Greb1l | growth regulation by estrogen in breast cancer-like

GeneMGI:3576497Synonyms: mKIAA4095, AK220484

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Adipose tissue Embryo Growth/size/body region Nervous system Vision/eye Mortality/aging

12 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:7Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

cataract1 supporting datasetGreb1lem1(IMPC)JheterozygoteEarly adult2.63x10-5 
embryonic growth retardation1 supporting datasetGreb1lem1(IMPC)JhomozygoteE9.5N/A * 
abnormal neural tube closure1 supporting datasetGreb1lem1(IMPC)JhomozygoteE9.5N/A * 
decreased lean body mass2 supporting datasetsGreb1lem1(IMPC)JheterozygoteEarly adult5.4x10-8 
preweaning lethality, complete penetrance1 supporting datasetGreb1lem1(IMPC)JhomozygoteEarly adultN/A * 
abnormal embryo turning1 supporting datasetGreb1lem1(IMPC)JhomozygoteE9.5N/A * 
increased total body fat amount1 supporting datasetGreb1lem1(IMPC)JheterozygoteEarly adult7.8x10-11 
* Does not have a P-value assigned because it was manually marked as significant.
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* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  

lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Greb1lem1(IMPC)JExon Deletionmouse
Greb1ltm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Greb1ltm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Greb1ltm1e(EUCOMM)HmguTargeted, non-conditional allelees cell
Greb1ltm1e(KOMP)WtsiTargeted, non-conditional allelees cell

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