Shank1 | SH3 and multiple ankyrin repeat domains 1
GeneMGI:3613677
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Reproductive system Endocrine/exocrine gland Integument Growth/size/body region Vision/eye Liver/biliary system Behavior/neurological
13 No significant impact
4 Not tested
Data collections
Gene metrics:16Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
decreased exploration in new environment | 1 supporting dataset | Shank1em1(IMPC)Mbp | homozygote | Late adult | 6.15x10-14 | ||
increased grip strength | 2 supporting datasets | Shank1em1(IMPC)Mbp | homozygote | Middle aged adult | 1.04x10-9 | ||
abnormal skin morphology | 2 supporting datasets | Shank1em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
decreased locomotor activity | 5 supporting datasets | Shank1em1(IMPC)Mbp | homozygote | Early adult | 1.64x10-6 | ||
abnormal gait | 1 supporting dataset | Shank1em1(IMPC)Mbp | homozygote | Late adult | 5.34x10-5 | ||
small liver | 1 supporting dataset | Shank1em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
abnormal liver morphology | 1 supporting dataset | Shank1em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
enlarged gallbladder | 1 supporting dataset | Shank1em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
abnormal vitreous body morphology | 1 supporting dataset | Shank1em1(IMPC)Mbp | homozygote | Early adult | 7.3x10-5 | ||
cataract | 1 supporting dataset | Shank1em1(IMPC)Mbp | homozygote | Early adult | 9.23x10-5 |
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This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Shank1.
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Shank1em1(IMPC)Mbp | Exon Deletion | | mouse |
Shank1tm39541(L1L2_gt2) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |