Acadm | acyl-Coenzyme A dehydrogenase, medium chain

GeneMGI:87867Synonyms: MCAD

Physiological systems

16 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Integument Limbs/digits/tail Behavior/neurological Skeleton

12 No significant impact

8 Not tested

Gene metrics:3Significant phenotypes
2Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues

Phenotypes

increased grip strength1 supporting datasetAcadmtm1b(EUCOMM)HmguhomozygoteEarly adult1.21x10-5 
short tibia1 supporting datasetAcadmtm1b(EUCOMM)HmguhomozygoteEarly adult2.46x10-6 
abnormal vibrissa morphology1 supporting datasetAcadmtm1b(EUCOMM)HmguhomozygoteEarly adult2.72x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a100% (2/2)0.7% (4/570)
aortaheterozygoten/a100% (2/2)0.19% (1/533)
boneheterozygoten/a0% (0/2)0% (0/394)
brainheterozygoten/a100% (2/2)0.86% (5/579)
brainstemheterozygoten/a50% (1/2)0.41% (2/490)
brown adipose tissueheterozygoten/a100% (2/2)0% (0/588)
cartilage tissueheterozygoten/a100% (2/2)0.22% (1/454)
cerebellumheterozygoten/a100% (2/2)0.56% (3/532)
cerebral cortexheterozygoten/a50% (1/2)0.41% (2/491)
esophagusheterozygoten/a100% (2/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Acadmtm1(NCOM)MfgcReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
Acadmtm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Acadmtm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Acadmtm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell
Acadmtm2a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Acadmtm2e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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