Grhl3 | grainyhead like transcription factor 3

GeneMGI:2655333Synonyms: ct, Som, +1 more

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Vision/eye Behavior/neurological Mortality/aging

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:12Significant phenotypes
6Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased circulating triglyceride level1 supporting datasetGrhl3tm1a(EUCOMM)WtsiheterozygoteEarly adult7.71x10-6 
increased circulating calcium level1 supporting datasetGrhl3tm1a(EUCOMM)WtsiheterozygoteEarly adult1.6x10-5 
increased startle reflex1 supporting datasetGrhl3tm1a(EUCOMM)WtsiheterozygoteEarly adult2.21x10-6 
decreased circulating alkaline phosphatase level1 supporting datasetGrhl3tm1a(EUCOMM)WtsiheterozygoteEarly adult3.28x10-10 
increased circulating glucose level1 supporting datasetGrhl3tm1a(EUCOMM)WtsiheterozygoteEarly adult2.76x10-7 
increased circulating phosphate level1 supporting datasetGrhl3tm1a(EUCOMM)WtsiheterozygoteEarly adult3.67x10-7 
preweaning lethality, complete penetrance1 supporting datasetGrhl3tm1a(EUCOMM)WtsihomozygoteEarly adultN/A * 
abnormal eye morphology1 supporting datasetGrhl3tm1a(EUCOMM)WtsiheterozygoteEarly adult1.22x10-5 
decreased blood urea nitrogen level1 supporting datasetGrhl3tm1a(EUCOMM)WtsiheterozygoteEarly adult3.92x10-6 
abnormal retina morphology2 supporting datasetsGrhl3tm1a(EUCOMM)WtsiheterozygoteEarly adult3.66x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Grhl3tm1(EGFP_CreERT2)WtsiReporter-tagged deletion allele (with selection cassette)ES Cell
Grhl3tm1.1(EGFP_CreERT2)WtsiReporter-tagged deletion allele (post Cre, with no selection cassette)ES Cell
Grhl3tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Grhl3tm2(EGFP_CreERT2)WtsiReporter-tagged deletion allele (with selection cassette)ES Cell
Grhl3tm2a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Grhl3tm2e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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