Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

fructose bisphosphatase 1
Fbp-2,  FBPase liver,  FBPase brain isoform,  Fbp3

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Fbp1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Fbp1 by orthology or direct annotation.

Disease Similarity of
Matching phenotypes Source
Fructose-1,6-Bisphosphatase Deficiency
Neonatal hypoglycemia, Hypoglycemia, Fasting hypoglycemia ORPHA:348
Fructose-1,6-Bisphosphatase Deficiency
Hypoglycemia OMIM:229700

The table below shows human diseases predicted to be associated to Fbp1 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
3-Hydroxy-3-Methylglutaryl-Coa Synthase Deficiency
Hypoglycemia ORPHA:35701
Hyperinsulinemic Hypoglycemia, Familial, 7
Hypoglycemic seizures, Hypoglycemia, Hyperinsulinemia, Hyperinsulinemic hypoglycemia OMIM:610021
Glycogen Storage Disease 0, Liver
Neonatal hypoglycemia, Postprandial hyperglycemia, Fasting hypoglycemia OMIM:240600
Maturity-Onset Diabetes Of The Young, Type 3
Maturity-onset diabetes of the young, Hyperglycemia, Type II diabetes mellitus OMIM:600496
Dwarfism, Low-Birth-Weight Type, With Unresponsiveness To Growth Hormone
Hypoglycemia OMIM:223500
Hyperinsulinism Due To Insr Deficiency
Hyperinsulinemic hypoglycemia, Hypoglycemia, Recurrent hypoglycemia, Insulin resistance, Fasting ... ORPHA:263458
Hypoinsulinemic Hypoglycemia And Body Hemihypertrophy
Nonketotic hypoglycemia, Hypoglycemic seizures, Neonatal hypoglycemia, Hypoketotic hypoglycemia ORPHA:293964
Fructose And Galactose Intolerance
Hypoglycemia OMIM:229500
Hyperinsulinemia, Hyperglycemia OMIM:616214
Hyperinsulinemic Hypoglycemia, Familial, 2
Hyperinsulinemic hypoglycemia, Hypoglycemia OMIM:601820
Hyperinsulinemic Hypoglycemia, Familial, 3
Hypoglycemic seizures, Diabetes mellitus, Hyperinsulinemic hypoglycemia OMIM:602485
Short Stature Due To Partial Ghr Deficiency
Hypoglycemia ORPHA:314802
Phosphoenolpyruvate Carboxykinase Deficiency, Mitochondrial
Hypoglycemia, Impaired gluconeogenesis OMIM:261650
Maturity-Onset Diabetes Of The Young, Type 10
Diabetic ketoacidosis, Diabetes mellitus, Maturity-onset diabetes of the young, Hyperglycemia OMIM:613370
Congenital Glucokinase-Related Hyperinsulinism
Hypoketotic hypoglycemia, Type II diabetes mellitus, Recurrent hypoglycemia, Hyperinsulinemic hyp... ORPHA:79299
Hypoinsulinemic Hypoglycemia With Hemihypertrophy
Neonatal hypoglycemia, Hypoinsulinemia, Hypoglycemia, Fasting hypoglycemia OMIM:240900
Glycogen Storage Disease Due To Glycogen Debranching Enzyme Deficiency
Hypoglycemia ORPHA:366
Insulin Autoimmune Syndrome
Hyperinsulinemic hypoglycemia, Fasting hypoglycemia, Nonketotic hypoglycemia, Insulin resistance,... ORPHA:411593
Long-Chain 3-Hydroxyacyl-Coa Dehydrogenase Deficiency
Hypoglycemia OMIM:609016
Hypoglycemia, Leucine-Induced
Hyperinsulinemic hypoglycemia, Hypoglycemia OMIM:240800
Pituitary Hormone Deficiency, Combined, 4
Hypoglycemia OMIM:262700
Short Stature Due To Ghsr Deficiency
Hypoglycemia ORPHA:314811
Isolated Growth Hormone Deficiency, Type Ia
Hypoglycemia OMIM:262400
Dicarboxylic Aminoaciduria
Fasting hypoglycemia OMIM:222730
Mitochondrial Complex Iii Deficiency, Nuclear Type 3
Hypoglycemia OMIM:615158
Orthostatic Hypotension 2
Hypoglycemia OMIM:618182
3-Methylglutaconic Aciduria Type 1
