Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
fibronectin 1
Synonyms:
Fn-1,  Fn

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Fn1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Fn1 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Fibronectin Glomerulopathy
Hypoalbuminemia ORPHA:84090
Spondylometaphyseal Dysplasia, 'Corner Fracture' Type
Tetralogy of Fallot, Mild short stature ORPHA:93315
Spondylometaphyseal Dysplasia, Corner Fracture Type
Short stature OMIM:184255
Glomerulopathy With Fibronectin Deposits 2
Hypertension OMIM:601894

The table below shows human diseases predicted to be associated to Fn1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Proliferating Trichilemmal Cyst
Epidermoid cyst, Skin ulcer ORPHA:492
Non-Epidermolytic Palmoplantar Keratoderma
Papule, Skin ulcer, Erythema ORPHA:2337
Chilblain Lupus 1
Skin ulcer OMIM:610448
Laryngoonychocutaneous Syndrome
Skin ulcer OMIM:245660
Dermatofibrosarcoma Protuberans
Subcutaneous nodule, Skin ulcer, Erythema ORPHA:31112
Hyperkeratosis Lenticularis Perstans
Papule, Aplasia/Hypoplasia of the skin, Skin ulcer ORPHA:409
Necrobiosis Lipoidica
Indurated nodule, Annular cutaneous lesion, Atrophic scars, Skin plaque, Erythema, Papule, Skin u... ORPHA:542592
Aplasia Cutis Congenita
Aplasia cutis congenita over the scalp vertex, Skin ulcer, Congenital localized absence of skin ORPHA:1114
Juvenile Hyaline Fibromatosis
Subcutaneous nodule, Aplasia/Hypoplasia of the skin, Papule, Skin ulcer ORPHA:2028
Severe Hereditary Thrombophilia Due To Congenital Protein S Deficiency
Thin skin, Aplasia/Hypoplasia of the skin, Skin ulcer, Purpura ORPHA:743
Buerger Disease
Skin ulcer ORPHA:36258
Dracunculiasis
Subcutaneous nodule, Skin ulcer ORPHA:231
Acrogeria
Thin skin, Aplasia/Hypoplasia of the skin, Excessive wrinkled skin, Skin ulcer ORPHA:2500
Familial Keratoacanthoma
Subcutaneous nodule, Papule, Skin ulcer ORPHA:493
Aplasia Cutis-Myopia Syndrome
Aplasia cutis congenita, Skin ulcer ORPHA:1117
Classic Mycosis Fungoides
Skin plaque, Erythema, Hypopigmented skin patches, Skin ulcer, Dry skin ORPHA:2584
Mutilating Hereditary Sensory Neuropathy With Spastic Paraplegia
Acral ulceration, Skin ulcer ORPHA:139578
Congenital Factor Xii Deficiency
Penetrating foot ulcers ORPHA:330
Lichen Planopilaris
Dermal atrophy, Papule, Skin ulcer, Hypopigmented skin patches ORPHA:525
Cervical Hypertrichosis-Peripheral Neuropathy Syndrome
Skin ulcer ORPHA:2218
Neuropathy, Hereditary Sensory And Autonomic, Type Ic
Skin ulcer OMIM:613640
Chilblain Lupus
Erythematous papule, Skin ulcer ORPHA:90280
Dermatoosteolysis, Kirghizian Type
Skin ulcer OMIM:221810
Subcutaneous Panniculitis-Like T-Cell Lymphoma
Erythematous papule, Erythematous plaque, Skin ulcer ORPHA:86884
Limited Cutaneous Systemic Sclerosis
Skin ulcer, Hypopigmented skin patches ORPHA:220402
Pyoderma Gangrenosum
Atrophic scars, Skin vesicle, Papule, Skin ulcer ORPHA:48104
Brooke-Spiegler Syndrome
Skin-colored papule, Nodular changes affecting the eyelids, Skin ulcer, Skin nodule ORPHA:79493
Familial Multiple Nevi Flammei
Nevus flammeus, Papule, Hypermelanotic macule, Skin ulcer ORPHA:624
