Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
fructose bisphosphatase 1
Synonyms:
Fbp-2,  FBPase liver,  FBPase brain isoform,  Fbp3

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Fbp1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Fbp1 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Fructose-1,6-Bisphosphatase Deficiency
Fasting hypoglycemia, Hypoglycemia, Neonatal hypoglycemia ORPHA:348
Fructose-1,6-Bisphosphatase Deficiency
Hypoglycemia OMIM:229700

The table below shows human diseases predicted to be associated to Fbp1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
3-Hydroxy-3-Methylglutaryl-Coa Synthase Deficiency
Hypoglycemia ORPHA:35701
Glucocorticoid Deficiency 3
Recurrent hypoglycemia OMIM:609197
Hyperinsulinemic Hypoglycemia, Familial, 7
Hyperinsulinemic hypoglycemia, Hypoglycemic seizures, Hypoglycemia, Hyperinsulinemia OMIM:610021
Glycogen Storage Disease 0, Liver
Fasting hypoglycemia, Postprandial hyperglycemia, Neonatal hypoglycemia OMIM:240600
Hypoinsulinemic Hypoglycemia And Body Hemihypertrophy
Hypoketotic hypoglycemia, Neonatal hypoglycemia, Abnormal circulating insulin level, Nonketotic h... ORPHA:293964
Hyperinsulinemic Hypoglycemia, Familial, 2
Hyperinsulinemic hypoglycemia, Hypoglycemia OMIM:601820
Maturity-Onset Diabetes Of The Young, Type 3
Hyperglycemia, Maturity-onset diabetes of the young, Type II diabetes mellitus OMIM:600496
Dwarfism, Low-Birth-Weight Type, With Unresponsiveness To Growth Hormone
Hypoglycemia OMIM:223500
Hyperinsulinism Due To Insr Deficiency
Hypoglycemia, Insulin resistance, Hyperinsulinemic hypoglycemia, Recurrent hypoglycemia, Fasting ... ORPHA:263458
Fructose And Galactose Intolerance
Hypoglycemia OMIM:229500
Hyperproinsulinemia
Hyperglycemia, Hyperinsulinemia OMIM:616214
Hyperinsulinemic Hypoglycemia, Familial, 3
Hyperinsulinemic hypoglycemia, Hypoglycemic seizures, Diabetes mellitus OMIM:602485
Hyperinsulinemic Hypoglycemia, Familial, 4
Hyperinsulinemic hypoglycemia, Hypoglycemic seizures OMIM:609975
Isolated Growth Hormone Deficiency, Type Ia
Hypoglycemia OMIM:262400
Mitochondrial Complex Iii Deficiency, Nuclear Type 3
Hypoglycemia OMIM:615158
Hyperinsulinemic Hypoglycemia, Familial, 5
Fasting hyperinsulinemia, Hyperinsulinemic hypoglycemia, Hypoglycemic seizures OMIM:609968
Hypoinsulinemic Hypoglycemia With Hemihypertrophy
Neonatal hypoglycemia OMIM:240900
Phosphoenolpyruvate Carboxykinase Deficiency, Mitochondrial
Impaired gluconeogenesis, Hypoglycemia OMIM:261650
Maturity-Onset Diabetes Of The Young, Type 10
Hyperglycemia, Diabetic ketoacidosis, Maturity-onset diabetes of the young, Diabetes mellitus OMIM:613370
Combined Oxidative Phosphorylation Deficiency 36
Hypoglycemia OMIM:617950
Hyperinsulinism Due To Glucokinase Deficiency
Type II diabetes mellitus, Hypoketotic hypoglycemia, Hyperinsulinemic hypoglycemia, Recurrent hyp... ORPHA:79299
Glycogen Storage Disease Due To Glycogen Debranching Enzyme Deficiency
Hypoglycemia ORPHA:366
Insulin Autoimmune Syndrome