Hypoglycemia ORPHA:67046
Hyperinsulinism Due To Hnf1A Deficiency
Hypoglycemic seizures, Neonatal hypoglycemia, Hyperinsulinemia, Maturity-onset diabetes of the yo... ORPHA:324575
Hyperinsulinism-Hyperammonemia Syndrome
Hyperinsulinemic hypoglycemia, Fasting hyperinsulinemia, Reactive hypoglycemia ORPHA:35878
Homozygous 11P15-P14 Deletion Syndrome
Hypoglycemia, Hyperinsulinemia OMIM:606528
Monocarboxylate Transporter 1 Deficiency
Ketotic hypoglycemia OMIM:616095
Glycogen Storage Disease Vi
Hypoglycemia OMIM:232700
Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, And Somatic Abnormalities
Hyperinsulinemia, Fasting hypoglycemia, Hyperglycemia, Diabetic ketoacidosis, Hypoglycemia, Postp... OMIM:262190
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Hyperinsulinemia, Fasting hypoglycemia, Hypoketotic hypoglycemia, Hyperinsulinemic hypoglycemia, ... ORPHA:276608
Neonatal Hemochromatosis
Hypoglycemia ORPHA:446
Hyperinsulinemic Hypoglycemia, Familial, 8
Hypoglycemic seizures, Hypoglycemia, Hyperinsulinemia OMIM:620211
Pyridoxamine 5-Prime-Phosphate Oxidase Deficiency
Hypoglycemia OMIM:610090
Diarrhea 13
Recurrent hypoglycemia OMIM:620357
Short Stature-Delayed Bone Age Due To Thyroid Hormone Metabolism Deficiency
Fasting hypoglycemia ORPHA:171706
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Hypoglycemic seizures, Hyperinsulinemia, Maternal diabetes, Hypoketotic hypoglycemia, Fasting hyp... ORPHA:276580
Ornithine Transcarbamylase Deficiency
Hypoglycemia ORPHA:664
Propionic Acidemia
Hypoglycemia ORPHA:35
3-Methylcrotonyl-Coa Carboxylase Deficiency
Hypoglycemia ORPHA:6
Endocardial Fibroelastosis
Hypoglycemia ORPHA:2022
Isobutyryl-Coa Dehydrogenase Deficiency
Ketotic hypoglycemia ORPHA:79159
Hyperinsulinism Due To Ucp2 Deficiency
Hypoglycemic seizures, Hypoketotic hypoglycemia, Recurrent hypoglycemia, Hyperinsulinemic hypogly... ORPHA:276556
Mitochondrial Complex Iii Deficiency, Nuclear Type 9
Hypoglycemia OMIM:616111
Riboflavin Deficiency
Hypoglycemia OMIM:615026
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Hypoglycemic seizures, Hyperinsulinemia, Hypoketotic hypoglycemia, Fasting hypoglycemia, Hyperins... ORPHA:276575
Intellectual Developmental Disorder With Macrocephaly, Seizures, And Speech Delay
Recurrent hypoglycemia OMIM:618158
Silver-Russell Syndrome Due To An Imprinting Defect Of 11P15
Neonatal hypoglycemia, Hypoglycemia ORPHA:231140
Silver-Russell Syndrome Due To Maternal Uniparental Disomy Of Chromosome 11
Hypoglycemia ORPHA:231147
2-Methylbutyryl-Coa Dehydrogenase Deficiency
Hypoglycemia OMIM:610006
Glucocorticoid Deficiency 3
Recurrent hypoglycemia OMIM:609197
3-Methylglutaconic Aciduria Type 4
Hypoglycemia ORPHA:67048
Mitochondrial Pyruvate Carrier Deficiency
Hypoglycemia OMIM:614741
Diabetes Mellitus, Permanent Neonatal, 4
Diabetic ketoacidosis, Type I diabetes mellitus, Hyperglycemia OMIM:618858
Glycogen Storage Disease Due To Hepatic Glycogen Synthase Deficiency
Glycosuria, Ketotic hypoglycemia, Postprandial hyperglycemia ORPHA:2089
Mehmo Syndrome
Hypoglycemia OMIM:300148
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency
Hypoglycemia ORPHA:364
Diabetes Mellitus, Transient Neonatal, 3
Hyperglycemia, Maternal diabetes, Transient neonatal diabetes mellitus OMIM:610582
Mitochondrial Complex Iii Deficiency, Nuclear Type 11
