IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Eif4e.
There are 8 publications which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|The P-body protein 4E-T represses translation to regulate the balance between cell genesis and establishment of the postnatal NSC pool.||Cell reports (March 2023)||Eif4enif1tm2c(KOMP)Wtsi Eif4enif1tm2a(KOMP)Wtsi||36924490|
|Targeting eIF4F translation complex sensitizes B-ALL cells to tyrosine kinase inhibition.||Scientific reports (November 2021)||Eif4etm1c(EUCOMM)Hmgu||34737376|
|Reduced eIF4E function impairs B-cell leukemia without altering normal B-lymphocyte function.||iScience (June 2021)||Eif4etm1c(EUCOMM)Hmgu||PMC8261676|
|4E-BP2-dependent translation in parvalbumin neurons controls epileptic seizure threshold.||Proceedings of the National Academy of Sciences of the United States of America (April 2021)||Eif4ebp3tm1.1(KOMP)Vlcg||33876772|
|4E-BP-Dependent Translational Control of Irf8 Mediates Adipose Tissue Macrophage Inflammatory Response.||Journal of immunology (Baltimore, Md. : 1950) (March 2020)||Eif4ebp3tm1.1(KOMP)Vlcg||32213561|
|Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation.||Cell reports (January 2020)||Eif4ebp3tm1.1(KOMP)Vlcg||PMC7183097|
|Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.||Nature communications (August 2019)||Eif4e3tm1a(KOMP)Wtsi||PMC6671969|
|Mouse screen reveals multiple new genes underlying mouse and human hearing loss.||PLoS biology (April 2019)||Eif4e3tm1a(KOMP)Wtsi||PMC6459510|
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
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|MGI Allele||Allele Type||Produced|
|Eif4etm1e(EUCOMM)Hmgu||Targeted, non-conditional allele||ES Cells|
|Eif4etm1(NCOM)Mfgc||Reporter-tagged deletion allele (with selection cassette)||Targeting vectors, ES Cells|
|Eif4etm1b(EUCOMM)Hmgu||Reporter-tagged deletion allele (with selection cassette)||Mice|
|Eif4etm1a(EUCOMM)Hmgu||KO first allele (reporter-tagged insertion with conditional potential)||Mice, Targeting vectors, ES Cells|
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