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Gene: Adrb3 MGI:87939

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Gene Summary

Name:
adrenergic receptor, beta 3
Synonyms:
beta 3-AR,  Adrb-3,  beta3-adrenergic receptor,  Beta-3 AR,  Beta-3 adrenoceptor

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

Images Slit Lamp

17 Images

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X-ray

XRay Images Forepaw

16 Images

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X-ray

XRay Images Skull Lateral Orientation

16 Images

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X-ray

XRay Images Hind Leg and Hip

16 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

16 Images

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X-ray

XRay Images Whole Body Dorso Ventral

16 Images

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X-ray

XRay Images Whole Body Lateral Orientation

16 Images

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Eye Morphology

Images Ophthalmoscopy

15 Images

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Human diseases caused by Adrb3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Adrb3 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Obesity
Obesity, Increased waist to hip ratio OMIM:601665

The table below shows human diseases predicted to be associated to Adrb3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Obesity Due To Melanocortin 4 Receptor Deficiency
Polyphagia, Obesity, Childhood-onset truncal obesity, Increased adipose tissue ORPHA:71529
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Aggressive behavior, Obesity, Polyphagia ORPHA:329249
Obesity, Hyperphagia, And Developmental Delay
Polyphagia, Obesity, Motor stereotypy OMIM:613886
Body Mass Index Quantitative Trait Locus 20
Polyphagia, Obesity OMIM:618406
Obesity Due To Prohormone Convertase I Deficiency
Failure to thrive, Obesity, Polyphagia, Childhood-onset truncal obesity, Increased adipose tissue ORPHA:71528
Obesity Due To Pro-Opiomelanocortin Deficiency
Failure to thrive, Obesity, Polyphagia, Childhood-onset truncal obesity, Increased adipose tissue ORPHA:71526
Kleine-Levin Hibernation Syndrome
Polyphagia OMIM:148840
Obesity And Hypopigmentation
Polyphagia, Obesity OMIM:620195
Pick Disease Of Brain
Polyphagia, Inappropriate laughter, Motor stereotypy, Disinhibition OMIM:172700
Bardet-Biedl Syndrome 22
Polyphagia, Obesity, Large for gestational age OMIM:617119
Intellectual Developmental Disorder, Autosomal Dominant 39
Polyphagia, Obesity, Aggressive behavior, Self-mutilation OMIM:616521
Hypermetabolism Due To Uncoupled Mitochondrial Oxidative Phosphorylation 2
Polyphagia, Failure to thrive, Decreased body weight OMIM:620085
Obesity Due To Sim1 Deficiency
Attention deficit hyperactivity disorder, Polyphagia, Obesity ORPHA:369873
Leptin Deficiency Or Dysfunction
Polyphagia, Obesity OMIM:614962
Renal Glucosuria
Polyphagia, Polydipsia OMIM:233100
Leptin Receptor Deficiency
Aggressive behavior, Obesity, Abnormal eating behavior, Polyphagia OMIM:614963
Frontotemporal Dementia
Polyphagia, Inappropriate laughter, Disinhibition OMIM:600274
Hypotonia-Cystinuria Syndrome
Polyphagia, Failure to thrive ORPHA:163690
14Q11.2 Microduplication Syndrome
Attention deficit hyperactivity disorder, Polyphagia, Obesity, Aggressive behavior ORPHA:261229
Type 1 Diabetes Mellitus
Polyphagia, Polydipsia OMIM:222100
Angelman Syndrome Due To Imprinting Defect In 15Q11-Q13
Polyphagia, Obesity, Inappropriate laughter, Hyperactivity ORPHA:411515
Huntington Disease
Decreased body mass index, Oral-pharyngeal dysphagia, Disinhibition, Polyphagia, Addictive alcoho... ORPHA:399
