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Gene: Fbp1 MGI:95492

Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:

fructose bisphosphatase 1

Synonyms:

Fbp-2, FBPase liver, FBPase brain isoform, Fbp3

Order Alleles

IMPC Data Collections

No Body Weight Data
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Fbp1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Fbp1 (2 diseases)
Human diseases predicted to be associated with Fbp1 (294 diseases)

The table below shows human diseases associated to Fbp1 by orthology or direct annotation.

Disease	Similarity of phenotypes	Matching phenotypes	Source
Fructose-1,6-Bisphosphatase Deficiency		Fasting hypoglycemia, Hypoglycemia, Neonatal hypoglycemia	ORPHA:348
Fructose-1,6-Bisphosphatase Deficiency		Hypoglycemia	OMIM:229700

The table below shows human diseases predicted to be associated to Fbp1 by phenotypic similarity.

Disease	Matching phenotypes	Source
3-Hydroxy-3-Methylglutaryl-Coa Synthase Deficiency	Hypoglycemia	ORPHA:35701
Glucocorticoid Deficiency 3	Recurrent hypoglycemia	OMIM:609197
Hyperinsulinemic Hypoglycemia, Familial, 7	Hyperinsulinemia, Hypoglycemia, Hypoglycemic seizures, Hyperinsulinemic hypoglycemia	OMIM:610021
Glycogen Storage Disease 0, Liver	Postprandial hyperglycemia, Neonatal hypoglycemia, Fasting hypoglycemia	OMIM:240600
Maturity-Onset Diabetes Of The Young, Type 3	Hyperglycemia, Type II diabetes mellitus, Maturity-onset diabetes of the young	OMIM:600496
Dwarfism, Low-Birth-Weight Type, With Unresponsiveness To Growth Hormone	Hypoglycemia	OMIM:223500
Hyperinsulinism Due To Insr Deficiency	Hypoglycemia, Insulin resistance, Fasting hyperinsulinemia, Recurrent hypoglycemia, Hyperinsuline...	ORPHA:263458
Fructose And Galactose Intolerance	Hypoglycemia	OMIM:229500
Hyperproinsulinemia	Hyperglycemia, Hyperinsulinemia	OMIM:616214
Hyperinsulinemic Hypoglycemia, Familial, 2	Hypoglycemia, Hyperinsulinemic hypoglycemia	OMIM:601820
Hyperinsulinemic Hypoglycemia, Familial, 3	Diabetes mellitus, Hypoglycemic seizures, Hyperinsulinemic hypoglycemia	OMIM:602485
Phosphoenolpyruvate Carboxykinase Deficiency, Mitochondrial	Impaired gluconeogenesis, Hypoglycemia	OMIM:261650
Maturity-Onset Diabetes Of The Young, Type 10	Diabetic ketoacidosis, Hyperglycemia, Diabetes mellitus, Maturity-onset diabetes of the young	OMIM:613370
Congenital Glucokinase-Related Hyperinsulinism	Fasting hyperinsulinemia, Recurrent hypoglycemia, Type II diabetes mellitus, Hyperinsulinemic hyp...	ORPHA:79299
Hypoinsulinemic Hypoglycemia With Hemihypertrophy	Neonatal hypoglycemia, Hypoglycemia, Hypoinsulinemia, Fasting hypoglycemia	OMIM:240900
Short Stature Due To Partial Ghr Deficiency	Hypoglycemia	ORPHA:314802
Glycogen Storage Disease Due To Glycogen Debranching Enzyme Deficiency	Hypoglycemia	ORPHA:366
Insulin Autoimmune Syndrome	Nonketotic hypoglycemia, Reactive hypoglycemia, Insulin-resistant diabetes mellitus, Insulin resi...	ORPHA:411593
Long-Chain 3-Hydroxyacyl-Coa Dehydrogenase Deficiency	Hypoglycemia	OMIM:609016
Hypoglycemia, Leucine-Induced	Hypoglycemia, Hyperinsulinemic hypoglycemia	OMIM:240800
Pituitary Hormone Deficiency, Combined, 4	Hypoglycemia	OMIM:262700
Short Stature Due To Ghsr Deficiency	Hypoglycemia	ORPHA:314811
Isolated Growth Hormone Deficiency, Type Ia	Hypoglycemia	OMIM:262400
