Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

leucine rich repeat containing 7

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Lrrc7 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Lrrc7 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Severe Primary Trimethylaminuria
Depression, Anxiety, Low self esteem, Aggressive behavior, Emotional lability, Negative affectivity ORPHA:468726
Intellectual Developmental Disorder, Autosomal Recessive 25
Anxiety OMIM:614346
Panic Disorder 1
Anxiety OMIM:167870
Obsessive-Compulsive Disorder
Depression, Anxiety, Skin-picking OMIM:164230
Familial Alzheimer-Like Prion Disease
Cognitive impairment, Depression, Deficit in phonologic short-term memory, Anxiety, Attention def... ORPHA:280397
Autism, Susceptibility To, 20
Impaired social interactions OMIM:618830
Asperger Syndrome, X-Linked, Susceptibility To, 2
Impaired ability to form peer relationships, Abnormal nonverbal communicative behavior OMIM:300497
Asperger Syndrome, X-Linked, Susceptibility To, 1
Impaired ability to form peer relationships, Abnormal nonverbal communicative behavior OMIM:300494
Asperger Syndrome, Susceptibility To, 1
Impaired ability to form peer relationships, Abnormal nonverbal communicative behavior OMIM:608638
Asperger Syndrome, Susceptibility To, 2
Impaired ability to form peer relationships, Abnormal nonverbal communicative behavior OMIM:608631
Intellectual Developmental Disorder, Autosomal Recessive 66
Shyness, Gait ataxia, Attention deficit hyperactivity disorder, Aggressive behavior OMIM:618221
Spinocerebellar Ataxia Type 27
Akinesia, Limb ataxia, Depression, Truncal ataxia, Memory impairment, Gait disturbance, Difficult... ORPHA:98764
Hereditary Geniospasm
Abnormal social behavior ORPHA:53372
Impaired ability to form peer relationships, Abnormal nonverbal communicative behavior OMIM:209850
Autism, Susceptibility To, X-Linked 3
Lack of peer relationships, Abnormal nonverbal communicative behavior OMIM:300496
Chromosome 15Q11-Q13 Duplication Syndrome
Impaired ability to form peer relationships, Abnormal nonverbal communicative behavior OMIM:608636
Autism, Susceptibility To, 8
Impaired ability to form peer relationships, Abnormal nonverbal communicative behavior OMIM:607373
Autism, Susceptibility To, X-Linked 1
Lack of peer relationships, Abnormal nonverbal communicative behavior OMIM:300425
Prkar1B-Related Neurodegenerative Dementia With Intermediate Filaments
Apathy, Anxiety, Inappropriate behavior, Falls, Memory impairment, Shuffling gait, Motor deterior... ORPHA:412066
Epilepsy, Progressive Myoclonic, 12
Ataxia, Dysmetria, Depression, Mental deterioration, Anxiety, Difficulty walking, Attention defic... OMIM:619191
Chronic Hiccup
Depression, Dehydration ORPHA:396
Manganese Poisoning
Akinesia, Impairment in personality functioning, Depression, Memory impairment, Gait disturbance,... ORPHA:306682
Spinocerebellar Ataxia 21
Apathy, Ataxia, Progressive cerebellar ataxia, Impulsivity, Limb ataxia, Akinesia, Mental deterio... OMIM:607454
Perry Syndrome
Apathy, Akinesia, Depression, Anxiety, Inappropriate behavior, Suicidal ideation, Disinhibition, ... OMIM:168605
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Abnormal social behavior ORPHA:436151
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Impaired social interactions, No social interaction, Aggressive behavior ORPHA:329249
Early-Onset Schizophrenia
Impairment in personality functioning, Cognitive impairment, Abnormal emotion/affect behavior, De... ORPHA:96369
Progressive Supranuclear Palsy-Pure Akinesia With Gait Freezing Syndrome
