Fnip1 | folliculin interacting protein 1

GeneMGI:2444668Synonyms: A730024A03Rik

Physiological systems

23 / 24 physiological systems tested

13 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Integument Endocrine/exocrine gland Growth/size/body region Muscle Digestive/alimentary Respiratory system Liver/biliary system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

10 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:41Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal heart morphology2 supporting datasetsFnip1em1(IMPC)CcpczhomozygoteEarly adultN/A * 
increased lung compliance2 supporting datasetsFnip1em1(IMPC)CcpczhomozygoteEarly adult4.42x10-10 
decreased airway resistance3 supporting datasetsFnip1em1(IMPC)CcpczhomozygoteEarly adult1.6x10-8 
increased thigmotaxis4 supporting datasetsFnip1em1(IMPC)CcpczhomozygoteEarly adult1.46x10-5 
decreased grip strength4 supporting datasetsFnip1em1(IMPC)CcpczhomozygoteEarly adult4.2x10-9 
abnormal spleen morphology2 supporting datasetsFnip1em1(IMPC)CcpczhomozygoteEarly adultN/A * 
decreased body weight1 supporting datasetFnip1em1(IMPC)CcpczhomozygoteEarly adult2.13x10-5 
decreased lymphocyte cell number1 supporting datasetFnip1em1(IMPC)CcpczhomozygoteEarly adult1.12x10-12 
decreased respiratory quotient1 supporting datasetFnip1em1(IMPC)CcpczhomozygoteEarly adult6.71x10-6 
abnormal skeletal muscle morphology1 supporting datasetFnip1em1(IMPC)CcpczhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* Does not have a P-value assigned because it was manually marked as significant.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Fnip1em1(IMPC)CcpczInter-exon deletionmouse
Fnip1tm50343(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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