Hypoglycemia OMIM:620137
Dihydrolipoamide Dehydrogenase Deficiency
Hypoglycemia OMIM:246900
Short Chain Acyl-Coa Dehydrogenase Deficiency
Ketotic hypoglycemia ORPHA:26792
Hsd10 Mitochondrial Disease
Hypoglycemia OMIM:300438
2P21 Microdeletion Syndrome
Hypoglycemia ORPHA:163693
Glycogen Storage Disease Iii
Hypoglycemia OMIM:232400
Glycogen Storage Disease Ixb
Hypoglycemia OMIM:261750
Mitochondrial Complex Iv Deficiency, Nuclear Type 4
Hypoglycemia OMIM:619048
Combined Oxidative Phosphorylation Deficiency 34
Hypoglycemia OMIM:617872
Mitochondrial Complex I Deficiency, Nuclear Type 19
Hypoglycemia OMIM:618241
Neonatal hypoglycemia, Hypoinsulinemia, Glycosuria, Hyperglycemia, Transient neonatal diabetes me... ORPHA:552
Combined Malonic And Methylmalonic Acidemia
Hypoglycemia ORPHA:289504
Hyperinsulinemia, Nonketotic hypoglycemia, Recurrent hypoglycemia, Hyperinsulinemic hypoglycemia,... ORPHA:97279
Combined Oxidative Phosphorylation Deficiency 36
Hypoglycemia OMIM:617950
Acth Deficiency, Isolated
Fasting hypoglycemia OMIM:201400
Hemochromatosis, Neonatal
Hypoglycemia OMIM:231100
Pyridoxine-Dependent Epilepsy
Hypoglycemia ORPHA:3006
Glycogen Storage Disease Ixa1
Hypoglycemia OMIM:306000
Pyruvate Carboxylase Deficiency
Hypoglycemia OMIM:266150
Combined Oxidative Phosphorylation Deficiency 47
Hypoglycemia OMIM:618958
Histidinuria-Renal Tubular Defect Syndrome
Hypoglycemia ORPHA:2158
Congenital Cataracts-Facial Dysmorphism-Neuropathy Syndrome
Hypoglycemia ORPHA:48431
Congenital Isolated Acth Deficiency
Hypoglycemic seizures, Neonatal hypoglycemia ORPHA:199296
Mitochondrial Complex Iii Deficiency, Nuclear Type 5
Hypoglycemia OMIM:615160
Combined Oxidative Phosphorylation Deficiency 52
Hypoglycemia OMIM:619386
Mitochondrial Complex V (Atp Synthase) Deficiency, Nuclear Type 5
Hypoglycemia OMIM:618120
Adrenal Hyperplasia, Congenital, Due To 21-Hydroxylase Deficiency
Hypoglycemia OMIM:201910
Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic
Hypoglycemia, Fasting hypoglycemia, Impaired gluconeogenesis OMIM:261680
Hypoadrenocorticism, Familial
Hypoglycemia OMIM:240200
Proprotein Convertase 1/3 Deficiency
Hypoinsulinemia, Reactive hypoglycemia OMIM:600955
Glycogen Storage Disease Ixc
Hypoglycemia, Fasting hypoglycemia OMIM:613027
Blue Diaper Syndrome
Increased proinsulin:insulin ratio, Recurrent hypoglycemia ORPHA:94086
Glycogen Storage Disease Due To Liver Glycogen Phosphorylase Deficiency
Hypoglycemia ORPHA:369
Infantile Liver Failure Syndrome 2
Hypoglycemia OMIM:616483
Combined Oxidative Phosphorylation Deficiency 41
Hypoglycemia OMIM:618838
Silver-Russell Syndrome 2
Neonatal hypoglycemia OMIM:618905
Non-Acquired Isolated Growth Hormone Deficiency
Neonatal hypoglycemia ORPHA:631
Autosomal Recessive Hyperinsulinism Due To Kir6.2 Deficiency
Hyperinsulinemic hypoglycemia, Neonatal hypoglycemia, Recurrent hypoglycemia ORPHA:79644
Silver-Russell Syndrome Due To 7P11.2P13 Microduplication
Hypoglycemia ORPHA:231137
Long Chain 3-Hydroxyacyl-Coa Dehydrogenase Deficiency
Hypoglycemia, Hypoketotic hypoglycemia ORPHA:5
Congenital Hyperinsulinism Due To Hnf4A Deficiency
Neonatal hypoglycemia, Hyperinsulinemia, Hypoketotic hypoglycemia, Fasting hypoglycemia, Glycosur... ORPHA:263455
Malonyl-Coa Decarboxylase Deficiency
Hypoglycemia OMIM:248360
