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Gene: Ets2 MGI:95456

Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:

E26 avian leukemia oncogene 2, 3' domain

Synonyms:

Ets-2

Order Alleles

IMPC Data Collections

No Body Weight Data
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ets2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Ets2 (0 diseases)
Human diseases predicted to be associated with Ets2 (294 diseases)

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ets2 by phenotypic similarity.

Disease	Matching phenotypes	Source
Woolly Hair, Autosomal Recessive 3	Fine hair, Trichorrhexis nodosa, Sparse eyelashes, Curly hair, Sparse hair, Sparse scalp hair	OMIM:616760
Uncombable Hair Syndrome 3	Pili canaliculi, Brittle hair, Uncombable hair, Curly hair	OMIM:617252
Ringed Hair Disease	Abnormal hair pattern, Fine hair	ORPHA:169
Pili Bifurcati	Abnormal hair morphology, Abnormality of hair texture	ORPHA:720
Uncombable Hair Syndrome 2	Pili canaliculi, Uncombable hair	OMIM:617251
Hypotrichosis 4	Alopecia, Sparse eyebrow, Sparse body hair, Sparse eyelashes, Uncombable hair, Sparse scalp hair	OMIM:146550
Palmoplantar Keratoderma, Epidermolytic, 2	Curly hair	OMIM:620411
Woolly Hair Nevus	Congenital posterior occipital alopecia, Fine hair, Woolly scalp hair, Curly hair, Patchy hypopig...	ORPHA:79414
Pili Torti-Developmental Delay-Neurological Abnormalities Syndrome	Abnormality of hair texture, Sparse or absent eyelashes, Pili torti, Aplasia/Hypoplasia of the ey...	ORPHA:2891
Acrokeratoderma, Hereditary Papulotranslucent	Fine hair	OMIM:101840
Cardiofaciocutaneous Syndrome 2	Sparse hair, Absent eyebrow, Fine hair, Curly hair	OMIM:615278
Naxos Disease	Abnormality of hair texture, Woolly hair, Sparse scalp hair, Curly hair	ORPHA:34217
Ichthyosis, Congenital, Autosomal Recessive 11	Sparse eyebrow, Sparse body hair, Curly eyelashes, Curly hair, Sparse eyelashes, Pili torti, Brit...	OMIM:602400
Uncombable Hair Syndrome	Coarse hair, White hair, Abnormal hair morphology, Patchy alopecia, Trichodysplasia, Woolly hair	ORPHA:1410
Woolly Hair	Sparse lateral eyebrow, Fine hair, Sparse body hair, Slow-growing hair, Brittle hair, Abnormality...	ORPHA:170
Chand Syndrome	Nail dysplasia, Curly hair	OMIM:214350
Trichodysplasia-Xeroderma Syndrome	Alopecia, Coarse hair, Sparse eyebrow, Sparse body hair, Trichorrhexis nodosa, Trichodysplasia, P...	ORPHA:3361
Pili Torti	Alopecia, Abnormal eyebrow morphology, Pili torti, Brittle hair, Abnormality of hair texture, Abn...	ORPHA:2889
Arrhythmogenic Right Ventricular Dysplasia, Familial, 11	Woolly hair	OMIM:610476
Monilethrix	Alopecia, Nail dystrophy, Nail dysplasia, Brittle hair, Abnormality of hair texture, Sparse hair	OMIM:158000
Angioma Serpiginosum, X-Linked	Sparse hair, Nail dystrophy, Fine hair	OMIM:300652
Hidrotic Ectodermal Dysplasia	Generalized hypotrichosis, Alopecia, Sparse pubic hair, Brittle scalp hair, Small nail, Sparse ey...	ORPHA:189
Sin3A-Related Intellectual Disability Syndrome Due To A Point Mutation	Fine hair, Fragile nails	ORPHA:500166
Copper Deficiency, Familial Benign	Early balding, Curly hair	OMIM:121270
Woolly Hair, Hypotrichosis, Everted Lower Lip, And Outstanding Ears	Woolly hair, Sparse hair	OMIM:278200
Monilethrix	Fine hair, Abnormal eyebrow morphology, Patchy alopecia, Slow-growing hair, Brittle hair, Abnorma...	ORPHA:573
Intellectual Developmental Disorder, Autosomal Dominant 34	Synophrys, Coarse hair, Curly hair	OMIM:616351
Leopard Syndrome 2	Curly hair	OMIM:611554
Crandall Syndrome	Alopecia, Fine hair, Sparse body hair, Brittle hair, Pili torti, Aplasia/Hypoplasia of the eyebrow	ORPHA:202
Carvajal Syndrome	Woolly hair	ORPHA:65282
Spondyloepiphyseal Dysplasia-Brachydactyly-Speech Disorder Syndrome	Multiple rows of eyelashes, Facial hirsutism, Thick eyebrow, Curly eyelashes, Low posterior hairl...	ORPHA:163654
Marie Unna Hereditary Hypotrichosis	Alopecia, Coarse hair, Sparse or absent eyelashes, Aplasia/Hypoplasia of the eyebrow, Sparse scal...	ORPHA:444
Hair Defect With Photosensitivity And Impaired Intellectual Development	Sparse eyebrow, Coarse hair, Sparse eyelashes, Brittle hair, Sparse hair	OMIM:234030
Smith-Kingsmore Syndrome	Umbilical hernia, Curly hair	OMIM:616638
Noonan Syndrome 6	Low posterior hairline, Long eyebrows, Sparse hair, Curly hair	OMIM:613224
Cardiofaciocutaneous Syndrome 3	Curly hair	OMIM:615279
