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Gene: Fn1 MGI:95566

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
fibronectin 1
Synonyms:
Fn,  Fn-1

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Fn1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Fn1 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Fibronectin Glomerulopathy
Hypoalbuminemia ORPHA:84090
Spondylometaphyseal Dysplasia, 'Corner Fracture' Type
Iron deficiency anemia ORPHA:93315
Glomerulopathy With Fibronectin Deposits 2
Hypertension OMIM:601894
Spondylometaphyseal Dysplasia, Corner Fracture Type
Short stature OMIM:184255

The table below shows human diseases predicted to be associated to Fn1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Proliferating Trichilemmal Cyst
Skin ulcer, Epidermoid cyst ORPHA:492
Diffuse Palmoplantar Keratoderma, Bothnian Type
Erythema, Papule, Skin ulcer ORPHA:2337
Immunodeficiency 107, Susceptibility To Invasive Staphylococcus Aureus Infection
Pyoderma gangrenosum OMIM:619986
Dermatofibrosarcoma Protuberans
Erythema, Subcutaneous nodule, Skin ulcer ORPHA:31112
Congenital Factor Xii Deficiency
Penetrating foot ulcers ORPHA:330
Hyperkeratosis Lenticularis Perstans
Aplasia/Hypoplasia of the skin, Papule, Skin ulcer ORPHA:409
Necrobiosis Lipoidica
Erythema, Indurated nodule, Skin ulcer, Skin nodule, Atrophic scars, Skin plaque, Papule, Annular... ORPHA:542592
Aplasia Cutis Congenita
Erythema, Skin ulcer, Aplasia cutis congenita, Aplasia cutis congenita over the scalp vertex, Con... ORPHA:1114
Juvenile Hyaline Fibromatosis
Aplasia/Hypoplasia of the skin, Subcutaneous nodule, Papule, Skin ulcer ORPHA:2028
Chilblain Lupus 1
Skin ulcer OMIM:610448
Aplasia Cutis-Myopia Syndrome
Aplasia cutis congenita, Skin ulcer ORPHA:1117
Neuropathy, Hereditary Sensory, Type Iic
Acral ulceration OMIM:614213
Severe Hereditary Thrombophilia Due To Congenital Protein S Deficiency
Aplasia/Hypoplasia of the skin, Purpura, Skin ulcer, Thin skin ORPHA:743
Dracunculiasis
Subcutaneous nodule, Skin ulcer ORPHA:231
Acrogeria
Aplasia/Hypoplasia of the skin, Skin ulcer, Excessive wrinkled skin, Thin skin ORPHA:2500
Familial Keratoacanthoma
Subcutaneous nodule, Papule, Skin ulcer ORPHA:493
Classic Mycosis Fungoides
Erythema, Skin ulcer, Hypopigmented skin patches, Dry skin, Skin plaque ORPHA:2584
Mutilating Hereditary Sensory Neuropathy With Spastic Paraplegia
Acral ulceration, Skin ulcer ORPHA:139578
Cervical Hypertrichosis-Peripheral Neuropathy Syndrome
Skin ulcer ORPHA:2218
Lichen Planopilaris
Dermal atrophy, Papule, Skin ulcer, Hypopigmented skin patches ORPHA:525
Buerger Disease
Skin ulcer ORPHA:36258
Chilblain Lupus
Erythematous papule, Skin ulcer ORPHA:90280
Brooke-Spiegler Syndrome
Skin nodule, Skin-colored papule, Skin ulcer, Nodular changes affecting the eyelids ORPHA:79493
Limited Cutaneous Systemic Sclerosis
Skin ulcer, Hypopigmented skin patches ORPHA:220402
Subcutaneous Panniculitis-Like T-Cell Lymphoma
Erythematous plaque, Erythematous papule, Skin ulcer ORPHA:86884
Pyoderma Gangrenosum
Atrophic scars, Papule, Skin vesicle, Skin ulcer ORPHA:48104
Ollier Disease
Subcutaneous nodule, Skin ulcer ORPHA:296
Autosomal Dominant Epidermolytic Ichthyosis
Skin ulcer ORPHA:312
Familial Multiple Nevi Flammei