Fasting hypoglycemia, Insulin resistance, Insulin-resistant diabetes mellitus, Hyperinsulinemic h... ORPHA:411593
Short Stature Due To Partial Ghr Deficiency
Hypoglycemia ORPHA:314802
Riboflavin Deficiency
Hypoglycemia OMIM:615026
Hypoglycemia, Leucine-Induced
Hyperinsulinemic hypoglycemia, Hypoglycemia OMIM:240800
Long-Chain 3-Hydroxyacyl-Coa Dehydrogenase Deficiency
Hypoglycemia OMIM:609016
Orthostatic Hypotension 2
Hypoglycemia OMIM:618182
Glycogen Storage Disease Ixa1
Hypoglycemia OMIM:306000
Pituitary Hormone Deficiency, Combined, 4
Hypoglycemia OMIM:262700
Short Stature Due To Ghsr Deficiency
Hypoglycemia ORPHA:314811
Mitochondrial Complex Iii Deficiency, Nuclear Type 9
Hypoglycemia OMIM:616111
Polyendocrine-Polyneuropathy Syndrome
Hypoglycemia OMIM:616113
Dicarboxylic Aminoaciduria
Fasting hypoglycemia OMIM:222730
Hyperinsulinism Due To Hnf1A Deficiency
Fasting hypoglycemia, Hypoketotic hypoglycemia, Maternal diabetes, Maturity-onset diabetes of the... ORPHA:324575
Homozygous 11P15-P14 Deletion Syndrome
Hypoglycemia, Hyperinsulinemia OMIM:606528
Hyperinsulinism-Hyperammonemia Syndrome
Fasting hyperinsulinemia, Hyperinsulinemic hypoglycemia, Reactive hypoglycemia ORPHA:35878
Monocarboxylate Transporter 1 Deficiency
Ketotic hypoglycemia OMIM:616095
Glycogen Storage Disease Vi
Hypoglycemia OMIM:232700
Short Stature-Delayed Bone Age Due To Thyroid Hormone Metabolism Deficiency
Fasting hypoglycemia, Abnormal circulating insulin level ORPHA:171706
Glucocorticoid Deficiency 2
Recurrent hypoglycemia OMIM:607398
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Fasting hypoglycemia, Hypoketotic hypoglycemia, Hyperinsulinemic hypoglycemia, Reactive hypoglyce... ORPHA:276608
Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, And Somatic Abnormalities
Fasting hypoglycemia, Hypoglycemia, Insulin-resistant diabetes mellitus, Diabetic ketoacidosis, H... OMIM:262190
3-Methylglutaconic Aciduria Type 1
Hypoglycemia ORPHA:67046
Diabetes Mellitus, Transient Neonatal, 3
Hyperglycemia, Maternal diabetes, Transient neonatal diabetes mellitus OMIM:610582
Neonatal Hemochromatosis
Hypoglycemia ORPHA:446
Diabetes Mellitus, Transient Neonatal, 1
Hyperglycemia, Transient neonatal diabetes mellitus OMIM:601410
Histidinuria-Renal Tubular Defect Syndrome
Hypoglycemia ORPHA:2158
Growth Hormone Insensitivity Syndrome
Type II diabetes mellitus, Hypoglycemia, Diabetes mellitus, Insulin resistance ORPHA:181393
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Fasting hypoglycemia, Hypoketotic hypoglycemia, Maternal diabetes, Hyperinsulinemic hypoglycemia,... ORPHA:276580
Pyridoxamine 5-Prime-Phosphate Oxidase Deficiency
Hypoglycemia OMIM:610090
Ornithine Transcarbamylase Deficiency
Hypoglycemia ORPHA:664
Endocardial Fibroelastosis
Hypoglycemia ORPHA:2022
Propionic Acidemia
Hypoglycemia ORPHA:35
3-Methylcrotonyl-Coa Carboxylase Deficiency
Hypoglycemia ORPHA:6
Hyperinsulinism Due To Ucp2 Deficiency
Hypoketotic hypoglycemia, Hyperinsulinemic hypoglycemia, Recurrent hypoglycemia, Reactive hypogly... ORPHA:276556
