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Gene: Fbp1 MGI:95492

Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:

fructose bisphosphatase 1

Synonyms:

Fbp-2, FBPase liver, FBPase brain isoform, Fbp3

Order Alleles

IMPC Data Collections

No Body Weight Data
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Fbp1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Fbp1 (2 diseases)
Human diseases predicted to be associated with Fbp1 (305 diseases)

The table below shows human diseases associated to Fbp1 by orthology or direct annotation.

Disease	Similarity of phenotypes	Matching phenotypes	Source
Fructose-1,6-Bisphosphatase Deficiency		Hypoglycemia, Neonatal hypoglycemia, Fasting hypoglycemia	ORPHA:348
Fructose-1,6-Bisphosphatase Deficiency		Hypoglycemia	OMIM:229700

The table below shows human diseases predicted to be associated to Fbp1 by phenotypic similarity.

Disease	Matching phenotypes	Source
3-Hydroxy-3-Methylglutaryl-Coa Synthase Deficiency	Hypoglycemia	ORPHA:35701
Hyperinsulinemic Hypoglycemia, Familial, 7	Hypoglycemic seizures, Hyperinsulinemia, Hyperinsulinemic hypoglycemia, Hypoglycemia	OMIM:610021
Glycogen Storage Disease 0, Liver	Postprandial hyperglycemia, Neonatal hypoglycemia, Fasting hypoglycemia	OMIM:240600
Maturity-Onset Diabetes Of The Young, Type 3	Hyperglycemia, Type II diabetes mellitus, Maturity-onset diabetes of the young	OMIM:600496
Dwarfism, Low-Birth-Weight Type, With Unresponsiveness To Growth Hormone	Hypoglycemia	OMIM:223500
Hypoinsulinemic Hypoglycemia And Body Hemihypertrophy	Hypoglycemic seizures, Hypoketotic hypoglycemia, Neonatal hypoglycemia, Nonketotic hypoglycemia	ORPHA:293964
Hyperinsulinism Due To Insr Deficiency	Insulin resistance, Hypoglycemia, Fasting hyperinsulinemia, Recurrent hypoglycemia, Hyperinsuline...	ORPHA:263458
Fructose And Galactose Intolerance	Hypoglycemia	OMIM:229500
Hyperproinsulinemia	Hyperglycemia, Hyperinsulinemia	OMIM:616214
Hyperinsulinemic Hypoglycemia, Familial, 2	Hyperinsulinemic hypoglycemia, Hypoglycemia	OMIM:601820
Hyperinsulinemic Hypoglycemia, Familial, 3	Hypoglycemic seizures, Diabetes mellitus, Hyperinsulinemic hypoglycemia	OMIM:602485
Short Stature Due To Partial Ghr Deficiency	Hypoglycemia	ORPHA:314802
Phosphoenolpyruvate Carboxykinase Deficiency, Mitochondrial	Impaired gluconeogenesis, Hypoglycemia	OMIM:261650
Maturity-Onset Diabetes Of The Young, Type 10	Hyperglycemia, Diabetes mellitus, Maturity-onset diabetes of the young, Diabetic ketoacidosis	OMIM:613370
Congenital Glucokinase-Related Hyperinsulinism	Fasting hyperinsulinemia, Recurrent hypoglycemia, Hypoketotic hypoglycemia, Type II diabetes mell...	ORPHA:79299
Glycogen Storage Disease Due To Glycogen Debranching Enzyme Deficiency	Hypoglycemia	ORPHA:366
Hypoinsulinemic Hypoglycemia With Hemihypertrophy	Fasting hypoglycemia, Hypoinsulinemia, Neonatal hypoglycemia, Hypoglycemia	OMIM:240900
Insulin Autoimmune Syndrome	Insulin resistance, Insulin-resistant diabetes mellitus, Reactive hypoglycemia, Nonketotic hypogl...	ORPHA:411593
Long-Chain 3-Hydroxyacyl-Coa Dehydrogenase Deficiency	Hypoglycemia	OMIM:609016
Hypoglycemia, Leucine-Induced	Hyperinsulinemic hypoglycemia, Hypoglycemia	OMIM:240800
Pituitary Hormone Deficiency, Combined, 4	Hypoglycemia	OMIM:262700
Short Stature Due To Ghsr Deficiency	Hypoglycemia	ORPHA:314811
Isolated Growth Hormone Deficiency, Type Ia	Hypoglycemia	OMIM:262400
