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Gene: Ckm MGI:88413

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
creatine kinase, muscle
Synonyms:
Ckmm,  MCK,  M-CK

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ckm mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ckm by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Multifocal Atrial Tachycardia
Hypotension, Atrial flutter, Hypertrophic cardiomyopathy, Effort-induced polymorphic ventricular ... ORPHA:3282
Obesity Due To Sim1 Deficiency
Hypotension, Glucose intolerance, Postural hypotension with compensatory tachycardia, Hyperinsuli... ORPHA:369873
Cardiomyopathy, Familial Restrictive, 3
Hypotension, Restrictive cardiomyopathy, Reduced left ventricular ejection fraction, Left axis de... OMIM:612422
Carnitine-Acylcarnitine Translocase Deficiency
Ventricular hypertrophy, Hypotension, Atrioventricular block, Cardiomyopathy, Hypoglycemia, Rhabd... OMIM:212138
Tako-Tsubo Cardiomyopathy
Dilatation of the ventricular cavity, Mitral regurgitation, Arrhythmia, Ventricular fibrillation,... ORPHA:66529
Glycogen Storage Disease Of Heart, Lethal Congenital
Macroglossia, Hypotension, Cardiomyopathy, Congestive heart failure, Hypertrophic cardiomyopathy,... OMIM:261740
Congenital Tricuspid Stenosis
Hypotension, Congestive heart failure, Tricuspid regurgitation, Pulmonary arterial hypertension, ... ORPHA:95459
Snakebite Envenomation
Epistaxis, Hypotension, Cardiogenic shock, Cerebral ischemia, Rhabdomyolysis, Muscle fiber necros... ORPHA:449285
Mitochondrial Trifunctional Protein Deficiency 2
Hypotension, Dilated cardiomyopathy, Hypoglycemia, Tricuspid regurgitation, Mitral regurgitation,... OMIM:620300
Congenital Isolated Acth Deficiency
Hypoglycemic seizures, Hypotension, Neonatal hypoglycemia ORPHA:199296
Aromatic L-Amino Acid Decarboxylase Deficiency
Hypotension, Limb hypertonia, Hypoglycemia, Joint contracture ORPHA:35708
Cardiogenic Shock
Hypotension, Right ventricular failure, Abnormal left ventricular function, Congestive heart fail... ORPHA:97292
Adult Acute Respiratory Distress Syndrome
Shock, Vasculitis, Hypotension, Diabetic ketoacidosis ORPHA:70578
Chromosome 5Q12 Deletion Syndrome
Hypotension, Patent foramen ovale, Ventricular septal defect, Atrial septal defect, Macroglossia OMIM:615668
Carnitine-Acylcarnitine Translocase Deficiency
Hypotension, Cardiomyopathy, Hypoketotic hypoglycemia, Rhabdomyolysis, Arrhythmia, Ventricular ta... ORPHA:159
Malignant Hyperthermia, Susceptibility To, 1
Tachycardia, Hypotension, Rhabdomyolysis OMIM:145600
Neuroendocrine Tumor Of The Colon
Abnormal pulmonary valve cusp morphology, Hypotension, Right ventricular failure, Tricuspid regur... ORPHA:100080
Post-Traumatic Pituitary Deficiency
Hypotension, Hypoglycemia ORPHA:95619
Analbuminemia
Hypotension OMIM:616000
Necrotizing Enterocolitis
Hypotension, Shock, Hyperglycemia, Abnormal heart morphology, Abnormal glucose homeostasis, Brady... ORPHA:391673
Perry Syndrome
Hypotension ORPHA:178509
Neuroendocrine Tumor Of The Rectum
Hematochezia, Hypotension, Abnormal pulmonary valve cusp morphology, Right ventricular failure, T... ORPHA:100081
Neuroendocrine Tumor Of Anal Canal