Pituitary Hormone Deficiency, Combined, 2
Hypoglycemic seizures, Neonatal hypoglycemia OMIM:262600
Congenital Disorder Of Glycosylation, Type Im
Hypoketotic hypoglycemia OMIM:610768
Glucocorticoid Resistance, Generalized
Hypoglycemia OMIM:615962
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Fasting hypoglycemia, Hypoketotic hypoglycemia, Hyperinsulinemic hypoglycemia, Type I diabetes me... ORPHA:276575
Combined Oxidative Phosphorylation Deficiency 34
Hypoglycemia OMIM:617872
Isobutyryl-Coa Dehydrogenase Deficiency
Ketotic hypoglycemia ORPHA:79159
Shashi-Pena Syndrome
Hypoglycemia OMIM:617190
Silver-Russell Syndrome Due To An Imprinting Defect Of 11P15
Hypoglycemia, Neonatal hypoglycemia ORPHA:231140
Silver-Russell Syndrome Due To Maternal Uniparental Disomy Of Chromosome 11
Hypoglycemia ORPHA:231147
Intellectual Developmental Disorder With Macrocephaly, Seizures, And Speech Delay
Recurrent hypoglycemia OMIM:618158
3-Methylglutaconic Aciduria Type 4
Hypoglycemia ORPHA:67048
Mitochondrial Pyruvate Carrier Deficiency
Hypoglycemia OMIM:614741
2-Methylbutyryl-Coa Dehydrogenase Deficiency
Hypoglycemia OMIM:610006
Combined Oxidative Phosphorylation Deficiency 10
Hypoglycemia OMIM:614702
Dihydrolipoamide Dehydrogenase Deficiency
Hypoglycemia OMIM:246900
Mitochondrial Dna Depletion Syndrome 15 (Hepatocerebral Type)
Hypoglycemia OMIM:617156
Mehmo Syndrome
Hypoglycemia OMIM:300148
Glycogen Storage Disease Due To Hepatic Glycogen Synthase Deficiency
Postprandial hyperglycemia, Glycosuria, Ketotic hypoglycemia ORPHA:2089
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency
Hypoglycemia ORPHA:364
Diabetes Mellitus, Permanent Neonatal, 4
Hyperglycemia, Diabetic ketoacidosis, Type I diabetes mellitus OMIM:618858
Short Chain Acyl-Coa Dehydrogenase Deficiency
Ketotic hypoglycemia ORPHA:26792
Adrenal Hyperplasia, Congenital, Due To 21-Hydroxylase Deficiency
Hypoglycemia OMIM:201910
Carnitine Deficiency, Systemic Primary
Recurrent hypoglycemia, Impaired gluconeogenesis, Hypoglycemia OMIM:212140
2P21 Microdeletion Syndrome
Hypoglycemia ORPHA:163693
Glycogen Storage Disease Iii
Hypoglycemia OMIM:232400
Mitochondrial Complex Iv Deficiency, Nuclear Type 4
Hypoglycemia OMIM:619048
Mitochondrial Complex I Deficiency, Nuclear Type 33
Hypoglycemia OMIM:618253
Hsd10 Mitochondrial Disease
Hypoglycemia OMIM:300438
Pyruvate Carboxylase Deficiency
Hypoglycemia OMIM:266150
Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic
Impaired gluconeogenesis, Fasting hypoglycemia, Hypoglycemia OMIM:261680
Combined Malonic And Methylmalonic Acidemia
Hypoglycemia ORPHA:289504
Mitochondrial Complex V (Atp Synthase) Deficiency, Nuclear Type 5
Hypoglycemia OMIM:618120
Hemochromatosis, Neonatal
Hypoglycemia OMIM:231100
Combined Oxidative Phosphorylation Deficiency 47
Hypoglycemia OMIM:618958
Insulinoma
Hyperinsulinemic hypoglycemia, Fasting hyperinsulinemia, Recurrent hypoglycemia, Reactive hypogly... ORPHA:97279
Glucocorticoid Deficiency 4 With Or Without Mineralocorticoid Deficiency
Hypoglycemia OMIM:614736
Acth Deficiency, Isolated
Fasting hypoglycemia OMIM:201400
Congenital Cataracts-Facial Dysmorphism-Neuropathy Syndrome
Hypoglycemia ORPHA:48431
Fanconi Renotubular Syndrome 4 With Maturity-Onset Diabetes Of The Young
Hypoglycemia, Diabetes mellitus, Glycosuria OMIM:616026
Pyridoxine-Dependent Epilepsy
Hypoglycemia ORPHA:3006
Congenital Isolated Acth Deficiency
Hypoglycemic seizures, Neonatal hypoglycemia ORPHA:199296
Glycogen Storage Disease Ixc
Fasting hypoglycemia, Hypoglycemia OMIM:613027
Combined Oxidative Phosphorylation Deficiency 52
Hypoglycemia OMIM:619386
Glycerol Kinase Deficiency
Hypoglycemia OMIM:307030
Mitochondrial Complex Iii Deficiency, Nuclear Type 5
Hypoglycemia OMIM:615160
Mody
Insulin-resistant diabetes mellitus, Hyperinsulinemic hypoglycemia, Hyperglycemia, Glucose intole... ORPHA:552
Blue Diaper Syndrome
Recurrent hypoglycemia, Increased proinsulin:insulin ratio ORPHA:94086
Hypoadrenocorticism, Familial
Hypoglycemia OMIM:240200
Autosomal Recessive Hyperinsulinism Due To Kir6.2 Deficiency
Recurrent hypoglycemia, Hyperinsulinemic hypoglycemia, Neonatal hypoglycemia ORPHA:79644
Glycogen Storage Disease Due To Liver Glycogen Phosphorylase Deficiency
Hypoglycemia ORPHA:369
Hyperinsulinism Due To Hnf4A Deficiency
Fasting hypoglycemia, Hypoketotic hypoglycemia, Hyperinsulinemic hypoglycemia, Glycosuria, Neonat... ORPHA:263455
Silver-Russell Syndrome 2
Neonatal hypoglycemia OMIM:618905
Mitochondrial Complex Iv Deficiency, Nuclear Type 5
Hyperglycemia, Hypoglycemia OMIM:220111
Silver-Russell Syndrome Due To 7P11.2P13 Microduplication
Hypoglycemia ORPHA:231137
Combined Oxidative Phosphorylation Deficiency 41
Hypoglycemia OMIM:618838
Infantile Liver Failure Syndrome 2
Hypoglycemia OMIM:616483
Mental Retardation, Autosomal Dominant 35
Hypoglycemia OMIM:616355
Long Chain 3-Hydroxyacyl-Coa Dehydrogenase Deficiency
Hypoketotic hypoglycemia, Hypoglycemia ORPHA:5
Proprotein Convertase 1/3 Deficiency
Reactive hypoglycemia OMIM:600955
Pyridoxal Phosphate-Responsive Seizures
Hypoglycemia ORPHA:79096
Glucocorticoid Deficiency 1
Recurrent hypoglycemia OMIM:202200
Orthostatic Hypotension 1
Neonatal hypoglycemia OMIM:223360
Temple Syndrome
Recurrent hypoglycemia, Type II diabetes mellitus ORPHA:254516
Laron Syndrome
Hypoglycemia ORPHA:633
3-Methylglutaconic Aciduria With Deafness, Encephalopathy, And Leigh-Like Syndrome
Hypoglycemia OMIM:614739
Malonyl-Coa Decarboxylase Deficiency
Hypoglycemia OMIM:248360
3-Hydroxyacyl-Coa Dehydrogenase Deficiency
Hypoglycemic seizures, Hypoketotic hypoglycemia OMIM:231530
Pyruvate Dehydrogenase E3 Deficiency
Hypoglycemia ORPHA:2394
Timothy Syndrome
Hypoglycemia OMIM:601005
Mitochondrial Dna Depletion Syndrome 6 (Hepatocerebral Type)
Hypoglycemia OMIM:256810
Carbonic Anhydrase Va Deficiency, Hyperammonemia Due To
Hypoglycemia OMIM:615751
Carnitine Palmitoyl Transferase 1A Deficiency
Hypoglycemia ORPHA:156
Mitochondrial Dna Depletion Syndrome 9 (Encephalomyopathic Type With Methylmalonic Aciduria)
Hypoglycemia OMIM:245400
