Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

solute carrier family 2 (facilitated glucose transporter), member 3
Glut3,  Glut-3

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Slc2a3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Slc2a3 by orthology or direct annotation.

Disease Similarity of
Matching phenotypes Source
Huntington Disease
Suicidal ideation, Dystonia, Disinhibition, Anxiety, Aggressive behavior, Apathy, Irritability, H... ORPHA:399

The table below shows human diseases predicted to be associated to Slc2a3 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Severe Primary Trimethylaminuria
Anxiety, Negative affectivity, Aggressive behavior, Emotional lability, Low self esteem, Depression ORPHA:468726
Obsessive-Compulsive Disorder
Anxiety, Depression, Skin-picking OMIM:164230
Dystonia 11, Myoclonic
Anxiety, Agoraphobia, Torticollis, Depression, Writer's cramp, Tremor OMIM:159900
Myoclonus-Dystonia Syndrome
Dystonia, Anxiety, Panic attack, Personality disorder, Torticollis, Depression, Writer's cramp ORPHA:36899
Convulsions, Familial Infantile, With Paroxysmal Choreoathetosis
Anxiety, Paroxysmal dystonia, Normal interictal EEG OMIM:602066
Parkinsonism With Polyneuropathy
Resting tremor, Decreased amplitude of sensory action potentials, Anxiety, Decreased motor nerve ... OMIM:619279
Huntington Disease-Like 2
Action tremor, Dystonia, Anxiety, Apathy, Irritability, Depression OMIM:606438
Abnormal fear/anxiety-related behavior, Emotional lability, Irritability, Separation insecurity, ... ORPHA:66624
Dystonia 26, Myoclonic
Dystonia, Blepharospasm, Anxiety, Laryngeal dystonia, Torticollis, Depression OMIM:616398
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Resting tremor, Abnormal aggressive, impulsive or violent behavior, Aggressive behavior, Irritabi... ORPHA:3077
Stiff Person Spectrum Disorder
Emotional lability, Anxiety, Agoraphobia, Exaggerated startle response ORPHA:3198
Gm2 Gangliosidosis, Ab Variant
Dystonia, Anxiety, Inappropriate behavior, Exaggerated startle response, Abnormal fear/anxiety-re... ORPHA:309246
Hyperekplexia-Epilepsy Syndrome
EEG with temporal focal spikes, Exaggerated startle response ORPHA:163985
Hyperekplexia 3
Exaggerated startle response OMIM:614618
Stiff-Person Syndrome
Opisthotonus, Anxiety, Exaggerated startle response, Depression, Agoraphobia OMIM:184850
Developmental And Epileptic Encephalopathy 8
Exaggerated startle response OMIM:300607
Aromatic L-Amino Acid Decarboxylase Deficiency
Oculogyric crisis, Blepharospasm, Athetosis, Limb dystonia, Emotional lability, Irritability, Lim... OMIM:608643
Huntington Disease
Suicidal ideation, Dystonia, Disinhibition, Anxiety, Aggressive behavior, Apathy, Irritability, H... ORPHA:399
Tay-Sachs Disease
Apathy, Exaggerated startle response OMIM:272800
Gm2-Gangliosidosis, Ab Variant
Apathy, Dystonia, Exaggerated startle response OMIM:272750
Hyperekplexia 2
Exaggerated startle response OMIM:614619
Developmental And Epileptic Encephalopathy 68
Exaggerated startle response OMIM:618201
Asparagine Synthetase Deficiency
Exaggerated startle response, Hypsarrhythmia OMIM:615574
Neurodevelopmental Disorder With Microcephaly, Epilepsy, And Hypomyelination
Exaggerated startle response OMIM:618367
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To A Point Mutation
Anxiety, Dystonia, Exaggerated startle response ORPHA:438216
Spastic Tetraplegia And Axial Hypotonia, Progressive
Exaggerated startle response OMIM:618598
Tay-Sachs Disease
Dystonia, Anxiety, Laryngeal dystonia, Exaggerated startle response, Depression, Tremor ORPHA:845
Hyperekplexia 1
Exaggerated startle response OMIM:149400
Spastic Paraplegia, Optic Atrophy, And Neuropathy
Exaggerated startle response OMIM:609541
Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome
Exaggerated startle response ORPHA:320406
Plaa-Associated Neurodevelopmental Disorder
Exaggerated startle response, Dystonia, Hypsarrhythmia ORPHA:521426
Glycine Encephalopathy With Normal Serum Glycine
Exaggerated startle response OMIM:617301
Sandhoff Disease
Exaggerated startle response OMIM:268800
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
Exaggerated startle response OMIM:253800
Gm1 Gangliosidosis Type 1
Exaggerated startle response ORPHA:79255
Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies
Exaggerated startle response OMIM:617527
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Dystonia, Exaggerated startle response ORPHA:438213
Neurodevelopmental-Craniofacial Syndrome With Variable Renal And Cardiac Abnormalities
Exaggerated startle response OMIM:619522


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Slc2a3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Slc2a3.

There are 4 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth. eLife (June 2020) Slc2a3tm1a(KOMP)Wtsi PMC7311173
Glucose Metabolism Is Required for Platelet Hyperactivation in a Murine Model of Type 1 Diabetes. Diabetes (February 2019) Slc2a3tm1c(KOMP)Wtsi PMC6477909
Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell reports (July 2017) Slc2a3tm1c(KOMP)Wtsi PMC5600478
Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation. Arteriosclerosis, thrombosis, and vascular biology (June 2017) Slc2a3tm1c(KOMP)Wtsi PMC5570649

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MGI Allele Allele Type Produced
Slc2a3tm189959(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Slc2a3tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Slc2a3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Slc2a3tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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