Gene Summary

eukaryotic translation initiation factor 4E
If4e,  eIF-4E

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Eif4etm1b(EUCOMM)Hmgu HOM   Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Eif4e mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Eif4e

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Eif4e.

There are 8 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
The P-body protein 4E-T represses translation to regulate the balance between cell genesis and establishment of the postnatal NSC pool. Cell reports (March 2023) Eif4enif1tm2c(KOMP)Wtsi Eif4enif1tm2a(KOMP)Wtsi 36924490
Targeting eIF4F translation complex sensitizes B-ALL cells to tyrosine kinase inhibition. Scientific reports (November 2021) Eif4etm1c(EUCOMM)Hmgu 34737376
Reduced eIF4E function impairs B-cell leukemia without altering normal B-lymphocyte function. iScience (June 2021) Eif4etm1c(EUCOMM)Hmgu PMC8261676
4E-BP2-dependent translation in parvalbumin neurons controls epileptic seizure threshold. Proceedings of the National Academy of Sciences of the United States of America (April 2021) Eif4ebp3tm1.1(KOMP)Vlcg 33876772
4E-BP-Dependent Translational Control of Irf8 Mediates Adipose Tissue Macrophage Inflammatory Response. Journal of immunology (Baltimore, Md. : 1950) (March 2020) Eif4ebp3tm1.1(KOMP)Vlcg 32213561
Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation. Cell reports (January 2020) Eif4ebp3tm1.1(KOMP)Vlcg PMC7183097
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Eif4e3tm1a(KOMP)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Eif4e3tm1a(KOMP)Wtsi PMC6459510

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Eif4etm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Eif4etm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Eif4etm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice
Eif4etm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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