Glycogen Storage Disease Ixd
Hypoglycemia OMIM:300559
Temple Syndrome
Type II diabetes mellitus, Recurrent hypoglycemia ORPHA:254516
3-Methylglutaconic Aciduria With Deafness, Encephalopathy, And Leigh-Like Syndrome
Hypoglycemia OMIM:614739
Combined Oxidative Phosphorylation Deficiency 10
Hypoglycemia OMIM:614702
Glucocorticoid Resistance, Generalized
Hypoglycemia OMIM:615962
Pyruvate Dehydrogenase E3 Deficiency
Hypoglycemia ORPHA:2394
Polyendocrine-Polyneuropathy Syndrome
Hypoglycemia, Hypoinsulinemia, Type II diabetes mellitus ORPHA:453533
Laron Syndrome
Hypoglycemia ORPHA:633
Pituitary Hormone Deficiency, Combined, 6
Neonatal hypoglycemia, Hypoglycemia OMIM:613986
Glucocorticoid Deficiency 2
Hypoglycemia, Recurrent hypoglycemia OMIM:607398
3-Hydroxyacyl-Coa Dehydrogenase Deficiency
Hypoglycemic seizures, Hypoketotic hypoglycemia OMIM:231530
Pituitary Hormone Deficiency, Combined, 2
Hypoglycemic seizures, Neonatal hypoglycemia OMIM:262600
Fanconi Renotubular Syndrome 4 With Maturity-Onset Diabetes Of The Young
Glycosuria, Hypoglycemia, Diabetes mellitus OMIM:616026
Pyridoxal Phosphate-Responsive Seizures
Hypoglycemia ORPHA:79096
Mitochondrial Dna Depletion Syndrome 9 (Encephalomyopathic Type With Methylmalonic Aciduria)
Hypoglycemia OMIM:245400
Carnitine Palmitoyl Transferase 1A Deficiency
Hypoglycemia ORPHA:156
Aromatic L-Amino Acid Decarboxylase Deficiency
Hypoglycemia ORPHA:35708
Carnitine Palmitoyltransferase Ii Deficiency, Infantile
Hypoketotic hypoglycemia OMIM:600649
Primary Microcephaly-Mild Intellectual Disability-Young-Onset Diabetes Syndrome
Hypoglycemia, Diabetes mellitus ORPHA:391408
Cataract-Growth Hormone Deficiency-Sensory Neuropathy-Sensorineural Hearing Loss-Skeletal Dysplasia Syndrome
Fasting hypoglycemia ORPHA:436174
Galactokinase Deficiency
Hypoglycemia, Hyperinsulinemia ORPHA:79237
Mitochondrial Complex Iii Deficiency, Nuclear Type 6
Hypoglycemia, Hyperglycemia OMIM:615453
Medium Chain Acyl-Coa Dehydrogenase Deficiency
Hypoglycemia ORPHA:42
Classic Galactosemia
Hypoglycemia ORPHA:79239
Mitochondrial Complex I Deficiency, Nuclear Type 33
Hypoglycemia OMIM:618253
Houge-Janssens Syndrome 1
Hypoglycemia OMIM:616355
Polyendocrine-Polyneuropathy Syndrome
Type I diabetes mellitus, Hypoglycemia OMIM:616113
Post-Traumatic Pituitary Deficiency
Hypoglycemia ORPHA:95619
Solitary Fibrous Tumor
Hypoglycemia, Hypoinsulinemia, Recurrent hypoglycemia ORPHA:2126
Neurodevelopmental Disorder, Mitochondrial, With Abnormal Movements And Lactic Acidosis, With Or Without Seizures
Hypoglycemia OMIM:617710
Glucocorticoid Deficiency 4 With Or Without Mineralocorticoid Deficiency
Hypoglycemia OMIM:614736
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Insulin resistance, Hypoglycemia ORPHA:73272
Aica-Ribosiduria Due To Atic Deficiency
Hypoglycemia OMIM:608688
Fructose-1,6-Bisphosphatase Deficiency
Neonatal hypoglycemia, Hypoglycemia, Fasting hypoglycemia ORPHA:348
Hypoglycemia ORPHA:95428
Acyl-Coa Dehydrogenase, Medium-Chain, Deficiency Of
Hypoglycemia OMIM:201450
Insulin-Resistance Syndrome Type B
Hyperinsulinemia, Hyperinsulinemic hypoglycemia, Fasting hypoglycemia, Glycosuria, Hyperglycemia,... ORPHA:2298
Hsd10 Disease, Infantile Type
Hypoglycemia ORPHA:391428
Donohue Syndrome