Cataract-Growth Hormone Deficiency-Sensory Neuropathy-Sensorineural Hearing Loss-Skeletal Dysplasia Syndrome
Fasting hypoglycemia ORPHA:436174
Primary Microcephaly-Mild Intellectual Disability-Young-Onset Diabetes Syndrome
Hypoglycemia, Diabetes mellitus ORPHA:391408
Mitochondrial Complex I Deficiency, Nuclear Type 19
Hypoglycemia OMIM:618241
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Hypoglycemia, Insulin resistance ORPHA:73272
Galactokinase Deficiency
Hypoglycemia, Hyperinsulinemia ORPHA:79237
Polyendocrine-Polyneuropathy Syndrome
Type II diabetes mellitus, Hypoinsulinemia, Hypoglycemia ORPHA:453533
Solitary Fibrous Tumor/Hemangiopericytoma
Recurrent hypoglycemia, Hypoinsulinemia, Hypoglycemia ORPHA:2126
Acyl-Coa Dehydrogenase, Medium-Chain, Deficiency Of
Hypoglycemia OMIM:201450
Classic Galactosemia
Hypoglycemia ORPHA:79239
Insulin-Resistance Syndrome Type B
Fasting hypoglycemia, Type II diabetes mellitus, Insulin resistance, Insulin-resistant diabetes m... ORPHA:2298
Carnitine Palmitoyltransferase Ii Deficiency, Infantile
Hypoketotic hypoglycemia OMIM:600649
Fructose-1,6-Bisphosphatase Deficiency
Fasting hypoglycemia, Hypoglycemia, Neonatal hypoglycemia ORPHA:348
Donohue Syndrome
Hyperglycemia, Fasting hypoglycemia, Postprandial hyperglycemia, Hyperinsulinemia OMIM:246200
Pancreatic And Cerebellar Agenesis
Hyperglycemia, Hypoglycemia, Diabetes mellitus OMIM:609069
Medium Chain Acyl-Coa Dehydrogenase Deficiency
Hypoglycemia ORPHA:42
Maple Syrup Urine Disease
Hypoglycemia OMIM:248600
Post-Traumatic Pituitary Deficiency
Hypoglycemia ORPHA:95619
3-Methylcrotonyl-Coa Carboxylase 1 Deficiency
Hypoglycemia OMIM:210200
Cog8-Cdg
Hypoglycemia ORPHA:95428
Hsd10 Disease, Infantile Type
Hypoglycemia ORPHA:391428
Mitochondrial Complex I Deficiency, Nuclear Type 20
Hypoglycemia OMIM:611126
Smith-Kingsmore Syndrome
Hypoglycemia OMIM:616638
Carnitine-Acylcarnitine Translocase Deficiency
Hypoglycemia, Neonatal hypoglycemia OMIM:212138
Mitochondrial Complex Iv Deficiency, Nuclear Type 3
Neonatal hypoglycemia OMIM:619046
Fanconi-Bickel Syndrome
Fasting hypoglycemia, Impaired glucose tolerance, Glycosuria, Diabetes mellitus, Postprandial hyp... ORPHA:2088
Nephrotic Syndrome, Type 14
Hypoglycemia OMIM:617575
Hypotonia-Cystinuria Syndrome
Neonatal hypoglycemia OMIM:606407
3-Hydroxy-3-Methylglutaryl-Coa Lyase Deficiency
Hypoglycemia OMIM:246450
Combined Oxidative Phosphorylation Deficiency 40
Hypoglycemia OMIM:618835
Combined Oxidative Phosphorylation Deficiency 42
Hypoglycemia OMIM:618839
Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency
Hypoketotic hypoglycemia, Hyperinsulinemic hypoglycemia, Neonatal hypoglycemia, Fasting hyperinsu... ORPHA:71212
Microcephaly, Short Stature, And Impaired Glucose Metabolism 2
Recurrent hypoglycemia OMIM:616817
Fructose-1,6-Bisphosphatase Deficiency
Hypoglycemia OMIM:229700
Immunodeficiency, Common Variable, 10
Hypoglycemia OMIM:615577
Midface Hypoplasia, Obesity, Developmental Delay, And Neonatal Hypotonia
Hypoglycemia OMIM:608624
Carnitine Palmitoyltransferase I Deficiency