Hypotrichosis 7	Abnormal sweat gland morphology, Sparse eyebrow, Sparse body hair, Sparse eyelashes, Sparse axill...	OMIM:604379
Cardiofaciocutaneous Syndrome 4	Alopecia of scalp, Sparse eyelashes, Absent eyebrow, Curly hair, Sparse hair	OMIM:615280
Autosomal Recessive Hypohidrotic Ectodermal Dysplasia	Alopecia, Fine hair, Abnormal fingernail morphology, Abnormal hair morphology, Abnormal toenail m...	ORPHA:248
Noonan Syndrome 5	Sparse eyebrow, Small nail, Fine hair, Curly hair	OMIM:611553
Palmoplantar Keratoderma And Woolly Hair	Sparse eyebrow, Sparse body hair, Leukonychia, Sparse eyelashes, Woolly hair, Sparse scalp hair	OMIM:616099
Hypodontia-Dysplasia Of Nails Syndrome	Ridged fingernail, Thin toenail, Fine hair, Hypoplastic fingernail, Abnormal fingernail morpholog...	ORPHA:2228
Noonan Syndrome 9	Sparse eyebrow, Curly hair	OMIM:616559
Leopard Syndrome 3	Low posterior hairline, Curly hair	OMIM:613707
Neurodevelopmental Disorder With Facial Dysmorphism, Absent Language, And Pseudo-Pelger-Huet Anomaly	Synophrys, Sparse eyebrow, Sparse hair, Curly hair	OMIM:620075
Ectodermal Dysplasia 4, Hair/Nail Type	Abnormal sweat gland morphology, Alopecia, Sparse body hair, Congenital onychodystrophy, Nail dys...	OMIM:602032
Onychotrichodysplasia And Neutropenia	Sparse pubic hair, Hypoplastic fingernail, Trichorrhexis nodosa, Curly eyelashes, Concave nail, C...	OMIM:258360
Hypotrichosis 8	Sparse eyebrow, Dry hair, Coarse hair, Fair hair, Ridged nail, Sparse eyelashes, Sparse axillary ...	OMIM:278150
Witkop Syndrome	Abnormal sweat gland morphology, Fine hair, Ridged nail, Concave nail, Hypoplastic fifth toenail,...	OMIM:189500
Trichodental Dysplasia	Sparse hair, Slow-growing hair, Fine hair, Brittle hair	OMIM:601453
Hypotrichosis 12	Abnormal sweat gland morphology, Sparse pubic hair, Dry hair, Sparse or absent eyelashes, Sparse ...	OMIM:615885
Braddock-Carey Syndrome 1	Sparse hair, Curly hair	OMIM:619980
Cerebellar Ataxia-Ectodermal Dysplasia Syndrome	Sparse hair, Fine hair	ORPHA:1174
Hypotrichosis 6	Sparse eyebrow, Sparse eyelashes, Pili torti, Brittle hair, Sparse hair	OMIM:607903
Ectodermal Dysplasia 10A, Hypohidrotic/Hair/Nail Type, Autosomal Dominant	Sparse eyebrow, Fine hair, Ridged nail, Sparse eyelashes, Slow-growing hair, Sparse hair	OMIM:129490
Woolly Hair, Autosomal Dominant	Dry hair, Coarse hair, Abnormal eyebrow morphology, Slow-growing hair, Abnormal eyelash morpholog...	OMIM:194300
Uncombable Hair Syndrome 1	Dry hair, Pili canaliculi, Uncombable hair	OMIM:191480
Ectodermal Dysplasia 7, Hair/Nail Type	Abnormal sweat gland morphology, Alopecia, Sparse eyebrow, Dystrophic toenail, Sparse eyelashes, ...	OMIM:614929
Noonan Syndrome 8	Curly hair	OMIM:615355
Trichothiodystrophy 7, Nonphotosensitive	Tiger tail banding, Brittle hair	OMIM:618546
Congenital Heart Defects, Dysmorphic Facial Features, And Intellectual Developmental Disorder	Highly arched eyebrow, Intrauterine growth retardation, Thick eyebrow, Low posterior hairline, Cu...	OMIM:617360
Choroidal Atrophy-Alopecia Syndrome	Ridged fingernail, Fine hair, Supernumerary nipple, Abnormal fingernail morphology, Bifid nail, T...	ORPHA:1433
Giant Axonal Neuropathy 1, Autosomal Recessive	Curly hair	OMIM:256850
Bazex-Dupré-Christol Syndrome	Sparse eyebrow, Coarse hair, Trichorrhexis nodosa, Sparse or absent eyelashes, Pili torti, Sparse...	ORPHA:113
Noonan Syndrome 7	Low posterior hairline, Curly hair	OMIM:613706
Pili Torti, Early-Onset	Hair shafts flattened at irregular intervals and twisted through 180 degrees about their axes, Co...	OMIM:261900
Clouston Syndrome	Alopecia, Sparse eyebrow, Small nail, Fine hair, Alopecia totalis, Brittle hair, Nail dystrophy, ...	OMIM:129500
Ectodermal Dysplasia-Syndactyly Syndrome 1	Alopecia, Coarse hair, Small nail, Hypoplastic toenails, Sparse eyelashes, Patchy alopecia, Pili ...	OMIM:613573
Björnstad Syndrome	Alopecia, Brittle hair	ORPHA:123
Hypohidrotic Ectodermal Dysplasia-Hypothyroidism-Ciliary Dyskinesia Syndrome	Alopecia, Sparse eyebrow, Dystrophic toenail, Fine hair, Dystrophic fingernails, Sparse scalp hair	ORPHA:1882
Trichohepatoenteric Syndrome 1	Sparse hair, Fine hair, Trichorrhexis nodosa, Intrauterine growth retardation, Large placenta, Cu...	OMIM:222470
Intellectual Developmental Disorder, X-Linked, Syndromic, Bain Type	Curly hair	OMIM:300986
