Tbl1xr1 | transducin (beta)-like 1X-linked receptor 1
Physiological systems
23 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Integument Endocrine/exocrine gland Growth/size/body region Digestive/alimentary Hearing/vestibular/ear Liver/biliary system Behavior/neurological Mortality/aging Cardiovascular system
12 No significant impact
1 Not tested
Data collections
Gene metrics:12Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
enlarged ovary | 1 supporting dataset | Tbl1xr1tm1b(EUCOMM)Hmgu | heterozygote | Late adult | N/A * | ||
enlarged cecum | 1 supporting dataset | Tbl1xr1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | N/A * | ||
decreased circulating HDL cholesterol level | 1 supporting dataset | Tbl1xr1tm1b(EUCOMM)Hmgu | heterozygote | Late adult | 7.33x10-5 | ||
preweaning lethality, incomplete penetrance | 1 supporting dataset | Tbl1xr1tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
abnormal liver morphology | 1 supporting dataset | Tbl1xr1tm1b(EUCOMM)Hmgu | heterozygote | Late adult | N/A * | ||
increased heart weight | 1 supporting dataset | Tbl1xr1tm1b(EUCOMM)Hmgu | heterozygote | Late adult | 4.23x10-7 | ||
increased circulating phosphate level | 1 supporting dataset | Tbl1xr1tm1b(EUCOMM)Hmgu | heterozygote | Late adult | 1.05x10-12 | ||
increased blood urea nitrogen level | 1 supporting dataset | Tbl1xr1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.03x10-5 | ||
abnormal auditory brainstem response | 1 supporting dataset | Tbl1xr1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.05x10-5 | ||
increased heart weight | 1 supporting dataset | Tbl1xr1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.81x10-6 |
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External links
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Tbl1xr1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Tbl1xr1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
Tbl1xr1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |