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Gene: Fn1 MGI:95566

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
fibronectin 1
Synonyms:
Fn,  Fn-1

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Fn1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Fn1 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Fibronectin Glomerulopathy
Hypoalbuminemia ORPHA:84090
Spondylometaphyseal Dysplasia, 'Corner Fracture' Type
Iron deficiency anemia ORPHA:93315
Glomerulopathy With Fibronectin Deposits 2
Hypertension OMIM:601894
Spondylometaphyseal Dysplasia, Corner Fracture Type
Short stature OMIM:184255

The table below shows human diseases predicted to be associated to Fn1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Proliferating Trichilemmal Cyst
Skin ulcer, Epidermoid cyst ORPHA:492
Non-Epidermolytic Palmoplantar Keratoderma
Erythema, Skin ulcer, Papule ORPHA:2337
Immunodeficiency 107, Susceptibility To Invasive Staphylococcus Aureus Infection
Pyoderma gangrenosum OMIM:619986
Dermatofibrosarcoma Protuberans
Skin ulcer, Subcutaneous nodule, Erythema ORPHA:31112
Hyperkeratosis Lenticularis Perstans
Skin ulcer, Aplasia/Hypoplasia of the skin, Papule ORPHA:409
Congenital Factor Xii Deficiency
Penetrating foot ulcers ORPHA:330
Necrobiosis Lipoidica
Annular cutaneous lesion, Atrophic scars, Skin ulcer, Skin nodule, Papule, Skin plaque, Erythema,... ORPHA:542592
Chilblain Lupus 1
Skin ulcer OMIM:610448
Juvenile Hyaline Fibromatosis
Skin ulcer, Subcutaneous nodule, Aplasia/Hypoplasia of the skin, Papule ORPHA:2028
Aplasia Cutis Congenita
Congenital localized absence of skin, Aplasia cutis congenita over the scalp vertex, Skin ulcer ORPHA:1114
Aplasia Cutis-Myopia Syndrome
Skin ulcer, Aplasia cutis congenita ORPHA:1117
Severe Hereditary Thrombophilia Due To Congenital Protein S Deficiency
Thin skin, Skin ulcer, Purpura, Aplasia/Hypoplasia of the skin ORPHA:743
Buerger Disease
Skin ulcer ORPHA:36258
Dracunculiasis
Skin ulcer, Subcutaneous nodule ORPHA:231
Acrogeria
Thin skin, Skin ulcer, Aplasia/Hypoplasia of the skin, Excessive wrinkled skin ORPHA:2500
Familial Keratoacanthoma
Skin ulcer, Subcutaneous nodule, Papule ORPHA:493
Classic Mycosis Fungoides
Skin ulcer, Hypopigmented skin patches, Skin plaque, Erythema, Dry skin ORPHA:2584
Mutilating Hereditary Sensory Neuropathy With Spastic Paraplegia
Acral ulceration, Skin ulcer ORPHA:139578
Cervical Hypertrichosis-Peripheral Neuropathy Syndrome
Skin ulcer ORPHA:2218
Lichen Planopilaris
Dermal atrophy, Skin ulcer, Papule, Hypopigmented skin patches ORPHA:525
Chilblain Lupus
Erythematous papule, Skin ulcer ORPHA:90280
Brooke-Spiegler Syndrome
Nodular changes affecting the eyelids, Skin-colored papule, Skin ulcer, Skin nodule ORPHA:79493
Limited Cutaneous Systemic Sclerosis
Skin ulcer, Hypopigmented skin patches ORPHA:220402
Subcutaneous Panniculitis-Like T-Cell Lymphoma
Erythematous plaque, Erythematous papule, Skin ulcer ORPHA:86884
Pyoderma Gangrenosum
Skin vesicle, Atrophic scars, Skin ulcer, Papule ORPHA:48104
Ollier Disease
Skin ulcer, Subcutaneous nodule ORPHA:296
Familial Multiple Nevi Flammei
Hypermelanotic macule, Skin ulcer, Papule, Nevus flammeus ORPHA:624
Bare Lymphocyte Syndrome, Type I
Skin ulcer OMIM:604571
Autosomal Dominant Epidermolytic Ichthyosis
Skin ulcer ORPHA:312
Leishmaniasis
Skin plaque, Skin ulcer, Papule, Pallor ORPHA:507
Hemoglobin D Disease
Anemia, Reduced alpha/beta synthesis ratio, HbS hemoglobin, Increased HbA2 hemoglobin, Reduced he... ORPHA:90039
Polyarteritis Nodosa
Skin ulcer, Subcutaneous nodule, Erythema ORPHA:767
Reticular Dysgenesis
Skin ulcer ORPHA:33355
Flynn-Aird Syndrome
Dermal atrophy, Skin ulcer ORPHA:2047
Combined Immunodeficiency Due To Dock8 Deficiency
Skin ulcer ORPHA:217390
Adult Polyglucosan Body Disease
Skin ulcer ORPHA:206583
Attenuated Chédiak-Higashi Syndrome
Skin ulcer ORPHA:352723
Hereditary Sensory And Autonomic Neuropathy Type 1
Penetrating foot ulcers, Skin ulcer ORPHA:36386
Beta-Thalassemia
Skin ulcer, Pallor ORPHA:848
Acquired Purpura Fulminans
Macular purpura, Macule, Pyoderma gangrenosum, Erythematous macule ORPHA:49566
Neuropathy, Hereditary Sensory And Autonomic, Type Ic
Skin ulcer OMIM:613640
Calciphylaxis
Skin ulcer ORPHA:280062
Dermatoosteolysis, Kirghizian Type
Skin ulcer, Aplasia/Hypoplasia of the skin ORPHA:1657
Isolated Agammaglobulinemia
Skin ulcer ORPHA:229717
Squamous Cell Carcinoma Of The Anal Canal
Skin ulcer ORPHA:424019
Pyogenic Arthritis-Pyoderma Gangrenosum-Acne Syndrome
Skin ulcer ORPHA:69126
Free Sialic Acid Storage Disease
Skin ulcer ORPHA:834
Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne
Pyoderma gangrenosum OMIM:604416
Prolidase Deficiency
Thin skin, Skin ulcer, Papule, Aplasia/Hypoplasia of the skin, Erythema, Dry skin ORPHA:742
Takayasu Arteritis
Skin ulcer, Subcutaneous nodule ORPHA:3287
Immunodeficiency, Common Variable, 12, With Autoimmunity
Pyoderma gangrenosum OMIM:616576
Infantile Myofibromatosis
Skin ulcer, Subcutaneous nodule ORPHA:2591
Meige Disease
Skin dimple, Atypical scarring of skin, Skin ulcer, Skin erosion ORPHA:90186
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques
Skin fissure, Skin ulcer, Erythema ORPHA:659
Cryoglobulinemic Vasculitis
Skin ulcer, Purpura, Petechiae ORPHA:91138
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome
Pyoderma gangrenosum OMIM:150550
Neutrophilic Dermatosis, Acute Febrile
Pyoderma gangrenosum, Erythema OMIM:608068
X-Linked Agammaglobulinemia
Skin ulcer, Hypopigmented skin patches ORPHA:47
Epidermolysis Bullosa, Junctional 2C, Laryngoonychocutaneous
Skin ulcer OMIM:245660
Chronic Granulomatous Disease
Macule, Skin ulcer, Hypermelanotic macule ORPHA:379
Prolidase Deficiency
Skin ulcer, Petechiae OMIM:170100
Autosomal Dominant Hyper-Ige Syndrome
Skin vesicle, Skin ulcer, Papule ORPHA:2314
Adult Syndrome
Thin skin, Skin ulcer, Melanocytic nevus, Dry skin ORPHA:978
Diamond-Blackfan Anemia 16
Anemia, Pulmonic stenosis, Atrial septal defect OMIM:617408
Chronic Mucocutaneous Candidiasis
Papule, Skin ulcer, Erythema ORPHA:1334
Attrv122I Amyloidosis
Anemia, Restrictive cardiomyopathy, Reduced left ventricular ejection fraction, Abnormal EKG, Lef... ORPHA:85451
Reynolds Syndrome
Skin ulcer ORPHA:779
Livedoid Vasculopathy
