Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
E26 avian leukemia oncogene 2, 3' domain
Synonyms:
Ets-2

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ets2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ets2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Woolly Hair, Autosomal Recessive 3
Sparse hair, Curly hair, Sparse scalp hair, Trichorrhexis nodosa, Fine hair, Sparse eyelashes OMIM:616760
Uncombable Hair Syndrome 3
Pili canaliculi, Curly hair, Uncombable hair OMIM:617252
Ringed Hair Disease
Abnormal hair pattern, Fine hair ORPHA:169
Pseudopili Annulati
Abnormality of the scalp hair, Abnormality of hair texture OMIM:613241
Pili Bifurcati
Abnormal hair morphology, Abnormality of hair texture ORPHA:720
Witkop Syndrome
Nail pits, Small nail, Sparse hair, Ridged nail, Concave nail, Fine hair OMIM:189500
Hypotrichosis 13
Woolly hair, Sparse and thin eyebrow, Sparse hair OMIM:615896
Uncombable Hair Syndrome 2
Pili canaliculi, Uncombable hair OMIM:617251
Hypotrichosis 7
Woolly hair, Sparse and thin eyebrow, Sparse hair, Sparse eyelashes OMIM:604379
Pili Torti-Developmental Delay-Neurological Abnormalities Syndrome
Abnormality of hair texture, Sparse or absent eyelashes, Pili torti, Aplasia/Hypoplasia of the ey... ORPHA:2891
Acrokeratoderma, Hereditary Papulotranslucent
Fine hair OMIM:101840
Cardiofaciocutaneous Syndrome 2
Fine hair, Curly hair, Sparse hair, Absent eyebrow OMIM:615278
Naxos Disease
Sparse scalp hair, Curly hair, Woolly hair, Abnormality of hair texture ORPHA:34217
Ichthyosis, Congenital, Autosomal Recessive 11
Sparse hair, Curly hair, Sparse and thin eyebrow, Brittle hair, Pili torti OMIM:602400
Uncombable Hair Syndrome
Trichodysplasia, Abnormal hair morphology, White hair, Coarse hair, Patchy alopecia, Woolly hair ORPHA:1410
Trichodysplasia-Xeroderma Syndrome
Trichodysplasia, Coarse hair, Sparse scalp hair, Sparse and thin eyebrow, Brittle hair, Alopecia,... ORPHA:3361
Chand Syndrome
Nail dysplasia, Curly hair OMIM:214350
Woolly Hair
Hypopigmentation of hair, Slow-growing hair, Sparse lateral eyebrow, Brittle hair, Abnormality of... ORPHA:170
Alopecia-Mental Retardation Syndrome With Convulsions And Hypergonadotropic Hypogonadism
Woolly hair, Woolly scalp hair, Alopecia OMIM:601217
Pili Torti
Abnormal eyebrow morphology, Abnormality of the nail, Brittle hair, Alopecia, Abnormality of hair... ORPHA:2889
Ectodermal Dysplasia 4, Hair/Nail Type
Onycholysis, Absent eyelashes, Absent eyebrow, Brittle hair, Alopecia, Congenital onychodystrophy... OMIM:602032
Monilethrix
Sparse hair, Nail dysplasia, Brittle hair, Alopecia, Abnormality of hair texture, Nail dystrophy OMIM:158000
Trichodysplasia-Xeroderma
Trichodysplasia, Sparse hair, Dry hair, Coarse hair, Sparse axillary hair, Slow-growing hair, Spa... OMIM:190360
Sin3A-Related Intellectual Disability Syndrome Due To A Point Mutation
Fine hair, Fragile nails ORPHA:500166
Angioma Serpiginosum, X-Linked
Fine hair, Sparse hair, Nail dystrophy OMIM:300652
Palmoplantar Keratoderma And Woolly Hair
Leukonychia, Sparse scalp hair, Sparse and thin eyebrow, Sparse body hair, Woolly hair, Woolly sc... OMIM:616099
Ectodermal Dysplasia 7, Hair/Nail Type
Onycholysis, Sparse hair, Sparse and thin eyebrow, Brittle hair, Alopecia, Dystrophic toenail, Dy... OMIM:614929
Mental Retardation, Autosomal Dominant 34
Curly hair, Coarse hair, Synophrys OMIM:616351
Leopard Syndrome 2
Curly hair OMIM:611554
Hypotrichosis 8
Nail pits, Sparse hair, Dry hair, Ridged nail, Coarse hair, Sparse axillary hair, Fair hair, Spar... OMIM:278150
Monilethrix
Abnormal eyebrow morphology, Abnormality of the nail, Sparse hair, Abnormal eyelash morphology, S... ORPHA:573
Woolly Hair, Hypotrichosis, Everted Lower Lip, And Outstanding Ears
Woolly hair, Sparse hair OMIM:278200
Crandall Syndrome