Hematochezia, Hypotension, Abnormal pulmonary valve cusp morphology, Right ventricular failure, T... ORPHA:100082
Nipah Virus Disease
Hypotension ORPHA:99825
Cutaneous Mastocytoma
Telangiectasia of the skin, Hypotension, Telangiectasia macularis eruptiva perstans ORPHA:79455
Infant Acute Respiratory Distress Syndrome
Tachycardia, Hypotension, Cardiac arrest, Bradycardia ORPHA:70587
Acquired Von Willebrand Syndrome
Aortic valve stenosis, Aortic regurgitation, Gastrointestinal hemorrhage, Hypotension, Epistaxis,... ORPHA:99147
Bronchial Neuroendocrine Tumor
Abnormal pulmonary valve cusp morphology, Hypotension, Cardiogenic shock, Right ventricular failu... ORPHA:97287
Whipple Disease
Insulin resistance, Hypotension, Gastrointestinal hemorrhage, Myositis, Myocarditis, Myocardial i... ORPHA:3452
Corticosteroid-Binding Globulin Deficiency
Hypotension, Hypertension OMIM:611489
Staphylococcal Necrotizing Pneumonia
Shock, Hypotension, Diabetes mellitus ORPHA:36238
Systemic Capillary Leak Syndrome
Myocarditis, Hypotension, Arrhythmia, Pericarditis ORPHA:188
Aa Amyloidosis
Abnormal heart morphology, Hypotension ORPHA:85445
Car T Cell Therapy-Associated Cytokine Release Syndrome
Hypotension, Reduced left ventricular ejection fraction, Arrhythmia, Tachycardia, Capillary leak,... ORPHA:542323
Pituitary Deficiency Due To Empty Sella Turcica Syndrome
Hypotension ORPHA:91354
Late-Onset Familial Hypoaldosteronism
Hypotension, Orthostatic hypotension ORPHA:556037
Neuroendocrine Tumor Of Stomach
Abnormal pulmonary valve cusp morphology, Hypotension, Cardiogenic shock, Right ventricular failu... ORPHA:100075
Hydroxykynureninuria
Tachycardia, Hypotension ORPHA:79155
Early-Onset Familial Hypoaldosteronism
Hypotension, Orthostatic hypotension ORPHA:556030
Pseudohypoaldosteronism, Type Ib2, Autosomal Recessive
Hypotension OMIM:620125
Dengue Fever
Hypotension, Gastrointestinal hemorrhage, Epistaxis, Cerebral hemorrhage ORPHA:99828
Erythrocytosis, Familial, 2
Hypotension, Pulmonary arterial hypertension, Cerebral hemorrhage OMIM:263400
Beta-Ketothiolase Deficiency
Hyperglycemia, Hypotension, Hypertension, Hypoglycemia ORPHA:134
Poliomyelitis
Hypovolemic shock, Hypotension, Hypoplasia of the musculature, Skeletal muscle atrophy, Upper lim... ORPHA:2912
Scrub Typhus
Myocarditis, Hypotension ORPHA:83317
Inhalational Anthrax
Hypotension, Internal hemorrhage ORPHA:247257
Corticosterone Methyloxidase Type I Deficiency
Hypotension OMIM:203400
Pseudohypoaldosteronism, Type Ib1, Autosomal Recessive
Hypotension OMIM:264350
Familial Glucocorticoid Deficiency
Hypertrophic cardiomyopathy, Hypotension, Hypoglycemic seizures, Ketotic hypoglycemia ORPHA:361
Legionnaires Disease
Hypotension, Arrhythmia, Myocarditis, Endocarditis, Pericarditis ORPHA:549
Mercury Poisoning
Tachycardia, Hypotension, Hypertension ORPHA:330021
Congenital Enterovirus Infection
Myocarditis, Hypotension, Pericardial effusion, Cardiomyopathy ORPHA:292
Serotonin Syndrome
Tachycardia, Hypotension, Hypertension, Rhabdomyolysis ORPHA:43116
Meningococcal Meningitis
Shock, Hypotension ORPHA:33475
Infant Botulism
Cardiac arrest, Hypotension, Hypertension ORPHA:178478
Relapsing Fever
Tachycardia, Hypotension, Epistaxis ORPHA:91547
Pseudohypoaldosteronism, Type I, Autosomal Dominant
Hypotension OMIM:177735
Cocaine Intoxication
Diffuse alveolar hemorrhage, Hypotension, Prolonged QRS complex, Ischemic stroke, Rhabdomyolysis,... ORPHA:90068
3-Hydroxy-3-Methylglutaric Aciduria
Hypotension, Dilated cardiomyopathy, Recurrent hypoglycemia, Nonketotic hypoglycemia, Cardiac arrest ORPHA:20
Cholera
Tachycardia, Hypotension, Hypovolemic shock, Hypoglycemia ORPHA:173
Aggressive Systemic Mastocytosis
Hypotension, Gastrointestinal hemorrhage, Portal hypertension ORPHA:98850
Colchicine Poisoning
Hypotension, Cardiogenic shock, Congestive heart failure, Arrhythmia, Myocarditis, Hypovolemia ORPHA:31824
Ileal Neuroendocrine Tumor
Hypotension, Cardiogenic shock, Right ventricular failure, Arterial occlusion, Palpitations, Arrh... ORPHA:100078
Late-Onset Isolated Acth Deficiency
Type I diabetes mellitus, Hypotension, Orthostatic hypotension, Hypoglycemia ORPHA:199299
Diffuse Cutaneous Mastocytosis
Hypotension, Gastrointestinal hemorrhage ORPHA:79456
Ethylene Glycol Poisoning
Hypotension, Congestive heart failure, Shock, Prolonged QT interval, Atrial fibrillation, Tachyca... ORPHA:31826
Pde4D Haploinsufficiency Syndrome
Hypotension ORPHA:439822
Renal Tubular Dysgenesis
Hypotension OMIM:267430
Familial Hypoaldosteronism
Hypotension, Orthostatic hypotension, Hypovolemia ORPHA:427
Bacterial Toxic-Shock Syndrome
Hypotension, Shock, Myositis, Myocarditis, Tachycardia, Capillary leak ORPHA:36234
Gitelman Syndrome
Insulin resistance, Type I diabetes mellitus, Prominent U wave, Abnormal T-wave, Pericardial effu... ORPHA:358
Pituitary Apoplexy
Hypotension, Hypertension, Hypoglycemia ORPHA:95613
Alexander Disease
Hypotension, Sudden cardiac death, Facial palsy, Hypertension, Diabetes mellitus ORPHA:58
Acute Radiation Syndrome
Telangiectasia, Hypotension ORPHA:454831
Methylmalonic Aciduria And Homocystinuria, Cblc Type
Hypotension, Decreased methylmalonyl-CoA mutase activity, Pulmonary arterial hypertension, Bradyc... OMIM:277400
Hennekam-Beemer Syndrome
Hypotension, Arrhythmia, Telangiectasia of the skin, Camptodactyly of finger ORPHA:2135
Neuroleptic Malignant Syndrome
Hypertensive crisis, Hypotension, Pulmonary embolism, Rhabdomyolysis, Arrhythmia, Bradycardia, Ta... ORPHA:94093
Acute Adrenal Insufficiency
Hypotension, Hypoglycemia, Orthostatic hypotension, Myocardial infarction, Hypovolemia ORPHA:95409
Aromatic L-Amino Acid Decarboxylase Deficiency
Hypotension, Limb hypertonia, Torticollis OMIM:608643
Congenital Adrenal Hyperplasia Due To 3-Beta-Hydroxysteroid Dehydrogenase Deficiency
Hypotension, Neonatal hypoglycemia ORPHA:90791
Lujo Hemorrhagic Fever
Hypotension, Shock, Bradycardia, Myocarditis, Subconjunctival hemorrhage ORPHA:319213
Gitelman Syndrome
Hypotension, Palpitations, Rhabdomyolysis, Ventricular tachycardia, Prolonged QT interval OMIM:263800
Crimean-Congo Hemorrhagic Fever
Epistaxis, Diffuse alveolar hemorrhage, Hypotension, Melena, Subdural hemorrhage, Subconjunctival... ORPHA:99827
Hemorrhagic Fever-Renal Syndrome
Epistaxis, Hypotension, Subconjunctival hemorrhage, Shock, Palpitations, Hematemesis, Internal he... ORPHA:340