Bjornstad Syndrome	Hair shafts flattened at irregular intervals and twisted through 180 degrees about their axes, Al...	OMIM:262000
Sabinas Brittle Hair Syndrome	Dry hair, Nail dystrophy, Nail dysplasia, Brittle hair, Sparse hair	OMIM:211390
Hawkinsinuria	Sparse hair, Fine hair	ORPHA:2118
Macrocephaly-Intellectual Disability-Neurodevelopmental Disorder-Small Thorax Syndrome	Curly hair	ORPHA:457485
Naxos Disease	Subungual hyperkeratosis, Sparse eyebrow, Sparse body hair, Nail dystrophy, Onycholysis, Curly ha...	OMIM:601214
Hypotrichosis 13	Abnormal sweat gland morphology, Sparse hair, Woolly hair, Sparse eyelashes	OMIM:615896
Progeroid Syndrome, Petty Type	Umbilical hernia, Abnormal hair morphology, Intrauterine growth retardation, Thick eyebrow, Long ...	ORPHA:2963
Hypotrichosis With Juvenile Macular Degeneration	Sparse scalp hair, Pili torti, Fine hair, Brittle hair	ORPHA:1573
Pili Torti-Onychodysplasia Syndrome	Alopecia universalis, Alopecia, Sparse body hair, Congenital onychodystrophy, Nail dystrophy, Abs...	ORPHA:2890
Ritscher-Schinzel Syndrome 4	Curly hair	OMIM:619435
Noonan Syndrome 4	Sparse eyebrow, High anterior hairline, Curly hair	OMIM:610733
Craniofrontonasal Syndrome	Umbilical hernia, Breast hypoplasia, Ridged nail, Low posterior hairline, Unilateral breast hypop...	OMIM:304110
Palmoplantar Keratoderma And Congenital Alopecia 1	Alopecia, Sparse eyebrow, Leukonychia, Nail dysplasia, Brittle hair, Sparse hair	OMIM:104100
Ectodermal Dysplasia 13, Hair/Tooth Type	Sparse eyelashes, Thin eyebrow, Low anterior hairline, Brittle hair	OMIM:617392
Oculodentodigital Dysplasia	Fine hair, Umbilical hernia, Abnormal fingernail morphology, Curly hair, Slow-growing hair, Britt...	ORPHA:2710
Noonan Syndrome 14	Low posterior hairline, Sparse eyebrow, Sparse hair, Curly hair	OMIM:619745
Chops Syndrome	Coarse hair, Long eyelashes, Thick eyebrow, Thick hair, Curly hair, Synophrys	OMIM:616368
Glycosylphosphatidylinositol Biosynthesis Defect 25	Sparse hair, Coarse hair	OMIM:619985
Craniometadiaphyseal Dysplasia, Wormian Bone Type	Curly hair	ORPHA:85184
Trichothiodystrophy 2, Photosensitive	Tiger tail banding, Coarse hair	OMIM:616390
Amaurosis-Hypertrichosis Syndrome	Abnormal eyelash morphology, Coarse hair, Thick eyebrow, Synophrys	ORPHA:1021
Erythrokeratodermia Variabilis Et Progressiva 7	Woolly hair, Dystrophic toenail	OMIM:619209
Trichohepatoenteric Syndrome 2	Sparse hair, Trichorrhexis nodosa, Intrauterine growth retardation, Uncombable hair, Brittle hair...	OMIM:614602
Trichothiodystrophy 4, Nonphotosensitive	Small nail, Trichorrhexis nodosa, Concave nail, Nail dystrophy, Sparse eyelashes, Nail dysplasia,...	OMIM:234050
Trichohepatoneurodevelopmental Syndrome	Thoracic hypertrichosis, Coarse hair, Long eyelashes, Hypoplastic nipples, Curly hair, Woolly hai...	OMIM:618268
Odontotrichoungual-Digital-Palmar Syndrome	Abnormality of hair texture, Nail dysplasia, Nail dystrophy	OMIM:601957
Cardiofaciocutaneous Syndrome 1	Absent eyelashes, Low posterior hairline, Absent eyebrow, Slow-growing hair, Curly hair, Sparse hair	OMIM:115150
Noonan Syndrome-Like Disorder With Loose Anagen Hair 2	Highly arched eyebrow, High anterior hairline, Coarse hair, Sparse lateral eyebrow, Low posterior...	OMIM:617506
Arrhythmogenic Right Ventricular Dysplasia, Familial, 12	Woolly hair	OMIM:611528
Tricho-Retino-Dento-Digital Syndrome	Sparse hair, Uncombable hair	ORPHA:1264
Hypotrichosis Simplex Of The Scalp	Slow-growing scalp hair, Sparse scalp hair, Alopecia of scalp, Fine hair	ORPHA:90368
Bazex-Dupre-Christol Syndrome	Coarse hair, Trichorrhexis nodosa, Pili torti, Sparse hair, Trichoepithelioma	OMIM:301845
Mucopolysaccharidosis, Type Iiia	Hirsutism, Coarse hair, Umbilical hernia, Synophrys	OMIM:252900
Zellweger-Like Syndrome Without Peroxisomal Anomalies	Intrauterine growth retardation, Alopecia, Brittle hair	ORPHA:50812
Osteopenia-Intellectual Disability-Sparse Hair Syndrome	Sparse scalp hair, Fine hair	ORPHA:2324
Ectodermal Dysplasia-Sensorineural Deafness Syndrome	Sparse hair, Brittle hair, Coarse hair	ORPHA:1883
Fg Syndrome 3	Sparse hair, Frontal upsweep of hair, Fine hair	OMIM:300406
Craniofrontonasal Dysplasia	Ridged fingernail, Low posterior hairline, Abnormality of hair texture, Woolly hair, Widow's peak	ORPHA:1520
Woolly Hair-Skin Fragility Syndrome	Woolly hair	OMIM:620415
Acquired Hypertrichosis Lanuginosa	Generalized hirsutism, Abnormal eyebrow morphology, Hypopigmentation of hair, Fine hair	ORPHA:2221
