Tbl1xr1 | transducin (beta)-like 1X-linked receptor 1

GeneMGI:2441730Synonyms: C21, 8030499H02Rik, +5 more

Physiological systems

23 / 24 physiological systems tested

11 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Integument Endocrine/exocrine gland Growth/size/body region Digestive/alimentary Hearing/vestibular/ear Liver/biliary system Behavior/neurological Mortality/aging Cardiovascular system

12 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:12Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

enlarged ovary1 supporting datasetTbl1xr1tm1b(EUCOMM)HmguheterozygoteLate adultN/A * 
enlarged cecum1 supporting datasetTbl1xr1tm1b(EUCOMM)HmguheterozygoteEarly adultN/A * 
decreased circulating HDL cholesterol level1 supporting datasetTbl1xr1tm1b(EUCOMM)HmguheterozygoteLate adult7.33x10-5 
preweaning lethality, incomplete penetrance1 supporting datasetTbl1xr1tm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
abnormal liver morphology1 supporting datasetTbl1xr1tm1b(EUCOMM)HmguheterozygoteLate adultN/A * 
increased heart weight1 supporting datasetTbl1xr1tm1b(EUCOMM)HmguheterozygoteLate adult4.23x10-7 
increased circulating phosphate level1 supporting datasetTbl1xr1tm1b(EUCOMM)HmguheterozygoteLate adult1.05x10-12 
increased blood urea nitrogen level1 supporting datasetTbl1xr1tm1b(EUCOMM)HmguheterozygoteEarly adult1.03x10-5 
abnormal auditory brainstem response1 supporting datasetTbl1xr1tm1b(EUCOMM)HmguhomozygoteEarly adult2.05x10-5 
increased heart weight1 supporting datasetTbl1xr1tm1b(EUCOMM)HmguheterozygoteEarly adult1.81x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Tbl1xr1tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Tbl1xr1tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Tbl1xr1tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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