Hypoketotic hypoglycemia OMIM:255120
Silver-Russell Syndrome Due To A Point Mutation
Hypoglycemia ORPHA:397590
Bachmann-Bupp Syndrome
Hypoglycemia OMIM:619075
Propionic Acidemia
Hypoglycemia OMIM:606054
Neurodevelopmental Disorder, Mitochondrial, With Abnormal Movements And Lactic Acidosis, With Or Without Seizures
Hypoglycemia OMIM:617710
Cholestasis, Progressive Familial Intrahepatic, 5
Hypoglycemia OMIM:617049
Glutaric Acidemia I
Hypoglycemia OMIM:231670
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)
Hypoglycemia OMIM:251880
Multiple Acyl-Coa Dehydrogenase Deficiency
Hypoglycemia, Glycosuria OMIM:231680
Dopamine Beta-Hydroxylase Deficiency
Hypoglycemia, Hyperinsulinemia, Insulin resistance ORPHA:230
Pituitary Stalk Interruption Syndrome
Hypoglycemia ORPHA:95496
Tenorio Syndrome
Hypoinsulinemia, Hypoglycemia OMIM:616260
Beta-Ketothiolase Deficiency
Hyperglycemia, Hypoglycemia ORPHA:134
Silver-Russell Syndrome 1
Fasting hypoglycemia OMIM:180860
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency
Recurrent hypoglycemia, Fasting hypoglycemia, Ketotic hypoglycemia ORPHA:79240
Mitochondrial Complex Iv Deficiency, Nuclear Type 12
Hypoglycemia, Neonatal hypoglycemia OMIM:619055
Multiple Acyl-Coa Dehydrogenase Deficiency
Hypoglycemia ORPHA:26791
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency
Fasting hypoglycemia, Hypoglycemia ORPHA:264580
Carnitine-Acylcarnitine Translocase Deficiency
Fasting hypoglycemia, Hypoketotic hypoglycemia ORPHA:159
3-Methylcrotonyl-Coa Carboxylase 2 Deficiency
Hypoglycemia OMIM:210210
Intellectual Disability-Macrocephaly-Hypotonia-Behavioral Abnormalities Syndrome
Hypoglycemia ORPHA:457279
Recurrent Metabolic Encephalomyopathic Crises-Rhabdomyolysis-Cardiac Arrhythmia-Intellectual Disability Syndrome
Hypoglycemic seizures, Hypoglycemia ORPHA:480864
Rabson-Mendenhall Syndrome
Fasting hypoglycemia, Insulin resistance, Insulin-resistant diabetes mellitus, Diabetic ketoacido... ORPHA:769
Macrocephaly-Intellectual Disability-Neurodevelopmental Disorder-Small Thorax Syndrome
Neonatal hypoglycemia ORPHA:457485
Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of
Nonketotic hypoglycemia OMIM:201475
Mitochondrial Complex Iv Deficiency, Nuclear Type 22
Hypoglycemia OMIM:619355
Carnitine Palmitoyl Transferase Ii Deficiency, Severe Infantile Form
Hypoketotic hypoglycemia ORPHA:228305
Mitochondrial Complex Iii Deficiency, Nuclear Type 1
Hypoglycemia OMIM:124000
Congenital Disorder Of Glycosylation, Type Iie
Hypoglycemia OMIM:608779
Combined Oxidative Phosphorylation Defect Type 39
Neonatal hypoglycemia ORPHA:565624
Congenital Disorder Of Glycosylation With Defective Fucosylation 1
Hypoglycemia OMIM:618005
Cerebral Visual Impairment
Neonatal hypoglycemia ORPHA:447788
Silver-Russell Syndrome
Recurrent hypoglycemia, Insulin resistance ORPHA:813
Mirage Syndrome
Hypoglycemia OMIM:617053
Immunodeficiency 59 And Hypoglycemia
Hypoglycemia OMIM:233600
Leigh Syndrome
Hypoglycemia ORPHA:506
Metabolic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration
Hypoglycemia OMIM:616878
Late-Onset Isolated Acth Deficiency
Hypoglycemia, Type I diabetes mellitus ORPHA:199299
Combined Oxidative Phosphorylation Deficiency 37
Hypoglycemia OMIM:618329
Mitochondrial Trifunctional Protein Deficiency
Hypoketotic hypoglycemia OMIM:609015
Isolated Complex I Deficiency
Hypoglycemia, Diabetes mellitus ORPHA:2609
3-Methylglutaconic Aciduria Type 7
Neonatal hypoglycemia ORPHA:445038
Pituitary Apoplexy
Hypoglycemia ORPHA:95613
Congenital Disorder Of Glycosylation, Type It
Hypoglycemia OMIM:614921
Acyl-Coa Dehydrogenase 9 Deficiency
Nonketotic hypoglycemia ORPHA:99901
Glycogen Storage Disease Of Heart, Lethal Congenital
Neonatal hypoglycemia OMIM:261740
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal
Nonketotic hypoglycemia OMIM:608836
X-Linked Dominant Chondrodysplasia Punctata
Neonatal hypoglycemia ORPHA:35173
Familial Glucocorticoid Deficiency
Hypoglycemic seizures, Ketotic hypoglycemia ORPHA:361
Cholera
Hypoglycemia ORPHA:173
Oculodentodigital Dysplasia
Hypoglycemia ORPHA:2710
Dilated Cardiomyopathy With Ataxia
Neonatal hypoglycemia ORPHA:66634
Mitochondrial Trifunctional Protein Deficiency
Hypoketotic hypoglycemia ORPHA:746
Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency
Hypoglycemia ORPHA:90790
Bannayan-Riley-Ruvalcaba Syndrome
Hypoglycemia ORPHA:109
Wars2-Related Combined Oxidative Phosphorylation Defect
Neonatal hypoglycemia ORPHA:572798
Pyruvate Carboxylase Deficiency
Hyperglycemia, Hypoglycemia ORPHA:3008
Glycogen Storage Disease Ia
Hypoglycemia OMIM:232200
Glycogen Storage Disease Ib
Hypoglycemia OMIM:232220
3-Hydroxy-3-Methylglutaric Aciduria
Recurrent hypoglycemia, Nonketotic hypoglycemia ORPHA:20
Sheehan Syndrome
Hypoglycemia ORPHA:91355
Holoprosencephaly
Hypoglycemia, Diabetes mellitus ORPHA:2162
Neurologic, Endocrine, And Pancreatic Disease, Multisystem, Infantile-Onset 2
Hypoglycemia, Neonatal hypoglycemia OMIM:619418
Shigellosis
Hypoglycemia ORPHA:810
Kabuki Syndrome 2
Neonatal hypoglycemia OMIM:300867
Multiple Endocrine Neoplasia, Type I
Hypoglycemia OMIM:131100
Glycogen Storage Disease Due To Phosphorylase Kinase Deficiency
Fasting hypoglycemia ORPHA:370
Renal Agenesis, Bilateral
Nonketotic hypoglycemia ORPHA:1848
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Hypoketotic hypoglycemia ORPHA:26793
Intellectual Developmental Disorder, X-Linked, Syndromic, With Pigmentary Mosaicism And Coarse Facies
Hypoglycemia OMIM:301066
Methylmalonic Acidemia With Homocystinuria, Type Cblc
Hypoglycemia ORPHA:79282
Visceral Steatosis, Congenital
Hypoglycemia OMIM:228100
Deficiency In Anterior Pituitary Function-Variable Immunodeficiency Syndrome
Recurrent hypoglycemia ORPHA:293978
Glutaryl-Coa Dehydrogenase Deficiency
Fasting hypoglycemia ORPHA:25
Acute Adrenal Insufficiency
Hypoglycemia ORPHA:95409
Congenital Adrenal Hyperplasia Due To 3-Beta-Hydroxysteroid Dehydrogenase Deficiency
Neonatal hypoglycemia ORPHA:90791
Alg12-Cdg
Recurrent hypoglycemia ORPHA:79324
Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria
Hypoglycemia ORPHA:17
