Ago1 | argonaute RISC catalytic subunit 1
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging
15 No significant impact
4 Not tested
Data collections
Gene metrics:8Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
decreased body weight | 4 supporting datasets | Ago1tm1a(KOMP)Wtsi | homozygote | Early adult | 5.58x10-10 | ||
preweaning lethality, incomplete penetrance | 1 supporting dataset | Ago1tm1a(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
increased lactate dehydrogenase level | 1 supporting dataset | Ago1tm1a(KOMP)Wtsi | homozygote | Early adult | 3.07x10-7 | ||
increased circulating LDL cholesterol level | 1 supporting dataset | Ago1tm1a(KOMP)Wtsi | homozygote | Early adult | 5.14x10-7 | ||
abnormal behavior | 1 supporting dataset | Ago1tm1a(KOMP)Wtsi | homozygote | Early adult | 5.22x10-5 | ||
increased circulating cholesterol level | 1 supporting dataset | Ago1tm1a(KOMP)Wtsi | homozygote | Early adult | 1.56x10-5 | ||
increased hematocrit | 1 supporting dataset | Ago1tm1a(KOMP)Wtsi | homozygote | Early adult | 2.9x10-5 | ||
increased circulating alanine transaminase level | 1 supporting dataset | Ago1tm1a(KOMP)Wtsi | homozygote | Early adult | 2.87x10-5 |
| | | | | | | | | |
adrenal gland | heterozygote | n/a | 50% (1/2) | 0.7% (4/570) |
aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
cartilage tissue | heterozygote | n/a | 50% (1/2) | 0.22% (1/454) |
cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
External links
No external links available for Ago1.
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Ago1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Ago1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
Ago1tm36769(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |