702
Early-Onset Autosomal Dominant Alzheimer Disease
Agitation, Abnormal social behavior, Memory impairment, Confusion, Semantic dementia, Ataxia, Dis... ORPHA:1020
Hypogonadotropic Hypogonadism 4 With Or Without Anosmia
Hyposmia, Anosmia OMIM:610628
Bardet-Biedl Syndrome 19
Hyposmia OMIM:615996
Hypogonadotropic Hypogonadism 20 With Or Without Anosmia
Anosmia OMIM:615270
Hypogonadotropic Hypogonadism 14 With Or Without Anosmia
Anosmia OMIM:614858
Hypogonadotropic Hypogonadism 18 With Or Without Anosmia
Anosmia OMIM:615267
Hypogonadotropic Hypogonadism 5 With Or Without Anosmia
Anosmia OMIM:612370
Hypogonadotropic Hypogonadism 3 With Or Without Anosmia
Hyposmia, Anosmia OMIM:244200
Hyperostosis Cranialis Interna
Hyposmia, Anosmia OMIM:144755
Hypogonadotropic Hypogonadism 2 With Or Without Anosmia
Hyposmia, Anosmia, Choanal atresia OMIM:147950
Hypogonadotropic Hypogonadism 24 With Or Without Anosmia
Abnormality of the sense of smell OMIM:229070
Superficial Siderosis
Limb ataxia, Partial anosmia, Dementia, Memory impairment, Dysdiadochokinesis, Anosmia, Cognitive... ORPHA:247245
Parkinson Disease 8, Autosomal Dominant
Hyposmia, Dementia OMIM:607060
Blepharophimosis With Ptosis, Syndactyly, And Short Stature
Wide nasal bridge, Anosmia OMIM:210745
Hypogonadotropic Hypogonadism 27 Without Anosmia
Anosmia OMIM:619755
Ventricular Extrasystoles With Syncopal Episodes-Perodactyly-Robin Sequence Syndrome
Abnormality of the sense of smell ORPHA:3201
Refsum Disease, Classic
Ataxia, Anosmia OMIM:266500
Neuropathy, Hereditary Motor And Sensory, Type Via, With Optic Atrophy
Steppage gait, Anosmia OMIM:601152
Hypogonadotropic Hypogonadism 15 With Or Without Anosmia
Anosmia OMIM:614880
Indifference To Pain, Congenital, Autosomal Recessive
Hyposmia, Anosmia OMIM:243000
Blepharophimosis-Ptosis-Esotropia-Syndactyly-Short Stature Syndrome
Anosmia ORPHA:2057
Hypogonadotropic Hypogonadism 16 With Or Without Anosmia
Hyposmia, Anosmia OMIM:614897
Hypogonadotropic Hypogonadism 1 With Or Without Anosmia
Hyposmia, Ataxia, Anosmia OMIM:308700
Marcus-Gunn Syndrome
Choanal atresia, Abnormality of the sense of smell ORPHA:91412
Polyendocrine-Polyneuropathy Syndrome
Ataxia, Abnormality of the sense of smell OMIM:616113
Brachytelephalangy-Dysmorphism-Kallmann Syndrome
Abnormal nostril morphology, Short nose, Anosmia ORPHA:1295
Kallmann Syndrome With Spastic Paraplegia
Ataxia, Anosmia OMIM:308750
Solitary Median Maxillary Central Incisor
Anosmia, Choanal atresia, Midnasal stenosis, Abnormal nasopharynx morphology, Pyriform aperture s... OMIM:147250
Hypogonadotropic Hypogonadism 13 With Or Without Anosmia
Anosmia OMIM:614842
Hypogonadotropic Hypogonadism 25 With Anosmia
Anosmia OMIM:618841
Hydrolethalus
Abnormality of the sense of smell ORPHA:2189
Hypogonadotropic Hypogonadism 10 With Or Without Anosmia
Anosmia OMIM:614839
Johnson Neuroectodermal Syndrome
Bulbous nose, Anosmia, Choanal atresia ORPHA:2316
Refsum Disease
Ataxia, Anosmia ORPHA:773
Septo-Optic Dysplasia Spectrum
Polydipsia, Anosmia ORPHA:3157
Hypogonadotropic Hypogonadism 22 With Or Without Anosmia
Anosmia OMIM:616030
Hypogonadotropic Hypogonadism 23 With Or Without Anosmia
Abnormality of the sense of smell OMIM:228300
Hypogonadotropic Hypogonadism 12 With Or Without Anosmia
Anosmia OMIM:614841
8Q21.11 Microdeletion Syndrome
Underdeveloped nasal alae, Wide nose, Abnormality of the sense of smell ORPHA:284160
Hypogonadotropic Hypogonadism 8 With Or Without Anosmia
Anosmia OMIM:614837
Kallmann Syndrome
Hyposmia, Ataxia, Anosmia, Gait disturbance ORPHA:478
Acro-Renal-Mandibular Syndrome
Abnormality of the sense of smell ORPHA:958
Moebius Syndrome
Dysphagia, Abnormality of the sense of smell ORPHA:570
Ciliary Dyskinesia, Primary, 1
Nasal polyposis, Anosmia, Chronic rhinitis OMIM:244400
Meningioma
Difficulty walking, Transient global amnesia, Memory impairment, Emotional lability, Cognitive im... ORPHA:2495
Neuropathy, Hereditary Sensory And Autonomic, Type Viii
Hyposmia OMIM:616488
Campomelic Dysplasia
Depressed nasal bridge, Abnormality of the sense of smell ORPHA:140
Holoprosencephaly
Hyposmia, Anteverted nares, Anosmia, Choanal atresia, Depressed nasal tip, Depressed nasal ridge,... ORPHA:2162
Amoebiasis Due To Free-Living Amoebae
Irritability, Hyposmia, Confusion, Ataxia, Restlessness ORPHA:68
Gorlin Syndrome
Wide nasal bridge, Abnormality of the sense of smell ORPHA:377
Intellectual Developmental Disorder With Impaired Language And Dysmorphic Facies
Hyposmia, Difficulty walking, Motor stereotypy OMIM:618653
Hyposmia-Nasal And Ocular Hypoplasia-Hypogonadotropic Hypogonadism Syndrome
Hyposmia, Absent nares, Single naris, Anosmia ORPHA:2250
Kallmann Syndrome-Heart Disease Syndrome
Partial anosmia, Total anosmia ORPHA:2326
Bardet-Biedl Syndrome
Emotional lability, Depression, Short attention span, Cognitive impairment, Rhinitis, Prominent n... ORPHA:110
Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, And Hirschsprung Disease
Ataxia, Anosmia OMIM:609136
8P11.2 Deletion Syndrome
Anosmia, Depressed nasal bridge ORPHA:251066
Occipital Horn Syndrome
Dysphagia, Abnormality of the sense of smell ORPHA:198
Wilson Disease
Hyposmia, Dysphagia, Dementia OMIM:277900
Charge Syndrome
Anosmia, Choanal atresia, Compulsive behaviors, Dysphagia, Attention deficit hyperactivity disord... ORPHA:138
Waardenburg Syndrome, Type 2E
Anosmia OMIM:611584
Hypogonadotropic Hypogonadism 26 With Or Without Anosmia
Anosmia OMIM:619718
Leopard Syndrome 1
Hyposmia, Depressed nasal ridge OMIM:151100
Bosma Arhinia Microphthalmia Syndrome
Aplasia of the nose, Anosmia, Choanal atresia OMIM:603457
Waardenburg Syndrome, Type 4C
Anosmia OMIM:613266
Lacrimoauriculodentodigital Syndrome
Anosmia, Dysphagia, Choanal atresia ORPHA:2363
Charge Syndrome
Self-mutilation, Anosmia, Dysphagia, Choanal atresia OMIM:214800
Autosomal Dominant Focal Dystonia, Dyt25 Type
ORPHA:329466
Dystonia 25
OMIM:615073

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gnal

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gnal.

No publications found that use IMPC mice or data for Gnal.

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MGI Allele Allele Type Produced
Gnaltm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Gnaltm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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