Carnitine Palmitoyltransferase Ii Deficiency
Hypoketotic hypoglycemia ORPHA:157
Silver-Russell Syndrome Due To Maternal Uniparental Disomy Of Chromosome 7
Fasting hypoglycemia, Insulin resistance ORPHA:96182
Menkes Disease
Hypoglycemia ORPHA:565
Leprechaunism
Fasting hypoglycemia, Insulin resistance, Recurrent infantile hypoglycemia, Postprandial hypergly... ORPHA:508
Hereditary Fructose Intolerance
Reactive hypoglycemia ORPHA:469
Generalized Glucocorticoid Resistance Syndrome
Hypoglycemia ORPHA:786
Mitochondrial Complex I Deficiency, Nuclear Type 1
Hypoglycemia OMIM:252010
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ib
Hypoglycemic seizures, Hypoglycemia ORPHA:79259
Addison Disease
Hypoglycemia, Type I diabetes mellitus ORPHA:85138
Bannayan-Riley-Ruvalcaba syndrome
Hypoglycemia OMIM:153480
Carnitine Palmitoyl Transferase Ii Deficiency, Neonatal Form
Hypoketotic hypoglycemia ORPHA:228308
Tyrosinemia, Type I
Hypoglycemia OMIM:276700
Hepatocellular Carcinoma
Type II diabetes mellitus, Hypoglycemia ORPHA:88673
Glycogen Storage Disease Ic
Hypoglycemia OMIM:232240
Histiocytoid Cardiomyopathy
Hypoglycemia ORPHA:137675
Fructose Intolerance, Hereditary
Hypoglycemia, Glycosuria OMIM:229600
Primary Fanconi Renotubular Syndrome
Hypoglycemia, Glycosuria ORPHA:3337
Simpson-Golabi-Behmel Syndrome
Hypoglycemia ORPHA:373
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Hypoglycemia ORPHA:226307
Deeah Syndrome
Neonatal hypoglycemia OMIM:619004
Rajab Interstitial Lung Disease With Brain Calcifications 1
Hypoglycemia OMIM:613658
46,Xy Disorder Of Sex Development-Adrenal Insufficiency Due To Cyp11A1 Deficiency
Neonatal hypoglycemia ORPHA:168558
Inherited Isolated Adrenal Insufficiency Due To Partial Cyp11A1 Deficiency
Neonatal hypoglycemia ORPHA:289548
Beckwith-Wiedemann Syndrome
Hypoglycemia, Neonatal hypoglycemia ORPHA:116
Marburg Hemorrhagic Fever
Hypoglycemia ORPHA:99826
Costello Syndrome
Hypoglycemia OMIM:218040
Acute Liver Failure
Hypoglycemia ORPHA:90062
Megalencephaly-Severe Kyphoscoliosis-Overgrowth Syndrome
Neonatal hypoglycemia ORPHA:457359
Non-Acquired Panhypopituitarism
Hypoglycemia ORPHA:90695
Beckwith-Wiedemann Syndrome
Neonatal hypoglycemia OMIM:130650
Combined Pituitary Hormone Deficiencies, Genetic Forms
Hypoglycemia ORPHA:95494
Holoprosencephaly 1
Hypoglycemia OMIM:236100
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Neonatal hypoglycemia ORPHA:90794
Sotos Syndrome
Neonatal hypoglycemia ORPHA:821

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Fbp1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Fbp1.

No publications found that use IMPC mice or data for Fbp1.

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MGI Allele Allele Type Produced
Fbp1tm436505(L1L2_GT2_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Fbp1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Fbp1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Fbp1tm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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