Brittle hair, Alopecia, Aplasia/Hypoplasia of the eyebrow, Sparse body hair, Fine hair, Pili torti ORPHA:202
Copper Deficiency, Familial Benign
Curly hair, Early balding OMIM:121270
Smith-Kingsmore Syndrome
Curly hair, Umbilical hernia OMIM:616638
Spondyloepiphyseal Dysplasia-Brachydactyly-Speech Disorder Syndrome
Curly hair, Nail dysplasia, Thick eyebrow, Facial hirsutism, Curly eyelashes, Low posterior hairl... ORPHA:163654
Woolly Hair, Autosomal Dominant
Dry hair, Abnormal hair morphology, Coarse hair, Slow-growing hair, Woolly hair OMIM:194300
Marie Unna Hereditary Hypotrichosis
Coarse hair, Sparse scalp hair, Sparse or absent eyelashes, Alopecia, Aplasia/Hypoplasia of the e... ORPHA:444
Hair Defect With Photosensitivity And Mental Retardation
Sparse hair, Coarse hair, Sparse and thin eyebrow, Brittle hair, Sparse eyelashes OMIM:234030
Carvajal Syndrome
Woolly hair ORPHA:65282
Noonan Syndrome 6
Curly hair, Low posterior hairline, Sparse hair, Long eyebrows OMIM:613224
Cardiofaciocutaneous Syndrome 3
Curly hair OMIM:615279
Giant Axonal Neuropathy 1, Autosomal Recessive
Curly hair OMIM:256850
Hypodontia-Dysplasia Of Nails Syndrome
Abnormality of the nail, Hypoplastic toenails, Thin toenail, Ridged fingernail, Hypoplastic finge... ORPHA:2228
Autosomal Recessive Hypohidrotic Ectodermal Dysplasia
Abnormal hair morphology, Alopecia, Abnormal toenail morphology, Fine hair, Abnormal fingernail m... ORPHA:248
Onychotrichodysplasia And Neutropenia
Short eyelashes, Curly hair, Sparse pubic hair, Concave nail, Hypoplastic fingernail, Curly eyela... OMIM:258360
Noonan Syndrome 5
Curly hair, Small nail, Sparse eyebrow, Fine hair OMIM:611553
Leopard Syndrome 3
Curly hair, Low posterior hairline OMIM:613707
Congenital Heart Defects, Dysmorphic Facial Features, And Intellectual Developmental Disorder
Curly hair OMIM:617360
Trichodental Dysplasia
Fine hair, Brittle hair, Sparse hair, Slow-growing hair OMIM:601453
Dwarfism, Familial, With Muscle Spasms
Sparse scalp hair, Brittle scalp hair, Fine hair OMIM:600771
Hypotrichosis 6
Sparse hair, Sparse and thin eyebrow, Brittle hair, Pili torti, Sparse eyelashes OMIM:607903
Ectodermal Dysplasia-Syndactyly Syndrome 1
Hypoplastic toenails, Small nail, Coarse hair, Absent facial hair, Sparse scalp hair, Sparse and ... OMIM:613573
Noonan Syndrome 9
Curly hair, Sparse eyebrow OMIM:616559
Cerebellar Ataxia-Ectodermal Dysplasia Syndrome
Fine hair, Sparse hair ORPHA:1174
Ectodermal Dysplasia 10A, Hypohidrotic/Hair/Nail Type, Autosomal Dominant
Sparse hair, Slow-growing hair, Nail dysplasia, Sparse and thin eyebrow, Fine hair, Sparse eyelashes OMIM:129490
Arrhythmogenic Right Ventricular Dysplasia, Familial, 11
Woolly hair OMIM:610476
Uncombable Hair Syndrome 1
Pili canaliculi, Uncombable hair, Dry hair OMIM:191480
Noonan Syndrome 8
Curly hair OMIM:615355
Trichothiodystrophy 7, Nonphotosensitive
Brittle hair, Tiger tail banding OMIM:618546
Choroidal Atrophy-Alopecia Syndrome
Sparse hair, Ungual fibroma, Sparse or absent eyelashes, Abnormal toenail morphology, Supernumera... ORPHA:1433
Bazex-Dupré-Christol Syndrome
Sparse hair, Coarse hair, Sparse scalp hair, Sparse and thin eyebrow, Sparse or absent eyelashes,... ORPHA:113
Trichohepatoenteric Syndrome 1
Sparse hair, Curly hair, Large placenta, Brittle hair, Intrauterine growth retardation, Woolly ha... OMIM:222470
Noonan Syndrome 7
Curly hair, Low posterior hairline OMIM:613706
Peeling Skin Syndrome 1
Onycholysis, Brittle hair, Abnormality of hair texture OMIM:270300
Hypotrichosis 12
Sparse hair, Dry hair, Slow-growing hair, Sparse or absent eyelashes, Aplasia/Hypoplasia of the e... OMIM:615885
Pili Torti, Early-Onset
Dry hair, Hair shafts flattened at irregular intervals and twisted through 180 degrees about thei... OMIM:261900
Clouston Syndrome
Onycholysis, Small nail, Absent pubic hair, Absent axillary hair, Slow-growing hair, Nail dysplas... OMIM:129500
