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Gene: Adrb3 MGI:87939

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Gene Summary

Name:
adrenergic receptor, beta 3
Synonyms:
beta 3-AR,  Adrb-3,  beta3-adrenergic receptor,  Beta-3 AR,  Beta-3 adrenoceptor

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

16 Images

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X-ray

XRay Images Skull Lateral Orientation

16 Images

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Eye Morphology

Images Slit Lamp

15 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

16 Images

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X-ray

XRay Images Hind Leg and Hip

16 Images

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X-ray

XRay Images Forepaw

16 Images

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Eye Morphology

Images Ophthalmoscopy

15 Images

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X-ray

XRay Images Whole Body Lateral Orientation

16 Images

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Human diseases caused by Adrb3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Adrb3 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Obesity
Obesity, Increased waist to hip ratio OMIM:601665

The table below shows human diseases predicted to be associated to Adrb3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Obesity Due To Melanocortin 4 Receptor Deficiency
Childhood-onset truncal obesity, Obesity, Increased adipose tissue, Polyphagia ORPHA:71529
Macrosomia Adiposa Congenita
Obesity, Polyphagia, Large for gestational age OMIM:248100
Kleine-Levin Hibernation Syndrome
Polyphagia OMIM:148840
Body Mass Index Quantitative Trait Locus 20
Obesity, Polyphagia OMIM:618406
Obesity Due To Prohormone Convertase I Deficiency
Childhood-onset truncal obesity, Increased adipose tissue, Failure to thrive, Polyphagia, Obesity ORPHA:71528
Obesity Due To Pro-Opiomelanocortin Deficiency
Childhood-onset truncal obesity, Increased adipose tissue, Failure to thrive, Polyphagia, Obesity ORPHA:71526
Obesity, Hyperphagia, And Developmental Delay
Obesity, Polyphagia OMIM:613886
Bardet-Biedl Syndrome 22
Obesity, Polyphagia, Large for gestational age OMIM:617119
Hypermetabolism Due To Uncoupled Mitochondrial Oxidative Phosphorylation 2
Failure to thrive, Polyphagia, Decreased body weight OMIM:620085
Leptin Deficiency Or Dysfunction
Obesity, Polyphagia OMIM:614962
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Obesity, Polyphagia ORPHA:329249
Renal Glucosuria
Polyphagia, Polydipsia OMIM:233100
Hypotonia-Cystinuria Syndrome
Failure to thrive, Polyphagia ORPHA:163690
Type 1 Diabetes Mellitus
Polyphagia, Polydipsia OMIM:222100
Obesity Due To Sim1 Deficiency
Attention deficit hyperactivity disorder, Polyphagia, Obesity ORPHA:369873
Pick Disease Of Brain
Disinhibition, Polyphagia OMIM:172700
Prader-Willi Syndrome Due To Imprinting Mutation
Obesity, Polyphagia ORPHA:177910
Leptin Receptor Deficiency
Obesity, Polyphagia, Abnormal eating behavior OMIM:614963
Intellectual Developmental Disorder, Autosomal Dominant 39
Obesity, Polyphagia OMIM:616521
Frontotemporal Dementia
Disinhibition, Polyphagia OMIM:600274
Angelman Syndrome Due To Imprinting Defect In 15Q11-Q13
Hyperactivity, Obesity, Polyphagia ORPHA:411515
Graves Disease, Susceptibility To, 1
Hyperactivity, Polyphagia, Weight loss OMIM:275000
Body Mass Index Quantitative Trait Locus 19
Obesity, Polyphagia OMIM:617885
Huntington Disease
Weight loss, Choking episodes, Agitation, Polyphagia, Decreased body mass index, Disinhibition, A... ORPHA:399
Hyperinsulinism Due To Hnf1A Deficiency
Small for gestational age, Polyphagia, Large for gestational age, Agitation ORPHA:324575
Hyperinsulinism Due To Ucp2 Deficiency
Polyphagia, Large for gestational age, Agitation ORPHA:276556
Schaaf-Yang Syndrome
Flexion contracture, Camptodactyly, Impulsivity, Polyphagia, Obesity, Failure to thrive in infanc... OMIM:615547
Bardet-Biedl Syndrome 9
Obesity, Polyphagia, Polydipsia, Truncal obesity OMIM:615986
6Q16 Microdeletion Syndrome
Obesity, Polyphagia ORPHA:171829
Temple Syndrome
Small for gestational age, Obesity, Polyphagia ORPHA:254516
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Polyphagia, Large for gestational age, Agitation ORPHA:276575
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Polyphagia, Large for gestational age, Agitation ORPHA:276580
Cebalid Syndrome
Congenital diaphragmatic hernia, Polyphagia OMIM:618774
Chromosome 22Q13 Duplication Syndrome
Impulsivity, Attention deficit hyperactivity disorder, Polyphagia OMIM:615538
Hypotonia-Cystinuria Syndrome
Failure to thrive, Polyphagia OMIM:606407
2Q23.1 Microdeletion Syndrome
Hyperactivity, Polyphagia ORPHA:228402
Man1B1-Cdg
Polyphagia, Truncal obesity ORPHA:397941
