Gad2 | glutamic acid decarboxylase 2

GeneMGI:95634Synonyms: GAD(65), Gad-2, +2 more

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Nervous system Behavior/neurological

15 No significant impact

6 Not tested

Gene metrics:13Significant phenotypes
0Associated diseases
Expression examined in:70Adult tissues
0Embryo tissues

Phenotypes

increased thigmotaxis2 supporting datasetsGad2tm1b(EUCOMM)WtsihomozygoteEarly adult7.69x10-6 
decreased locomotor activity2 supporting datasetsGad2tm1b(EUCOMM)WtsihomozygoteEarly adult1.64x10-8 
decreased exploration in new environment1 supporting datasetGad2tm1b(EUCOMM)WtsihomozygoteEarly adult1.63x10-7 
increased circulating chloride level1 supporting datasetGad2tm1b(EUCOMM)WtsihomozygoteEarly adult1.83x10-6 
increased circulating sodium level1 supporting datasetGad2tm1b(EUCOMM)WtsihomozygoteEarly adult5.21x10-6 
increased fasting circulating glucose level1 supporting datasetGad2tm1b(EUCOMM)WtsihomozygoteEarly adult5.13x10-6 
impaired glucose tolerance1 supporting datasetGad2tm1b(EUCOMM)WtsihomozygoteEarly adult1.01x10-6 
increased circulating alkaline phosphatase level1 supporting datasetGad2tm1b(EUCOMM)WtsihomozygoteEarly adult6.83x10-7 
increased vertical activity1 supporting datasetGad2tm1b(EUCOMM)WtsihomozygoteEarly adult1.64x10-7 
abnormal behavior1 supporting datasetGad2tm1b(EUCOMM)WtsihomozygoteEarly adult7.68x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Gad2tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Gad2tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Gad2tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse

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