Dicarboxylic Aminoaciduria	Fasting hypoglycemia	OMIM:222730
Mitochondrial Complex Iii Deficiency, Nuclear Type 3	Hypoglycemia	OMIM:615158
Orthostatic Hypotension 2	Hypoglycemia	OMIM:618182
3-Methylglutaconic Aciduria Type 1	Hypoglycemia	ORPHA:67046
Hyperinsulinism Due To Hnf1A Deficiency	Ketotic hypoglycemia, Maternal diabetes, Reactive hypoglycemia, Maturity-onset diabetes of the yo...	ORPHA:324575
Hyperinsulinism-Hyperammonemia Syndrome	Hyperinsulinemic hypoglycemia, Fasting hyperinsulinemia, Reactive hypoglycemia	ORPHA:35878
Homozygous 11P15-P14 Deletion Syndrome	Hyperinsulinemia, Hypoglycemia	OMIM:606528
Monocarboxylate Transporter 1 Deficiency	Ketotic hypoglycemia	OMIM:616095
Hypoinsulinemic Hypoglycemia And Body Hemihypertrophy	Nonketotic hypoglycemia, Neonatal hypoglycemia, Hypoglycemic seizures, Hypoketotic hypoglycemia	ORPHA:293964
Glycogen Storage Disease Vi	Hypoglycemia	OMIM:232700
Glucocorticoid Deficiency 2	Recurrent hypoglycemia	OMIM:607398
Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, And Somatic Abnormalities	Hypoglycemia, Insulin-resistant diabetes mellitus, Hyperinsulinemia, Diabetic ketoacidosis, Fasti...	OMIM:262190
Neonatal Hemochromatosis	Hypoglycemia	ORPHA:446
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome	Reactive hypoglycemia, Hyperinsulinemia, Fasting hypoglycemia, Hyperinsulinemic hypoglycemia, Hyp...	ORPHA:276608
Hyperinsulinemic Hypoglycemia, Familial, 8	Hyperinsulinemia, Hypoglycemia, Hypoglycemic seizures	OMIM:620211
Short Stature-Delayed Bone Age Due To Thyroid Hormone Metabolism Deficiency	Fasting hypoglycemia	ORPHA:171706
Diarrhea 13	Recurrent hypoglycemia	OMIM:620357
Pyridoxamine 5-Prime-Phosphate Oxidase Deficiency	Hypoglycemia	OMIM:610090
Ornithine Transcarbamylase Deficiency	Hypoglycemia	ORPHA:664
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency	Maternal diabetes, Hyperinsulinemia, Hypoglycemic seizures, Fasting hypoglycemia, Hyperinsulinemi...	ORPHA:276580
Propionic Acidemia	Hypoglycemia	ORPHA:35
3-Methylcrotonyl-Coa Carboxylase Deficiency	Hypoglycemia	ORPHA:6
Endocardial Fibroelastosis	Hypoglycemia	ORPHA:2022
Mitochondrial Complex Iii Deficiency, Nuclear Type 9	Hypoglycemia	OMIM:616111
Isobutyryl-Coa Dehydrogenase Deficiency	Ketotic hypoglycemia	ORPHA:79159
Hyperinsulinism Due To Ucp2 Deficiency	Reactive hypoglycemia, Hypoglycemic seizures, Recurrent hypoglycemia, Hyperinsulinemic hypoglycem...	ORPHA:276556
Riboflavin Deficiency	Hypoglycemia	OMIM:615026
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency	Hyperinsulinemia, Hypoglycemic seizures, Fasting hypoglycemia, Hyperinsulinemic hypoglycemia, Typ...	ORPHA:276575
Intellectual Developmental Disorder With Macrocephaly, Seizures, And Speech Delay	Recurrent hypoglycemia	OMIM:618158
Silver-Russell Syndrome Due To An Imprinting Defect Of 11P15	Hypoglycemia, Neonatal hypoglycemia	ORPHA:231140
Silver-Russell Syndrome Due To Maternal Uniparental Disomy Of Chromosome 11	Hypoglycemia	ORPHA:231147
3-Methylglutaconic Aciduria Type 4	Hypoglycemia	ORPHA:67048
2-Methylbutyryl-Coa Dehydrogenase Deficiency	Hypoglycemia	OMIM:610006
Mitochondrial Pyruvate Carrier Deficiency	Hypoglycemia	OMIM:614741
Diabetes Mellitus, Permanent Neonatal, 4	Type I diabetes mellitus, Diabetic ketoacidosis, Hyperglycemia	OMIM:618858
Mehmo Syndrome	Hypoglycemia	OMIM:300148
Glycogen Storage Disease Due To Hepatic Glycogen Synthase Deficiency	Postprandial hyperglycemia, Ketotic hypoglycemia, Glycosuria	ORPHA:2089
Diabetes Mellitus, Transient Neonatal, 3	Transient neonatal diabetes mellitus, Hyperglycemia, Maternal diabetes	OMIM:610582
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency	Hypoglycemia	ORPHA:364
Glycogen Storage Disease Ixb	Hypoglycemia	OMIM:261750
Dihydrolipoamide Dehydrogenase Deficiency	Hypoglycemia	OMIM:246900
Mitochondrial Complex Iii Deficiency, Nuclear Type 11	Hypoglycemia	OMIM:620137
Short Chain Acyl-Coa Dehydrogenase Deficiency	Ketotic hypoglycemia	ORPHA:26792
2P21 Microdeletion Syndrome	Hypoglycemia	ORPHA:163693
Glycogen Storage Disease Iii	Hypoglycemia	OMIM:232400
Mitochondrial Complex Iv Deficiency, Nuclear Type 4	Hypoglycemia	OMIM:619048
Adrenal Hyperplasia, Congenital, Due To 21-Hydroxylase Deficiency	Hypoglycemia	OMIM:201910
Mitochondrial Complex I Deficiency, Nuclear Type 19	Hypoglycemia	OMIM:618241
Combined Oxidative Phosphorylation Deficiency 34	Hypoglycemia	OMIM:617872
Glycogen Storage Disease Ixa1	Hypoglycemia	OMIM:306000
Hsd10 Mitochondrial Disease	Hypoglycemia	OMIM:300438
Combined Malonic And Methylmalonic Acidemia	Hypoglycemia	ORPHA:289504
Combined Oxidative Phosphorylation Deficiency 36	Hypoglycemia	OMIM:617950
Mody	Transient neonatal diabetes mellitus, Insulin-resistant diabetes mellitus, Diabetic ketoacidosis,...	ORPHA:552
Insulinoma	Nonketotic hypoglycemia, Reactive hypoglycemia, Fasting hyperinsulinemia, Hyperinsulinemia, Recur...	ORPHA:97279
Congenital Cataracts-Facial Dysmorphism-Neuropathy Syndrome	Hypoglycemia	ORPHA:48431
Hemochromatosis, Neonatal	Hypoglycemia	OMIM:231100
Pyridoxine-Dependent Epilepsy	Hypoglycemia	ORPHA:3006
Acth Deficiency, Isolated	Fasting hypoglycemia	OMIM:201400
Pyruvate Carboxylase Deficiency	Hypoglycemia	OMIM:266150
Proprotein Convertase 1/3 Deficiency	Hypoinsulinemia, Reactive hypoglycemia	OMIM:600955
Combined Oxidative Phosphorylation Deficiency 47	Hypoglycemia	OMIM:618958
Histidinuria-Renal Tubular Defect Syndrome	Hypoglycemia	ORPHA:2158
Glycogen Storage Disease Ixc	Hypoglycemia, Fasting hypoglycemia	OMIM:613027
Mitochondrial Complex Iii Deficiency, Nuclear Type 5	Hypoglycemia	OMIM:615160
Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic	Impaired gluconeogenesis, Hypoglycemia, Fasting hypoglycemia	OMIM:261680
Hypoadrenocorticism, Familial	Hypoglycemia	OMIM:240200
Combined Oxidative Phosphorylation Deficiency 52	Hypoglycemia	OMIM:619386
Mitochondrial Complex V (Atp Synthase) Deficiency, Nuclear Type 5	Hypoglycemia	OMIM:618120
Blue Diaper Syndrome	Recurrent hypoglycemia, Increased proinsulin:insulin ratio	ORPHA:94086
Glycogen Storage Disease Due To Liver Glycogen Phosphorylase Deficiency	Hypoglycemia	ORPHA:369
Infantile Liver Failure Syndrome 2	Hypoglycemia	OMIM:616483
Silver-Russell Syndrome 2	Neonatal hypoglycemia	OMIM:618905
Glycogen Storage Disease Ixd	Hypoglycemia	OMIM:300559
Combined Oxidative Phosphorylation Deficiency 41	Hypoglycemia	OMIM:618838
Silver-Russell Syndrome Due To 7P11.2P13 Microduplication	Hypoglycemia	ORPHA:231137
Long Chain 3-Hydroxyacyl-Coa Dehydrogenase Deficiency	Hypoglycemia, Hypoketotic hypoglycemia	ORPHA:5
Congenital Hyperinsulinism Due To Hnf4A Deficiency	Hyperinsulinemia, Fasting hypoglycemia, Glycosuria, Hyperinsulinemic hypoglycemia, Neonatal hypog...	ORPHA:263455