Weaver Syndrome	Fine hair, Abnormal fingernail morphology, Hypoplastic toenails, Thin nail, Deep-set nails	ORPHA:3447
Trichothiodystrophy 8, Nonphotosensitive	Trichorrhexis nodosa, Woolly hair, Sparse eyebrow, Sparse hair	OMIM:619691
Trichothiodystrophy 5, Nonphotosensitive	Sparse eyebrow, Reduced hair sulfur content, Tiger tail banding, Intrauterine growth retardation,...	OMIM:300953
Noonan Syndrome 10	Sparse eyebrow, Curly hair	OMIM:616564
Trichothiodystrophy 6, Nonphotosensitive	Tiger tail banding, Mild intrauterine growth retardation, Slow-growing hair, Brittle hair	OMIM:616943
Noonan Syndrome-Like Disorder With Loose Anagen Hair 1	Loose anagen hair, Long eyelashes, Curly hair, Sparse hair, Sparse scalp hair	OMIM:607721
Peeling Skin Syndrome 1	Onycholysis, Nail dystrophy, Brittle hair	OMIM:270300
Silver-Russell Syndrome Due To 7P11.2P13 Microduplication	Long eyelashes, Fine hair, High anterior hairline	ORPHA:231137
Vulto-Van Silfhout-De Vries Syndrome	Horizontal eyebrow, Widow's peak, Fine hair	OMIM:615828
Brain Malformation-Congenital Heart Disease-Postaxial Polydactyly Syndrome	Alopecia, Coarse hair, Intrauterine growth retardation, Nail dystrophy, Brittle hair	ORPHA:75389
Giant Axonal Neuropathy	Woolly hair, Pili canaliculi	ORPHA:643
Acrogeria	Fine hair	ORPHA:2500
Pachyonychia Congenita 2	Subungual hyperkeratosis, Dry hair, Sparse eyebrow, Nail dystrophy, Nail dysplasia, Sparse scalp ...	OMIM:167210
Distal Duplication 6P	Abnormal eyelash morphology, Fine hair, Intrauterine growth retardation, Abnormal hair quantity	ORPHA:1745
Hereditary Mucoepithelial Dysplasia	Alopecia, Sparse hair, Fine hair	ORPHA:1839
Frontonasal Dysplasia-Alopecia-Genital Anomalies Syndrome	Intrauterine growth retardation, Alopecia, Encephalocele, Fine hair	ORPHA:228390
Cardiomyopathy, Dilated, With Woolly Hair, Keratoderma, And Tooth Agenesis	Leukonychia, Woolly hair, Nail dystrophy, Fragile nails	OMIM:615821
Cognitive Impairment-Coarse Facies-Heart Defects-Obesity-Pulmonary Involvement-Short Stature-Skeletal Dysplasia Syndrome	Highly arched eyebrow, Abnormal fingernail morphology, Facial hirsutism, Long eyelashes, Thick ey...	ORPHA:444077
Menkes Disease	Intrauterine growth retardation, Alopecia, Sparse hair, Brittle hair	OMIM:309400
Chand Syndrome	Nail dysplasia, Curly hair	ORPHA:1401
Sulfite Oxidase Deficiency, Isolated	Fine hair	OMIM:272300
Intellectual Disability-Polydactyly-Uncombable Hair Syndrome	Abnormal hair morphology, Uncombable hair, Slow-growing hair, Aplasia/Hypoplasia of the eyebrow	ORPHA:3082
Gorlin-Chaudhry-Moss Syndrome	Generalized hirsutism, Coarse hair, Umbilical hernia, Low anterior hairline	ORPHA:2095
Arrhythmogenic Right Ventricular Dysplasia, Familial, 8	Woolly hair	OMIM:607450
2Q32Q33 Microdeletion Syndrome	Sparse hair, Fine hair	ORPHA:251019
Amelo-Onycho-Hypohidrotic Syndrome	Abnormal fingernail morphology, Hypoplastic toenails, Onycholysis, Fine hair	ORPHA:1028
Intellectual Disability, Buenos-Aires Type	Abnormal fingernail morphology, Hyperconvex thumb nails, Fine hair, Umbilical hernia	ORPHA:3079
Tessadori-Bicknell-Van Haaften Neurodevelopmental Syndrome 3	High anterior hairline, Horizontal eyebrow, Sparse lateral eyebrow, Long eyelashes, Thick eyebrow...	OMIM:619950
Conductive Deafness-Ptosis-Skeletal Anomalies Syndrome	Fine hair	ORPHA:3236
Netherton Syndrome	Sparse eyebrow, Fine hair, Abnormal hair morphology, Trichorrhexis nodosa, Sparse eyelashes, Spar...	ORPHA:634
Olmsted Syndrome 2	Alopecia universalis, Sparse hair, Woolly hair	OMIM:619208
Rodrigues Blindness	Sparse hair, Fine hair	OMIM:268320
Cutis Laxa, Autosomal Recessive, Type Iia	Abnormality of hair texture, Intrauterine growth retardation, Coarse hair, Brittle hair	OMIM:219200
Noonan Syndrome 2	Low posterior hairline, Sparse eyebrow, Curly hair	OMIM:605275
Spinocerebellar Ataxia-Dysmorphism Syndrome	Spina bifida occulta, Coarse hair	ORPHA:1185
Ectodermal Dysplasia 11A, Hypohidrotic/Hair/Tooth Type, Autosomal Dominant	Sparse hair, Absent nipple, Brittle hair, Absent hair	OMIM:614940
Mucopolysaccharidosis, Type Iiib	Hirsutism, Coarse hair, Synophrys	OMIM:252920
Microcephaly, Short Stature, And Impaired Glucose Metabolism 2	Intrauterine growth retardation, Sparse hair, Fine hair	OMIM:616817
Tonne-Kalscheuer Syndrome	Small nail, Fine hair, Concave nail	OMIM:300978