Dicarboxylic Aminoaciduria	Fasting hypoglycemia	OMIM:222730
Mitochondrial Complex Iii Deficiency, Nuclear Type 3	Hypoglycemia	OMIM:615158
Orthostatic Hypotension 2	Hypoglycemia	OMIM:618182
3-Methylglutaconic Aciduria Type 1	Hypoglycemia	ORPHA:67046
Hyperinsulinism Due To Hnf1A Deficiency	Maturity-onset diabetes of the young, Hyperinsulinemia, Hypoketotic hypoglycemia, Reactive hypogl...	ORPHA:324575
Monocarboxylate Transporter 1 Deficiency	Ketotic hypoglycemia	OMIM:616095
Hyperinsulinism-Hyperammonemia Syndrome	Hyperinsulinemic hypoglycemia, Reactive hypoglycemia, Fasting hyperinsulinemia	ORPHA:35878
Homozygous 11P15-P14 Deletion Syndrome	Hyperinsulinemia, Hypoglycemia	OMIM:606528
Glycogen Storage Disease Vi	Hypoglycemia	OMIM:232700
Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, And Somatic Abnormalities	Postprandial hyperglycemia, Insulin-resistant diabetes mellitus, Hypoglycemia, Hyperglycemia, Hyp...	OMIM:262190
Neonatal Hemochromatosis	Hypoglycemia	ORPHA:446
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome	Hyperinsulinemia, Hypoketotic hypoglycemia, Reactive hypoglycemia, Hyperinsulinemic hypoglycemia,...	ORPHA:276608
Hyperinsulinemic Hypoglycemia, Familial, 8	Hypoglycemic seizures, Hyperinsulinemia, Hypoglycemia	OMIM:620211
Short Stature-Delayed Bone Age Due To Thyroid Hormone Metabolism Deficiency	Fasting hypoglycemia	ORPHA:171706
Pyridoxamine 5-Prime-Phosphate Oxidase Deficiency	Hypoglycemia	OMIM:610090
Diarrhea 13	Recurrent hypoglycemia	OMIM:620357
Ornithine Transcarbamylase Deficiency	Hypoglycemia	ORPHA:664
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency	Type I diabetes mellitus, Hyperinsulinemia, Hypoketotic hypoglycemia, Maternal diabetes, Fasting ...	ORPHA:276580
Propionic Acidemia	Hypoglycemia	ORPHA:35
3-Methylcrotonyl-Coa Carboxylase Deficiency	Hypoglycemia	ORPHA:6
Endocardial Fibroelastosis	Hypoglycemia	ORPHA:2022
Isobutyryl-Coa Dehydrogenase Deficiency	Ketotic hypoglycemia	ORPHA:79159
Hyperinsulinism Due To Ucp2 Deficiency	Recurrent hypoglycemia, Hypoketotic hypoglycemia, Reactive hypoglycemia, Hyperinsulinemic hypogly...	ORPHA:276556
Mitochondrial Complex Iii Deficiency, Nuclear Type 9	Hypoglycemia	OMIM:616111
Riboflavin Deficiency	Hypoglycemia	OMIM:615026
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency	Type I diabetes mellitus, Hyperinsulinemia, Hypoketotic hypoglycemia, Hyperinsulinemic hypoglycem...	ORPHA:276575
Intellectual Developmental Disorder With Macrocephaly, Seizures, And Speech Delay	Recurrent hypoglycemia	OMIM:618158
Silver-Russell Syndrome Due To An Imprinting Defect Of 11P15	Neonatal hypoglycemia, Hypoglycemia	ORPHA:231140
Silver-Russell Syndrome Due To Maternal Uniparental Disomy Of Chromosome 11	Hypoglycemia	ORPHA:231147
Glucocorticoid Deficiency 3	Recurrent hypoglycemia	OMIM:609197
2-Methylbutyryl-Coa Dehydrogenase Deficiency	Hypoglycemia	OMIM:610006
3-Methylglutaconic Aciduria Type 4	Hypoglycemia	ORPHA:67048
Mitochondrial Pyruvate Carrier Deficiency	Hypoglycemia	OMIM:614741
Diabetes Mellitus, Permanent Neonatal, 4	Hyperglycemia, Type I diabetes mellitus, Diabetic ketoacidosis	OMIM:618858
Glycogen Storage Disease Due To Hepatic Glycogen Synthase Deficiency	Postprandial hyperglycemia, Ketotic hypoglycemia, Glycosuria	ORPHA:2089
Mehmo Syndrome	Hypoglycemia	OMIM:300148
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency	Hypoglycemia	ORPHA:364