Malonyl-Coa Decarboxylase Deficiency	Hypoglycemia	OMIM:248360
Congenital Isolated Acth Deficiency	Neonatal hypoglycemia, Hypoglycemic seizures	ORPHA:199296
Autosomal Recessive Hyperinsulinism Due To Kir6.2 Deficiency	Recurrent hypoglycemia, Neonatal hypoglycemia, Hyperinsulinemic hypoglycemia	ORPHA:79644
Temple Syndrome	Recurrent hypoglycemia, Type II diabetes mellitus	ORPHA:254516
Pyridoxal Phosphate-Responsive Seizures	Hypoglycemia	ORPHA:79096
3-Methylglutaconic Aciduria With Deafness, Encephalopathy, And Leigh-Like Syndrome	Hypoglycemia	OMIM:614739
Combined Oxidative Phosphorylation Deficiency 10	Hypoglycemia	OMIM:614702
Glucocorticoid Resistance, Generalized	Hypoglycemia	OMIM:615962
Pyruvate Dehydrogenase E3 Deficiency	Hypoglycemia	ORPHA:2394
Laron Syndrome	Hypoglycemia	ORPHA:633
Polyendocrine-Polyneuropathy Syndrome	Type II diabetes mellitus, Hypoglycemia, Hypoinsulinemia	ORPHA:453533
Pituitary Hormone Deficiency, Combined, 6	Hypoglycemia, Neonatal hypoglycemia	OMIM:613986
3-Hydroxyacyl-Coa Dehydrogenase Deficiency	Hypoglycemic seizures, Hypoketotic hypoglycemia	OMIM:231530
Pituitary Hormone Deficiency, Combined, 2	Neonatal hypoglycemia, Hypoglycemic seizures	OMIM:262600
Fanconi Renotubular Syndrome 4 With Maturity-Onset Diabetes Of The Young	Diabetes mellitus, Hypoglycemia, Glycosuria	OMIM:616026
Carnitine Palmitoyl Transferase 1A Deficiency	Hypoglycemia	ORPHA:156
Mitochondrial Dna Depletion Syndrome 9 (Encephalomyopathic Type With Methylmalonic Aciduria)	Hypoglycemia	OMIM:245400
Acyl-Coa Dehydrogenase, Medium-Chain, Deficiency Of	Hypoglycemia	OMIM:201450
Cataract-Growth Hormone Deficiency-Sensory Neuropathy-Sensorineural Hearing Loss-Skeletal Dysplasia Syndrome	Fasting hypoglycemia	ORPHA:436174
Carnitine Palmitoyltransferase Ii Deficiency, Infantile	Hypoketotic hypoglycemia	OMIM:600649
Primary Microcephaly-Mild Intellectual Disability-Young-Onset Diabetes Syndrome	Diabetes mellitus, Hypoglycemia	ORPHA:391408
Galactokinase Deficiency	Hyperinsulinemia, Hypoglycemia	ORPHA:79237
Houge-Janssens Syndrome 1	Hypoglycemia	OMIM:616355
Classic Galactosemia	Hypoglycemia	ORPHA:79239
Medium Chain Acyl-Coa Dehydrogenase Deficiency	Hypoglycemia	ORPHA:42
Mitochondrial Complex I Deficiency, Nuclear Type 33	Hypoglycemia	OMIM:618253
Mitochondrial Complex Iii Deficiency, Nuclear Type 6	Hyperglycemia, Hypoglycemia	OMIM:615453
Maple Syrup Urine Disease	Hypoglycemia	OMIM:248600
Polyendocrine-Polyneuropathy Syndrome	Type I diabetes mellitus, Hypoglycemia	OMIM:616113
Post-Traumatic Pituitary Deficiency	Hypoglycemia	ORPHA:95619
Solitary Fibrous Tumor	Recurrent hypoglycemia, Hypoglycemia, Hypoinsulinemia	ORPHA:2126
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency	Insulin resistance, Hypoglycemia	ORPHA:73272
Carnitine-Acylcarnitine Translocase Deficiency	Hypoglycemia, Neonatal hypoglycemia	OMIM:212138
Glucocorticoid Deficiency 4 With Or Without Mineralocorticoid Deficiency	Hypoglycemia	OMIM:614736
Neurodevelopmental Disorder, Mitochondrial, With Abnormal Movements And Lactic Acidosis, With Or Without Seizures	Hypoglycemia	OMIM:617710
Fructose-1,6-Bisphosphatase Deficiency	Fasting hypoglycemia, Hypoglycemia, Neonatal hypoglycemia	ORPHA:348
Cog8-Cdg	Hypoglycemia	ORPHA:95428