Macular purpura, Atrophic scars, Skin ulcer, Ecchymosis, Erythematous papule ORPHA:542643
Ectodermal Dysplasia-Blindness Syndrome
Skin ulcer ORPHA:1806
Microscopic Polyangiitis
Skin ulcer, Subcutaneous nodule, Erythema ORPHA:727
Peripartum Cardiomyopathy
Sinus tachycardia, Cardiogenic shock, Palpitations, Elevated jugular venous pressure, Abnormal at... ORPHA:563
Werner Syndrome
Lack of skin elasticity, Skin ulcer, Aplasia/Hypoplasia of the skin ORPHA:902
Acrodermatitis Enteropathica
Skin ulcer, Dry skin, Erythema ORPHA:37
Infantile Systemic Hyalinosis
Skin ulcer, Subcutaneous nodule ORPHA:2176
Diffuse Cutaneous Systemic Sclerosis
Skin ulcer ORPHA:220393
Hereditary Spherocytosis
Skin ulcer, Pallor ORPHA:822
Beta-Thalassemia Intermedia
Skin ulcer, Pallor ORPHA:231222
Autosomal Dominant Severe Congenital Neutropenia
Pyoderma gangrenosum ORPHA:486
Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency
Anemia, Congenital hemolytic anemia, Reticulocytosis, Poikilocytosis, Abnormal erythrocyte morpho... ORPHA:766
Sweet Syndrome
Skin vesicle, Pyoderma gangrenosum, Skin nodule, Erythematous plaque, Erythematous papule ORPHA:3243
Malakoplakia
Skin ulcer, Subcutaneous nodule, Papule ORPHA:556
Fusariosis
Skin detachment, Skin ulcer, Subcutaneous nodule, Papule ORPHA:228119
Hereditary Acrokeratotic Poikiloderma
Thin skin, Skin ulcer, Papule, Hypopigmented skin patches, Erythema ORPHA:2907
Catastrophic Antiphospholipid Syndrome
Skin ulcer ORPHA:464343
Neonatal Lupus Erythematosus
Anemia, Neutropenia, Hemolytic anemia, Hydrocephalus, Dilated cardiomyopathy, Pancytopenia, Heart... ORPHA:398124
Anemia, Congenital Dyserythropoietic, Type Iv
Anemia, Reduced hematocrit, Hemolytic anemia, Circulating nucleated red blood cells, Erythroid hy... OMIM:613673
Immunoglobulin A Vasculitis
Macule, Skin ulcer, Purpura, Erythema ORPHA:761
Juvenile Dermatomyositis
Skin ulcer, Dry skin, Erythema ORPHA:93672
Dyskeratosis Congenita
Skin vesicle, Skin ulcer, Hypopigmented skin patches, Macule, Aplasia/Hypoplasia of the skin, Hyp... ORPHA:1775
Leukocyte Adhesion Deficiency, Type I
Skin ulcer OMIM:116920
Giant Cell Arteritis
Skin ulcer ORPHA:397
Dominant Beta-Thalassemia
Skin ulcer, Pallor ORPHA:231226
Hb Bart'S Hydrops Fetalis
Anemia, Hydrocephalus, Congestive heart failure, Pericarditis, Abnormal hemoglobin, Splenomegaly ORPHA:163596
Toxic Epidermal Necrolysis
Macule, Skin ulcer, Erythema ORPHA:537
Parkes Weber Syndrome
Erythematous plaque, Scaling skin, Skin ulcer, Capillary malformation ORPHA:90307
Beta-Thalassemia Major
Skin ulcer, Pallor ORPHA:231214
Incontinentia Pigmenti
Skin ulcer, Erythema, Hypopigmented skin patches ORPHA:464
Adenocarcinoma Of The Anal Canal
Skin ulcer ORPHA:424016
Blau Syndrome
Skin ulcer, Intermittent generalized erythematous papular rash OMIM:186580
Granulomatosis With Polyangiitis
Skin ulcer OMIM:608710
Systemic Sclerosis
Digital pitting scar, Spotty hypopigmentation, Digital ulcer, Acral ulceration, Cutaneous sclerot... ORPHA:90291
Pgm3-Cdg
Skin ulcer ORPHA:443811
Dermatomyositis
Skin ulcer, Papule, Aplasia/Hypoplasia of the skin, Erythema, Dry skin ORPHA:221
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Urticarial plaque, Skin ulcer, Purpura OMIM:615688
Amoebiasis Due To Free-Living Amoebae
Skin ulcer, Subcutaneous nodule, Papule ORPHA:68
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Scaling skin, Skin ulcer, Subcutaneous nodule, Dry skin ORPHA:2526
Angioosteohypertrophic Syndrome
Hyperpigmented nevi, Skin ulcer, Melanocytic nevus ORPHA:2346
Charcot-Marie-Tooth Disease Type 4B2
Penetrating foot ulcers ORPHA:99956
Leprosy
Urticarial plaque, Skin nodule, Acral ulceration, Hypopigmented macule, Verrucous papule, Penetra... ORPHA:548
Chime Syndrome
Skin ulcer, Erythema ORPHA:3474
Diamond-Blackfan Anemia 10
Patent ductus arteriosus, Anemia, Ventricular septal defect, Steroid-responsive anemia, Reticuloc... OMIM:613309
Wiskott-Aldrich Syndrome
Skin ulcer, Purpura, Petechiae ORPHA:906
Hajdu-Cheney Syndrome
Skin ulcer, Dry skin ORPHA:955
Cushing Disease
Thin skin, Striae distensae, Skin ulcer, Purpura, Ecchymosis ORPHA:96253
Granulomatosis With Polyangiitis
Skin ulcer, Purpura, Papule ORPHA:900
Primary Sjögren Syndrome
Dry skin, Skin ulcer, Purpura, Lichenoid skin lesion ORPHA:289390
Oculocerebrorenal Syndrome Of Lowe
Atypical scarring of skin, Skin ulcer ORPHA:534
Blau Syndrome
Papule, Skin ulcer, Dry skin, Erythema ORPHA:90340
Atypical Werner Syndrome
Lack of skin elasticity, Thin skin, Skin ulcer, Aplasia/Hypoplasia of the skin ORPHA:79474
Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome
Skin ulcer, Ecchymosis ORPHA:2072
Chronic Graft Versus Host Disease
Skin vesicle, Skin ulcer, Intermittent generalized erythematous papular rash, Erythema ORPHA:99921
Plague
Localized skin lesion, Skin ulcer, Dry skin ORPHA:707
Cushing Syndrome Due To Ectopic Acth Secretion
Thin skin, Striae distensae, Skin ulcer, Purpura, Ecchymosis ORPHA:99889
Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum
Atypical scarring of skin, Skin ulcer ORPHA:95455
Split Cord Malformation
Skin dimple, Penetrating foot ulcers ORPHA:573278
Telangiectasia, Hereditary Hemorrhagic, Type 2
Facial telangiectasia, Ischemic stroke, Spontaneous, recurrent epistaxis, Fingerpad telangiectase... OMIM:600376
Leukocyte Adhesion Deficiency
Pyoderma gangrenosum ORPHA:2968
Homozygous Familial Hypercholesterolemia
Aortic atherosclerotic lesion, Abnormal tendon morphology, Tendon xanthomatosis, Premature arteri... ORPHA:391665
Visceral Steatosis, Congenital
Neonatal death, Myocardial steatosis OMIM:228100
Fibronectin Glomerulopathy
Hypoalbuminemia ORPHA:84090
Spondylometaphyseal Dysplasia, 'Corner Fracture' Type
Iron deficiency anemia ORPHA:93315
Glomerulopathy With Fibronectin Deposits 2
Hypertension OMIM:601894
Spondylometaphyseal Dysplasia, Corner Fracture Type
Short stature OMIM:184255

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Fn1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Fn1.

No publications found that use IMPC mice or data for Fn1.

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MGI Allele Allele Type Produced
Fn1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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