Obesity, Early-Onset, With Adrenal Insufficiency And Red Hair
Obesity, Polyphagia OMIM:609734
Trisomy 18P
Attention deficit hyperactivity disorder, Polyphagia ORPHA:1715
Insulinoma
Polyphagia, Increased body weight ORPHA:97279
Obesity Due To Congenital Leptin Deficiency
Obesity, Polyphagia ORPHA:66628
Pediatric-Onset Graves Disease
Failure to thrive, Hyperactivity, Polyphagia, Polydipsia ORPHA:525731
Obesity Due To Leptin Receptor Gene Deficiency
Obesity, Polyphagia ORPHA:179494
Secondary Short Bowel Syndrome
Failure to thrive, Polyphagia, Weight loss ORPHA:95427
Luscan-Lumish Syndrome
Obesity, Polyphagia OMIM:616831
Paternal Uniparental Disomy Of Chromosome 1
Obesity, Polyphagia, Abnormal dental enamel morphology ORPHA:251004
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related
Disinhibition, Polyphagia, Agitation OMIM:607485
Wagro Syndrome
Obesity, Polyphagia, Agitation OMIM:612469
Magel2-Related Prader-Willi-Like Syndrome
Flexion contracture, Failure to thrive, Impulsivity, Polyphagia, Abdominal obesity, Increased bod... ORPHA:398069
Angelman Syndrome
Hyperactivity, Obesity, Polyphagia, Dysphagia ORPHA:72
Lipodystrophy, Congenital Generalized, Type 1
Reduced intraabdominal adipose tissue, Reduced subcutaneous adipose tissue, Lipodystrophy, Reduce... OMIM:608594
Chromosome Xq26.3 Duplication Syndrome
Polyphagia OMIM:300942
Sim1-Related Prader-Willi-Like Syndrome
Failure to thrive, Obesity, Polyphagia, Abdominal obesity ORPHA:398079
Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Small for gestational age, Bulimia, Failure to thrive, Polyphagia, Obesity ORPHA:98754
Lipodystrophy, Congenital Generalized, Type 2
Reduced intraabdominal adipose tissue, Reduced subcutaneous adipose tissue, Lipodystrophy, Reduce... OMIM:269700
Weaver Syndrome
Joint contracture of the hand, Camptodactyly, Inguinal hernia, Polyphagia, Umbilical hernia OMIM:277590
Satb2-Associated Syndrome Due To A Chromosomal Rearrangement
Restlessness, Polyphagia ORPHA:251028
Prader-Willi Syndrome Due To Paternal 15Q11Q13 Deletion
Small for gestational age, Bulimia, Failure to thrive, Polyphagia, Obesity ORPHA:98793
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 2
Small for gestational age, Bulimia, Failure to thrive, Polyphagia, Obesity ORPHA:177904
Intellectual Developmental Disorder, Autosomal Dominant 1
Polyphagia OMIM:156200
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 1
Small for gestational age, Bulimia, Failure to thrive, Polyphagia, Obesity ORPHA:177901
7Q11.23 Microduplication Syndrome
Hyperactivity, Inguinal hernia, Congenital diaphragmatic hernia, Polyphagia, Obesity ORPHA:96121
Prader-Willi-Like Syndrome
Small for gestational age, Bulimia, Failure to thrive, Polyphagia, Obesity ORPHA:398073
Prader-Willi Syndrome
Attention deficit hyperactivity disorder, Polyphagia, Obesity, Failure to thrive in infancy, Abdo... OMIM:176270
Gangliocytoma
Polyphagia ORPHA:251937
Adnp Syndrome
Inguinal hernia, Attention deficit hyperactivity disorder, Polyphagia, Truncal obesity, Umbilical... ORPHA:404448
Prader-Willi Syndrome
Failure to thrive, Attention deficit hyperactivity disorder, Polyphagia, Abdominal obesity ORPHA:739
Early-Onset Schizophrenia
Addictive behavior, Restlessness, Attention deficit hyperactivity disorder, Polyphagia ORPHA:96369
X-Linked Acrogigantism
Polyphagia, Increased body mass index ORPHA:300373
Pseudohypoparathyroidism Type 1C
Enamel hypoplasia, Obesity, Polyphagia ORPHA:79444
Helsmoortel-Van Der Aa Syndrome
Hyperactivity, Failure to thrive, Truncal obesity, Polyphagia, Attention deficit hyperactivity di... OMIM:615873
Pseudohypoparathyroidism Type 1A
Enamel hypoplasia, Obesity, Polyphagia ORPHA:79443
Craniopharyngioma
Obesity, Polyphagia ORPHA:54595
1P36 Deletion Syndrome
Camptodactyly of finger, Failure to thrive, Polyphagia, Dysphagia, Obesity ORPHA:1606
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Obesity, Polyphagia, Polydipsia ORPHA:293987
Chromosome 1P36 Deletion Syndrome, Distal
Camptodactyly of finger, Camptodactyly, Polyphagia, Dysphagia, Obesity OMIM:607872
Obesity
Obesity, Increased waist to hip ratio OMIM:601665
Alström Syndrome
Obesity, Polyphagia, Truncal obesity, Dorsocervical fat pad ORPHA:64

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Adrb3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Adrb3.

No publications found that use IMPC mice or data for Adrb3.

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MGI Allele Allele Type Produced
Adrb3tm445452(Ifitm2_intron_L1L2_GT1_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Adrb3tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Adrb3em1(IMPC)Krb Deletion Mice
Adrb3tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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