Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

fibronectin 1
Fn,  Fn-1

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Fn1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Fn1 by orthology or direct annotation.

Disease Similarity of
Matching phenotypes Source
Fibronectin Glomerulopathy
Hypoalbuminemia ORPHA:84090
Spondylometaphyseal Dysplasia, 'Corner Fracture' Type
Iron deficiency anemia ORPHA:93315
Spondylometaphyseal Dysplasia, Corner Fracture Type
Short stature OMIM:184255
Glomerulopathy With Fibronectin Deposits 2
Hypertension OMIM:601894

The table below shows human diseases predicted to be associated to Fn1 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Proliferating Trichilemmal Cyst
Skin ulcer, Epidermoid cyst ORPHA:492
Non-Epidermolytic Palmoplantar Keratoderma
Skin ulcer, Erythema, Papule ORPHA:2337
Epidermolysis Bullosa, Junctional 2C, Laryngoonychocutaneous
Skin ulcer OMIM:245660
Dermatofibrosarcoma Protuberans
Subcutaneous nodule, Skin ulcer, Erythema ORPHA:31112
Hyperkeratosis Lenticularis Perstans
Aplasia/Hypoplasia of the skin, Skin ulcer, Papule ORPHA:409
Congenital Factor Xii Deficiency
Penetrating foot ulcers ORPHA:330
Necrobiosis Lipoidica
Annular cutaneous lesion, Erythema, Papule, Atrophic scars, Skin nodule, Skin ulcer, Skin plaque,... ORPHA:542592
Chilblain Lupus 1
Skin ulcer OMIM:610448
Aplasia Cutis Congenita
Congenital localized absence of skin, Skin ulcer, Aplasia cutis congenita over the scalp vertex ORPHA:1114
Juvenile Hyaline Fibromatosis
Subcutaneous nodule, Skin ulcer, Aplasia/Hypoplasia of the skin, Papule ORPHA:2028
Severe Hereditary Thrombophilia Due To Congenital Protein S Deficiency
Aplasia/Hypoplasia of the skin, Skin ulcer, Purpura, Thin skin ORPHA:743
Buerger Disease
Skin ulcer ORPHA:36258
Subcutaneous nodule, Skin ulcer ORPHA:231
Aplasia Cutis-Myopia Syndrome
Skin ulcer, Aplasia cutis congenita ORPHA:1117
Skin ulcer, Excessive wrinkled skin, Aplasia/Hypoplasia of the skin, Thin skin ORPHA:2500
Familial Keratoacanthoma
Subcutaneous nodule, Skin ulcer, Papule ORPHA:493
Classic Mycosis Fungoides
Hypopigmented skin patches, Erythema, Skin ulcer, Skin plaque, Dry skin ORPHA:2584
Mutilating Hereditary Sensory Neuropathy With Spastic Paraplegia
Skin ulcer, Acral ulceration ORPHA:139578
Lichen Planopilaris
Skin ulcer, Dermal atrophy, Papule, Hypopigmented skin patches ORPHA:525
Cervical Hypertrichosis-Peripheral Neuropathy Syndrome
Skin ulcer ORPHA:2218
Chilblain Lupus
Skin ulcer, Erythematous papule ORPHA:90280
Dermatoosteolysis, Kirghizian Type
Skin ulcer OMIM:221810
Pyoderma Gangrenosum
Skin ulcer, Papule, Skin vesicle, Atrophic scars ORPHA:48104
Brooke-Spiegler Syndrome
Nodular changes affecting the eyelids, Skin nodule, Skin ulcer, Skin-colored papule ORPHA:79493
Limited Cutaneous Systemic Sclerosis
Skin ulcer, Hypopigmented skin patches ORPHA:220402
Subcutaneous Panniculitis-Like T-Cell Lymphoma
Skin ulcer, Erythematous papule, Erythematous plaque ORPHA:86884
Ollier Disease
Subcutaneous nodule, Skin ulcer ORPHA:296
Familial Multiple Nevi Flammei
Nevus flammeus, Skin ulcer, Papule, Hypermelanotic macule ORPHA:624