Björnstad Syndrome
Brittle hair, Alopecia ORPHA:123
Hypohidrotic Ectodermal Dysplasia-Hypothyroidism-Ciliary Dyskinesia Syndrome
Sparse scalp hair, Sparse and thin eyebrow, Alopecia, Dystrophic toenail, Dystrophic fingernails,... ORPHA:1882
Trichohepatoenteric Syndrome 2
Sparse hair, Uncombable hair, Brittle hair, Intrauterine growth retardation, Pili canaliculi, Woo... OMIM:614602
Trichothiodystrophy 2, Photosensitive
Brittle hair, Coarse hair, Tiger tail banding OMIM:616390
Onychogryposis, Pedal, With Keratosis Plantaris And Coarse Hair
Coarse hair, Onychogryposis of toenails, Sparse hair, Dry hair OMIM:164680
Naxos Disease
Onycholysis, Curly hair, Sparse and thin eyebrow, Sparse body hair, Woolly hair, Nail dystrophy OMIM:601214
Cleft Lip/Palate-Ectodermal Dysplasia Syndrome
Nail dysplasia, Sparse and thin eyebrow, Brittle hair, Abnormality of hair texture, Progressive h... OMIM:225060
Hawkinsinuria
Fine hair, Sparse hair ORPHA:2118
Bjornstad Syndrome
Dry hair, Hair shafts flattened at irregular intervals and twisted through 180 degrees about thei... OMIM:262000
Macrocephaly-Intellectual Disability-Neurodevelopmental Disorder-Small Thorax Syndrome
Curly hair ORPHA:457485
Sabinas Brittle Hair Syndrome
Sparse hair, Dry hair, Nail dysplasia, Brittle hair, Nail dystrophy OMIM:211390
Hypotrichosis With Juvenile Macular Degeneration
Sparse scalp hair, Brittle hair, Pili torti, Fine hair ORPHA:1573
Progeroid Syndrome, Petty Type
Generalized hirsutism, Abnormality of the nail, Sparse hair, Abnormal hair morphology, Long eyela... ORPHA:2963
Pili Torti-Onychodysplasia Syndrome
Trichodysplasia, Absent eyelashes, Absent eyebrow, Alopecia universalis, Alopecia, Brittle hair, ... ORPHA:2890
Palmoplantar Keratoderma And Congenital Alopecia 1
Sparse eyebrow, Sparse hair, Leukonychia, Nail dysplasia, Brittle hair, Alopecia OMIM:104100
Noonan Syndrome 4
Curly hair, Sparse eyebrow, High anterior hairline OMIM:610733
Pilodental Dysplasia With Refractive Errors
Sparse scalp hair, Brittle scalp hair, Abnormality of the nail, Brittle hair OMIM:262020
Craniometadiaphyseal Dysplasia, Wormian Bone Type
Curly hair ORPHA:85184
Oculodentodigital Dysplasia
Abnormality of the nail, Sparse hair, Curly hair, Umbilical hernia, Slow-growing hair, Brittle ha... ORPHA:2710
Trichohepatoneurodevelopmental Syndrome
Curly hair, Coarse hair, Synophrys, Hypoplastic nipples, Hypertrichosis, Woolly hair OMIM:618268
Amaurosis-Hypertrichosis Syndrome
Abnormal eyelash morphology, Thick eyebrow, Coarse hair, Synophrys ORPHA:1021
Cataract, Aberrant Oral Frenula, And Growth Retardation
Curly hair OMIM:115645
Erythrokeratodermia Variabilis Et Progressiva 7
Woolly hair, Dystrophic toenail OMIM:619209
Trichothiodystrophy 4, Nonphotosensitive
Small nail, Sparse hair, Nail dysplasia, Concave nail, Brittle hair, Abnormality of hair texture,... OMIM:234050
Skin Fragility-Woolly Hair Syndrome
Nail dysplasia, Sparse and thin eyebrow, Alopecia, Woolly hair, Nail dystrophy, Sparse eyelashes OMIM:607655
Bazex Syndrome
Sparse hair, Coarse hair, Trichorrhexis nodosa, Pili torti, Trichoepithelioma OMIM:301845
Trichothiodystrophy 6, Nonphotosensitive
Mild intrauterine growth retardation, Brittle hair, Tiger tail banding, Slow-growing hair OMIM:616943
Tricho-Retino-Dento-Digital Syndrome
Uncombable hair, Sparse hair ORPHA:1264
Growth Hormone Insensitivity Syndrome
Abnormality of the nail, Fine hair ORPHA:181393
Odontotrichoungual-Digital-Palmar Syndrome
Nail dysplasia, Nail dystrophy, Abnormality of hair texture OMIM:601957
Cardiofaciocutaneous Syndrome 1
Sparse hair, Absent eyelashes, Curly hair, Absent eyebrow, Slow-growing hair, Low posterior hairline OMIM:115150
Trichothiodystrophy 3, Photosensitive
Brittle hair, Tiger tail banding OMIM:616395
X-Linked Dominant Chondrodysplasia Punctata
Abnormality of hair texture, Scarring alopecia of scalp, Abnormal fingernail morphology ORPHA:35173
Hidrotic Ectodermal Dysplasia
Onycholysis, Sparse hair, Sparse eyelashes, Hyperconvex nail, Sparse axillary hair, Abnormality o... ORPHA:189
Zellweger-Like Syndrome Without Peroxisomal Anomalies
Intrauterine growth retardation, Brittle hair, Alopecia ORPHA:50812
Pachyonychia Congenita 2
Dry hair, Nail dysplasia, Subungual hyperkeratosis, Sparse scalp hair, Sparse and thin eyebrow, N... OMIM:167210
Ectodermal Dysplasia-Sensorineural Deafness Syndrome
Coarse hair, Brittle hair, Sparse hair ORPHA:1883
Osteopenia-Intellectual Disability-Sparse Hair Syndrome
Sparse scalp hair, Fine hair ORPHA:2324
Macroepiphyseal Dysplasia With Osteoporosis, Wrinkled Skin, And Aged Appearance
Coarse hair OMIM:248010
Noonan Syndrome-Like Disorder With Loose Anagen Hair 2
Highly arched eyebrow, Sparse hair, Curly hair, High anterior hairline, Slow-growing hair, Low po... OMIM:617506
Weaver Syndrome
Hypoplastic toenails, Deep-set nails, Thin nail, Fine hair, Abnormal fingernail morphology ORPHA:3447
Acquired Hypertrichosis Lanuginosa
Generalized hirsutism, Hypopigmentation of hair, Abnormal eyebrow morphology, Fine hair ORPHA:2221
Noonan Syndrome-Like Disorder With Loose Anagen Hair 1
Sparse hair, Curly hair, Long eyelashes, Sparse scalp hair, Loose anagen hair OMIM:607721
Trichothiodystrophy 5, Nonphotosensitive
Sparse hair, Tiger tail banding, Slow-growing hair, Brittle hair, Intrauterine growth retardation OMIM:300953
Noonan Syndrome 2
Curly hair, Low posterior hairline, Sparse eyebrow OMIM:605275
Uncombable Hair, Retinal Pigmentary Dystrophy, Dental Anomalies, And Brachydactyly
Pili canaliculi, Uncombable hair OMIM:191482
Noonan Syndrome 10
Curly hair, Sparse eyebrow OMIM:616564
Craniofrontonasal Dysplasia
Widow's peak, Ridged fingernail, Abnormality of hair texture, Woolly hair, Low posterior hairline ORPHA:1520
Cardiomyopathy, Dilated, With Woolly Hair And Keratoderma
Woolly hair OMIM:605676
Cerebellofaciodental Syndrome
Fine hair, Sparse and thin eyebrow, Sparse hair OMIM:616202
Acrogeria
Fine hair ORPHA:2500
Silver-Russell Syndrome Due To 7P11.2P13 Microduplication
Long eyelashes, High anterior hairline, Fine hair ORPHA:231137
Brain Malformation-Congenital Heart Disease-Postaxial Polydactyly Syndrome
Coarse hair, Brittle hair, Alopecia, Intrauterine growth retardation, Nail dystrophy ORPHA:75389
Cardiomyopathy, Dilated, With Woolly Hair, Keratoderma, And Tooth Agenesis
Woolly hair, Leukonychia, Nail dystrophy, Fragile nails OMIM:615821
Hereditary Mucoepithelial Dysplasia
Fine hair, Sparse hair, Alopecia ORPHA:1839
Distal Trisomy 6P
Intrauterine growth retardation, Abnormal eyelash morphology, Fine hair, Abnormal hair quantity ORPHA:1745
Chand Syndrome
Nail dysplasia, Curly hair ORPHA:1401
Odontoonychodermal Dysplasia
Dry hair, Sparse hair, Anonychia, Nail dysplasia, Sparse scalp hair, Sparse and thin eyebrow, Dys... OMIM:257980
Giant Axonal Neuropathy
Pili canaliculi, Woolly hair ORPHA:643
Brachymetapody-Anodontia-Hypotrichosis-Albinoidism
Sparse hair, Absent pubic hair, Absent axillary hair, Hypoplastic nipples, Distichiasis, Fine hai... OMIM:211370
Spinocerebellar Ataxia With Dysmorphism
Coarse hair OMIM:271270
Cognitive Impairment-Coarse Facies-Heart Defects-Obesity-Pulmonary Involvement-Short Stature-Skeletal Dysplasia Syndrome
Highly arched eyebrow, Hypoplastic toenails, Thick hair, Curly hair, Long eyelashes, Synophrys, T... ORPHA:444077
Short Stature, Optic Nerve Atrophy, And Pelger-Huet Anomaly
Thick eyebrow, Fine hair OMIM:614800
Gorlin-Chaudhry-Moss Syndrome
Generalized hirsutism, Low anterior hairline, Coarse hair, Umbilical hernia ORPHA:2095
Mucopolysaccharidosis, Type Iiia
Hirsutism, Coarse hair, Synophrys OMIM:252900
Intellectual Disability, Buenos-Aires Type
Hyperconvex thumb nails, Fine hair, Umbilical hernia, Abnormal fingernail morphology ORPHA:3079
Intellectual Disability-Polydactyly-Uncombable Hair Syndrome
Abnormal hair morphology, Uncombable hair, Aplasia/Hypoplasia of the eyebrow, Slow-growing hair ORPHA:3082
Trichothiodystrophy 1, Photosensitive
Small nail, Sparse hair, Tiger tail banding, Nail dystrophy, Brittle hair, Abnormality of hair te... OMIM:601675
Cutis Laxa, Autosomal Recessive, Type Iia
Intrauterine growth retardation, Brittle hair, Coarse hair, Abnormality of hair texture OMIM:219200
Conductive Deafness-Ptosis-Skeletal Anomalies Syndrome
Fine hair ORPHA:3236
Amelo-Onycho-Hypohidrotic Syndrome
Hypoplastic toenails, Onycholysis, Fine hair, Abnormal fingernail morphology ORPHA:1028
2Q32Q33 Microdeletion Syndrome
Fine hair, Sparse hair ORPHA:251019
Spinocerebellar Ataxia-Dysmorphism Syndrome
Coarse hair, Spina bifida occulta ORPHA:1185
Rodrigues Blindness
Fine hair, Sparse hair OMIM:268320
Sulfite Oxidase Deficiency, Isolated
Fine hair OMIM:272300
Zttk Syndrome
Intrauterine growth retardation, Curly hair, Sparse eyebrow, Broad eyebrow OMIM:617140
Fetal Hydantoin Syndrome
Intrauterine growth retardation, Low posterior hairline, Coarse hair, Hypoplastic fingernail ORPHA:1912
Netherton Syndrome
Sparse scalp hair, Brittle scalp hair, Sparse and thin eyebrow, Brittle hair OMIM:256500
Olmsted Syndrome 2
Alopecia universalis, Woolly hair, Sparse hair OMIM:619208
Microcephaly, Short Stature, And Impaired Glucose Metabolism 2
Intrauterine growth retardation, Sparse hair, Fine hair OMIM:616817
Netherton Syndrome
Abnormal hair morphology, Sparse scalp hair, Sparse and thin eyebrow, Trichorrhexis nodosa, Fine ... ORPHA:634
Mucopolysaccharidosis, Type Iiib
Hirsutism, Coarse hair, Synophrys OMIM:252920
Hall-Riggs Syndrome
Coarse hair, Thick hair, Slow-growing hair ORPHA:2107
Brachycephaly, Trichomegaly, And Developmental Delay
Highly arched eyebrow, Long eyelashes, Synophrys, Thick eyebrow, Brittle hair OMIM:617412
Tonne-Kalscheuer Syndrome
Small nail, Fine hair OMIM:300978
Frontonasal Dysplasia-Alopecia-Genital Anomalies Syndrome
Intrauterine growth retardation, Fine hair, Alopecia ORPHA:228390
19Q13.11 Microdeletion Syndrome
Sparse hair, Nail dysplasia, Sparse lateral eyebrow, Sparse or absent eyelashes, Intrauterine gro... ORPHA:217346
Adult Syndrome
Nail pits, Abnormality of the nail, Absent nipple, Breast hypoplasia, Fingernail dysplasia, Hypop... ORPHA:978
Mandibuloacral Dysplasia With Type B Lipodystrophy
Brittle hair, Sparse hair, Alopecia, Abnormality of hair texture OMIM:608612
Costello Syndrome
Sparse hair, Deep-set nails, Curly hair, Concave nail, Thin nail, Fragile nails OMIM:218040
Primary Microcephaly-Mild Intellectual Disability-Young-Onset Diabetes Syndrome
Low anterior hairline, Sparse hair, Synophrys, Intrauterine growth retardation, Fine hair ORPHA:391408
Acrofacial Dysostosis, Catania Type
Intrauterine growth retardation, Abnormal hair pattern, Coarse hair, Spina bifida occulta ORPHA:1786
Rapp-Hodgkin Syndrome
Decreased number of sweat glands, Small nail, Sparse hair, Pili canaliculi, Progressive alopecia,... OMIM:129400
Mucopolysaccharidosis, Type Iiid
Thick eyebrow, Hirsutism, Coarse hair, Synophrys OMIM:252940
Mucopolysaccharidosis, Type Iiic
Hirsutism, Coarse hair, Synophrys OMIM:252930
Trichodermodysplasia-Dental Alterations Syndrome
Sparse scalp hair, Sparse lateral eyebrow, Sparse or absent eyelashes, Brittle hair, Aplasia/Hypo... ORPHA:3353
Revesz Syndrome
Nail pits, Sparse hair, Ridged fingernail, Intrauterine growth retardation, Fine hair, Nail dystr... OMIM:268130
Trichorhinophalangeal Syndrome, Type I
Sparse hair, Leukonychia, Slow-growing hair, Concave nail, Thin nail, Sparse lateral eyebrow, Thi... OMIM:190350
X-Linked Intellectual Disability, Golabi-Ito-Hall Type
Brittle hair, Dry hair, Nail dystrophy ORPHA:93947
3-Phosphoglycerate Dehydrogenase Deficiency, Infantile/Juvenile Form
Intrauterine growth retardation, Umbilical hernia, Abnormality of hair texture ORPHA:79351
Cartilage-Hair Hypoplasia
Sparse hair, Sparse facial hair, Fair hair, Sparse and thin eyebrow, Fine hair, Sparse eyelashes OMIM:250250
Pontocerebellar Hypoplasia, Hypotonia, And Respiratory Insufficiency Syndrome, Neonatal Lethal
Neonatal death, Sparse eyebrow, Brittle hair OMIM:618810
Cutis Laxa, Autosomal Recessive, Type Iiib
Fine hair, Sparse hair OMIM:614438
Costello Syndrome
Hypoplastic toenails, Abnormal hair morphology, Deep-set nails, Concave nail, Woolly hair, Abnorm... ORPHA:3071
Dyskeratosis Congenita, Autosomal Dominant 3
Premature graying of hair, Nail dysplasia, Alopecia, Intrauterine growth retardation, Fine hair OMIM:613990
Incontinentia Pigmenti
Nail pits, Sparse hair, Breast hypoplasia, Ridged nail, Coarse hair, Breast aplasia, Nail dysplas... OMIM:308300
Ectodermal Dysplasia-Blindness Syndrome
Fine hair, Sparse hair, Abnormal fingernail morphology ORPHA:1806
Schimke Immunoosseous Dysplasia
Intrauterine growth retardation, Coarse hair, Fine hair OMIM:242900
Trisomy 20P
Low anterior hairline, Spina bifida, Highly arched eyebrow, Thick hair, Coarse hair, Umbilical he... ORPHA:261318
Sener Syndrome
Coarse hair, Umbilical hernia OMIM:606156
Brain Malformations-Musculoskeletal Abnormalities-Facial Dysmorphism-Intellectual Disability Syndrome
Intrauterine growth retardation, Curly hair, Broad lateral eyebrow, Sparse eyebrow ORPHA:500150
Cerebrofaciothoracic Dysplasia
Coarse hair, Synophrys, Thick eyebrow, Abnormal hair pattern, Low posterior hairline ORPHA:1394
Lateral Meningocele Syndrome
Meningocele, Coarse hair, Umbilical hernia OMIM:130720
Chondrodysplasia Punctata, Autosomal Dominant
Coarse hair, Sparse hair OMIM:118650
Bone Fragility With Contractures, Arterial Rupture, And Deafness
Intrauterine growth retardation, Nail dysplasia, Coarse hair OMIM:612394
Mucoepithelial Dysplasia, Hereditary
Coarse hair, Nail dysplasia, Chronic monilial nail infection, Alopecia, Nail dystrophy OMIM:158310
Short-Rib Thoracic Dysplasia 7 With Or Without Polydactyly
Nail dysplasia, Fine hair, Sparse hair, Aplasia/Hypoplasia of the eyebrow OMIM:614091
X-Linked Female Restricted Facial Dysmorphism-Short Stature-Choanal Atresia-Intellectual Disability
Hypoplastic nipples, Curly hair, Hypertrichosis ORPHA:480880
Severe Intellectual Disability-Poor Language-Strabismus-Grimacing Face-Long Fingers Syndrome
Intrauterine growth retardation, Fine hair ORPHA:363686
Ogden Syndrome
Fine hair, Aplasia/Hypoplasia of the eyebrow ORPHA:276432
Mucopolysaccharidosis-Plus Syndrome
Low anterior hairline, Hirsutism, Coarse hair, Synophrys, Long eyelashes, Low posterior hairline OMIM:617303
Koolen-De Vries Syndrome
Hypopigmentation of hair, Abnormality of hair texture ORPHA:96169
Weaver Syndrome
Sparse hair, Deep-set nails, Umbilical hernia, Thin nail, Fine hair OMIM:277590
Multiple Sulfatase Deficiency
Thick eyebrow, Coarse hair ORPHA:585
S-Adenosylhomocysteine Hydrolase Deficiency
Abnormality of hair texture ORPHA:88618
Trichothiodystrophy
Ridged nail, Tiger tail banding, Umbilical hernia, Sparse scalp hair, Alopecia of scalp, Split na... ORPHA:33364
Hallermann-Streiff Syndrome
Spina bifida, Sparse hair, Sparse scalp hair, Sparse and thin eyebrow, Fine hair, Sparse eyelashes OMIM:234100
Homocystinuria Due To Cystathionine Beta-Synthase Deficiency
Brittle hair OMIM:236200
Short Stature, Facial Dysmorphism, And Skeletal Anomalies With Or Without Cardiac Anomalies 2
Intrauterine growth retardation, Brittle hair OMIM:619184
Popov-Chang syndrome
Coarse hair OMIM:618428
Ectodermal Dysplasia-Intellectual Disability-Central Nervous System Malformation Syndrome