Hyperinsulinemia, Hyperglycemia, Postprandial hyperglycemia, Fasting hypoglycemia OMIM:246200
Maple Syrup Urine Disease, Type Ia
Hypoglycemia OMIM:248600
Carnitine-Acylcarnitine Translocase Deficiency
Neonatal hypoglycemia, Hypoglycemia OMIM:212138
Carnitine Deficiency, Systemic Primary
Recurrent hypoglycemia, Impaired gluconeogenesis OMIM:212140
Glucocorticoid Deficiency 1
Recurrent hypoglycemia OMIM:202200
Timothy Syndrome
Hypoglycemia OMIM:601005
Propionic Acidemia
Hypoglycemia OMIM:606054
Mitochondrial Complex Iv Deficiency, Nuclear Type 3
Neonatal hypoglycemia OMIM:619046
Combined Oxidative Phosphorylation Deficiency 40
Hypoglycemia OMIM:618835
Combined Oxidative Phosphorylation Deficiency 42
Hypoglycemia OMIM:618839
Smith-Kingsmore Syndrome
Hypoglycemia OMIM:616638
3-Methylcrotonyl-Coa Carboxylase 1 Deficiency
Hypoglycemia OMIM:210200
Fructose-1,6-Bisphosphatase Deficiency
Hypoglycemia OMIM:229700
Microcephaly, Short Stature, And Impaired Glucose Metabolism 2
Recurrent hypoglycemia OMIM:616817
Fanconi-Bickel Syndrome
Fasting hypoglycemia, Impaired glucose tolerance, Glycosuria, Diabetes mellitus, Postprandial hyp... ORPHA:2088
Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency
Hypoglycemic seizures, Neonatal hypoglycemia, Hypoketotic hypoglycemia, Hyperinsulinemic hypoglyc... ORPHA:71212
Bachmann-Bupp Syndrome
Hypoglycemia OMIM:619075
Long-Olsen-Distelmaier Syndrome
Hypoglycemia OMIM:620609
Mitochondrial Complex I Deficiency, Nuclear Type 20
Hypoglycemia OMIM:611126
Hypotonia-Cystinuria Syndrome
Neonatal hypoglycemia OMIM:606407
Immunodeficiency, Common Variable, 10
Hypoglycemia OMIM:615577
Cholestasis, Progressive Familial Intrahepatic, 5
Hypoglycemia OMIM:617049
Basilicata-Akhtar Syndrome
Neonatal hypoglycemia OMIM:301032
Reni Syndrome
Hypoglycemia OMIM:617575
Silver-Russell Syndrome Due To A Point Mutation
Hypoglycemia ORPHA:397590
Mitochondrial Complex Iv Deficiency, Nuclear Type 23
Hypoglycemia OMIM:620275
Silver-Russell Syndrome 1
Fasting hypoglycemia OMIM:180860
Shashi-Pena Syndrome
Hypoglycemia OMIM:617190
3-Hydroxy-3-Methylglutaryl-Coa Synthase-2 Deficiency
Hypoglycemia OMIM:605911
Tenorio Syndrome
Hypoglycemia, Hypoinsulinemia OMIM:616260
Intellectual Developmental Disorder, Autosomal Dominant 45
Neonatal hypoglycemia OMIM:617600
Immunodeficiency 10
Hypoglycemia OMIM:612783
Methylmalonic Aciduria Due To Methylmalonyl-Coa Mutase Deficiency
Hypoglycemia OMIM:251000
Mitochondrial Trifunctional Protein Deficiency 2
Hypoglycemia OMIM:620300
Pituitary Stalk Interruption Syndrome
Hypoglycemia ORPHA:95496
Glutaric Acidemia I
Hypoglycemia OMIM:231670
D-Glyceric Aciduria
Hypoglycemia OMIM:220120
Multiple Acyl-Coa Dehydrogenase Deficiency
Glycosuria, Hypoglycemia OMIM:231680
Dopamine Beta-Hydroxylase Deficiency
Insulin resistance, Hypoglycemia, Hyperinsulinemia ORPHA:230
Beta-Ketothiolase Deficiency
Hypoglycemia, Hyperglycemia ORPHA:134
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal
Nonketotic hypoglycemia, Hypoglycemia OMIM:608836
Congenital Disorder Of Glycosylation, Type Ig
Hypoglycemia OMIM:607143
Multiple Acyl-Coa Dehydrogenase Deficiency
Hypoglycemia ORPHA:26791
Mitochondrial Complex Iv Deficiency, Nuclear Type 12
Neonatal hypoglycemia, Hypoglycemia OMIM:619055
Recurrent Metabolic Encephalomyopathic Crises-Rhabdomyolysis-Cardiac Arrhythmia-Intellectual Disability Syndrome
