Gene Summary

Name:
adrenergic receptor, beta 3
Synonyms:
beta 3-AR,  Adrb-3,  beta3-adrenergic receptor,  Beta-3 AR,  Beta-3 adrenoceptor

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

Images Slit Lamp

15 Images

X-ray

XRay Images Whole Body Lateral Orientation

16 Images

X-ray

XRay Images Whole Body Dorso Ventral

16 Images

Eye Morphology

Images Ophthalmoscopy

15 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

16 Images

X-ray

XRay Images Skull Lateral Orientation

16 Images

X-ray

XRay Images Forepaw

16 Images

X-ray

XRay Images Hind Leg and Hip

16 Images

Human diseases caused by Adrb3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Adrb3 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Obesity
Obesity, Increased waist to hip ratio OMIM:601665

The table below shows human diseases predicted to be associated to Adrb3 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Obesity Due To Melanocortin 4 Receptor Deficiency
Increased adipose tissue, Obesity, Childhood-onset truncal obesity, Polyphagia ORPHA:71529
Macrosomia Adiposa Congenita
Obesity, Polyphagia, Large for gestational age OMIM:248100
Kleine-Levin Hibernation Syndrome
Polyphagia OMIM:148840
Body Mass Index Quantitative Trait Locus 20
Obesity, Polyphagia OMIM:618406
Obesity Due To Prohormone Convertase I Deficiency
Increased adipose tissue, Polyphagia, Failure to thrive, Obesity, Childhood-onset truncal obesity ORPHA:71528
Obesity Due To Pro-Opiomelanocortin Deficiency
Increased adipose tissue, Polyphagia, Failure to thrive, Obesity, Childhood-onset truncal obesity ORPHA:71526
Obesity, Hyperphagia, And Developmental Delay
Obesity, Polyphagia OMIM:613886
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Obesity, Polyphagia ORPHA:329249
Leptin Deficiency Or Dysfunction
Obesity, Abnormal eating behavior, Polyphagia OMIM:614962
Bardet-Biedl Syndrome 22
Obesity, Polyphagia, Large for gestational age OMIM:617119
Renal Glucosuria
Polyphagia, Polydipsia OMIM:233100
Hypotonia-Cystinuria Syndrome
Failure to thrive, Polyphagia ORPHA:163690
Obesity Due To Sim1 Deficiency
Obesity, Polyphagia ORPHA:369873
Obesity, Early-Onset, With Adrenal Insufficiency And Red Hair
Obesity, Polyphagia OMIM:609734
Type 1 Diabetes Mellitus
Polyphagia, Polydipsia OMIM:222100
Leptin Receptor Deficiency
Obesity, Abnormal eating behavior, Polyphagia OMIM:614963
Prader-Willi Syndrome Due To Imprinting Mutation
Obesity, Polyphagia ORPHA:177910
Pick Disease Of Brain
Polyphagia OMIM:172700
Graves Disease, Susceptibility To, 1
Weight loss, Polyphagia OMIM:275000
Frontotemporal Dementia
Polyphagia OMIM:600274
Angelman Syndrome Due To Imprinting Defect In 15Q11-Q13
Obesity, Polyphagia ORPHA:411515
Bardet-Biedl Syndrome 9
Obesity, Polydipsia, Truncal obesity, Polyphagia OMIM:615986
6Q16 Microdeletion Syndrome
Obesity, Polyphagia ORPHA:171829
Schaaf-Yang Syndrome
Failure to thrive in infancy, Polyphagia, Arthrogryposis multiplex congenita, Flexion contracture... OMIM:615547
Temple Syndrome
Obesity, Small for gestational age, Polyphagia ORPHA:254516
Hyperinsulinism Due To Hnf1A Deficiency
Small for gestational age, Polyphagia, Large for gestational age ORPHA:324575
Hyperinsulinism Due To Ucp2 Deficiency
Polyphagia, Large for gestational age ORPHA:276556
Huntington Disease
Polyphagia, Decreased body mass index, Choking episodes, Weight loss, Oral-pharyngeal dysphagia ORPHA:399
Cebalid Syndrome
Congenital diaphragmatic hernia, Polyphagia OMIM:618774
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Polyphagia, Large for gestational age ORPHA:276575
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Polyphagia, Large for gestational age ORPHA:276580
Hypotonia-Cystinuria Syndrome
Failure to thrive, Polyphagia OMIM:606407
Man1B1-Cdg
Truncal obesity, Polyphagia ORPHA:397941
Chromosome 22Q13 Duplication Syndrome
Polyphagia OMIM:615538
Insulinoma
Increased body weight, Polyphagia ORPHA:97279
2Q23.1 Microdeletion Syndrome
Polyphagia ORPHA:228402
Trisomy 18P