Fetal Hydantoin Syndrome	Low posterior hairline, Intrauterine growth retardation, Coarse hair, Hypoplastic fingernail	ORPHA:1912
Zttk Syndrome	Broad eyebrow, Sparse eyebrow, Intrauterine growth retardation, Curly hair	OMIM:617140
Brachycephaly, Trichomegaly, And Developmental Delay	Highly arched eyebrow, Long eyelashes, Thick eyebrow, Brittle hair, Synophrys	OMIM:617412
Mucopolysaccharidosis, Type Iiic	Hirsutism, Hypertrichosis, Coarse hair, Synophrys	OMIM:252930
Hall-Riggs Syndrome	Coarse hair, Thick hair, Slow-growing hair	ORPHA:2107
Cleft Lip/Palate-Ectodermal Dysplasia Syndrome	Sparse eyebrow, Dry hair, Sparse eyelashes, Nail dysplasia, Pili torti, Brittle hair, Progressive...	OMIM:225060
Rapp-Hodgkin Syndrome	Sparse hair, Sparse eyebrow, Small nail, Decreased number of sweat glands, Supernumerary nipple, ...	OMIM:129400
Netherton Syndrome	Brittle scalp hair, Sparse eyebrow, Sparse scalp hair, Brittle hair	OMIM:256500
19Q13.11 Microdeletion Syndrome	Sparse lateral eyebrow, Fine hair, Supernumerary nipple, Intrauterine growth retardation, Sparse ...	ORPHA:217346
Trichothiodystrophy 1, Photosensitive	Small nail, Fine hair, Trichorrhexis nodosa, Tiger tail banding, Nail dystrophy, Trichoschisis, P...	OMIM:601675
Odontoonychodermal Dysplasia	Sparse eyebrow, Dry hair, Short nail, Dystrophic toenail, Fine hair, Sparse body hair, Ridged nai...	OMIM:257980
Trichothiodystrophy 3, Photosensitive	Trichorrhexis nodosa, Intrauterine growth retardation, Tiger tail banding, Brittle hair	OMIM:616395
Adult Syndrome	Alopecia, Toenail dysplasia, Absent nipple, Fine hair, Breast hypoplasia, Fingernail dysplasia, H...	ORPHA:978
Costello Syndrome	Curly hair, Concave nail, Thin nail, Deep-set nails, Sparse hair, Fragile nails	OMIM:218040
Primary Microcephaly-Mild Intellectual Disability-Young-Onset Diabetes Syndrome	Fine hair, Intrauterine growth retardation, Low anterior hairline, Sparse hair, Synophrys	ORPHA:391408
Acrofacial Dysostosis, Catania Type	Spina bifida occulta, Intrauterine growth retardation, Abnormal hair pattern, Coarse hair	ORPHA:1786
Pontocerebellar Hypoplasia, Hypotonia, And Respiratory Insufficiency Syndrome, Neonatal Lethal	Neonatal death, Sparse eyebrow, Brittle hair	OMIM:618810
Neurodevelopmental Disorder With Cerebral Atrophy And Variable Facial Dysmorphism	Highly arched eyebrow, Hirsutism, Low anterior hairline, Broad eyebrow, Woolly hair	OMIM:619244
Focal Segmental Glomerulosclerosis And Neurodevelopmental Syndrome	Fine hair, Synophrys	OMIM:619428
Trichorhinophalangeal Syndrome, Type Iii	Sparse hair, Sparse lateral eyebrow, Fine hair	OMIM:190351
Cardiomyopathy, Dilated, With Woolly Hair And Keratoderma	Alopecia, Sparse eyebrow, Nail dystrophy, Sparse eyelashes, Woolly hair	OMIM:605676
3-Phosphoglycerate Dehydrogenase Deficiency, Infantile/Juvenile Form	Abnormality of hair texture, Intrauterine growth retardation, Umbilical hernia	ORPHA:79351
Jaberi-Elahi Syndrome	Sparse eyebrow, Fine hair, Sparse eyelashes, Brittle hair, Sparse hair	OMIM:617988
Trichodermodysplasia-Dental Alterations Syndrome	Sparse lateral eyebrow, Fine hair, Aplasia/Hypoplasia of the eyebrow, Sparse or absent eyelashes,...	ORPHA:3353
X-Linked Intellectual Disability, Golabi-Ito-Hall Type	Dry hair, Nail dystrophy, Brittle hair	ORPHA:93947
X-Linked Dominant Chondrodysplasia Punctata	Sparse eyebrow, Coarse hair, Sparse eyelashes, Patchy alopecia, Scarring alopecia of scalp, Abnor...	ORPHA:35173
Severe Intellectual Disability-Poor Language-Strabismus-Grimacing Face-Long Fingers Syndrome	Intrauterine growth retardation, Fine hair	ORPHA:363686
Frontonasal Dysplasia 2	Sparse eyebrow, Fine hair, Alopecia totalis, Intrauterine growth retardation, Encephalocele, Spar...	OMIM:613451
Arrhythmogenic Right Ventricular Dysplasia, Familial, 10	Woolly hair	OMIM:610193
Arrhythmogenic Cardiomyopathy With Variable Ectodermal Abnormalities	High anterior hairline, Dry hair, Coarse hair, Nail dystrophy, Woolly scalp hair, Onycholysis, Sp...	OMIM:620519
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies	Thoracic hypertrichosis, High anterior hairline, Horizontal eyebrow, Medial flaring of the eyebro...	OMIM:619503
Costello Syndrome	Abnormal hair morphology, Abnormal fingernail morphology, Hypoplastic toenails, Deep-set nails, C...	ORPHA:3071
Ectodermal Dysplasia-Blindness Syndrome	Abnormal fingernail morphology, Sparse hair, Fine hair	ORPHA:1806
Neurodevelopmental Disorder With Seizures, Spasticity, And Complete Or Partial Agenesis Of The Corpus Callosum	Long eyelashes, Fine hair, Synophrys	OMIM:620250
Incontinentia Pigmenti	Alopecia, Coarse hair, Fine hair, Supernumerary nipple, Breast aplasia, Breast hypoplasia, Ridged...	OMIM:308300
Trisomy 20P	Highly arched eyebrow, Coarse hair, Umbilical hernia, Thick eyebrow, Low anterior hairline, Low p...	ORPHA:261318
Brain Malformations-Musculoskeletal Abnormalities-Facial Dysmorphism-Intellectual Disability Syndrome	Intrauterine growth retardation, Sparse eyebrow, Broad lateral eyebrow, Curly hair	ORPHA:500150
Trichorhinophalangeal Syndrome, Type I	Sparse lateral eyebrow, Fine hair, Thin eyebrow, Leukonychia, Concave nail, Slow-growing hair, Th...	OMIM:190350
Cerebrofaciothoracic Dysplasia	Coarse hair, Thick eyebrow, Low posterior hairline, Abnormal hair pattern, Synophrys	ORPHA:1394
Mucoepithelial Dysplasia, Hereditary	Alopecia, Coarse hair, Chronic monilial nail infection, Nail dystrophy, Nail dysplasia, Sparse hair	OMIM:158310
Galloway-Mowat Syndrome 9	Coarse hair	OMIM:619603
S-Adenosylhomocysteine Hydrolase Deficiency	Abnormality of hair texture	ORPHA:88618
Ogden Syndrome	Fine hair, Aplasia/Hypoplasia of the eyebrow	ORPHA:276432
Revesz Syndrome	Ridged fingernail, Fine hair, Intrauterine growth retardation, Nail dystrophy, Sparse hair, Nail ...	OMIM:268130
X-Linked Female Restricted Facial Dysmorphism-Short Stature-Choanal Atresia-Intellectual Disability	Hypoplastic nipples, Hypertrichosis, Curly hair	ORPHA:480880
Short-Rib Thoracic Dysplasia 7 With Or Without Polydactyly	Nail dysplasia, Sparse hair, Fine hair, Aplasia/Hypoplasia of the eyebrow	OMIM:614091
Cartilage-Hair Hypoplasia	Sparse eyebrow, Fair hair, Fine hair, Sparse eyelashes, Sparse facial hair, Sparse hair	OMIM:250250
Multiple Sulfatase Deficiency	Coarse hair, Thick eyebrow	ORPHA:585
Cutis Laxa, Autosomal Recessive, Type Iiib	Intrauterine growth retardation, Sparse hair, Fine hair	OMIM:614438
Koolen-De Vries Syndrome	Abnormality of hair texture, Hypopigmentation of hair	ORPHA:96169
Chondrodysplasia Punctata, Autosomal Dominant	Sparse hair, Coarse hair	OMIM:118650
Macrocephaly/Autism Syndrome	Coarse hair	OMIM:605309
Dyskeratosis Congenita, Autosomal Dominant 3	Alopecia, Fine hair, Premature graying of hair, Intrauterine growth retardation, Nail dystrophy, ...	OMIM:613990
Mucopolysaccharidosis-Plus Syndrome	Coarse hair, Long eyelashes, Low anterior hairline, Low posterior hairline, Hirsutism, Synophrys	OMIM:617303
Ectodermal Dysplasia 1, Hypohidrotic, X-Linked	Sparse eyebrow, Absent nipple, Fine hair, Sparse body hair, Concave nail, Sparse eyelashes, Absen...	OMIM:305100
Homocystinuria Due To Cystathionine Beta-Synthase Deficiency	Brittle hair	OMIM:236200
Short Stature, Optic Nerve Atrophy, And Pelger-Huet Anomaly	Thick eyebrow, Fine hair	OMIM:614800
Lateral Meningocele Syndrome	Meningocele, Coarse hair, Umbilical hernia	OMIM:130720
Trichothiodystrophy	Aplasia/Hypoplasia of the nails, Umbilical hernia, Ridged nail, Tiger tail banding, Alopecia of s...	ORPHA:33364
Mucopolysaccharidosis, Type Vii	Umbilical hernia, Coarse hair, Thick eyebrow, Hirsutism	OMIM:253220
Mandibuloacral Dysplasia With Type B Lipodystrophy	Alopecia, Sparse hair, Brittle hair	OMIM:608612
Bcard Syndrome	Nail dysplasia, Intrauterine growth retardation, Coarse hair	OMIM:612394
Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate Syndrome	Sparse eyebrow, Coarse hair, Dystrophic toenail, Supernumerary nipple, Hyperconvex fingernails, S...	ORPHA:1071
Autosomal Recessive Cutis Laxa Type 2, Classic Type	Intrauterine growth retardation, Sparse hair, Thick hair, Coarse hair	ORPHA:357074
Ectodermal Dysplasia-Intellectual Disability-Central Nervous System Malformation Syndrome	Aplastic/hypoplastic toenail, Aplasia/Hypoplasia of the eyebrow, Fine hair, Supernumerary nipple	ORPHA:1812
Short Stature, Facial Dysmorphism, And Skeletal Anomalies With Or Without Cardiac Anomalies 2	Intrauterine growth retardation, Brittle hair	OMIM:619184
Schimke Immunoosseous Dysplasia	Intrauterine growth retardation, Coarse hair, Fine hair	OMIM:242900
Weaver Syndrome	Fine hair, Umbilical hernia, Thin nail, Deep-set nails, Sparse hair	OMIM:277590
Koolen-De Vries Syndrome	Abnormality of hair texture, Intrauterine growth retardation, Fair hair	OMIM:610443