Hypoglycemic seizures, Hypoglycemia ORPHA:480864
Carnitine-Acylcarnitine Translocase Deficiency
Fasting hypoglycemia, Hypoketotic hypoglycemia ORPHA:159
Mitochondrial Complex Iv Deficiency, Nuclear Type 22
Hypoglycemia OMIM:619355
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency
Ketotic hypoglycemia, Fasting hypoglycemia, Recurrent hypoglycemia ORPHA:79240
Intellectual Disability-Macrocephaly-Hypotonia-Behavioral Abnormalities Syndrome
Hypoglycemia ORPHA:457279
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency
Hypoglycemia, Fasting hypoglycemia ORPHA:264580
Macrocephaly-Intellectual Disability-Neurodevelopmental Disorder-Small Thorax Syndrome
Neonatal hypoglycemia ORPHA:457485
Combined Oxidative Phosphorylation Deficiency 59
Ketotic hypoglycemia OMIM:620646
Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of
Nonketotic hypoglycemia OMIM:201475
Glycogen Storage Disease Ia
Hypoglycemia, Fasting hypoglycemia OMIM:232200
Pancreatic And Cerebellar Agenesis
Hypoglycemia, Diabetes mellitus, Hyperglycemia OMIM:609069
Rabson-Mendenhall Syndrome
Fasting hypoglycemia, Impaired glucose tolerance, Diabetic ketoacidosis, Insulin resistance, Fast... ORPHA:769
Midface Hypoplasia, Obesity, Developmental Delay, And Neonatal Hypotonia
Neonatal hypoglycemia OMIM:608624
Mirage Syndrome
Hypoglycemia OMIM:617053
Methylmalonic Aciduria, Cblb Type
Hypoglycemia OMIM:251110
Carnitine Palmitoyl Transferase Ii Deficiency, Severe Infantile Form
Hypoketotic hypoglycemia ORPHA:228305
Neurodevelopmental Disorder With Hypotonia, Dysmorphic Facies, And Skeletal Anomalies, With Or Without Seizures
Hypoglycemia OMIM:620224
Carnitine Palmitoyltransferase I Deficiency
Hypoketotic hypoglycemia OMIM:255120
Combined Oxidative Phosphorylation Defect Type 39
Neonatal hypoglycemia ORPHA:565624
3-Hydroxy-3-Methylglutaryl-Coa Lyase Deficiency
Hypoglycemia OMIM:246450
Combined Oxidative Phosphorylation Deficiency 37
Hypoglycemia OMIM:618329
3-Methylcrotonyl-Coa Carboxylase 2 Deficiency
Hypoglycemia OMIM:210210
Congenital Disorder Of Glycosylation, Type Iie
Hypoglycemia OMIM:608779
Congenital Disorder Of Glycosylation, Type Iiaa
Hypoglycemia OMIM:620454
Combined Oxidative Phosphorylation Deficiency 58
Hypoglycemia OMIM:620451
Isolated Complex I Deficiency
Hypoglycemia, Diabetes mellitus ORPHA:2609
Late-Onset Isolated Acth Deficiency
Type I diabetes mellitus, Hypoglycemia ORPHA:199299
Growth Retardation, Impaired Intellectual Development, Hypotonia, And Hepatopathy
Hypoglycemia OMIM:617093
Sotos Syndrome
Neonatal hypoglycemia, Glucose intolerance OMIM:117550
Congenital Disorder Of Glycosylation With Defective Fucosylation 1
Hypoglycemia OMIM:618005
Metabolic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration
Hypoglycemia OMIM:616878
Silver-Russell Syndrome
Insulin resistance, Recurrent hypoglycemia ORPHA:813
Leigh Syndrome
Hypoglycemia ORPHA:506
Cataracts, Growth Hormone Deficiency, Sensory Neuropathy, Sensorineural Hearing Loss, And Skeletal Dysplasia
Hypoglycemia OMIM:616007
Multiple Mitochondrial Dysfunctions Syndrome 7
Hypoglycemia, Hyperglycemia OMIM:620423
3-Methylglutaconic Aciduria Type 7
Neonatal hypoglycemia ORPHA:445038
Mitochondrial Trifunctional Protein Deficiency 1
Hypoketotic hypoglycemia OMIM:609015
Cerebral Visual Impairment