Bare Lymphocyte Syndrome, Type I
Skin ulcer OMIM:604571
Autosomal Dominant Epidermolytic Ichthyosis
Skin ulcer ORPHA:312
Hemoglobin D Disease
Reduced beta/alpha synthesis ratio, Decreased mean corpuscular hemoglobin concentration, Sickled ... ORPHA:90039
Pallor, Skin ulcer, Papule, Skin plaque ORPHA:507
Polyarteritis Nodosa
Subcutaneous nodule, Skin ulcer, Erythema ORPHA:767
Reticular Dysgenesis
Skin ulcer ORPHA:33355
Attenuated Chédiak-Higashi Syndrome
Skin ulcer ORPHA:352723
Combined Immunodeficiency Due To Dock8 Deficiency
Skin ulcer ORPHA:217390
Pallor, Skin ulcer ORPHA:848
Flynn-Aird Syndrome
Skin ulcer, Dermal atrophy ORPHA:2047
Hereditary Sensory And Autonomic Neuropathy Type 1
Skin ulcer, Penetrating foot ulcers ORPHA:36386
Neuropathy, Hereditary Sensory And Autonomic, Type Ic
Skin ulcer OMIM:613640
Dermatoosteolysis, Kirghizian Type
Skin ulcer, Aplasia/Hypoplasia of the skin ORPHA:1657
Adult Polyglucosan Body Disease
Skin ulcer ORPHA:206583
Acquired Purpura Fulminans
Macule, Pyoderma gangrenosum, Erythematous macule, Macular purpura ORPHA:49566
Skin ulcer ORPHA:280062
Isolated Agammaglobulinemia
Skin ulcer ORPHA:229717
Pyogenic Arthritis-Pyoderma Gangrenosum-Acne Syndrome
Skin ulcer ORPHA:69126
Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne
Pyoderma gangrenosum OMIM:604416
Squamous Cell Carcinoma Of The Anal Canal
Skin ulcer ORPHA:424019
Takayasu Arteritis
Subcutaneous nodule, Skin ulcer ORPHA:3287
Immunodeficiency, Common Variable, 12, With Autoimmunity
Pyoderma gangrenosum OMIM:616576
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques
Skin ulcer, Erythema, Skin fissure ORPHA:659
Prolidase Deficiency
Erythema, Papule, Thin skin, Skin ulcer, Aplasia/Hypoplasia of the skin, Dry skin ORPHA:742
Meige Disease
Skin ulcer, Skin dimple, Atypical scarring of skin, Skin erosion ORPHA:90186
Infantile Myofibromatosis
Subcutaneous nodule, Skin ulcer ORPHA:2591
Cryoglobulinemic Vasculitis
Skin ulcer, Petechiae, Purpura ORPHA:91138
Neutrophilic Dermatosis, Acute Febrile
Pyoderma gangrenosum, Erythema OMIM:608068
Charcot-Marie-Tooth Disease, Guadalajara Neuronal Type
Penetrating foot ulcers OMIM:118230
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome
Pyoderma gangrenosum OMIM:150550
X-Linked Agammaglobulinemia
Skin ulcer, Hypopigmented skin patches ORPHA:47
Free Sialic Acid Storage Disease
Skin ulcer ORPHA:834
Chronic Granulomatous Disease
Macule, Skin ulcer, Hypermelanotic macule ORPHA:379
Prolidase Deficiency
Skin ulcer, Petechiae OMIM:170100
Autosomal Dominant Hyper-Ige Syndrome
Skin ulcer, Papule, Skin vesicle ORPHA:2314
Adult Syndrome
Melanocytic nevus, Skin ulcer, Dry skin, Thin skin ORPHA:978
Diamond-Blackfan Anemia 16
Atrial septal defect, Anemia, Pulmonic stenosis OMIM:617408
Chronic Mucocutaneous Candidiasis
Skin ulcer, Erythema, Papule ORPHA:1334
Charcot-Marie-Tooth Disease With Ptosis And Parkinsonism
Penetrating foot ulcers OMIM:118301
Livedoid Vasculopathy
Macular purpura, Ecchymosis, Skin ulcer, Erythematous papule, Atrophic scars ORPHA:542643
Reynolds Syndrome
Skin ulcer ORPHA:779
Attrv122I Amyloidosis
Reduced ejection fraction, Arrhythmia, Congestive heart failure, Tendon rupture, Angina pectoris,... ORPHA:85451