Supernumerary nipple, Aplastic/hypoplastic toenail, Fine hair, Aplasia/Hypoplasia of the eyebrow ORPHA:1812
Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate Syndrome
Sparse hair, Hyperconvex nail, Coarse hair, Hyperconvex fingernails, Sparse and thin eyebrow, Dys... ORPHA:1071
Ablepharon Macrostomia Syndrome
Sparse hair, Absent eyelashes, Breast hypoplasia, Absent eyebrow, Umbilical hernia, Abnormal hair... ORPHA:920
Autosomal Recessive Cutis Laxa Type 2, Classic Type
Intrauterine growth retardation, Sparse hair, Coarse hair, Thick hair ORPHA:357074
Kid Syndrome
Hypoplastic toenails, Sparse hair, Aplasia/Hypoplasia of the eyebrow, Abnormal eyelash morphology... ORPHA:477
Microcephaly, Developmental Delay, And Brittle Hair Syndrome
Intrauterine growth retardation, Brittle hair, Sparse hair, Fine hair OMIM:618891
Cranioectodermal Dysplasia 3
Broad nail, Short nail, Sparse hair, Fine hair OMIM:614099
Hallermann-Streiff Syndrome
Sparse hair, Sparse and thin eyebrow, Alopecia, Abnormality of hair texture, Sparse body hair, Sp... ORPHA:2108
Ectodermal Dysplasia 1, Hypohidrotic, X-Linked
Absent nipple, Sparse hair, Absent eyelashes, Absent eyebrow, Hypoplastic nipples, Concave nail, ... OMIM:305100
Argininosuccinic Aciduria
Trichorrhexis nodosa, Brittle hair, Dry hair OMIM:207900
Craniolenticulosutural Dysplasia
Sparse hair, Brittle hair, Coarse hair ORPHA:50814
Cardiofaciocutaneous Syndrome
Sparse hair, Abnormal eyelash morphology, Slow-growing hair, Sparse or absent eyelashes, Brittle ... ORPHA:1340
Scalp-Ear-Nipple Syndrome
Abnormality of the nail, Sparse hair, Abnormal hair morphology, Breast aplasia, Nail dysplasia, F... OMIM:181270
Microcephalic Osteodysplastic Primordial Dwarfism Type Ii
Intrauterine growth retardation, Fine hair, Aplasia/Hypoplasia of the eyebrow ORPHA:2637
Neurodevelopmental Disorder With Ataxia, Hypotonia, And Microcephaly
Low anterior hairline, Dry hair OMIM:618569
2P15P16.1 Microdeletion Syndrome
Long eyelashes, Sparse and thin eyebrow, Intrauterine growth retardation, Supernumerary nipple, F... ORPHA:261349
Oculodentodigital Dysplasia, Autosomal Recessive
Fine hair, Sparse eyelashes OMIM:257850
Short-Limb Skeletal Dysplasia With Severe Combined Immunodeficiency
White hair, Fine hair ORPHA:935
Opitz-Kaveggia Syndrome
Sparse hair, Frontal upsweep of hair, Umbilical hernia, Fine hair OMIM:305450
Koolen-De Vries Syndrome
Intrauterine growth retardation, Abnormality of hair texture, Fair hair OMIM:610443
Genitopatellar Syndrome
Sparse scalp hair, Fine hair ORPHA:85201
Menkes Disease
Hypopigmentation of hair, Sparse hair, Umbilical hernia, Intrauterine growth retardation, Woolly ... ORPHA:565
Oculodentodigital Dysplasia
Sparse hair, Dry hair, Slow-growing hair, Fine hair, Fragile nails OMIM:164200
Syndromic Diarrhea
Hypopigmentation of hair, Uncombable hair, Brittle hair, Intrauterine growth retardation, Woolly ... ORPHA:84064
Autosomal Recessive Faciodigitogenital Syndrome
Widow's peak, Coarse hair, Hypopigmentation of hair, Dry hair ORPHA:1974
Mucolipidosis Type Ii
Fine hair, White hair, Dry hair, Umbilical hernia ORPHA:576
Dubowitz Syndrome
Low anterior hairline, Hypoplastic toenails, Sparse scalp hair, Sparse lateral eyebrow, Spina bif... ORPHA:235
Sideroblastic Anemia With B-Cell Immunodeficiency, Periodic Fevers, And Developmental Delay
Brittle hair OMIM:616084
Satb2-Associated Syndrome Due To A Chromosomal Rearrangement
Fine hair, Sparse hair ORPHA:251028
Mitochondrial Complex Iii Deficiency, Nuclear Type 1
Brittle hair OMIM:124000
Eec Syndrome
Nail pits, Coarse hair, Slow-growing hair, Thick eyebrow, Sparse and thin eyebrow, Fine hair, Nai... ORPHA:1896
Ogden Syndrome
Long eyelashes, Sparse and thin eyebrow, Fine hair OMIM:300855
Focal Dermal Hypoplasia