Polyphagia ORPHA:1715
Obesity Due To Congenital Leptin Deficiency
Obesity, Polyphagia ORPHA:66628
Luscan-Lumish Syndrome
Obesity, Polyphagia OMIM:616831
Paternal Uniparental Disomy Of Chromosome 1
Obesity, Abnormal dental enamel morphology, Polyphagia ORPHA:251004
Obesity Due To Leptin Receptor Gene Deficiency
Obesity, Polyphagia ORPHA:179494
Secondary Short Bowel Syndrome
Failure to thrive, Weight loss, Polyphagia ORPHA:95427
Pediatric-Onset Graves Disease
Failure to thrive, Polydipsia, Polyphagia ORPHA:525731
Intellectual Developmental Disorder, Autosomal Dominant 1
Polyphagia OMIM:156200
Lipodystrophy, Congenital Generalized, Type 1
Polyphagia, Reduced intrathoracic adipose tissue, Lipodystrophy, Reduced subcutaneous adipose tis... OMIM:608594
Chromosome Xq26.3 Duplication Syndrome
Polyphagia OMIM:300942
Lipodystrophy, Congenital Generalized, Type 2
Polyphagia, Reduced intrathoracic adipose tissue, Lipodystrophy, Reduced subcutaneous adipose tis... OMIM:269700
Magel2-Related Prader-Willi-Like Syndrome
Polyphagia, Failure to thrive, Abdominal obesity, Flexion contracture, Increased body weight ORPHA:398069
Sim1-Related Prader-Willi-Like Syndrome
Failure to thrive, Obesity, Abdominal obesity, Polyphagia ORPHA:398079
Angelman Syndrome
Obesity, Dysphagia, Polyphagia ORPHA:72
Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Small for gestational age, Polyphagia, Failure to thrive, Bulimia, Obesity ORPHA:98754
Prader-Willi Syndrome Due To Paternal 15Q11Q13 Deletion
Small for gestational age, Polyphagia, Failure to thrive, Bulimia, Obesity ORPHA:98793
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 2
Small for gestational age, Polyphagia, Failure to thrive, Bulimia, Obesity ORPHA:177904
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 1
Small for gestational age, Polyphagia, Failure to thrive, Bulimia, Obesity ORPHA:177901
Prader-Willi Syndrome
Obesity, Failure to thrive in infancy, Abdominal obesity, Polyphagia OMIM:176270
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related
Polyphagia OMIM:607485
Satb2-Associated Syndrome Due To A Chromosomal Rearrangement
Polyphagia ORPHA:251028
Gangliocytoma
Polyphagia ORPHA:251937
7Q11.23 Microduplication Syndrome
Congenital diaphragmatic hernia, Obesity, Inguinal hernia, Polyphagia ORPHA:96121
Prader-Willi-Like Syndrome
Small for gestational age, Polyphagia, Failure to thrive, Bulimia, Obesity ORPHA:398073
X-Linked Acrogigantism
Increased body mass index, Polyphagia ORPHA:300373
Adnp Syndrome
Polyphagia, Inguinal hernia, Truncal obesity, Oral-pharyngeal dysphagia, Umbilical hernia ORPHA:404448
Prader-Willi Syndrome
Failure to thrive, Abdominal obesity, Polyphagia ORPHA:739
Pseudohypoparathyroidism Type 1C
Obesity, Enamel hypoplasia, Polyphagia ORPHA:79444
Craniopharyngioma
Obesity, Polyphagia ORPHA:54595
Pseudohypoparathyroidism Type 1A
Obesity, Enamel hypoplasia, Polyphagia ORPHA:79443
1P36 Deletion Syndrome
Dysphagia, Polyphagia, Failure to thrive, Camptodactyly of finger, Obesity ORPHA:1606
Early-Onset Schizophrenia
Polyphagia ORPHA:96369
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Obesity, Polydipsia, Polyphagia ORPHA:293987
Chromosome 1P36 Deletion Syndrome, Distal
Dysphagia, Polyphagia, Camptodactyly of finger, Camptodactyly, Obesity OMIM:607872
Obesity
Obesity, Increased waist to hip ratio OMIM:601665
Alström Syndrome
Obesity, Dorsocervical fat pad, Truncal obesity, Polyphagia ORPHA:64

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Adrb3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Adrb3.

No publications found that use IMPC mice or data for Adrb3.

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MGI Allele Allele Type Produced
Adrb3tm445452(Ifitm2_intron_L1L2_GT1_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Adrb3tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Adrb3em1(IMPC)KMPC Deletion Mice
Adrb3tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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