Papule, Skin ulcer, Hypermelanotic macule, Nevus flammeus ORPHA:624
Mhc Class I Deficiency 1
Skin ulcer OMIM:604571
Leishmaniasis
Skin plaque, Papule, Pallor, Skin ulcer ORPHA:507
Reticular Dysgenesis
Skin ulcer ORPHA:33355
Hemoglobin D Disease
Reduced beta/alpha synthesis ratio, Reduced hemoglobin A, Imbalanced hemoglobin synthesis, Spleno... ORPHA:90039
Neuropathy, Hereditary Sensory And Autonomic, Type Iib
Acral ulceration OMIM:613115
Polyarteritis Nodosa
Erythema, Subcutaneous nodule, Skin ulcer ORPHA:767
Hereditary Sensory And Autonomic Neuropathy Type 1
Skin ulcer, Penetrating foot ulcers ORPHA:36386
Disabling Pansclerotic Morphea Of Childhood
Skin ulcer OMIM:620443
Flynn-Aird Syndrome
Dermal atrophy, Skin ulcer ORPHA:2047
Combined Immunodeficiency Due To Dock8 Deficiency
Skin ulcer ORPHA:217390
Adult Polyglucosan Body Disease
Skin ulcer ORPHA:206583
Beta-Thalassemia
Pallor, Skin ulcer ORPHA:848
Attenuated Chédiak-Higashi Syndrome
Skin ulcer ORPHA:352723
Acquired Purpura Fulminans
Pyoderma gangrenosum, Macular purpura, Macule, Erythematous macule ORPHA:49566
Neuropathy, Hereditary Sensory And Autonomic, Type Ic
Skin ulcer OMIM:613640
Isolated Agammaglobulinemia
Skin ulcer ORPHA:229717
Immunodeficiency 114, Folate-Responsive
Skin ulcer OMIM:620603
Papa Syndrome
Skin ulcer ORPHA:69126
Dermatoosteolysis, Kirghizian Type
Aplasia/Hypoplasia of the skin, Skin ulcer ORPHA:1657
Squamous Cell Carcinoma Of The Anal Canal
Skin ulcer ORPHA:424019
Immunodeficiency, Common Variable, 12, With Autoimmunity
Pyoderma gangrenosum OMIM:616576
Free Sialic Acid Storage Disease
Skin ulcer ORPHA:834
Calciphylaxis
Skin ulcer ORPHA:280062
Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne
Pyoderma gangrenosum OMIM:604416
Prolidase Deficiency
Erythema, Skin ulcer, Dry skin, Aplasia/Hypoplasia of the skin, Papule, Thin skin ORPHA:742
Takayasu Arteritis
Subcutaneous nodule, Skin ulcer ORPHA:3287
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques
Erythema, Skin ulcer, Skin fissure ORPHA:659
Meige Disease
Atypical scarring of skin, Skin ulcer, Skin erosion, Skin dimple ORPHA:90186
Infantile Myofibromatosis
Subcutaneous nodule, Skin ulcer ORPHA:2591
Cryoglobulinemic Vasculitis
Petechiae, Purpura, Skin ulcer ORPHA:91138
Acute Radiation Syndrome
Dermal atrophy, Skin ulcer, Scaling skin ORPHA:454831
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome
Pyoderma gangrenosum OMIM:150550
Prolidase Deficiency
Petechiae, Skin ulcer OMIM:170100
X-Linked Agammaglobulinemia
Skin ulcer, Hypopigmented skin patches ORPHA:47
Neutrophilic Dermatosis, Acute Febrile
Pyoderma gangrenosum, Erythema OMIM:608068
Epidermolysis Bullosa, Junctional 2C, Laryngoonychocutaneous
Skin ulcer OMIM:245660
Chronic Granulomatous Disease
Hypermelanotic macule, Skin ulcer, Macule ORPHA:379
Autosomal Dominant Hyper-Ige Syndrome Due To Stat3 Deficiency
Skin vesicle, Papule, Skin ulcer ORPHA:2314
Chronic Mucocutaneous Candidiasis
Erythema, Papule, Skin ulcer ORPHA:1334
Adult Syndrome
Dry skin, Melanocytic nevus, Skin ulcer, Thin skin ORPHA:978
Neuropathy, Hereditary Sensory And Autonomic, Type Ia
Acral ulceration OMIM:162400
Attrv122I Amyloidosis
Aortic valve stenosis, Abnormal atrioventricular conduction, Restrictive cardiomyopathy, Congesti... ORPHA:85451
Reynolds Syndrome
Skin ulcer ORPHA:779
Livedoid Vasculopathy
Erythematous papule, Skin ulcer, Macular purpura, Atrophic scars, Ecchymosis ORPHA:542643
Ectodermal Dysplasia-Blindness Syndrome
Skin ulcer ORPHA:1806
Acrodermatitis Enteropathica
Erythema, Skin ulcer, Dry skin ORPHA:37
Hydrops, Lactic Acidosis, And Sideroblastic Anemia
Second degree atrioventricular block, Increased mean corpuscular volume, Extramedullary hematopoi... OMIM:617021
Microscopic Polyangiitis
Erythema, Subcutaneous nodule, Skin ulcer ORPHA:727
Werner Syndrome
Aplasia/Hypoplasia of the skin, Skin ulcer, Lack of skin elasticity ORPHA:902
Peripartum Cardiomyopathy
Abnormal cardiac atrium morphology, Mitral regurgitation, Elevated jugular venous pressure, Left ... ORPHA:563
Diffuse Cutaneous Systemic Sclerosis
Skin ulcer ORPHA:220393
Infantile Systemic Hyalinosis
Subcutaneous nodule, Skin ulcer ORPHA:2176
Hereditary Spherocytosis
Pallor, Skin ulcer ORPHA:822
Beta-Thalassemia Intermedia
Pallor, Skin ulcer ORPHA:231222
Autosomal Dominant Severe Congenital Neutropenia
Pyoderma gangrenosum ORPHA:486
Neuropathy, Hereditary Sensory And Autonomic, Type Iia
Acral ulceration OMIM:201300
Malakoplakia
Subcutaneous nodule, Papule, Skin ulcer ORPHA:556
Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency
Reduced red cell pyruvate kinase level, Congenital hemolytic anemia, Abnormal erythrocyte morphol... ORPHA:766
Hereditary Acrokeratotic Poikiloderma
Erythema, Skin ulcer, Hypopigmented skin patches, Papule, Thin skin ORPHA:2907
Fusariosis
Subcutaneous nodule, Papule, Skin detachment, Skin ulcer ORPHA:228119
Sweet Syndrome
Erythematous papule, Erythematous plaque, Skin vesicle, Pyoderma gangrenosum, Skin nodule ORPHA:3243
Neuropathy, Hereditary Sensory, With Spastic Paraplegia, Autosomal Recessive
Acral ulceration OMIM:256840
Catastrophic Antiphospholipid Syndrome
Skin ulcer ORPHA:464343
Dyskeratosis Congenita
Skin ulcer, Hypopigmented skin patches, Skin vesicle, Aplasia/Hypoplasia of the skin, Macule, Hyp... ORPHA:1775
Immunoglobulin A Vasculitis
Erythema, Purpura, Macule, Skin ulcer ORPHA:761
Alpha-Thalassemia
Extramedullary hematopoiesis, Congestive heart failure, Microcytic anemia, Hemoglobin Barts, Hype... ORPHA:846
Dominant Beta-Thalassemia
Pallor, Skin ulcer ORPHA:231226
Anemia, Congenital Dyserythropoietic, Type Iv
Increased RBC distribution width, Persistence of hemoglobin F, Hypertrophic cardiomyopathy, Hepat... OMIM:613673
Giant Cell Arteritis
Skin ulcer ORPHA:397
Leukocyte Adhesion Deficiency, Type I
Skin ulcer OMIM:116920
Juvenile Dermatomyositis
Erythema, Skin ulcer, Dry skin ORPHA:93672
Neuropathy, Hereditary Sensory And Autonomic, Type V
Acral ulceration OMIM:608654
Toxic Epidermal Necrolysis
Erythema, Skin ulcer, Macule ORPHA:537
Parkes Weber Syndrome
Capillary malformation, Erythematous plaque, Skin ulcer, Scaling skin ORPHA:90307
Hb Bart'S Hydrops Fetalis
Congestive heart failure, Abnormal hemoglobin, Splenomegaly, Hydrocephalus, Anemia, Pericarditis ORPHA:163596
Incontinentia Pigmenti
Erythema, Skin ulcer, Hypopigmented skin patches ORPHA:464
Beta-Thalassemia Major
Pallor, Skin ulcer ORPHA:231214
Hereditary Elliptocytosis
Skin ulcer ORPHA:288
Blau Syndrome
Intermittent generalized erythematous papular rash, Skin ulcer OMIM:186580