Neonatal hypoglycemia ORPHA:447788
Carbonic Anhydrase Va Deficiency, Hyperammonemia Due To
Hypoglycemia OMIM:615751
Congenital Disorder Of Glycosylation, Type It
Hypoglycemia OMIM:614921
Acyl-Coa Dehydrogenase 9 Deficiency
Nonketotic hypoglycemia ORPHA:99901
Immunodeficiency 59 And Hypoglycemia
Hypoglycemia OMIM:233600
Fanconi-Bickel Syndrome
Glycosuria, Postprandial hyperglycemia, Fasting hypoglycemia OMIM:227810
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)
Hypoglycemia OMIM:251880
Familial Glucocorticoid Deficiency
Ketotic hypoglycemia, Hypoglycemic seizures ORPHA:361
Congenital Disorder Of Glycosylation, Type Im
Hypoketotic hypoglycemia OMIM:610768
Oculodentodigital Dysplasia
Hypoglycemia ORPHA:2710
X-Linked Dominant Chondrodysplasia Punctata
Neonatal hypoglycemia ORPHA:35173
Orthostatic Hypotension 1
Neonatal hypoglycemia OMIM:223360
Hypoglycemia ORPHA:173
Pituitary Apoplexy
Hypoglycemia ORPHA:95613
3-Methylglutaconic Aciduria, Type Viib
Neonatal hypoglycemia OMIM:616271
Mitochondrial Dna Depletion Syndrome 6 (Hepatocerebral Type)
Hypoglycemia, Recurrent hypoglycemia OMIM:256810
Dilated Cardiomyopathy With Ataxia
Neonatal hypoglycemia ORPHA:66634
Neurodevelopmental Disorder With Hypotonia, Craniofacial Abnormalities, And Seizures
Hypoglycemia OMIM:614501
Bannayan-Riley-Ruvalcaba Syndrome
Hypoglycemia ORPHA:109
3-Hydroxy-3-Methylglutaric Aciduria
Nonketotic hypoglycemia, Recurrent hypoglycemia ORPHA:20
Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency
Hypoglycemia ORPHA:90790
Neurologic, Endocrine, And Pancreatic Disease, Multisystem, Infantile-Onset 2
Neonatal hypoglycemia, Hypoglycemia OMIM:619418
Pyruvate Carboxylase Deficiency
Hypoglycemia, Hyperglycemia ORPHA:3008
Wars2-Related Combined Oxidative Phosphorylation Defect
Neonatal hypoglycemia ORPHA:572798
Congenital Syphilis
Hypoglycemia ORPHA:499009
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Hypoketotic hypoglycemia ORPHA:26793
Mitochondrial Trifunctional Protein Deficiency
Hypoketotic hypoglycemia ORPHA:746
Hypoglycemia ORPHA:810
Kabuki Syndrome 2
Neonatal hypoglycemia OMIM:300867
Sheehan Syndrome
Hypoglycemia ORPHA:91355
Hypoglycemia, Diabetes mellitus ORPHA:2162
Multiple Endocrine Neoplasia, Type I
Hypoglycemia OMIM:131100
Glutaryl-Coa Dehydrogenase Deficiency
Fasting hypoglycemia ORPHA:25
Glycogen Storage Disease Ib
Hypoglycemia OMIM:232220
Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria
Hypoglycemia ORPHA:17
Intellectual Developmental Disorder, X-Linked, Syndromic, With Pigmentary Mosaicism And Coarse Facies
Hypoglycemia OMIM:301066
Recurrent hypoglycemia ORPHA:79324
Renal Agenesis, Bilateral
Nonketotic hypoglycemia ORPHA:1848
Mitochondrial Complex Iii Deficiency, Nuclear Type 1
Hypoglycemia, Hyperglycemia, Recurrent hypoglycemia OMIM:124000
Congenital Adrenal Hyperplasia Due To 3-Beta-Hydroxysteroid Dehydrogenase Deficiency
Neonatal hypoglycemia ORPHA:90791
Mitochondrial Dna Depletion Syndrome 15 (Hepatocerebral Type)
Hypoglycemia OMIM:617156
Methylmalonic Acidemia With Homocystinuria, Type Cblc
Hypoglycemia ORPHA:79282
Silver-Russell Syndrome Due To Maternal Uniparental Disomy Of Chromosome 7
Insulin resistance, Fasting hypoglycemia ORPHA:96182
Carnitine Palmitoyltransferase Ii Deficiency
Hypoketotic hypoglycemia ORPHA:157
