Gene Summary

Name:
dolichol kinase
Synonyms:
Tmem15

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
embryonic lethality prior to organogenesis Dolkem1(IMPC)J HOM   E9.5 0.00
preweaning lethality, complete penetrance Dolkem1(IMPC)J HOM   Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Lateral Orientation

8 Images

X-ray

XRay Images Whole Body Dorso Ventral

8 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

8 Images

X-ray

XRay Images Whole Body Lateral Orientation

8 Images

X-ray

XRay Images Forepaw

8 Images

Eye Morphology

Images Slit Lamp

2 Images

Sleep Wake

Wake state (bmp file)

1 Images

Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

7 Images

Electroretinography 2

Rod and cone PDF

4 Images

Human diseases caused by Dolk mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Dolk by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Familial Isolated Dilated Cardiomyopathy
ORPHA:154
Dk1-Cdg
ORPHA:91131
Congenital Disorder Of Glycosylation, Type Im
OMIM:610768

The table below shows human diseases predicted to be associated to Dolk by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Major Affective Disorder 1
Depression, Mania OMIM:125480
Major Depressive Disorder
Depression OMIM:608516
Intellectual Developmental Disorder, Autosomal Recessive 54
Emotional lability, Exaggerated startle response OMIM:617028
Trigeminal Neuralgia
Depression, Allodynia ORPHA:221091
Complex Regional Pain Syndrome
Allodynia ORPHA:83452
Pudendal Neuralgia
Allodynia ORPHA:60039
Anterior Cutaneous Nerve Entrapment Syndrome
Allodynia ORPHA:51890
Neurotrophic Keratopathy
Allodynia ORPHA:137596
Spinal Cord Injury
Allodynia ORPHA:90058
Benign Schwannoma
Allodynia ORPHA:252164
Mitochondrial Dna Depletion Syndrome 1 (Mngie Type)
Allodynia OMIM:603041
Familial Isolated Dilated Cardiomyopathy
ORPHA:154
Dk1-Cdg
ORPHA:91131
Congenital Disorder Of Glycosylation, Type Im
OMIM:610768

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dolk

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dolk.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Identification of functional lipid metabolism biomarkers of brown adipose tissue aging. Molecular metabolism (April 2019) Dolkem1(IMPC)J PMC6531832

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Dolkem1(IMPC)J Indel Mice
Dolktm444645(Ifitm2_intron_L1L2_GT1_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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