Ablepharon Macrostomia Syndrome	Fine hair, Umbilical hernia, Breast hypoplasia, Absent eyelashes, Abnormal hair pattern, Absent e...	ORPHA:920
Cardiofaciocutaneous Syndrome	Fine hair, Aplasia/Hypoplasia of the eyebrow, Sparse or absent eyelashes, Low posterior hairline,...	ORPHA:1340
Cerebroretinal Microangiopathy With Calcifications And Cysts 1	Fine hair, Premature graying of hair, Intrauterine growth retardation, Nail dystrophy, Nail dyspl...	OMIM:612199
Craniolenticulosutural Dysplasia	Sparse hair, Coarse hair, Brittle hair	ORPHA:50814
Microcephaly, Developmental Delay, And Brittle Hair Syndrome	Intrauterine growth retardation, Sparse hair, Fine hair, Brittle hair	OMIM:618891
Hallermann-Streiff Syndrome	Alopecia, Sparse eyebrow, Sparse body hair, Sparse eyelashes, Abnormality of hair texture, Sparse...	ORPHA:2108
Nicolaides-Baraitser Syndrome	Dry hair, Sparse medial eyebrow, Hypertrichosis, Umbilical hernia, Long eyelashes, Intrauterine g...	OMIM:601358
Diamond-Blackfan Anemia 21	Coarse hair, Horizontal eyebrow, Widow's peak, Synophrys	OMIM:620072
Argininosuccinic Aciduria	Trichorrhexis nodosa, Dry hair, Brittle hair	OMIM:207900
Oculodentodigital Dysplasia, Autosomal Recessive	Sparse hair, Fine hair, Sparse eyelashes	OMIM:257850
2P15P16.1 Microdeletion Syndrome	Sparse eyebrow, Fine hair, Supernumerary nipple, Long eyelashes, Intrauterine growth retardation	ORPHA:261349
Neurodevelopmental Disorder With Ataxia, Hypotonia, And Microcephaly	Dry hair, Low anterior hairline	OMIM:618569
Cranioectodermal Dysplasia 3	Short nail, Sparse hair, Fine hair, Broad nail	OMIM:614099
Short-Limb Skeletal Dysplasia With Severe Combined Immunodeficiency	White hair, Fine hair	ORPHA:935
Microcephalic Osteodysplastic Primordial Dwarfism Type Ii	Intrauterine growth retardation, Fine hair, Aplasia/Hypoplasia of the eyebrow	ORPHA:2637
Opitz-Kaveggia Syndrome	Sparse hair, Frontal upsweep of hair, Fine hair, Umbilical hernia	OMIM:305450
Hallermann-Streiff Syndrome	Sparse eyebrow, Fine hair, Sparse eyelashes, Spina bifida, Sparse hair, Sparse scalp hair	OMIM:234100
Genitopatellar Syndrome	Sparse scalp hair, Fine hair	ORPHA:85201
Mucopolysaccharidosis, Type Iiid	Coarse hair, Facial hirsutism, Thick eyebrow, Hirsutism, Synophrys	OMIM:252940
Menkes Disease	Sparse hair, Umbilical hernia, Intrauterine growth retardation, Hypopigmentation of hair, Woolly ...	ORPHA:565
Syndromic Diarrhea	Trichorrhexis nodosa, Intrauterine growth retardation, Uncombable hair, Brittle hair, Hypopigment...	ORPHA:84064
Mucolipidosis Type Ii	Fine hair, Dry hair, White hair, Umbilical hernia	ORPHA:576
Dubowitz Syndrome	Sparse lateral eyebrow, Fine hair, Abnormal fingernail morphology, Intrauterine growth retardatio...	ORPHA:235
Cerebellofaciodental Syndrome	Sparse eyebrow, Fine hair	OMIM:616202
Autosomal Recessive Faciodigitogenital Syndrome	Hypopigmentation of hair, Dry hair, Widow's peak, Coarse hair	ORPHA:1974
Oculodentodigital Dysplasia	Dry hair, Fine hair, Slow-growing hair, Sparse hair, Fragile nails	OMIM:164200
Satb2-Associated Syndrome Due To A Chromosomal Rearrangement	Sparse hair, Fine hair	ORPHA:251028
Sideroblastic Anemia With B-Cell Immunodeficiency, Periodic Fevers, And Developmental Delay	Brittle hair	OMIM:616084
Craniolenticulosutural Dysplasia	Sparse hair, Coarse hair, Brittle hair	OMIM:607812
Mucopolysaccharidosis Type 3	Coarse hair, Umbilical hernia, Hirsutism, Generalized hirsutism, Thick hair, Synophrys	ORPHA:581
Mucolipidosis Ii Alpha/Beta	Sparse eyebrow, Myelopathy, Umbilical hernia, Brittle hair, Sparse hair	OMIM:252500
Eec Syndrome	Sparse eyebrow, Coarse hair, Fine hair, Thick eyebrow, Nail dystrophy, Slow-growing hair, Nail pits	ORPHA:1896
Hajdu-Cheney Syndrome	Coarse hair, Umbilical hernia, Abnormal fingernail morphology, Thick eyebrow, Low anterior hairli...	ORPHA:955
Cerebellar-Facial-Dental Syndrome	Sparse eyebrow, Sparse hair, Fine hair	ORPHA:444072
Marshall-Smith Syndrome	Highly arched eyebrow, Hypertrichosis, Umbilical hernia, Thick eyebrow, Brittle hair, Sparse hair...	OMIM:602535
Orofaciodigital Syndrome I	Sparse hair, Alopecia, Dry hair, Myelomeningocele	OMIM:311200
Adrenomyeloneuropathy	Frontal balding, Fine hair	ORPHA:139399
Coloboma, Congenital Heart Disease, Ichthyosiform Dermatosis, Impaired Intellectual Development, And Ear Anomalies Syndrome	Highly arched eyebrow, Sparse lateral eyebrow, Fine hair, Umbilical hernia, Hypoplastic nipples, ...	OMIM:280000