Gait imbalance, Akinesia, Freezing of gait, Loss of ambulation, Falls, Unsteady gait, Short stepp... ORPHA:240094
Alpha-Methylacetoacetic Aciduria
Dehydration OMIM:203750
Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant
Narcolepsy, Ataxia, Depression, Memory impairment, Dementia OMIM:604121
Central Diabetes Insipidus
Depression, Dehydration, Anxiety ORPHA:178029
Diarrhea 4, Malabsorptive, Congenital
Dehydration OMIM:610370
Lactase Deficiency, Congenital
Dehydration OMIM:223000
Childhood Disintegrative Disorder
Social and occupational deterioration, Progressive language deterioration, Abnormal emotion/affec... ORPHA:168782
Diabetes Mellitus, Transient Neonatal, 1
Dehydration OMIM:601410
Inflammatory Skin And Bowel Disease, Neonatal, 2
Dehydration, Edema OMIM:616069
Combined Malonic And Methylmalonic Aciduria
Dehydration OMIM:614265
Combined Malonic And Methylmalonic Acidemia
Dehydration, Memory impairment ORPHA:289504
Diarrhea 2, With Microvillus Atrophy, With Or Without Cholestasis
Dehydration OMIM:251850
Isobutyryl-Coa Dehydrogenase Deficiency
Dehydration ORPHA:79159
Autism, Susceptibility To, X-Linked 2
Lack of peer relationships, Abnormal nonverbal communicative behavior OMIM:300495
Spinocerebellar Ataxia Type 21
Akinesia, Gait ataxia, Progressive cerebellar ataxia, Cognitive impairment ORPHA:98773
Familial Cold Urticaria
Dysesthesia, Dehydration ORPHA:47045
Female Restricted Epilepsy With Intellectual Disability
Hyperactivity, Impulsivity, Abnormal social behavior, Anxiety, Aggressive behavior ORPHA:101039
Transient Neonatal Diabetes Mellitus
Dehydration ORPHA:99886
Medium Chain 3-Ketoacyl-Coa Thiolase Deficiency
Dehydration, Neonatal death OMIM:602199
Combined Oxidative Phosphorylation Deficiency 47
Dehydration OMIM:618958
Hereditary Late-Onset Parkinson Disease
Akinesia, Apathy, Impulsivity, Depression, Mental deterioration, Shuffling gait, Dementia, Low fr... ORPHA:411602
Vitamin B12-Unresponsive Methylmalonic Acidemia
Dehydration, Choreoathetosis, Ataxia ORPHA:27
Cerebrooculofacioskeletal Syndrome 1
Dehydration, Progressive neurologic deterioration OMIM:214150
Vitamin B12-Responsive Methylmalonic Acidemia
Dehydration ORPHA:28
Harlequin Ichthyosis
Dehydration, Self-injurious behavior ORPHA:457
Kufor-Rakeb Syndrome
Akinesia, Ataxia, Gait disturbance, Aggressive behavior, Dementia OMIM:606693
Familial Renal Glucosuria
Dehydration ORPHA:69076
Corticobasal Syndrome
Gait disturbance, Akinesia, Memory impairment, Dementia ORPHA:454887
Vitamin B12-Unresponsive Methylmalonic Acidemia Type Mut-
Dehydration, Choreoathetosis ORPHA:79312
Reticular Dysgenesis
Dehydration ORPHA:33355
Classic Progressive Supranuclear Palsy Syndrome
Gait imbalance, Akinesia, Social and occupational deterioration, Impulsivity, Mental deterioratio... ORPHA:240071
11Q22.2Q22.3 Microdeletion Syndrome
Anxiety, Poor eye contact, Abnormal social behavior ORPHA:444002
Enteric Anendocrinosis
Dehydration ORPHA:83620
Early-Onset Autosomal Dominant Alzheimer Disease
Ataxia, Semantic dementia, Abnormal social behavior, Memory impairment, Disinhibition, Dementia ORPHA:1020
Congenital Enterocyte Heparan Sulfate Deficiency
Dehydration, Edema ORPHA:103910
Lamellar Ichthyosis
Dehydration, Cognitive impairment ORPHA:313
Atypical Juvenile Parkinsonism
Akinesia, Inability to walk, Shuffling gait, Gait ataxia, Short stepped shuffling gait ORPHA:391411
Renal Tubulopathy, Diabetes Mellitus, And Cerebellar Ataxia
Dehydration, Ataxia OMIM:560000
Niemann-Pick Disease Type C
Narcolepsy, Apathy, Ataxia, Abnormal social behavior, Depression, Mental deterioration, Cognitive... ORPHA:646
Postencephalitic Parkinsonism