Ollier Disease
Subcutaneous nodule, Skin ulcer ORPHA:296
Autosomal Dominant Epidermolytic Ichthyosis
Skin ulcer ORPHA:312
Bare Lymphocyte Syndrome, Type I
Skin ulcer OMIM:604571
Leishmaniasis
Papule, Skin plaque, Pallor, Skin ulcer ORPHA:507
Polyarteritis Nodosa
Subcutaneous nodule, Skin ulcer, Erythema ORPHA:767
Reticular Dysgenesis
Skin ulcer ORPHA:33355
Attenuated Chédiak-Higashi Syndrome
Skin ulcer ORPHA:352723
Combined Immunodeficiency Due To Dock8 Deficiency
Skin ulcer ORPHA:217390
Beta-Thalassemia
Pallor, Skin ulcer ORPHA:848
Flynn-Aird Syndrome
Dermal atrophy, Skin ulcer ORPHA:2047
Dermatoosteolysis, Kirghizian Type
Aplasia/Hypoplasia of the skin, Skin ulcer ORPHA:1657
Adult Polyglucosan Body Disease
Skin ulcer ORPHA:206583
Immunodeficiency, Common Variable, 12, With Autoimmunity
Pyoderma gangrenosum OMIM:616576
Calciphylaxis
Skin ulcer ORPHA:280062
Pyogenic Arthritis-Pyoderma Gangrenosum-Acne Syndrome
Skin ulcer ORPHA:69126
Squamous Cell Carcinoma Of The Anal Canal
Skin ulcer ORPHA:424019
Acquired Purpura Fulminans
Macular purpura, Macule, Pyoderma gangrenosum, Erythematous macule ORPHA:49566
Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne
Pyoderma gangrenosum OMIM:604416
Isolated Agammaglobulinemia
Skin ulcer ORPHA:229717
Takayasu Arteritis
Subcutaneous nodule, Skin ulcer ORPHA:3287
Meige Disease
Atypical scarring of skin, Skin dimple, Skin ulcer, Skin erosion ORPHA:90186
Prolidase Deficiency
Thin skin, Erythema, Aplasia/Hypoplasia of the skin, Papule, Skin ulcer, Dry skin ORPHA:742
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques
Skin fissure, Skin ulcer, Erythema ORPHA:659
Infantile Myofibromatosis
Subcutaneous nodule, Skin ulcer ORPHA:2591
Cryoglobulinemic Vasculitis
Petechiae, Skin ulcer, Purpura ORPHA:91138
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome
Pyoderma gangrenosum OMIM:150550
Neutrophilic Dermatosis, Acute Febrile
Pyoderma gangrenosum, Erythema OMIM:608068
X-Linked Agammaglobulinemia
Skin ulcer, Hypopigmented skin patches ORPHA:47
Free Sialic Acid Storage Disease
Skin ulcer ORPHA:834
Charcot-Marie-Tooth Disease, Guadalajara Neuronal Type
Penetrating foot ulcers OMIM:118230
Chronic Granulomatous Disease
Macule, Hypermelanotic macule, Skin ulcer ORPHA:379
Autosomal Dominant Hyper-Ige Syndrome
Papule, Skin vesicle, Skin ulcer ORPHA:2314
Anemia, Congenital Dyserythropoietic, Type Iv
Reticulocytosis, Erythroid hyperplasia, Splenomegaly, Anemia, Anemia of inadequate production, Hy... OMIM:613673
Adult Syndrome
Thin skin, Melanocytic nevus, Skin ulcer, Dry skin ORPHA:978
Prolidase Deficiency
Petechiae, Skin ulcer OMIM:170100
Diamond-Blackfan Anemia 16
Pulmonic stenosis, Atrial septal defect, Anemia OMIM:617408
Eosinophilia, Familial
Leukocytosis, Thrombocytopenia, Anemia, Eosinophilia, Myocardial eosinophilic infiltration OMIM:131400
Reynolds Syndrome
Skin ulcer ORPHA:779
Livedoid Vasculopathy
Ecchymosis, Atrophic scars, Erythematous papule, Macular purpura, Skin ulcer ORPHA:542643
Chronic Mucocutaneous Candidiasis
Papule, Skin ulcer, Erythema ORPHA:1334
Charcot-Marie-Tooth Disease With Ptosis And Parkinsonism
Penetrating foot ulcers OMIM:118301