Fontaine Progeroid Syndrome	Absent nipple, Coarse hair, Small nail, Hypertrichosis, Umbilical hernia, Intrauterine growth ret...	OMIM:612289
Noonan Syndrome-Like Disorder With Or Without Juvenile Myelomonocytic Leukemia	Low posterior hairline, Highly arched eyebrow, Sparse hair, Fine hair	OMIM:613563
Scalp-Ear-Nipple Syndrome	Sparse pubic hair, Fine hair, Breast aplasia, Nail dysplasia, Patchy alopecia, Sparse axillary ha...	OMIM:181270
Woodhouse-Sakati Syndrome	Alopecia, Sparse hair, Fine hair	OMIM:241080
Epidermolysis Bullosa, Junctional 7, With Interstitial Lung Disease And Nephrotic Syndrome	Sparse eyebrow, Fine hair, Nail dystrophy, Sparse eyelashes, Onycholysis, Sparse scalp hair	OMIM:614748
Orofaciodigital Syndrome Type 1	Alopecia, Sparse hair, Coarse hair, Brittle hair	ORPHA:2750
Cockayne Syndrome B	Abnormal hair morphology, Intrauterine growth retardation, Sparse hair, Dry hair	OMIM:133540
Lysinuric Protein Intolerance	Sparse hair, Fine hair	OMIM:222700
Melnick-Needles Syndrome	Frontal hirsutism, Coarse hair, Stillbirth	OMIM:309350
Global Developmental Delay-Osteopenia-Ectodermal Defect Syndrome	Abnormality of hair texture, Thick eyebrow, Hypoplastic sweat glands, Synophrys	ORPHA:73223
Cranioectodermal Dysplasia 1	Short nail, Fine hair, Slow-growing hair, Thin nail, Sparse hair	OMIM:218330
Coffin-Siris Syndrome 1	Facial hypertrichosis, Dry hair, Hypertrichosis, Umbilical hernia, Long eyelashes, Hypoplastic fi...	OMIM:135900
Focal Dermal Hypoplasia	Supernumerary nipple, Myelomeningocele, Umbilical hernia, Ridged nail, Absent toenail, Nail dystr...	OMIM:305600
Chime Syndrome	Sparse hair, Fine hair	ORPHA:3474
Myhre Syndrome	Intrauterine growth retardation, Sparse hair, Thick eyebrow, Fine hair	OMIM:139210
Autosomal Recessive Malignant Osteopetrosis	Abnormality of hair texture	ORPHA:667
Cockayne Syndrome A	Sparse hair, Intrauterine growth retardation, Dry hair	OMIM:216400
Neuroocular Syndrome 1	Highly arched eyebrow, Small nail, Umbilical hernia, Long eyelashes, Thick eyebrow, Distichiasis,...	OMIM:619539
Occipital Horn Syndrome	Pili torti, Coarse hair	OMIM:304150
Ogden Syndrome	Sparse eyebrow, Fine hair, Umbilical hernia, Intrauterine growth retardation, Long eyelashes	OMIM:300855
Noonan Syndrome	Low posterior hairline, Coarse hair, Abnormal hair quantity	ORPHA:648
Cockayne Syndrome Type 3	Dry hair, Premature graying of hair	ORPHA:90324
Distal Deletion 12Q	Small nail, Fine hair	ORPHA:96149
Oculocerebrorenal Syndrome Of Lowe	Sparse scalp hair, Fine hair, Umbilical hernia	ORPHA:534
Mitochondrial Complex Iii Deficiency, Nuclear Type 1	Neonatal death, Brittle hair	OMIM:124000
Microcephalic Osteodysplastic Primordial Dwarfism, Type I	Sparse eyebrow, Fine hair, Intrauterine growth retardation, Sparse eyelashes, Stillbirth, Sparse ...	OMIM:210710
Renpenning Syndrome 1	Sparse hair, Sparse lateral eyebrow, Brittle hair	OMIM:309500
Occipital Horn Syndrome	Coarse hair, Thick hair	ORPHA:198
Cockayne Syndrome	Dry hair, Fine hair	ORPHA:191
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome	Intrauterine growth retardation, Coarse hair	ORPHA:83617
Coffin-Lowry Syndrome	Hyperconvex fingernails, Highly arched eyebrow, Coarse hair, Thick eyebrow	OMIM:303600
Witteveen-Kolk Syndrome	High anterior hairline, Branchial fistula, Fine hair, Intrauterine growth retardation, Medial fla...	OMIM:613406
Liver Disease, Severe Congenital	Intrauterine growth retardation, Dry hair, Nail dystrophy, Umbilical hernia	OMIM:619991
Vascular Ehlers-Danlos Syndrome	Alopecia, Umbilical hernia, Aplasia/Hypoplasia of the eyebrow, Abnormality of hair texture, Abnor...	ORPHA:286
Noonan Syndrome 1	Low posterior hairline, Woolly hair	OMIM:163950
Alström Syndrome	Frontal balding, Fine hair, Hirsutism	ORPHA:64

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ets2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ets2.

No publications found that use IMPC mice or data for Ets2.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele	Allele Type	Produced
Ets2^{tm1(NCOM)Mfgc}	Reporter-tagged deletion allele (with selection cassette)	Targeting vectors, ES Cells

Sequence

Guides

Sequence	Guide sequence	pam	chr	start	stop	strand	Genome build	gRNA Concentration	Truncated Guide	Reversed	Sanger service	Guide format	Guide source

Nucleases

Nuclease type	Nuclease class

Genotype primers

Sequence	Name

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