Depression, Happy demeanor, Akinesia, Abnormal aggressive, impulsive or violent behavior ORPHA:97349
Akinesia, Apathy, Ataxia, Limb ataxia, Cognitive impairment, Memory impairment, Gait ataxia ORPHA:48818
Alternating Hemiplegia Of Childhood
Ataxia, Impulsivity, Dehydration, Progressive neurologic deterioration, Chorea, Choreoathetosis, ... ORPHA:2131
Renal Tubular Acidosis, Distal, 3, With Or Without Sensorineural Hearing Loss
Dehydration OMIM:602722
Isovaleric Acidemia
Dehydration OMIM:243500
Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome
Narcolepsy, Ataxia, Depression, Mental deterioration, Memory impairment ORPHA:314404
Hypercalcemia, Infantile, 1
Dehydration OMIM:143880
Beta-Ketothiolase Deficiency
Dehydration, Apathy, Edema, Ataxia ORPHA:134
Supranuclear Palsy, Progressive, 2
Gait imbalance, Frontolimbic dementia, Akinesia, Apathy, Falls, Memory impairment, Irritability OMIM:609454
Dopa-Responsive Dystonia
Agoraphobia, Abnormal social behavior, Depression, Anxiety, Panic attack, Emotional lability, Irr... ORPHA:255
Hsd10 Disease
Ataxia, Choreoathetosis, Abnormal social behavior ORPHA:391417
Sporadic Adult-Onset Ataxia Of Unknown Etiology
Akinesia, Ataxia, Dysdiadochokinesis, Memory impairment, Shuffling gait, Gait ataxia, Dementia ORPHA:247234
Autism, Susceptibility To, 3
Impaired ability to form peer relationships, Abnormal nonverbal communicative behavior OMIM:608049
Parkinson Disease 17
Akinesia OMIM:614203
Congenital Short Bowel Syndrome
Dehydration OMIM:615237
Methylmalonyl-Coa Epimerase Deficiency
Dehydration OMIM:251120
Congenital Tufting Enteropathy
Dehydration, Irritability ORPHA:92050
Autosomal Agammaglobulinemia
Dehydration ORPHA:33110
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease
Dehydration, Oligohydramnios, Neonatal death OMIM:263200
3-Methylglutaconic Aciduria, Type Viib
Polyhydramnios, Dehydration, Choreoathetosis, Ataxia OMIM:616271
Diabetes Insipidus, Nephrogenic, 2, Autosomal
Hypertonic dehydration, Irritability OMIM:125800
Diabetes Insipidus, Nephrogenic, 1, X-Linked
Hypertonic dehydration, Irritability OMIM:304800
Propionic Acidemia
Dehydration OMIM:606054
Parkinson Disease 23, Autosomal Recessive Early-Onset
Mental deterioration, Akinesia, Dementia OMIM:616840
Corticosterone Methyloxidase Type I Deficiency
Dehydration OMIM:203400
Corticosterone Methyloxidase Type Ii Deficiency
Dehydration OMIM:610600
Pseudohypoaldosteronism, Type I, Autosomal Recessive
Dehydration OMIM:264350
Supranuclear Palsy, Progressive, 1
Gait imbalance, Frontolimbic dementia, Akinesia, Apathy, Falls, Memory impairment, Irritability OMIM:601104
Glucose/Galactose Malabsorption
Hypertonic dehydration OMIM:606824
Intellectual Developmental Disorder With Language Impairment And Early-Onset Dopa-Responsive Dystonia-Parkinsonism
Akinesia, Freezing of gait OMIM:619911
Myopathy, Congenital, With Respiratory Insufficiency And Bone Fractures
Akinesia OMIM:618822
Arthrogryposis, Renal Dysfunction, And Cholestasis 1
Dehydration, Oligohydramnios OMIM:208085
3-Hydroxy-3-Methylglutaric Aciduria
Dehydration, Apathy, Edema, Ataxia ORPHA:20
Pseudohypoaldosteronism, Type I, Autosomal Dominant
Dehydration OMIM:177735
Lissencephaly Type Iii And Bone Dysplasia
Akinesia OMIM:601160
Childhood Absence Epilepsy
Abnormal social behavior, Depression, Anxiety, Low self esteem, Attention deficit hyperactivity d... ORPHA:64280
Dehydration ORPHA:213
Methylmalonic Aciduria Due To Methylmalonyl-Coa Mutase Deficiency
Dehydration OMIM:251000
Pyruvate Carboxylase Deficiency
Dehydration, Poor eye contact, Apathy, Ataxia ORPHA:3008
Early-Onset Familial Hypoaldosteronism
Dehydration ORPHA:556030