Acute Adrenal Insufficiency
Hypoglycemia ORPHA:95409
Mitochondrial Complex I Deficiency, Nuclear Type 1
Hypoglycemia OMIM:252010
Perlman Syndrome
Hypoglycemia OMIM:267000
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ib
Hypoglycemic seizures, Hypoglycemia ORPHA:79259
Hyperinsulinemia, Fasting hypoglycemia, Insulin resistance, Postprandial hyperglycemia, Recurrent... ORPHA:508
Hereditary Fructose Intolerance
Reactive hypoglycemia ORPHA:469
Histiocytoid Cardiomyopathy
Hypoglycemia ORPHA:137675
Carnitine Palmitoyl Transferase Ii Deficiency, Neonatal Form
Hypoketotic hypoglycemia ORPHA:228308
Generalized Glucocorticoid Resistance Syndrome
Hypoglycemia ORPHA:786
Menkes Disease
Hypoglycemia ORPHA:565
Addison Disease
Type I diabetes mellitus, Hypoglycemia ORPHA:85138
Glycogen Storage Disease Ic
Hypoglycemia OMIM:232240
Deficiency In Anterior Pituitary Function-Variable Immunodeficiency Syndrome
Recurrent hypoglycemia ORPHA:293978
Tyrosinemia, Type I
Hypoglycemia OMIM:276700
Glycerol Kinase Deficiency
Hypoglycemia OMIM:307030
Fructose Intolerance, Hereditary
Glycosuria, Hypoglycemia OMIM:229600
Rajab Interstitial Lung Disease With Brain Calcifications 1
Hypoglycemia OMIM:613658
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Hypoglycemia ORPHA:226307
Primary Fanconi Renotubular Syndrome
Glycosuria, Hypoglycemia ORPHA:3337
Simpson-Golabi-Behmel Syndrome
Hypoglycemia ORPHA:373
Deeah Syndrome
Neonatal hypoglycemia OMIM:619004
Glycogen Storage Disease Of Heart, Lethal Congenital
Neonatal hypoglycemia OMIM:261740
46,Xy Difference Of Sex Development-Adrenal Insufficiency Due To Cyp11A1 Deficiency
Neonatal hypoglycemia ORPHA:168558
Inherited Isolated Adrenal Insufficiency Due To Partial Cyp11A1 Deficiency
Neonatal hypoglycemia ORPHA:289548
Beckwith-Wiedemann Syndrome
Neonatal hypoglycemia, Hypoglycemia ORPHA:116
Mitochondrial Complex Iv Deficiency, Nuclear Type 5
Hypoglycemia, Hyperglycemia OMIM:220111
Costello Syndrome
Hypoglycemia OMIM:218040
Marburg Hemorrhagic Fever
Hypoglycemia ORPHA:99826
Non-Acquired Panhypopituitarism
Hypoglycemia ORPHA:90695
Neurooculorenal Syndrome
Recurrent hypoglycemia OMIM:620305
Megalencephaly-Severe Kyphoscoliosis-Overgrowth Syndrome
Neonatal hypoglycemia ORPHA:457359
Acute Liver Failure
Hypoglycemia ORPHA:90062
3-Methylglutaconic Aciduria, Type Viii
Neonatal hypoglycemia OMIM:617248
Holoprosencephaly 1
Hypoglycemia OMIM:236100
Combined Pituitary Hormone Deficiencies, Genetic Forms
Hypoglycemia ORPHA:95494
Beckwith-Wiedemann Syndrome
Neonatal hypoglycemia OMIM:130650
Antley-Bixler Syndrome With Genital Anomalies And Disordered Steroidogenesis
Hypoglycemia OMIM:201750
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Neonatal hypoglycemia ORPHA:90794
Sotos Syndrome
Neonatal hypoglycemia ORPHA:821


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Fbp1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Fbp1.

No publications found that use IMPC mice or data for Fbp1.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Fbp1tm436505(L1L2_GT2_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Fbp1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Fbp1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Fbp1tm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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