Ectodermal Dysplasia-Blindness Syndrome
Skin ulcer ORPHA:1806
Microscopic Polyangiitis
Subcutaneous nodule, Skin ulcer, Erythema ORPHA:727
Leukocyte Adhesion Deficiency, Type I
Skin ulcer OMIM:116920
Peripartum Cardiomyopathy
Abnormal T-wave, Anemia, Myocarditis, Pulmonary arterial hypertension, Abnormal cardiac atrium mo... ORPHA:563
Infantile Systemic Hyalinosis
Subcutaneous nodule, Skin ulcer ORPHA:2176
Acrodermatitis Enteropathica
Dry skin, Skin ulcer, Erythema ORPHA:37
Hereditary Spherocytosis
Pallor, Skin ulcer ORPHA:822
Diffuse Cutaneous Systemic Sclerosis
Skin ulcer ORPHA:220393
Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency
Chronic hemolytic anemia, Reticulocytosis, Abnormal erythrocyte morphology, Congenital hemolytic ... ORPHA:766
Beta-Thalassemia Intermedia
Pallor, Skin ulcer ORPHA:231222
Neuropathy, Hereditary Sensory And Autonomic, Type Iib
Acral ulceration OMIM:613115
Hidrotic Ectodermal Dysplasia
Skin ulcer ORPHA:189
Neonatal Lupus Erythematosus
Heart block, Hemolytic anemia, Abnormal electrophysiology of sinoatrial node origin, Arrhythmia, ... ORPHA:398124
Sweet Syndrome
Erythematous papule, Pyoderma gangrenosum, Erythematous plaque, Skin vesicle, Skin nodule ORPHA:3243
Werner Syndrome
Lack of skin elasticity, Aplasia/Hypoplasia of the skin, Skin ulcer ORPHA:902
Autosomal Dominant Severe Congenital Neutropenia
Pyoderma gangrenosum ORPHA:486
Fusariosis
Subcutaneous nodule, Skin detachment, Papule, Skin ulcer ORPHA:228119
Hereditary Acrokeratotic Poikiloderma
Thin skin, Erythema, Hypopigmented skin patches, Papule, Skin ulcer ORPHA:2907
Malakoplakia
Subcutaneous nodule, Papule, Skin ulcer ORPHA:556
Juvenile Dermatomyositis
Dry skin, Skin ulcer, Erythema ORPHA:93672
Dominant Beta-Thalassemia
Pallor, Skin ulcer ORPHA:231226
Giant Cell Arteritis
Skin ulcer ORPHA:397
Neutropenia, Severe Congenital, 4, Autosomal Recessive
Erythroid hypoplasia, Monocytosis, Atrial septal defect, Lymphopenia, Patent ductus arteriosus, N... OMIM:612541
Neuropathy, Hereditary Sensory And Autonomic, Type V
Acral ulceration OMIM:608654
Catastrophic Antiphospholipid Syndrome
Skin ulcer ORPHA:464343
Immunoglobulin A Vasculitis
Purpura, Macule, Skin ulcer, Erythema ORPHA:761
Hb Bart'S Hydrops Fetalis
Pericarditis, Congestive heart failure, Anemia, Splenomegaly, Abnormal hemoglobin, Hydrocephalus ORPHA:163596
Dyskeratosis Congenita
Macule, Aplasia/Hypoplasia of the skin, Hypopigmented skin patches, Skin vesicle, Hypermelanotic ... ORPHA:1775
Blau Syndrome
Intermittent generalized erythematous papular rash, Skin ulcer OMIM:186580
Beta-Thalassemia Major
Pallor, Skin ulcer ORPHA:231214
Parkes Weber Syndrome
Scaling skin, Erythematous plaque, Skin ulcer, Capillary malformation ORPHA:90307
Kid Syndrome
Macule, Skin ulcer, Erythema ORPHA:477
Toxic Epidermal Necrolysis
Macule, Skin ulcer, Erythema ORPHA:537
Incontinentia Pigmenti
Hypopigmented skin patches, Skin ulcer, Erythema ORPHA:464
Dermatomyositis
Erythema, Aplasia/Hypoplasia of the skin, Papule, Skin ulcer, Dry skin ORPHA:221
Amoebiasis Due To Free-Living Amoebae
Subcutaneous nodule, Papule, Skin ulcer ORPHA:68
Systemic Sclerosis