Sepsis In Premature Infants
Tachycardia, Hypotension, Bradycardia ORPHA:90051
Deficiency In Anterior Pituitary Function-Variable Immunodeficiency Syndrome
Hypotension, Recurrent hypoglycemia ORPHA:293978
Systemic Mastocytosis With Associated Hematologic Neoplasm
Tachycardia, Hypotension, Syncope ORPHA:98849
Tubulointerstitial Kidney Disease, Autosomal Dominant, 2
Hypotension, Hypertension OMIM:174000
Autosomal Dominant Hypocalcemia
Hypotension, Arrhythmia, Congestive heart failure ORPHA:428
Marburg Hemorrhagic Fever
Hypotension, Subconjunctival hemorrhage, Hypoglycemia, Shock, Capillary leak, Internal hemorrhage... ORPHA:99826
Non-Functioning Pituitary Adenoma
Hypotension ORPHA:91349
Addison Disease
Type I diabetes mellitus, Hypotension, Orthostatic hypotension, Hypoglycemia ORPHA:85138
Hellp Syndrome
Hypotension, Internal hemorrhage, Cerebral hemorrhage ORPHA:244242
Neuroendocrine Neoplasm Of Appendix
Hypotension, Tricuspid stenosis, Palpitations, Heart murmur ORPHA:100079
Exercise-Induced Malignant Hyperthermia
Hypotension, Abnormal pulse pressure, Sinus tachycardia, Abnormal T-wave, Rhabdomyolysis, ST segm... ORPHA:466650
Fragile X-Associated Tremor/Ataxia Syndrome
Hypotension, Hypertension ORPHA:93256
46,Xy Difference Of Sex Development-Adrenal Insufficiency Due To Cyp11A1 Deficiency
Hypotension, Neonatal hypoglycemia, Hypovolemia ORPHA:168558
Tsh-Secreting Pituitary Adenoma
Hypotension, Congestive heart failure, Pericardial effusion, Palpitations, Supraventricular arrhy... ORPHA:91347
Inherited Isolated Adrenal Insufficiency Due To Partial Cyp11A1 Deficiency
Hypotension, Neonatal hypoglycemia, Hypovolemia ORPHA:289548
Prolactinoma
Hypotension ORPHA:2965
Leptospirosis
Hypotension, Pulmonary hemorrhage, Rhabdomyolysis, Arrhythmia, First degree atrioventricular bloc... ORPHA:509
Hereditary Angioedema Type 1
Hypotension ORPHA:100050
Bartter Syndrome, Type 3
Hypotension OMIM:607364
Acute Liver Failure
Hypotension, Gastrointestinal hemorrhage, Hypoglycemia, Shock, Intracranial hemorrhage ORPHA:90062
Lysosomal Acid Lipase Deficiency
Hypotension, Pulmonary arterial hypertension, Hypovolemia ORPHA:275761
Non-Acquired Panhypopituitarism
Hypotension, Hypoglycemia ORPHA:90695
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Shock, Hypotension, Neonatal hypoglycemia, Hypovolemia ORPHA:90794
Combined Pituitary Hormone Deficiencies, Genetic Forms
Hypotension, Hypoglycemia ORPHA:95494
Plague
Hypotension, Arrhythmia, Hematemesis, Tachycardia, Endocarditis ORPHA:707
Bartter Syndrome, Type 1, Antenatal
Low-to-normal blood pressure OMIM:601678
Bartter Syndrome, Type 2, Antenatal
Low-to-normal blood pressure OMIM:241200

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ckm

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ckm.

No publications found that use IMPC mice or data for Ckm.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ckmtm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ckmtm2e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Ckmtm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Ckmtm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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