Absent toenail, Abnormality of hair texture, Myelomeningocele, Sparse hair, Absent fingernail, Um... OMIM:305600
Mucopolysaccharidosis Type 3
Thick hair, Hirsutism, Coarse hair, Synophrys, Umbilical hernia, Generalized hirsutism ORPHA:581
Adrenomyeloneuropathy
Frontal balding, Fine hair ORPHA:139399
Hajdu-Cheney Syndrome
Low anterior hairline, Coarse hair, Synophrys, Umbilical hernia, Thick eyebrow, Generalized hirsu... ORPHA:955
Coloboma, Congenital Heart Disease, Ichthyosiform Dermatosis, Mental Retardation, And Ear Anomalies Syndrome
Hypoplastic nipples, Sparse hair, Fine hair OMIM:280000
Cerebellar-Facial-Dental Syndrome
Fine hair, Sparse eyebrow, Sparse hair ORPHA:444072
Fontaine Progeroid Syndrome
Low anterior hairline, Small nail, Absent nipple, Anonychia, Coarse hair, Umbilical hernia, Synop... OMIM:612289
Noonan Syndrome-Like Disorder With Or Without Juvenile Myelomonocytic Leukemia
Fine hair, Sparse hair OMIM:613563
Woodhouse-Sakati Syndrome
Fine hair, Sparse hair, Alopecia OMIM:241080
Craniolenticulosutural Dysplasia
Sparse hair, Brittle hair, Coarse hair OMIM:607812
Interstitial Lung Disease, Nephrotic Syndrome, And Epidermolysis Bullosa, Congenital
Onycholysis, Sparse scalp hair, Sparse and thin eyebrow, Fine hair, Nail dystrophy, Sparse eyelashes OMIM:614748
Cranioectodermal Dysplasia 1
Sparse hair, Slow-growing hair, Thin nail, Short nail, Fine hair OMIM:218330
Noonan Syndrome
Low posterior hairline, Coarse hair, Abnormal hair quantity ORPHA:648
Cockayne Syndrome B
Intrauterine growth retardation, Sparse hair, Dry hair, Abnormal hair morphology OMIM:133540
Melnick-Needles Syndrome
Frontal hirsutism, Coarse hair, Stillbirth OMIM:309350
Orofaciodigital Syndrome Type 1
Sparse hair, Brittle hair, Coarse hair, Alopecia ORPHA:2750
Coffin-Siris Syndrome 1
Dry hair, Anonychia, Hypoplastic fifth fingernail, Long eyelashes, Umbilical hernia, Facial hyper... OMIM:135900
Global Developmental Delay-Osteopenia-Ectodermal Defect Syndrome
Hypoplastic sweat glands, Thick eyebrow, Synophrys, Abnormality of hair texture ORPHA:73223
Lysinuric Protein Intolerance
Fine hair, Sparse hair OMIM:222700
Cockayne Syndrome A
Intrauterine growth retardation, Sparse hair, Dry hair OMIM:216400
Chime Syndrome
Fine hair, Sparse hair ORPHA:3474
Myhre Syndrome
Intrauterine growth retardation, Thick eyebrow, Sparse hair, Fine hair OMIM:139210
Occipital Horn Syndrome
Coarse hair OMIM:304150
Distal Monosomy 12Q
Small nail, Fine hair ORPHA:96149
Autosomal Recessive Malignant Osteopetrosis
Abnormality of hair texture ORPHA:667
Coffin-Lowry Syndrome
Highly arched eyebrow, Abnormal hair morphology, Coarse hair, Thick eyebrow, Hyperconvex fingernails OMIM:303600
Cockayne Syndrome Type 3
Dry hair, Premature graying of hair ORPHA:90324
Oculocerebrorenal Syndrome Of Lowe
Sparse scalp hair, Fine hair, Umbilical hernia ORPHA:534
Witteveen-Kolk Syndrome
Intrauterine growth retardation, High anterior hairline, Fine hair, Medial flaring of the eyebrow OMIM:613406
Occipital Horn Syndrome
Coarse hair, Thick hair ORPHA:198
Renpenning Syndrome 1
Sparse lateral eyebrow, Brittle hair, Sparse hair OMIM:309500
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome
Intrauterine growth retardation, Coarse hair ORPHA:83617
Cockayne Syndrome
Fine hair, Dry hair ORPHA:191
Vascular Ehlers-Danlos Syndrome
Aplasia/Hypoplasia of the eyebrow, Abnormal eyelash morphology, Umbilical hernia, Alopecia, Abnor... ORPHA:286
Alström Syndrome
Frontal balding, Hirsutism, Fine hair ORPHA:64

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ets2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ets2.

No publications found that use IMPC mice or data for Ets2.

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MGI Allele Allele Type Produced
Ets2tm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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