Cep126 | centrosomal protein 126

GeneMGI:2680221Synonyms: AK129341

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Vision/eye Behavior/neurological

13 No significant impact

7 Not tested

Gene metrics:3Significant phenotypes
1Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues

Phenotypes

impaired pupillary reflex1 supporting datasetCep126tm1b(KOMP)MbphomozygoteEarly adult9.89x10-8 
increased fasting circulating glucose level1 supporting datasetCep126tm1b(KOMP)MbphomozygoteEarly adult1.85x10-5 
male infertility1 supporting datasetCep126tm1b(KOMP)MbphomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoteSection images
100% (2/2)0.7% (4/570)
aortaheterozygoteSection images
100% (2/2)0.19% (1/533)
brainheterozygoteSection images
100% (2/2)0.86% (5/579)
brainstemheterozygoteSection images
100% (2/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoteSection images
100% (2/2)0.22% (1/454)
cerebellumheterozygoteSection images
100% (2/2)0.56% (3/532)
cerebral cortexheterozygoteSection images
100% (2/2)0.41% (2/491)
epididymisheterozygoteSection images
100% (1/1)87.5% (21/24)
esophagusheterozygoten/a0% (0/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Cep126tm112566(L1L2_Pgk_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Cep126tm1a(KOMP)MbpKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Cep126tm1b(KOMP)MbpReporter-tagged deletion allele (with selection cassette)mouse
Cep126tm1e(KOMP)MbpTargeted, non-conditional alleleES Cell

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