Diabetes Mellitus, Transient Neonatal, 3	Transient neonatal diabetes mellitus, Hyperglycemia, Maternal diabetes	OMIM:610582
Mitochondrial Complex Iii Deficiency, Nuclear Type 11	Hypoglycemia	OMIM:620137
Dihydrolipoamide Dehydrogenase Deficiency	Hypoglycemia	OMIM:246900
Hsd10 Mitochondrial Disease	Hypoglycemia	OMIM:300438
Short Chain Acyl-Coa Dehydrogenase Deficiency	Ketotic hypoglycemia	ORPHA:26792
2P21 Microdeletion Syndrome	Hypoglycemia	ORPHA:163693
Glycogen Storage Disease Iii	Hypoglycemia	OMIM:232400
Mitochondrial Complex Iv Deficiency, Nuclear Type 4	Hypoglycemia	OMIM:619048
Glycogen Storage Disease Ixb	Hypoglycemia	OMIM:261750
Combined Oxidative Phosphorylation Deficiency 34	Hypoglycemia	OMIM:617872
Hemochromatosis, Neonatal	Hypoglycemia	OMIM:231100
Mitochondrial Complex I Deficiency, Nuclear Type 19	Hypoglycemia	OMIM:618241
Mody	Glycosuria, Insulin-resistant diabetes mellitus, Hyperglycemia, Glucose intolerance, Transient ne...	ORPHA:552
Combined Malonic And Methylmalonic Acidemia	Hypoglycemia	ORPHA:289504
Combined Oxidative Phosphorylation Deficiency 36	Hypoglycemia	OMIM:617950
Insulinoma	Fasting hyperinsulinemia, Recurrent hypoglycemia, Hyperinsulinemia, Reactive hypoglycemia, Nonket...	ORPHA:97279
Acth Deficiency, Isolated	Fasting hypoglycemia	OMIM:201400
Pyridoxine-Dependent Epilepsy	Hypoglycemia	ORPHA:3006
Glycogen Storage Disease Ixa1	Hypoglycemia	OMIM:306000
Pyruvate Carboxylase Deficiency	Hypoglycemia	OMIM:266150
Combined Oxidative Phosphorylation Deficiency 47	Hypoglycemia	OMIM:618958
Histidinuria-Renal Tubular Defect Syndrome	Hypoglycemia	ORPHA:2158
Congenital Cataracts-Facial Dysmorphism-Neuropathy Syndrome	Hypoglycemia	ORPHA:48431
Congenital Isolated Acth Deficiency	Hypoglycemic seizures, Neonatal hypoglycemia	ORPHA:199296
Mitochondrial Complex Iii Deficiency, Nuclear Type 5	Hypoglycemia	OMIM:615160
Combined Oxidative Phosphorylation Deficiency 52	Hypoglycemia	OMIM:619386
Mitochondrial Complex V (Atp Synthase) Deficiency, Nuclear Type 5	Hypoglycemia	OMIM:618120
Adrenal Hyperplasia, Congenital, Due To 21-Hydroxylase Deficiency	Hypoglycemia	OMIM:201910
Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic	Hypoglycemia, Impaired gluconeogenesis, Fasting hypoglycemia	OMIM:261680
Hypoadrenocorticism, Familial	Hypoglycemia	OMIM:240200
Glycogen Storage Disease Ixc	Hypoglycemia, Fasting hypoglycemia	OMIM:613027
Proprotein Convertase 1/3 Deficiency	Hypoinsulinemia, Reactive hypoglycemia	OMIM:600955
Blue Diaper Syndrome	Increased proinsulin:insulin ratio, Recurrent hypoglycemia	ORPHA:94086
Glycogen Storage Disease Due To Liver Glycogen Phosphorylase Deficiency	Hypoglycemia	ORPHA:369
Infantile Liver Failure Syndrome 2	Hypoglycemia	OMIM:616483
Combined Oxidative Phosphorylation Deficiency 41	Hypoglycemia	OMIM:618838
Non-Acquired Isolated Growth Hormone Deficiency	Neonatal hypoglycemia	ORPHA:631
Silver-Russell Syndrome 2	Neonatal hypoglycemia	OMIM:618905
Silver-Russell Syndrome Due To 7P11.2P13 Microduplication	Hypoglycemia	ORPHA:231137
Autosomal Recessive Hyperinsulinism Due To Kir6.2 Deficiency	Neonatal hypoglycemia, Hyperinsulinemic hypoglycemia, Recurrent hypoglycemia	ORPHA:79644
Long Chain 3-Hydroxyacyl-Coa Dehydrogenase Deficiency	Hypoketotic hypoglycemia, Hypoglycemia	ORPHA:5
Congenital Hyperinsulinism Due To Hnf4A Deficiency	Glycosuria, Hypoketotic hypoglycemia, Hyperinsulinemia, Hyperinsulinemic hypoglycemia, Fasting hy...	ORPHA:263455