Hsd10 Disease, Infantile Type	Hypoglycemia	ORPHA:391428
Insulin-Resistance Syndrome Type B	Insulin resistance, Fasting hyperinsulinemia, Insulin-resistant diabetes mellitus, Hyperinsulinem...	ORPHA:2298
Donohue Syndrome	Postprandial hyperglycemia, Hyperglycemia, Hyperinsulinemia, Fasting hypoglycemia	OMIM:246200
Aica-Ribosuria Due To Atic Deficiency	Hypoglycemia	OMIM:608688
Carnitine Deficiency, Systemic Primary	Impaired gluconeogenesis, Recurrent hypoglycemia	OMIM:212140
Glucocorticoid Deficiency 1	Recurrent hypoglycemia	OMIM:202200
Propionic Acidemia	Hypoglycemia	OMIM:606054
Fructose-1,6-Bisphosphatase Deficiency	Hypoglycemia	OMIM:229700
3-Hydroxy-3-Methylglutaryl-Coa Lyase Deficiency	Hypoglycemia	OMIM:246450
Timothy Syndrome	Hypoglycemia	OMIM:601005
Mitochondrial Complex Iv Deficiency, Nuclear Type 3	Neonatal hypoglycemia	OMIM:619046
Combined Oxidative Phosphorylation Deficiency 40	Hypoglycemia	OMIM:618835
Smith-Kingsmore Syndrome	Hypoglycemia	OMIM:616638
Combined Oxidative Phosphorylation Deficiency 42	Hypoglycemia	OMIM:618839
3-Methylcrotonyl-Coa Carboxylase 1 Deficiency	Hypoglycemia	OMIM:210200
Fanconi-Bickel Syndrome	Diabetes mellitus, Impaired glucose tolerance, Fasting hypoglycemia, Glycosuria, Postprandial hyp...	ORPHA:2088
Cholestasis, Progressive Familial Intrahepatic, 5	Hypoglycemia	OMIM:617049
Microcephaly, Short Stature, And Impaired Glucose Metabolism 2	Recurrent hypoglycemia	OMIM:616817
Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency	Fasting hyperinsulinemia, Hypoglycemic seizures, Hyperinsulinemic hypoglycemia, Neonatal hypoglyc...	ORPHA:71212
Hypotonia-Cystinuria Syndrome	Neonatal hypoglycemia	OMIM:606407
Bachmann-Bupp Syndrome	Hypoglycemia	OMIM:619075
Mitochondrial Complex I Deficiency, Nuclear Type 20	Hypoglycemia	OMIM:611126
Immunodeficiency, Common Variable, 10	Hypoglycemia	OMIM:615577
Methylmalonic Aciduria Due To Methylmalonyl-Coa Mutase Deficiency	Hypoglycemia	OMIM:251000
Basilicata-Akhtar Syndrome	Neonatal hypoglycemia	OMIM:301032
Reni Syndrome	Hypoglycemia	OMIM:617575
Mitochondrial Complex Iv Deficiency, Nuclear Type 23	Hypoglycemia	OMIM:620275
Silver-Russell Syndrome Due To A Point Mutation	Hypoglycemia	ORPHA:397590
Silver-Russell Syndrome 1	Fasting hypoglycemia	OMIM:180860
Intellectual Developmental Disorder, Autosomal Dominant 45	Neonatal hypoglycemia	OMIM:617600
Shashi-Pena Syndrome	Hypoglycemia	OMIM:617190
Tenorio Syndrome	Hypoglycemia, Hypoinsulinemia	OMIM:616260
D-Glyceric Aciduria	Hypoglycemia	OMIM:220120
Mitochondrial Trifunctional Protein Deficiency 2	Hypoglycemia	OMIM:620300
Carnitine Palmitoyltransferase I Deficiency	Hypoketotic hypoglycemia	OMIM:255120
Pituitary Stalk Interruption Syndrome	Hypoglycemia	ORPHA:95496
Dopamine Beta-Hydroxylase Deficiency	Insulin resistance, Hyperinsulinemia, Hypoglycemia	ORPHA:230
Multiple Acyl-Coa Dehydrogenase Deficiency	Hypoglycemia, Glycosuria	OMIM:231680
Glutaric Acidemia I	Hypoglycemia	OMIM:231670
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal	Nonketotic hypoglycemia, Hypoglycemia	OMIM:608836
Congenital Disorder Of Glycosylation, Type Ig	Hypoglycemia	OMIM:607143
Beta-Ketothiolase Deficiency	Hyperglycemia, Hypoglycemia	ORPHA:134
Mitochondrial Complex Iv Deficiency, Nuclear Type 12	Hypoglycemia, Neonatal hypoglycemia	OMIM:619055
Multiple Acyl-Coa Dehydrogenase Deficiency	Hypoglycemia	ORPHA:26791