Kleine-Levin Syndrome
Polydipsia, Abnormal eating behavior, Sweet craving, Polyphagia, Repetitive compulsive behavior, ... ORPHA:33543
Prader-Willi Syndrome Due To Imprinting Mutation
Polyphagia, Obesity ORPHA:177910
6Q16 Microdeletion Syndrome
Abnormal temper tantrums, Polyphagia, Obesity ORPHA:171829
Schaaf-Yang Syndrome
Failure to thrive in infancy, Obesity, Polyphagia, Skin-picking, Camptodactyly, Flexion contractu... OMIM:615547
Body Mass Index Quantitative Trait Locus 19
Polyphagia, Obesity OMIM:617885
Graves Disease
Polyphagia, Weight loss, Hyperactivity OMIM:275000
Intellectual Developmental Disorder, Autosomal Dominant 72
Attention deficit hyperactivity disorder, Polyphagia, Obesity, Overfriendliness OMIM:620439
Joubert Syndrome 10
Polyphagia, Obesity, Frequent temper tantrums, Decreased body weight OMIM:300804
Bardet-Biedl Syndrome 9
Polyphagia, Obesity, Polydipsia, Truncal obesity OMIM:615986
Hyperinsulinism Due To Hnf1A Deficiency
Polyphagia, Large for gestational age, Small for gestational age, Agitation ORPHA:324575
Hyperinsulinism Due To Ucp2 Deficiency
Polyphagia, Large for gestational age, Agitation ORPHA:276556
Temple Syndrome
Polyphagia, Obesity, Small for gestational age ORPHA:254516
2Q23.1 Microdeletion Syndrome
Self-injurious behavior, Polyphagia, Motor stereotypy, Hyperactivity, Paroxysmal bursts of laughter ORPHA:228402
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Polyphagia, Large for gestational age, Agitation ORPHA:276575
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Polyphagia, Large for gestational age, Agitation ORPHA:276580
Cebalid Syndrome
Polyphagia, Congenital diaphragmatic hernia OMIM:618774
Hypotonia-Cystinuria Syndrome
Polyphagia, Failure to thrive OMIM:606407
Chromosome 22Q13 Duplication Syndrome
Polyphagia, Attention deficit hyperactivity disorder, Impulsivity OMIM:615538
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related
Disinhibition, Polyphagia, Repetitive compulsive behavior, Agitation, Hypersexuality OMIM:607485
Man1B1-Cdg
Polyphagia, Truncal obesity ORPHA:397941
Obesity, Early-Onset, With Adrenal Insufficiency And Red Hair
Polyphagia, Obesity OMIM:609734
Luscan-Lumish Syndrome
Polyphagia, Obesity, Aggressive behavior OMIM:616831
Trisomy 18P
Polyphagia, Attention deficit hyperactivity disorder ORPHA:1715
Wagro Syndrome
Obesity, Polyphagia, Aggressive behavior, Compulsive behaviors, Agitation OMIM:612469
Insulinoma
Increased body weight, Polyphagia ORPHA:97279
Angelman Syndrome
Self-injurious behavior, Obesity, Inappropriate laughter, Recurrent hand flapping, Polyphagia, Ag... ORPHA:72
Obesity Due To Congenital Leptin Deficiency
Polyphagia, Obesity ORPHA:66628
Obesity Due To Leptin Receptor Gene Deficiency
Polyphagia, Obesity ORPHA:179494
Pediatric-Onset Graves Disease
Polyphagia, Polydipsia, Failure to thrive, Hyperactivity ORPHA:525731
Secondary Short Bowel Syndrome
Polyphagia, Weight loss, Failure to thrive ORPHA:95427
Paternal Uniparental Disomy Of Chromosome 1
Abnormal dental enamel morphology, Polyphagia, Obesity ORPHA:251004
Magel2-Related Prader-Willi-Like Syndrome
Abnormal temper tantrums, Failure to thrive, Increased body weight, Polyphagia, Skin-picking, Abd... ORPHA:398069
Intellectual Developmental Disorder, Autosomal Dominant 1
Self-injurious behavior, Bruxism, Inappropriate laughter, Recurrent hand flapping, Polyphagia, Ag... OMIM:156200
Prader-Willi Syndrome Due To Paternal 15Q11Q13 Deletion
Self-injurious behavior, Abnormal temper tantrums, Failure to thrive, Bulimia, Obesity, Obsessive... ORPHA:98793