Malonyl-Coa Decarboxylase Deficiency	Hypoglycemia	OMIM:248360
Glycogen Storage Disease Ixd	Hypoglycemia	OMIM:300559
Glucocorticoid Resistance, Generalized	Hypoglycemia	OMIM:615962
Temple Syndrome	Type II diabetes mellitus, Recurrent hypoglycemia	ORPHA:254516
3-Methylglutaconic Aciduria With Deafness, Encephalopathy, And Leigh-Like Syndrome	Hypoglycemia	OMIM:614739
Combined Oxidative Phosphorylation Deficiency 10	Hypoglycemia	OMIM:614702
Pyruvate Dehydrogenase E3 Deficiency	Hypoglycemia	ORPHA:2394
Laron Syndrome	Hypoglycemia	ORPHA:633
Polyendocrine-Polyneuropathy Syndrome	Hypoinsulinemia, Type II diabetes mellitus, Hypoglycemia	ORPHA:453533
Pituitary Hormone Deficiency, Combined, 6	Neonatal hypoglycemia, Hypoglycemia	OMIM:613986
Glucocorticoid Deficiency 2	Hypoglycemia, Recurrent hypoglycemia	OMIM:607398
3-Hydroxyacyl-Coa Dehydrogenase Deficiency	Hypoglycemic seizures, Hypoketotic hypoglycemia	OMIM:231530
Pituitary Hormone Deficiency, Combined, 2	Hypoglycemic seizures, Neonatal hypoglycemia	OMIM:262600
Fanconi Renotubular Syndrome 4 With Maturity-Onset Diabetes Of The Young	Diabetes mellitus, Glycosuria, Hypoglycemia	OMIM:616026
Pyridoxal Phosphate-Responsive Seizures	Hypoglycemia	ORPHA:79096
Carnitine Palmitoyl Transferase 1A Deficiency	Hypoglycemia	ORPHA:156
Mitochondrial Dna Depletion Syndrome 9 (Encephalomyopathic Type With Methylmalonic Aciduria)	Hypoglycemia	OMIM:245400
Carnitine Palmitoyltransferase Ii Deficiency, Infantile	Hypoketotic hypoglycemia	OMIM:600649
Aromatic L-Amino Acid Decarboxylase Deficiency	Hypoglycemia	ORPHA:35708
Primary Microcephaly-Mild Intellectual Disability-Young-Onset Diabetes Syndrome	Diabetes mellitus, Hypoglycemia	ORPHA:391408
Cataract-Growth Hormone Deficiency-Sensory Neuropathy-Sensorineural Hearing Loss-Skeletal Dysplasia Syndrome	Fasting hypoglycemia	ORPHA:436174
Galactokinase Deficiency	Hyperinsulinemia, Hypoglycemia	ORPHA:79237
Mitochondrial Complex Iii Deficiency, Nuclear Type 6	Hyperglycemia, Hypoglycemia	OMIM:615453
Classic Galactosemia	Hypoglycemia	ORPHA:79239
Medium Chain Acyl-Coa Dehydrogenase Deficiency	Hypoglycemia	ORPHA:42
Mitochondrial Complex I Deficiency, Nuclear Type 33	Hypoglycemia	OMIM:618253
Houge-Janssens Syndrome 1	Hypoglycemia	OMIM:616355
Polyendocrine-Polyneuropathy Syndrome	Type I diabetes mellitus, Hypoglycemia	OMIM:616113
Post-Traumatic Pituitary Deficiency	Hypoglycemia	ORPHA:95619
Neurodevelopmental Disorder, Mitochondrial, With Abnormal Movements And Lactic Acidosis, With Or Without Seizures	Hypoglycemia	OMIM:617710
Glucocorticoid Deficiency 4 With Or Without Mineralocorticoid Deficiency	Hypoglycemia	OMIM:614736
Solitary Fibrous Tumor	Hypoinsulinemia, Hypoglycemia, Recurrent hypoglycemia	ORPHA:2126
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency	Insulin resistance, Hypoglycemia	ORPHA:73272
Aica-Ribosiduria Due To Atic Deficiency	Hypoglycemia	OMIM:608688
Fructose-1,6-Bisphosphatase Deficiency	Hypoglycemia, Neonatal hypoglycemia, Fasting hypoglycemia	ORPHA:348
Cog8-Cdg	Hypoglycemia	ORPHA:95428
Acyl-Coa Dehydrogenase, Medium-Chain, Deficiency Of	Hypoglycemia	OMIM:201450
Carnitine-Acylcarnitine Translocase Deficiency	Neonatal hypoglycemia, Hypoglycemia	OMIM:212138
Hsd10 Disease, Infantile Type	Hypoglycemia	ORPHA:391428
Insulin-Resistance Syndrome Type B	Postprandial hyperglycemia, Insulin resistance, Glycosuria, Insulin-resistant diabetes mellitus, ...	ORPHA:2298