Carnitine-Acylcarnitine Translocase Deficiency	Fasting hypoglycemia, Hypoketotic hypoglycemia	ORPHA:159
Recurrent Metabolic Encephalomyopathic Crises-Rhabdomyolysis-Cardiac Arrhythmia-Intellectual Disability Syndrome	Hypoglycemia, Hypoglycemic seizures	ORPHA:480864
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency	Recurrent hypoglycemia, Ketotic hypoglycemia, Fasting hypoglycemia	ORPHA:79240
Mitochondrial Complex Iv Deficiency, Nuclear Type 22	Hypoglycemia	OMIM:619355
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency	Hypoglycemia, Fasting hypoglycemia	ORPHA:264580
Intellectual Disability-Macrocephaly-Hypotonia-Behavioral Abnormalities Syndrome	Hypoglycemia	ORPHA:457279
Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of	Nonketotic hypoglycemia	OMIM:201475
Macrocephaly-Intellectual Disability-Neurodevelopmental Disorder-Small Thorax Syndrome	Neonatal hypoglycemia	ORPHA:457485
Pancreatic And Cerebellar Agenesis	Hyperglycemia, Diabetes mellitus, Hypoglycemia	OMIM:609069
Rabson-Mendenhall Syndrome	Impaired glucose tolerance, Insulin resistance, Fasting hyperinsulinemia, Insulin-resistant diabe...	ORPHA:769
Glycogen Storage Disease Ia	Hypoglycemia, Fasting hypoglycemia	OMIM:232200
Midface Hypoplasia, Obesity, Developmental Delay, And Neonatal Hypotonia	Neonatal hypoglycemia	OMIM:608624
3-Methylcrotonyl-Coa Carboxylase 2 Deficiency	Hypoglycemia	OMIM:210210
Carnitine Palmitoyl Transferase Ii Deficiency, Severe Infantile Form	Hypoketotic hypoglycemia	ORPHA:228305
Neurodevelopmental Disorder With Hypotonia, Dysmorphic Facies, And Skeletal Anomalies, With Or Without Seizures	Hypoglycemia	OMIM:620224
Mirage Syndrome	Hypoglycemia	OMIM:617053
Combined Oxidative Phosphorylation Defect Type 39	Neonatal hypoglycemia	ORPHA:565624
Combined Oxidative Phosphorylation Deficiency 37	Hypoglycemia	OMIM:618329
Orthostatic Hypotension 1	Neonatal hypoglycemia	OMIM:223360
Congenital Disorder Of Glycosylation, Type Iie	Hypoglycemia	OMIM:608779
Growth Retardation, Impaired Intellectual Development, Hypotonia, And Hepatopathy	Hypoglycemia	OMIM:617093
Congenital Disorder Of Glycosylation With Defective Fucosylation 1	Hypoglycemia	OMIM:618005
Metabolic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration	Hypoglycemia	OMIM:616878
Sotos Syndrome	Glucose intolerance, Neonatal hypoglycemia	OMIM:117550
Leigh Syndrome	Hypoglycemia	ORPHA:506
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)	Hypoglycemia	OMIM:251880
Silver-Russell Syndrome	Insulin resistance, Recurrent hypoglycemia	ORPHA:813
Cataracts, Growth Hormone Deficiency, Sensory Neuropathy, Sensorineural Hearing Loss, And Skeletal Dysplasia	Hypoglycemia	OMIM:616007
Isolated Complex I Deficiency	Diabetes mellitus, Hypoglycemia	ORPHA:2609
Late-Onset Isolated Acth Deficiency	Type I diabetes mellitus, Hypoglycemia	ORPHA:199299
Mitochondrial Trifunctional Protein Deficiency 1	Hypoketotic hypoglycemia	OMIM:609015
3-Methylglutaconic Aciduria Type 7	Neonatal hypoglycemia	ORPHA:445038
Cerebral Visual Impairment	Neonatal hypoglycemia	ORPHA:447788
Congenital Disorder Of Glycosylation, Type It	Hypoglycemia	OMIM:614921
Immunodeficiency 59 And Hypoglycemia	Hypoglycemia	OMIM:233600
Carbonic Anhydrase Va Deficiency, Hyperammonemia Due To	Hypoglycemia	OMIM:615751
Acyl-Coa Dehydrogenase 9 Deficiency	Nonketotic hypoglycemia	ORPHA:99901