Spotty hypopigmentation, Acral ulceration, Cutaneous sclerotic plaque, Digital ulcer, Digital pit... ORPHA:90291
Pgm3-Cdg
Skin ulcer ORPHA:443811
Granulomatosis With Polyangiitis
Skin ulcer OMIM:608710
Angioosteohypertrophic Syndrome
Melanocytic nevus, Hyperpigmented nevi, Skin ulcer ORPHA:2346
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Urticarial plaque, Skin ulcer, Purpura OMIM:615688
Adenocarcinoma Of The Anal Canal
Skin ulcer ORPHA:424016
Leprosy
Urticarial plaque, Verrucous papule, Hypopigmented macule, Penetrating foot ulcers, Acral ulcerat... ORPHA:548
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Subcutaneous nodule, Scaling skin, Skin ulcer, Dry skin ORPHA:2526
Diamond-Blackfan Anemia 10
Ventricular septal defect, Patent ductus arteriosus, Reticulocytopenia, Anemia, Congenital diaphr... OMIM:613309
Chime Syndrome
Skin ulcer, Erythema ORPHA:3474
Hajdu-Cheney Syndrome
Skin ulcer, Dry skin ORPHA:955
Granulomatosis With Polyangiitis
Papule, Skin ulcer, Purpura ORPHA:900
Primary Sjögren Syndrome
Dry skin, Lichenoid skin lesion, Skin ulcer, Purpura ORPHA:289390
Wiskott-Aldrich Syndrome
Petechiae, Skin ulcer, Purpura ORPHA:906
Oculocerebrorenal Syndrome Of Lowe
Atypical scarring of skin, Skin ulcer ORPHA:534
Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome
Skin ulcer, Ecchymosis ORPHA:2072
Idiopathic Aplastic Anemia
Neutropenia, Epistaxis, Reticulocytopenia, Thrombocytopenia, Pancytopenia, Anemia, Retinal hemorr... ORPHA:88
Blau Syndrome
Papule, Dry skin, Skin ulcer, Erythema ORPHA:90340
Chronic Graft Versus Host Disease
Skin vesicle, Intermittent generalized erythematous papular rash, Skin ulcer, Erythema ORPHA:99921
Atypical Werner Syndrome
Thin skin, Lack of skin elasticity, Aplasia/Hypoplasia of the skin, Skin ulcer ORPHA:79474
Plague
Localized skin lesion, Skin ulcer, Dry skin ORPHA:707
Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum
Atypical scarring of skin, Skin ulcer ORPHA:95455
Telangiectasia, Hereditary Hemorrhagic, Type 2
Conjunctival telangiectasia, Lip telangiectasia, Melena, Cerebral hemorrhage, Anemia, Pulmonary a... OMIM:600376
Leukocyte Adhesion Deficiency
Pyoderma gangrenosum ORPHA:2968
Split Cord Malformation
Skin dimple, Penetrating foot ulcers ORPHA:573278
Homozygous Familial Hypercholesterolemia
Myocardial steatosis, Calcification of the aorta, Premature coronary artery atherosclerosis, Aort... ORPHA:391665
Visceral Steatosis, Congenital
Neonatal death, Myocardial steatosis OMIM:228100
Fibronectin Glomerulopathy
Hypoalbuminemia ORPHA:84090
Spondylometaphyseal Dysplasia, 'Corner Fracture' Type
Tetralogy of Fallot, Mild short stature ORPHA:93315
Spondylometaphyseal Dysplasia, Corner Fracture Type
Short stature OMIM:184255
Glomerulopathy With Fibronectin Deposits 2
Hypertension OMIM:601894

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Fn1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Fn1.

No publications found that use IMPC mice or data for Fn1.

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MGI Allele Allele Type Produced
Fn1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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