Pgm3-Cdg
Skin ulcer ORPHA:443811
Granulomatosis With Polyangiitis
Skin ulcer OMIM:608710
Systemic Sclerosis
Digital ulcer, Acral ulceration, Spotty hypopigmentation, Cutaneous sclerotic plaque, Digital pit... ORPHA:90291
Dermatomyositis
Erythema, Skin ulcer, V-sign, Dry skin, Aplasia/Hypoplasia of the skin, Facial erythema, Gottron'... ORPHA:221
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Purpura, Skin ulcer, Urticarial plaque OMIM:615688
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Dry skin, Subcutaneous nodule, Skin ulcer, Scaling skin ORPHA:2526
Amoebiasis Due To Free-Living Amoebae
Subcutaneous nodule, Papule, Skin ulcer ORPHA:68
Adenocarcinoma Of The Anal Canal
Skin ulcer ORPHA:424016
Charcot-Marie-Tooth Disease Type 4B2
Penetrating foot ulcers ORPHA:99956
Leprosy
Penetrating foot ulcers, Hypopigmented macule, Urticarial plaque, Acral ulceration, Verrucous pap... ORPHA:548
Insensitivity To Pain, Congenital, With Anhidrosis
Acral ulceration OMIM:256800
Wiskott-Aldrich Syndrome
Petechiae, Purpura, Skin ulcer ORPHA:906
Hajdu-Cheney Syndrome
Dry skin, Skin ulcer ORPHA:955
Chime Syndrome
Erythema, Skin ulcer ORPHA:3474
Granulomatosis With Polyangiitis
Papule, Purpura, Skin ulcer ORPHA:900
Cushing Disease
Skin ulcer, Striae distensae, Ecchymosis, Purpura, Thin skin ORPHA:96253
Simple Cryoglobulinemia
Localized skin lesion, Purpura, Acral ulceration ORPHA:91139
Primary Sjögren Syndrome
Dry skin, Purpura, Lichenoid skin lesion, Skin ulcer ORPHA:289390
Oculocerebrorenal Syndrome Of Lowe
Atypical scarring of skin, Skin ulcer ORPHA:534
Blau Syndrome
Erythema, Papule, Skin ulcer, Dry skin ORPHA:90340
Chronic Graft Versus Host Disease
Erythema, Intermittent generalized erythematous papular rash, Skin vesicle, Skin ulcer ORPHA:99921
Atypical Werner Syndrome
Aplasia/Hypoplasia of the skin, Lack of skin elasticity, Skin ulcer, Thin skin ORPHA:79474
Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome
Skin ulcer, Ecchymosis ORPHA:2072
Plague
Localized skin lesion, Skin ulcer, Dry skin ORPHA:707
Mitochondrial Dna Depletion Syndrome 6 (Hepatocerebral Type)
Acral ulceration OMIM:256810
Cushing Syndrome Due To Ectopic Acth Secretion
Skin ulcer, Striae distensae, Ecchymosis, Purpura, Thin skin ORPHA:99889
Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum
Atypical scarring of skin, Skin ulcer ORPHA:95455
Leukocyte Adhesion Deficiency
Pyoderma gangrenosum ORPHA:2968
Homozygous Familial Hypercholesterolemia
Tendon xanthomatosis, Premature coronary artery atherosclerosis, Abnormal tendon morphology, Aort... ORPHA:391665
Fibronectin Glomerulopathy
Hypoalbuminemia ORPHA:84090
Spondylometaphyseal Dysplasia, 'Corner Fracture' Type
Iron deficiency anemia ORPHA:93315
Glomerulopathy With Fibronectin Deposits 2
Hypertension OMIM:601894
Spondylometaphyseal Dysplasia, Corner Fracture Type
Short stature OMIM:184255

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Fn1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Fn1.

No publications found that use IMPC mice or data for Fn1.

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MGI Allele Allele Type Produced
Fn1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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