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 2
Self-injurious behavior, Abnormal temper tantrums, Failure to thrive, Bulimia, Obesity, Obsessive... ORPHA:177904
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 1
Self-injurious behavior, Abnormal temper tantrums, Failure to thrive, Bulimia, Obesity, Obsessive... ORPHA:177901
Sim1-Related Prader-Willi-Like Syndrome
Abnormal temper tantrums, Failure to thrive, Obesity, Polyphagia, Skin-picking, Abdominal obesity ORPHA:398079
Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Self-injurious behavior, Abnormal temper tantrums, Failure to thrive, Bulimia, Obesity, Polyphagi... ORPHA:98754
Adnp Syndrome
Abnormal temper tantrums, Oral-pharyngeal dysphagia, Umbilical hernia, Inguinal hernia, Polyphagi... ORPHA:404448
Satb2-Associated Syndrome Due To A Chromosomal Rearrangement
Polyphagia, Restlessness, Aggressive behavior, Self-mutilation ORPHA:251028
7Q11.23 Microduplication Syndrome
Self-injurious behavior, Obesity, Inguinal hernia, Congenital diaphragmatic hernia, Aggressive be... ORPHA:96121
Lipodystrophy, Congenital Generalized, Type 1
Umbilical hernia, Reduced subcutaneous adipose tissue, Polyphagia, Lipodystrophy, Reduced intraab... OMIM:608594
Chromosome Xq26.3 Duplication Syndrome
Polyphagia OMIM:300942
Weaver Syndrome
Joint contracture of the hand, Umbilical hernia, Inguinal hernia, Polyphagia, Camptodactyly OMIM:277590
Prader-Willi Syndrome
Self-injurious behavior, Class III obesity, Failure to thrive in infancy, Obesity, Polyphagia, At... OMIM:176270
Lipodystrophy, Congenital Generalized, Type 2
Umbilical hernia, Reduced subcutaneous adipose tissue, Polyphagia, Lipodystrophy, Reduced intraab... OMIM:269700
Gangliocytoma
Polyphagia ORPHA:251937
Prader-Willi Syndrome
Polyphagia, Attention deficit hyperactivity disorder, Failure to thrive, Abdominal obesity ORPHA:739
Helsmoortel-Van Der Aa Syndrome
Failure to thrive, Bruxism, Obesity, Polyphagia, Attention deficit hyperactivity disorder, Dyspha... OMIM:615873
X-Linked Acrogigantism
Polyphagia, Increased body mass index ORPHA:300373
Pseudohypoparathyroidism Type 1C
Polyphagia, Obesity, Enamel hypoplasia ORPHA:79444
Craniopharyngioma
Polyphagia, Obesity ORPHA:54595
Intellectual Developmental Disorder, Autosomal Dominant 71, With Behavioral Abnormalities
Self-injurious behavior, Fixated interests, Umbilical hernia, Hair-pulling, Polyphagia, Attention... OMIM:620330
Pseudohypoparathyroidism Type 1A
Polyphagia, Obesity, Enamel hypoplasia ORPHA:79443
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Self-injurious behavior, Polydipsia, Obesity, Polyphagia, Aggressive behavior, Compulsive behaviors ORPHA:293987
1P36 Deletion Syndrome
Self-injurious behavior, Failure to thrive, Camptodactyly of finger, Obesity, Polyphagia, Dysphag... ORPHA:1606
Chromosome 1P36 Deletion Syndrome, Distal
Camptodactyly of finger, Obesity, Oppositional defiant disorder, Self-mutilation, Aggressive beha... OMIM:607872
Obesity
Obesity, Increased waist to hip ratio OMIM:601665
Alström Syndrome
Polyphagia, Obesity, Dorsocervical fat pad, Truncal obesity ORPHA:64

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Adrb3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Adrb3.

No publications found that use IMPC mice or data for Adrb3.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Adrb3tm445452(Ifitm2_intron_L1L2_GT1_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Adrb3tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Adrb3em1(IMPC)Krb Deletion Mice
Adrb3tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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