Ectodermal Dysplasia-Blindness Syndrome
Skin ulcer ORPHA:1806
Peripartum Cardiomyopathy
Left ventricular systolic dysfunction, Sinus tachycardia, Left bundle branch block, Anemia, Hyper... ORPHA:563
Microscopic Polyangiitis
Subcutaneous nodule, Skin ulcer, Erythema ORPHA:727
Leukocyte Adhesion Deficiency, Type I
Skin ulcer OMIM:116920
Acrodermatitis Enteropathica
Skin ulcer, Erythema, Dry skin ORPHA:37
Infantile Systemic Hyalinosis
Subcutaneous nodule, Skin ulcer ORPHA:2176
Hereditary Spherocytosis
Pallor, Skin ulcer ORPHA:822
Diffuse Cutaneous Systemic Sclerosis
Skin ulcer ORPHA:220393
Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency
Splenomegaly, Anisocytosis, Reduced red cell pyruvate kinase level, Anemia, Chronic hemolytic ane... ORPHA:766
Beta-Thalassemia Intermedia
Pallor, Skin ulcer ORPHA:231222
Subcutaneous nodule, Skin ulcer, Papule ORPHA:556
Neonatal Lupus Erythematosus
Hydrocephalus, Dilated cardiomyopathy, Pancytopenia, Arrhythmia, Splenomegaly, Neutropenia, Abnor... ORPHA:398124
Autosomal Dominant Severe Congenital Neutropenia
Pyoderma gangrenosum ORPHA:486
Sweet Syndrome
Erythematous plaque, Skin vesicle, Pyoderma gangrenosum, Skin nodule, Erythematous papule ORPHA:3243
Anemia, Congenital Dyserythropoietic, Type Iv
Schistocytosis, Reticulocytosis, Circulating nucleated red blood cells, Hepatosplenomegaly, Poiki... OMIM:613673
Subcutaneous nodule, Skin ulcer, Papule, Skin detachment ORPHA:228119
Hereditary Acrokeratotic Poikiloderma
Hypopigmented skin patches, Erythema, Papule, Thin skin, Skin ulcer ORPHA:2907
Immunoglobulin A Vasculitis
Macule, Skin ulcer, Erythema, Purpura ORPHA:761
Catastrophic Antiphospholipid Syndrome
Skin ulcer ORPHA:464343
Dominant Beta-Thalassemia
Pallor, Skin ulcer ORPHA:231226
Juvenile Dermatomyositis
Skin ulcer, Erythema, Dry skin ORPHA:93672
Giant Cell Arteritis
Skin ulcer ORPHA:397
Neutropenia, Severe Congenital, 4, Autosomal Recessive
Leukopenia, Monocytosis, Patent ductus arteriosus, Atrial septal defect, Erythroid hypoplasia, Sp... OMIM:612541
Hb Bart'S Hydrops Fetalis
Congestive heart failure, Splenomegaly, Anemia, Hydrocephalus, Abnormal hemoglobin, Pericarditis ORPHA:163596
Werner Syndrome
Skin ulcer, Aplasia/Hypoplasia of the skin, Lack of skin elasticity ORPHA:902
Dyskeratosis Congenita
Hypopigmented skin patches, Macule, Hypermelanotic macule, Skin ulcer, Aplasia/Hypoplasia of the ... ORPHA:1775
Blau Syndrome
Skin ulcer, Intermittent generalized erythematous papular rash OMIM:186580
Beta-Thalassemia Major
Pallor, Skin ulcer ORPHA:231214
Parkes Weber Syndrome
Capillary malformation, Skin ulcer, Scaling skin, Erythematous plaque ORPHA:90307
Toxic Epidermal Necrolysis
Macule, Skin ulcer, Erythema ORPHA:537
Incontinentia Pigmenti
Skin ulcer, Erythema, Hypopigmented skin patches ORPHA:464
Granulomatosis With Polyangiitis
Skin ulcer OMIM:608710
Skin ulcer ORPHA:443811
Erythema, Papule, Skin ulcer, Aplasia/Hypoplasia of the skin, Dry skin ORPHA:221
Systemic Sclerosis
Digital pitting scar, Cutaneous sclerotic plaque, Acral ulceration, Spotty hypopigmentation, Digi... ORPHA:90291