Methylmalonic Acidemia With Homocystinuria, Type Cblc
Ataxia, Mental deterioration, Dehydration, Hydrops fetalis, Memory impairment, Dementia ORPHA:79282
Netherton Syndrome
Dehydration ORPHA:634
Arthrogryposis Multiplex Congenita 6
Akinesia OMIM:619334
Dehydration, Irritability ORPHA:173
Secondary Short Bowel Syndrome
Dehydration ORPHA:95427
Generalized Pseudohypoaldosteronism Type 1
Dehydration ORPHA:171876
Disseminated Sclerosis With Narcolepsy
Narcolepsy OMIM:223300
Gaucher Disease, Perinatal Lethal
Akinesia, Apathy, Progressive neurologic deterioration OMIM:608013
Lethal Congenital Contracture Syndrome 2
Akinesia OMIM:607598
Proliferative Vasculopathy And Hydranencephaly-Hydrocephaly Syndrome
Akinesia OMIM:225790
Wolcott-Rallison Syndrome
Dehydration, Ascites ORPHA:1667
Diarrhea 1, Secretory Chloride, Congenital
Polyhydramnios, Dehydration OMIM:214700
Hyperchlorhidrosis, Isolated
Hypernatremic dehydration OMIM:143860
Metachromatic Leukodystrophy, Adult Form
Progressive psychomotor deterioration, Abnormal social behavior, Depression, Memory impairment, C... ORPHA:309271
Myopathy, Congenital, Compton-North
Akinesia OMIM:612540
Neuroleptic Malignant Syndrome
Dehydration, Anxiety, Chorea ORPHA:94093
Glucose-Galactose Malabsorption
Dehydration ORPHA:35710
Adrenal Hypoplasia, Congenital
Dehydration OMIM:300200
Microvillus Inclusion Disease
Dehydration ORPHA:2290
Autosomal Dominant Cerebellar Ataxia
Akinesia, Progressive cerebellar ataxia, Cognitive impairment, Gait disturbance, Choreoathetosis,... ORPHA:99
Neurodegeneration With Brain Iron Accumulation 1
Akinesia, Ataxia, Hyperactivity, Depression, Mental deterioration, Gait disturbance, Choreoatheto... OMIM:234200
Methylmalonic Aciduria, Cblb Type
Dehydration OMIM:251110
Narcolepsy 3
Narcolepsy OMIM:609039
Methylmalonic Aciduria, Cbla Type
Dehydration OMIM:251100
Narcolepsy 1
Narcolepsy OMIM:161400
Narcolepsy 7
Narcolepsy OMIM:614250
Renal Hypoplasia
Dehydration ORPHA:93101
Dend Syndrome
Dehydration ORPHA:79134
Lysosomal Acid Lipase Deficiency
Dehydration, Ascites, Psychomotor deterioration, Cognitive impairment ORPHA:275761
Multiple Pterygium Syndrome, Lethal Type
Akinesia OMIM:253290
Metachromatic Leukodystrophy, Juvenile Form
Emotional lability, Progressive gait ataxia, Progressive psychomotor deterioration, Abnormal soci... ORPHA:309263
Shiga Toxin-Associated Hemolytic Uremic Syndrome
Dehydration, Irritability ORPHA:90038
Fetal Akinesia Deformation Sequence
Akinesia ORPHA:994
Osteootohepatoenteric Syndrome
Dehydration OMIM:619377
Infantile Nephropathic Cystinosis
Dehydration, Cognitive impairment ORPHA:411629
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Narcolepsy, Self-injurious behavior, Depression, Aggressive behavior, Emotional lability, Impaire... ORPHA:293987
Congenital Adrenal Hyperplasia Due To 3-Beta-Hydroxysteroid Dehydrogenase Deficiency
Dehydration ORPHA:90791
Dopamine Beta-Hydroxylase Deficiency
Dehydration ORPHA:230
Lamb-Shaffer Syndrome
Ataxia, Abnormal social behavior ORPHA:530983
Dehydration ORPHA:2260
Netherton Syndrome
Angioedema, Hypernatremic dehydration OMIM:256500
Bartter Syndrome Type 4
Polyhydramnios, Dehydration, Emotional lability ORPHA:89938
Oculocerebrorenal Syndrome Of Lowe
Joint swelling, Self-injurious behavior, Depression, Dehydration, Anxiety ORPHA:534
African Trypanosomiasis
Narcolepsy, Apathy, Akinesia, Anxiety, Gait disturbance, Difficulty walking, Choreoathetosis, Agg... ORPHA:3385
Leukoencephalopathy, Progressive, Infantile-Onset, With Or Without Deafness
Akinesia OMIM:619147
Bartter Syndrome, Type 3
Dehydration OMIM:607364
Colchicine Poisoning