Donohue Syndrome	Postprandial hyperglycemia, Hyperglycemia, Hyperinsulinemia, Fasting hypoglycemia	OMIM:246200
Maple Syrup Urine Disease, Type Ia	Hypoglycemia	OMIM:248600
Carnitine Deficiency, Systemic Primary	Impaired gluconeogenesis, Recurrent hypoglycemia	OMIM:212140
Glucocorticoid Deficiency 1	Recurrent hypoglycemia	OMIM:202200
Timothy Syndrome	Hypoglycemia	OMIM:601005
Propionic Acidemia	Hypoglycemia	OMIM:606054
Mitochondrial Complex Iv Deficiency, Nuclear Type 3	Neonatal hypoglycemia	OMIM:619046
Combined Oxidative Phosphorylation Deficiency 40	Hypoglycemia	OMIM:618835
Combined Oxidative Phosphorylation Deficiency 42	Hypoglycemia	OMIM:618839
Smith-Kingsmore Syndrome	Hypoglycemia	OMIM:616638
3-Methylcrotonyl-Coa Carboxylase 1 Deficiency	Hypoglycemia	OMIM:210200
Fructose-1,6-Bisphosphatase Deficiency	Hypoglycemia	OMIM:229700
Fanconi-Bickel Syndrome	Postprandial hyperglycemia, Glycosuria, Fasting hypoglycemia, Diabetes mellitus, Impaired glucose...	ORPHA:2088
Microcephaly, Short Stature, And Impaired Glucose Metabolism 2	Recurrent hypoglycemia	OMIM:616817
Bachmann-Bupp Syndrome	Hypoglycemia	OMIM:619075
Long-Olsen-Distelmaier Syndrome	Hypoglycemia	OMIM:620609
Mitochondrial Complex I Deficiency, Nuclear Type 20	Hypoglycemia	OMIM:611126
Hypotonia-Cystinuria Syndrome	Neonatal hypoglycemia	OMIM:606407
Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency	Fasting hyperinsulinemia, Hypoketotic hypoglycemia, Hyperinsulinemic hypoglycemia, Hypoglycemic s...	ORPHA:71212
Immunodeficiency, Common Variable, 10	Hypoglycemia	OMIM:615577
Cholestasis, Progressive Familial Intrahepatic, 5	Hypoglycemia	OMIM:617049
Basilicata-Akhtar Syndrome	Neonatal hypoglycemia	OMIM:301032
Reni Syndrome	Hypoglycemia	OMIM:617575
Silver-Russell Syndrome Due To A Point Mutation	Hypoglycemia	ORPHA:397590
Mitochondrial Complex Iv Deficiency, Nuclear Type 23	Hypoglycemia	OMIM:620275
Silver-Russell Syndrome 1	Fasting hypoglycemia	OMIM:180860
Shashi-Pena Syndrome	Hypoglycemia	OMIM:617190
3-Hydroxy-3-Methylglutaryl-Coa Synthase-2 Deficiency	Hypoglycemia	OMIM:605911
Tenorio Syndrome	Hypoinsulinemia, Hypoglycemia	OMIM:616260
Intellectual Developmental Disorder, Autosomal Dominant 45	Neonatal hypoglycemia	OMIM:617600
Methylmalonic Aciduria Due To Methylmalonyl-Coa Mutase Deficiency	Hypoglycemia	OMIM:251000
Immunodeficiency 10	Hypoglycemia	OMIM:612783
Mitochondrial Trifunctional Protein Deficiency 2	Hypoglycemia	OMIM:620300
Pituitary Stalk Interruption Syndrome	Hypoglycemia	ORPHA:95496
Glutaric Acidemia I	Hypoglycemia	OMIM:231670
D-Glyceric Aciduria	Hypoglycemia	OMIM:220120
Dopamine Beta-Hydroxylase Deficiency	Insulin resistance, Hyperinsulinemia, Hypoglycemia	ORPHA:230
Multiple Acyl-Coa Dehydrogenase Deficiency	Glycosuria, Hypoglycemia	OMIM:231680
Beta-Ketothiolase Deficiency	Hyperglycemia, Hypoglycemia	ORPHA:134
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal	Nonketotic hypoglycemia, Hypoglycemia	OMIM:608836
Congenital Disorder Of Glycosylation, Type Ig	Hypoglycemia	OMIM:607143
Multiple Acyl-Coa Dehydrogenase Deficiency	Hypoglycemia	ORPHA:26791
Mitochondrial Complex Iv Deficiency, Nuclear Type 12	Neonatal hypoglycemia, Hypoglycemia	OMIM:619055
Recurrent Metabolic Encephalomyopathic Crises-Rhabdomyolysis-Cardiac Arrhythmia-Intellectual Disability Syndrome	Hypoglycemic seizures, Hypoglycemia	ORPHA:480864
Carnitine-Acylcarnitine Translocase Deficiency	Hypoketotic hypoglycemia, Fasting hypoglycemia	ORPHA:159
Mitochondrial Complex Iv Deficiency, Nuclear Type 22	Hypoglycemia	OMIM:619355
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency	Ketotic hypoglycemia, Fasting hypoglycemia, Recurrent hypoglycemia	ORPHA:79240
Intellectual Disability-Macrocephaly-Hypotonia-Behavioral Abnormalities Syndrome	Hypoglycemia	ORPHA:457279
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency	Hypoglycemia, Fasting hypoglycemia	ORPHA:264580
Macrocephaly-Intellectual Disability-Neurodevelopmental Disorder-Small Thorax Syndrome	Neonatal hypoglycemia	ORPHA:457485
Combined Oxidative Phosphorylation Deficiency 59	Ketotic hypoglycemia	OMIM:620646
Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of	Nonketotic hypoglycemia	OMIM:201475
Glycogen Storage Disease Ia	Hypoglycemia, Fasting hypoglycemia	OMIM:232200
Pancreatic And Cerebellar Agenesis	Hyperglycemia, Diabetes mellitus, Hypoglycemia	OMIM:609069
Rabson-Mendenhall Syndrome	Postprandial hyperglycemia, Insulin resistance, Insulin-resistant diabetes mellitus, Fasting hype...	ORPHA:769
Midface Hypoplasia, Obesity, Developmental Delay, And Neonatal Hypotonia	Neonatal hypoglycemia	OMIM:608624
Mirage Syndrome	Hypoglycemia	OMIM:617053
Methylmalonic Aciduria, Cblb Type	Hypoglycemia	OMIM:251110
Carnitine Palmitoyl Transferase Ii Deficiency, Severe Infantile Form	Hypoketotic hypoglycemia	ORPHA:228305
Neurodevelopmental Disorder With Hypotonia, Dysmorphic Facies, And Skeletal Anomalies, With Or Without Seizures	Hypoglycemia	OMIM:620224
Carnitine Palmitoyltransferase I Deficiency	Hypoketotic hypoglycemia	OMIM:255120
Combined Oxidative Phosphorylation Defect Type 39	Neonatal hypoglycemia	ORPHA:565624
Growth Retardation, Impaired Intellectual Development, Hypotonia, And Hepatopathy	Hypoglycemia	OMIM:617093
3-Hydroxy-3-Methylglutaryl-Coa Lyase Deficiency	Hypoglycemia	OMIM:246450
Combined Oxidative Phosphorylation Deficiency 37	Hypoglycemia	OMIM:618329
3-Methylcrotonyl-Coa Carboxylase 2 Deficiency	Hypoglycemia	OMIM:210210
Congenital Disorder Of Glycosylation, Type Iie	Hypoglycemia	OMIM:608779
Congenital Disorder Of Glycosylation, Type Iiaa	Hypoglycemia	OMIM:620454
Combined Oxidative Phosphorylation Deficiency 58	Hypoglycemia	OMIM:620451
Isolated Complex I Deficiency	Diabetes mellitus, Hypoglycemia	ORPHA:2609
Late-Onset Isolated Acth Deficiency	Type I diabetes mellitus, Hypoglycemia	ORPHA:199299
Sotos Syndrome	Neonatal hypoglycemia, Glucose intolerance	OMIM:117550
Congenital Disorder Of Glycosylation With Defective Fucosylation 1	Hypoglycemia	OMIM:618005
Metabolic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration	Hypoglycemia	OMIM:616878
Silver-Russell Syndrome	Insulin resistance, Recurrent hypoglycemia	ORPHA:813
Leigh Syndrome	Hypoglycemia	ORPHA:506
Cataracts, Growth Hormone Deficiency, Sensory Neuropathy, Sensorineural Hearing Loss, And Skeletal Dysplasia	Hypoglycemia	OMIM:616007
Multiple Mitochondrial Dysfunctions Syndrome 7	Hyperglycemia, Hypoglycemia	OMIM:620423
3-Methylglutaconic Aciduria Type 7	Neonatal hypoglycemia	ORPHA:445038
Mitochondrial Trifunctional Protein Deficiency 1	Hypoketotic hypoglycemia	OMIM:609015
Cerebral Visual Impairment	Neonatal hypoglycemia	ORPHA:447788
Carbonic Anhydrase Va Deficiency, Hyperammonemia Due To	Hypoglycemia	OMIM:615751
Congenital Disorder Of Glycosylation, Type It	Hypoglycemia	OMIM:614921
Acyl-Coa Dehydrogenase 9 Deficiency	Nonketotic hypoglycemia	ORPHA:99901