Fanconi-Bickel Syndrome	Postprandial hyperglycemia, Fasting hypoglycemia, Glycosuria	OMIM:227810
X-Linked Dominant Chondrodysplasia Punctata	Neonatal hypoglycemia	ORPHA:35173
Oculodentodigital Dysplasia	Hypoglycemia	ORPHA:2710
Congenital Disorder Of Glycosylation, Type Im	Hypoketotic hypoglycemia	OMIM:610768
Cholera	Hypoglycemia	ORPHA:173
Pituitary Apoplexy	Hypoglycemia	ORPHA:95613
Familial Glucocorticoid Deficiency	Ketotic hypoglycemia, Hypoglycemic seizures	ORPHA:361
3-Methylglutaconic Aciduria, Type Viib	Neonatal hypoglycemia	OMIM:616271
Dilated Cardiomyopathy With Ataxia	Neonatal hypoglycemia	ORPHA:66634
Neurodevelopmental Disorder With Hypotonia, Craniofacial Abnormalities, And Seizures	Hypoglycemia	OMIM:614501
Mitochondrial Dna Depletion Syndrome 6 (Hepatocerebral Type)	Recurrent hypoglycemia, Hypoglycemia	OMIM:256810
Bannayan-Riley-Ruvalcaba Syndrome	Hypoglycemia	ORPHA:109
Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency	Hypoglycemia	ORPHA:90790
Neurologic, Endocrine, And Pancreatic Disease, Multisystem, Infantile-Onset 2	Hypoglycemia, Neonatal hypoglycemia	OMIM:619418
3-Hydroxy-3-Methylglutaric Aciduria	Nonketotic hypoglycemia, Recurrent hypoglycemia	ORPHA:20
Wars2-Related Combined Oxidative Phosphorylation Defect	Neonatal hypoglycemia	ORPHA:572798
Mitochondrial Trifunctional Protein Deficiency	Hypoketotic hypoglycemia	ORPHA:746
Pyruvate Carboxylase Deficiency	Hyperglycemia, Hypoglycemia	ORPHA:3008
Very Long Chain Acyl-Coa Dehydrogenase Deficiency	Hypoketotic hypoglycemia	ORPHA:26793
Kabuki Syndrome 2	Neonatal hypoglycemia	OMIM:300867
Sheehan Syndrome	Hypoglycemia	ORPHA:91355
Holoprosencephaly	Diabetes mellitus, Hypoglycemia	ORPHA:2162
Shigellosis	Hypoglycemia	ORPHA:810
Glycogen Storage Disease Ib	Hypoglycemia	OMIM:232220
Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria	Hypoglycemia	ORPHA:17
Multiple Endocrine Neoplasia, Type I	Hypoglycemia	OMIM:131100
Glutaryl-Coa Dehydrogenase Deficiency	Fasting hypoglycemia	ORPHA:25
Intellectual Developmental Disorder, X-Linked, Syndromic, With Pigmentary Mosaicism And Coarse Facies	Hypoglycemia	OMIM:301066
Mitochondrial Complex Iii Deficiency, Nuclear Type 1	Recurrent hypoglycemia, Hypoglycemia, Hyperglycemia	OMIM:124000
Renal Agenesis, Bilateral	Nonketotic hypoglycemia	ORPHA:1848
Alg12-Cdg	Recurrent hypoglycemia	ORPHA:79324
Methylmalonic Acidemia With Homocystinuria, Type Cblc	Hypoglycemia	ORPHA:79282
Congenital Adrenal Hyperplasia Due To 3-Beta-Hydroxysteroid Dehydrogenase Deficiency	Neonatal hypoglycemia	ORPHA:90791
Mitochondrial Dna Depletion Syndrome 15 (Hepatocerebral Type)	Hypoglycemia	OMIM:617156
Carnitine Palmitoyltransferase Ii Deficiency	Hypoketotic hypoglycemia	ORPHA:157
Acute Adrenal Insufficiency	Hypoglycemia	ORPHA:95409
Silver-Russell Syndrome Due To Maternal Uniparental Disomy Of Chromosome 7	Insulin resistance, Fasting hypoglycemia	ORPHA:96182
Perlman Syndrome	Hypoglycemia	OMIM:267000
Mitochondrial Complex I Deficiency, Nuclear Type 1	Hypoglycemia	OMIM:252010
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ib	Hypoglycemia, Hypoglycemic seizures	ORPHA:79259
Leprechaunism	Insulin resistance, Hyperinsulinemia, Recurrent infantile hypoglycemia, Fasting hypoglycemia, Pos...	ORPHA:508
Hereditary Fructose Intolerance	Reactive hypoglycemia	ORPHA:469
Carnitine Palmitoyl Transferase Ii Deficiency, Neonatal Form	Hypoketotic hypoglycemia	ORPHA:228308
Histiocytoid Cardiomyopathy	Hypoglycemia	ORPHA:137675
Generalized Glucocorticoid Resistance Syndrome	Hypoglycemia	ORPHA:786
Menkes Disease	Hypoglycemia	ORPHA:565
Addison Disease	Type I diabetes mellitus, Hypoglycemia	ORPHA:85138
Glycerol Kinase Deficiency	Hypoglycemia	OMIM:307030
Tyrosinemia, Type I	Hypoglycemia	OMIM:276700
Glycogen Storage Disease Ic	Hypoglycemia	OMIM:232240
Primary Fanconi Renotubular Syndrome	Hypoglycemia, Glycosuria	ORPHA:3337
Fructose Intolerance, Hereditary	Hypoglycemia, Glycosuria	OMIM:229600
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function	Hypoglycemia	ORPHA:226307
Simpson-Golabi-Behmel Syndrome	Hypoglycemia	ORPHA:373
Deficiency In Anterior Pituitary Function-Variable Immunodeficiency Syndrome	Recurrent hypoglycemia	ORPHA:293978
Rajab Interstitial Lung Disease With Brain Calcifications 1	Hypoglycemia	OMIM:613658
Deeah Syndrome	Neonatal hypoglycemia	OMIM:619004
46,Xy Difference Of Sex Development-Adrenal Insufficiency Due To Cyp11A1 Deficiency	Neonatal hypoglycemia	ORPHA:168558
Glycogen Storage Disease Of Heart, Lethal Congenital	Neonatal hypoglycemia	OMIM:261740
Inherited Isolated Adrenal Insufficiency Due To Partial Cyp11A1 Deficiency	Neonatal hypoglycemia	ORPHA:289548
Beckwith-Wiedemann Syndrome	Hypoglycemia, Neonatal hypoglycemia	ORPHA:116
Mitochondrial Complex Iv Deficiency, Nuclear Type 5	Hyperglycemia, Hypoglycemia	OMIM:220111
Costello Syndrome	Hypoglycemia	OMIM:218040
Marburg Hemorrhagic Fever	Hypoglycemia	ORPHA:99826
Megalencephaly-Severe Kyphoscoliosis-Overgrowth Syndrome	Neonatal hypoglycemia	ORPHA:457359
Neurooculorenal Syndrome	Recurrent hypoglycemia	OMIM:620305
Acute Liver Failure	Hypoglycemia	ORPHA:90062
3-Methylglutaconic Aciduria, Type Viii	Neonatal hypoglycemia	OMIM:617248
Non-Acquired Panhypopituitarism	Hypoglycemia	ORPHA:90695
Holoprosencephaly 1	Hypoglycemia	OMIM:236100
Beckwith-Wiedemann Syndrome	Neonatal hypoglycemia	OMIM:130650
Combined Pituitary Hormone Deficiencies, Genetic Forms	Hypoglycemia	ORPHA:95494
Antley-Bixler Syndrome With Genital Anomalies And Disordered Steroidogenesis	Hypoglycemia	OMIM:201750
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency	Neonatal hypoglycemia	ORPHA:90794
Sotos Syndrome	Neonatal hypoglycemia	ORPHA:821

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Fbp1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Fbp1.

No publications found that use IMPC mice or data for Fbp1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele	Allele Type	Produced
Fbp1^{tm436505(L1L2_GT2_LF2A_LacZ_BetactP_neo)}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors
Fbp1^{tm1e(EUCOMM)Hmgu}	Targeted, non-conditional allele	ES Cells
Fbp1^{tm1a(EUCOMM)Hmgu}	KO first allele (reporter-tagged insertion with conditional potential)	Mice, Targeting vectors, ES Cells
Fbp1^tm1(KOMP)Mbp	Reporter-tagged deletion allele (with selection cassette)	Targeting vectors, ES Cells

Sequence

Guides

Sequence	Guide sequence	pam	chr	start	stop	strand	Genome build	gRNA Concentration	Truncated Guide	Reversed	Sanger service	Guide format	Guide source

Nucleases

Nuclease type	Nuclease class

Genotype primers

Sequence	Name

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