Dehydration ORPHA:31824
Dehydration ORPHA:810
Isolated Permanent Neonatal Diabetes Mellitus
Dehydration, Ataxia ORPHA:99885
Metachromatic Leukodystrophy, Late Infantile Form
Emotional lability, Gait ataxia, Progressive gait ataxia, Abnormal social behavior ORPHA:309256
Pearson Syndrome
Corneal stromal edema, Dehydration, Hydrops fetalis, Ataxia ORPHA:699
Pearson Marrow-Pancreas Syndrome
Dehydration, Hydrops fetalis OMIM:557000
Non-Progressive Cerebellar Ataxia With Intellectual Disability
Ataxia, Dysmetria, Abnormal social behavior, Palpebral edema, Nonprogressive cerebellar ataxia, M... ORPHA:314647
Head-banging, Inability to walk, Ataxia, Akinesia, Emotional blunting, Aggressive behavior ORPHA:86309
Marburg Hemorrhagic Fever
Dysesthesia, Dehydration, Aggressive behavior ORPHA:99826
46,Xy Disorder Of Sex Development-Adrenal Insufficiency Due To Cyp11A1 Deficiency
Dehydration ORPHA:168558
Inherited Isolated Adrenal Insufficiency Due To Partial Cyp11A1 Deficiency
Dehydration ORPHA:289548
Dehydration, Ascites ORPHA:97282
Bartter Syndrome, Type 1, Antenatal
Paresthesia, Polyhydramnios, Dehydration OMIM:601678
Paternal Uniparental Disomy Of Chromosome 6
Dehydration, Oligohydramnios ORPHA:96191
48,Xxxy Syndrome
Abnormal aggressive, impulsive or violent behavior, Anxiety, Irritability, Abnormal social behavior ORPHA:96263
Hyperoxaluria, Primary, Type I
Dehydration OMIM:259900
Cystinosis, Nephropathic
Dehydration, Progressive neurologic deterioration OMIM:219800
Distal Renal Tubular Acidosis
Dehydration ORPHA:18
Bartter Syndrome, Type 2, Antenatal
Paresthesia, Polyhydramnios, Dehydration OMIM:241200
Juvenile Nephropathic Cystinosis
Dehydration ORPHA:411634
Nephrogenic Diabetes Insipidus
Polyhydramnios, Hypernatremic dehydration ORPHA:223
Dehydration ORPHA:2552
Arthrogryposis Multiplex Congenita 5
Akinesia OMIM:618947
Severe Generalized Junctional Epidermolysis Bullosa
Dehydration, Edema ORPHA:79404
Multiple Endocrine Neoplasia Type 1
Depression, Dehydration ORPHA:652
Primary Fanconi Renotubular Syndrome
Dehydration ORPHA:3337
Proximal Renal Tubular Acidosis
Dehydration ORPHA:47159
Prader-Willi Syndrome Due To Translocation
Happy demeanor, Head-banging, Abnormal social behavior, Anxiety, Impaired social interactions, Ol... ORPHA:177907
Cystic Fibrosis
Dehydration OMIM:219700
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Dehydration ORPHA:90794
Fg Syndrome Type 1
Abnormal social behavior ORPHA:93932
Dihydropyrimidine Dehydrogenase Deficiency
Abnormal aggressive, impulsive or violent behavior, Irritability, Abnormal social behavior ORPHA:1675
Tuberous Sclerosis Complex
Impulsivity, Self-injurious behavior, Abnormal social behavior, Depression, Anxiety, Aggressive b... ORPHA:805
Mend Syndrome
Aggressive behavior, Abnormal social behavior ORPHA:401973
Koolen-De Vries Syndrome Due To A Point Mutation
Overfriendliness, Inappropriate laughter, Anxiety, Abnormal social behavior ORPHA:363965
17Q21.31 Microdeletion Syndrome
Overfriendliness, Inappropriate laughter, Anxiety, Abnormal social behavior ORPHA:363958
Williams Syndrome
Overfriendliness, Ataxia, Dysmetria, Abnormal social behavior, Depression, Anxiety, Periorbital e... ORPHA:904


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lrrc7

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lrrc7.

There are 6 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Lrrc71tm1a(KOMP)Wtsi PMC7263671
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Lrrc71tm1a(KOMP)Wtsi PMC7338221
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Lrrc71tm1a(KOMP)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Lrrc71tm1a(KOMP)Wtsi