Amoebiasis Due To Free-Living Amoebae
Subcutaneous nodule, Skin ulcer, Papule ORPHA:68
Angioosteohypertrophic Syndrome
Hyperpigmented nevi, Melanocytic nevus, Skin ulcer ORPHA:2346
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Skin ulcer, Purpura, Urticarial plaque OMIM:615688
Adenocarcinoma Of The Anal Canal
Skin ulcer ORPHA:424016
Penetrating foot ulcers, Hypopigmented macule, Acral ulceration, Skin nodule, Verrucous papule, U... ORPHA:548
Diamond-Blackfan Anemia 10
Patent ductus arteriosus, Steroid-responsive anemia, Congenital diaphragmatic hernia, Anemia, Ven... OMIM:613309
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Subcutaneous nodule, Skin ulcer, Scaling skin, Dry skin ORPHA:2526
Charcot-Marie-Tooth Disease Type 4B2
Penetrating foot ulcers ORPHA:99956
Hajdu-Cheney Syndrome
Skin ulcer, Dry skin ORPHA:955
Chime Syndrome
Skin ulcer, Erythema ORPHA:3474
Wiskott-Aldrich Syndrome
Skin ulcer, Petechiae, Purpura ORPHA:906
Cushing Disease
Ecchymosis, Striae distensae, Thin skin, Skin ulcer, Purpura ORPHA:96253
Granulomatosis With Polyangiitis
Skin ulcer, Purpura, Papule ORPHA:900
Primary Sjögren Syndrome
Skin ulcer, Purpura, Dry skin, Lichenoid skin lesion ORPHA:289390
Oculocerebrorenal Syndrome Of Lowe
Skin ulcer, Atypical scarring of skin ORPHA:534
Blau Syndrome
Skin ulcer, Erythema, Papule, Dry skin ORPHA:90340
Atypical Werner Syndrome
Skin ulcer, Aplasia/Hypoplasia of the skin, Lack of skin elasticity, Thin skin ORPHA:79474
Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome
Skin ulcer, Ecchymosis ORPHA:2072
Chronic Graft Versus Host Disease
Skin ulcer, Erythema, Skin vesicle, Intermittent generalized erythematous papular rash ORPHA:99921
Skin ulcer, Dry skin, Localized skin lesion ORPHA:707
Cushing Syndrome Due To Ectopic Acth Secretion
Ecchymosis, Striae distensae, Thin skin, Skin ulcer, Purpura ORPHA:99889
Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum
Skin ulcer, Atypical scarring of skin ORPHA:95455
Telangiectasia, Hereditary Hemorrhagic, Type 2
Nail bed telangiectasia, Gastrointestinal telangiectasia, Anemia, Hypertension, Hematemesis, Nasa... OMIM:600376
Leukocyte Adhesion Deficiency
Pyoderma gangrenosum ORPHA:2968
Split Cord Malformation
Skin dimple, Penetrating foot ulcers ORPHA:573278
Homozygous Familial Hypercholesterolemia
Abnormal tendon morphology, Premature arteriosclerosis, Cerebral artery atherosclerosis, Peripher... ORPHA:391665
Visceral Steatosis, Congenital
Neonatal death, Myocardial steatosis OMIM:228100
Fibronectin Glomerulopathy
Hypoalbuminemia ORPHA:84090
Spondylometaphyseal Dysplasia, 'Corner Fracture' Type
Iron deficiency anemia ORPHA:93315
Spondylometaphyseal Dysplasia, Corner Fracture Type
Short stature OMIM:184255
Glomerulopathy With Fibronectin Deposits 2
Hypertension OMIM:601894


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Fn1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Fn1.

No publications found that use IMPC mice or data for Fn1.

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MGI Allele Allele Type Produced
Fn1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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