Immunodeficiency 59 And Hypoglycemia	Hypoglycemia	OMIM:233600
Orthostatic Hypotension 1	Neonatal hypoglycemia	OMIM:223360
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)	Hypoglycemia	OMIM:251880
Fanconi-Bickel Syndrome	Postprandial hyperglycemia, Glycosuria, Fasting hypoglycemia	OMIM:227810
Familial Glucocorticoid Deficiency	Hypoglycemic seizures, Ketotic hypoglycemia	ORPHA:361
Congenital Disorder Of Glycosylation, Type Im	Hypoketotic hypoglycemia	OMIM:610768
Oculodentodigital Dysplasia	Hypoglycemia	ORPHA:2710
X-Linked Dominant Chondrodysplasia Punctata	Neonatal hypoglycemia	ORPHA:35173
Cholera	Hypoglycemia	ORPHA:173
Pituitary Apoplexy	Hypoglycemia	ORPHA:95613
3-Methylglutaconic Aciduria, Type Viib	Neonatal hypoglycemia	OMIM:616271
Mitochondrial Dna Depletion Syndrome 6 (Hepatocerebral Type)	Hypoglycemia, Recurrent hypoglycemia	OMIM:256810
Dilated Cardiomyopathy With Ataxia	Neonatal hypoglycemia	ORPHA:66634
Neurodevelopmental Disorder With Hypotonia, Craniofacial Abnormalities, And Seizures	Hypoglycemia	OMIM:614501
Bannayan-Riley-Ruvalcaba Syndrome	Hypoglycemia	ORPHA:109
3-Hydroxy-3-Methylglutaric Aciduria	Nonketotic hypoglycemia, Recurrent hypoglycemia	ORPHA:20
Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency	Hypoglycemia	ORPHA:90790
Neurologic, Endocrine, And Pancreatic Disease, Multisystem, Infantile-Onset 2	Neonatal hypoglycemia, Hypoglycemia	OMIM:619418
Pyruvate Carboxylase Deficiency	Hyperglycemia, Hypoglycemia	ORPHA:3008
Wars2-Related Combined Oxidative Phosphorylation Defect	Neonatal hypoglycemia	ORPHA:572798
Congenital Syphilis	Hypoglycemia	ORPHA:499009
Very Long Chain Acyl-Coa Dehydrogenase Deficiency	Hypoketotic hypoglycemia	ORPHA:26793
Mitochondrial Trifunctional Protein Deficiency	Hypoketotic hypoglycemia	ORPHA:746
Shigellosis	Hypoglycemia	ORPHA:810
Kabuki Syndrome 2	Neonatal hypoglycemia	OMIM:300867
Sheehan Syndrome	Hypoglycemia	ORPHA:91355
Holoprosencephaly	Diabetes mellitus, Hypoglycemia	ORPHA:2162
Multiple Endocrine Neoplasia, Type I	Hypoglycemia	OMIM:131100
Glutaryl-Coa Dehydrogenase Deficiency	Fasting hypoglycemia	ORPHA:25
Glycogen Storage Disease Ib	Hypoglycemia	OMIM:232220
Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria	Hypoglycemia	ORPHA:17
Intellectual Developmental Disorder, X-Linked, Syndromic, With Pigmentary Mosaicism And Coarse Facies	Hypoglycemia	OMIM:301066
Alg12-Cdg	Recurrent hypoglycemia	ORPHA:79324
Renal Agenesis, Bilateral	Nonketotic hypoglycemia	ORPHA:1848
Mitochondrial Complex Iii Deficiency, Nuclear Type 1	Hyperglycemia, Hypoglycemia, Recurrent hypoglycemia	OMIM:124000
Congenital Adrenal Hyperplasia Due To 3-Beta-Hydroxysteroid Dehydrogenase Deficiency	Neonatal hypoglycemia	ORPHA:90791
Mitochondrial Dna Depletion Syndrome 15 (Hepatocerebral Type)	Hypoglycemia	OMIM:617156
Methylmalonic Acidemia With Homocystinuria, Type Cblc	Hypoglycemia	ORPHA:79282
Silver-Russell Syndrome Due To Maternal Uniparental Disomy Of Chromosome 7	Insulin resistance, Fasting hypoglycemia	ORPHA:96182
Carnitine Palmitoyltransferase Ii Deficiency	Hypoketotic hypoglycemia	ORPHA:157
Acute Adrenal Insufficiency	Hypoglycemia	ORPHA:95409
Mitochondrial Complex I Deficiency, Nuclear Type 1	Hypoglycemia	OMIM:252010
Perlman Syndrome	Hypoglycemia	OMIM:267000
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ib	Hypoglycemic seizures, Hypoglycemia	ORPHA:79259
Histiocytoid Cardiomyopathy	Hypoglycemia	ORPHA:137675
Hereditary Fructose Intolerance	Reactive hypoglycemia	ORPHA:469
Leprechaunism	Postprandial hyperglycemia, Insulin resistance, Hyperinsulinemia, Recurrent infantile hypoglycemi...	ORPHA:508
Carnitine Palmitoyl Transferase Ii Deficiency, Neonatal Form	Hypoketotic hypoglycemia	ORPHA:228308
Generalized Glucocorticoid Resistance Syndrome	Hypoglycemia	ORPHA:786
Menkes Disease	Hypoglycemia	ORPHA:565
Addison Disease	Type I diabetes mellitus, Hypoglycemia	ORPHA:85138
Glycogen Storage Disease Ic	Hypoglycemia	OMIM:232240
Deficiency In Anterior Pituitary Function-Variable Immunodeficiency Syndrome	Recurrent hypoglycemia	ORPHA:293978
Tyrosinemia, Type I	Hypoglycemia	OMIM:276700
Glycerol Kinase Deficiency	Hypoglycemia	OMIM:307030
Fructose Intolerance, Hereditary	Glycosuria, Hypoglycemia	OMIM:229600
Rajab Interstitial Lung Disease With Brain Calcifications 1	Hypoglycemia	OMIM:613658
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function	Hypoglycemia	ORPHA:226307
Primary Fanconi Renotubular Syndrome	Glycosuria, Hypoglycemia	ORPHA:3337
Simpson-Golabi-Behmel Syndrome	Hypoglycemia	ORPHA:373
Deeah Syndrome	Neonatal hypoglycemia	OMIM:619004
Glycogen Storage Disease Of Heart, Lethal Congenital	Neonatal hypoglycemia	OMIM:261740
46,Xy Difference Of Sex Development-Adrenal Insufficiency Due To Cyp11A1 Deficiency	Neonatal hypoglycemia	ORPHA:168558
Inherited Isolated Adrenal Insufficiency Due To Partial Cyp11A1 Deficiency	Neonatal hypoglycemia	ORPHA:289548
Beckwith-Wiedemann Syndrome	Neonatal hypoglycemia, Hypoglycemia	ORPHA:116
Mitochondrial Complex Iv Deficiency, Nuclear Type 5	Hyperglycemia, Hypoglycemia	OMIM:220111
Costello Syndrome	Hypoglycemia	OMIM:218040
Marburg Hemorrhagic Fever	Hypoglycemia	ORPHA:99826
Non-Acquired Panhypopituitarism	Hypoglycemia	ORPHA:90695
Neurooculorenal Syndrome	Recurrent hypoglycemia	OMIM:620305
Megalencephaly-Severe Kyphoscoliosis-Overgrowth Syndrome	Neonatal hypoglycemia	ORPHA:457359
Acute Liver Failure	Hypoglycemia	ORPHA:90062
3-Methylglutaconic Aciduria, Type Viii	Neonatal hypoglycemia	OMIM:617248
Holoprosencephaly 1	Hypoglycemia	OMIM:236100
Combined Pituitary Hormone Deficiencies, Genetic Forms	Hypoglycemia	ORPHA:95494
Beckwith-Wiedemann Syndrome	Neonatal hypoglycemia	OMIM:130650
Antley-Bixler Syndrome With Genital Anomalies And Disordered Steroidogenesis	Hypoglycemia	OMIM:201750
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency	Neonatal hypoglycemia	ORPHA:90794
Sotos Syndrome	Neonatal hypoglycemia	ORPHA:821

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Fbp1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Fbp1.

No publications found that use IMPC mice or data for Fbp1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele	Allele Type	Produced
Fbp1^{tm436505(L1L2_GT2_LF2A_LacZ_BetactP_neo)}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors
Fbp1^{tm1e(EUCOMM)Hmgu}	Targeted, non-conditional allele	ES Cells
Fbp1^{tm1a(EUCOMM)Hmgu}	KO first allele (reporter-tagged insertion with conditional potential)	Mice, Targeting vectors, ES Cells
Fbp1^tm1(KOMP)Mbp	Reporter-tagged deletion allele (with selection cassette)	Targeting vectors, ES Cells

Sequence

Guides

Sequence	Guide sequence	pam	chr	start	stop	strand	Genome build	gRNA Concentration	Truncated Guide	Reversed	Sanger service	Guide format	Guide source

Nucleases

Nuclease type	Nuclease class

Genotype primers

Sequence	Name

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